CN107693657B - 治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法 - Google Patents

治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法 Download PDF

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CN107693657B
CN107693657B CN201710918523.8A CN201710918523A CN107693657B CN 107693657 B CN107693657 B CN 107693657B CN 201710918523 A CN201710918523 A CN 201710918523A CN 107693657 B CN107693657 B CN 107693657B
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马力
王维蔚
齐燕松
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Tianjin Shanji Hongxing Technology Development Co ltd
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Abstract

一种治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：生地黄9‑24、当归6‑15、赤芍9‑24、川芎6‑15、桃仁6‑15、红花6‑15、牡丹皮6‑15、紫草6‑15、仙鹤草12‑32、茜草9‑24、香附6‑15、生甘草4‑10。本发明制剂是采用水煮提取的方法来提取原料药物中有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，且有助于药物的吸收，从而能提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。

Description

治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法。
背景技术
非过敏性紫癜是由于各种非过敏病因和疾病所引起的以血管异常为特征的一种出血性疾病，临床上多表现为：皮肤紫癜或瘀斑，粘膜或内脏出血(不多见)，毛细血管脆性试验可为阳性，凝血功能、血小板计数、血小板功能等检查一般为正常。引起非过敏性紫癜的病因和疾病甚多，类似中医学“肌衄”病的记载。虽然目前临床上用于治疗非过敏性紫癜的药物品种较多，但由于导致非过敏性紫癜的因素有多种，而且非过敏性紫癜也分多种类型，因此这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于瘀血阻络所致的非过敏性紫癜这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法。
为了达到上述目的，本发明提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001426161730000011
所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
非过敏性紫癜症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于清热化湿，凉血止血。方中生地黄甘苦寒，清热凉血，养阴生津，是清热凉血止血之要药，故为君药。当归甘辛温，补血，活血止痛；川芎辛温，活血行气，祛风止痛；红花辛温，活血通经，祛瘀止痛；紫草甘咸寒，清热凉血，活血，解毒透疹；茜草苦寒，凉血化瘀止血，通经，以上诸药，行气补血，活血化瘀，共为臣药。赤芍苦微寒，清热凉血，散瘀止痛，善清泻肝火，凉血止血；桃仁苦甘平，活血祛瘀；牡丹皮苦甘微寒，清热凉血，活血祛瘀；仙鹤草苦涩平，收敛止血，补虚；香附辛微苦微甘温，疏肝解郁，调经止痛，理气调中，以上诸药，清热凉血，活血化瘀理气补虚，为佐药。生甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方清热解毒，燥湿利水，同时凉血止血，故适用于治疗瘀血阻络所致的非过敏性紫癜。
下面结合实施例对本发明提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法进行详细说明。
实施例1：
本实施例提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001426161730000031
所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001426161730000032
制备方法同实施例1。
实施例3：
本实施例提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂由用量为重量比的下列药物原料制成：
Figure BDA0001426161730000041
制备方法同实施例1。
本发明提供的治疗瘀血阻络所致非过敏性紫癜的复方制剂呈棕色至棕黄色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对350例患有瘀血阻络型非过敏性紫癜的患者进行了系统临床观察，其中21-30岁患者104例，31-40岁145例，41-50岁101例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)149例，占42.6％；有效(主要症状有改善)145例，占41.4％；无效(主要症状无改善)56例，占16.0％；总有效率为84.0％。经2个疗程治疗后共治愈266例，占76.0％；有效71例，占20.3％；无效13例，占3.7％；总有效率为96.3％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
Figure BDA0001426161730000042
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗瘀血阻络型非过敏性紫癜，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
Figure BDA0001426161730000051
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗瘀血阻络型非过敏性紫癜，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种治疗瘀血阻络所致非过敏性紫癜的复方制剂，其特征在于：所述的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄9-24 当归6-15 赤芍9-24 川芎6-15 桃仁6-15
红花6-15 牡丹皮6-15 紫草6-15 仙鹤草12-32 茜草9-24
香附6-15 生甘草4-10。
2.一种如权利要求1所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂的制备方法，其特征在于：所述的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的治疗瘀血阻络所致非过敏性紫癜的复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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