CN107137488A - 一种抗骨关节炎的复方白蚁巢颗粒 - Google Patents
一种抗骨关节炎的复方白蚁巢颗粒 Download PDFInfo
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Abstract
本发明公开了一种抗骨关节炎的复方白蚁巢颗粒，所述的白蚁巢颗粒的配方为：白蚁巢提取物5～20份、薄荷3～4份、菊花2～5份、麦芽糊精5～6份、红糖1～3份、陈皮2～5份、甘草6～7份、党参2～3份、黄芪1～3份。本发明所提供的制备方法所得到的白蚁巢颗粒，可以增进饮食，恢复体力，提高机体应激能力和机体免疫能力，有效的抗骨关节炎。
Description
技术领域
本发明属于药物制备技术领域，具体涉及一种抗骨关节炎的复方白蚁巢颗粒。
背景技术
风湿性关节炎是一种常见的急性或慢性结缔组织炎症，可反复发作并累及心脏，临床以关节和肌肉游走性酸楚、重著、疼痛为特征，属变态反应性疾病，是风湿热的主要表现之一，多以急性发热及关节疼痛起病。
典型风湿性关节炎表现是轻度或中度发热，游走性多关节炎，受累关节多为膝、踝、肩、肘、腕等大关节，常见由一个关节转移至另一个关节，病变局部呈现红、肿、灼热、剧痛，部分病又也有几个关节同吋发病。不典型的病人仅有关节疼痛而无其他炎症表现，急性炎症一般于2-4周消退，不留后遗症，但常反复发作。若风湿活动影响心脏，则可发生心肌炎，甚至遗留心脏瓣膜病变。
类风湿关节炎(RA)是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病，其特征是手、足小关节的多关节、对称性、侵袭性关节炎症，经常伴有关节外器官受累及血清类风湿因子阳性，可以导致关节畸形及功能丧失。
已报道的治疗风湿性及类风湿关节炎的化学药物大多具有副作用，传统的中成药也有很多报道，但其药物组方成分较多且比较复杂。
白蚁巢，俗称“白蚁坭”，是褐色或棕色的疏松坭块，是工蚁建巢时从巢内搬出的沙坭、加上排泄物和唾液加工的物质。排积物通常堆积在巢的外围。如门框两旁、梁或柱与墙地交接处。大树基部或树基近地面稍下有蚁巢。在树干上或树枝分叉处往往就有白蚁的排积物。
白蚁巢中的菌圃，是由白蚁的排泄物，经细致加工并经接种培养出白球菌而成的多孔块状物，是白蚁赖以生存而不可缺少的，缺少了则巢中的蚁群便会死亡。菌圃营养丰富，是鸡纵菌生长发育的最佳培养基。据《本草纲目》中记载：鸡纵菌气味“甘平，无毒”。主治“益胃、清神、治痔”。近年来的研究证明，鸡纵菌菌中含有16种氨基酸，是十分珍贵的药物。据分析，菌圃中含有16.5％的蛋白质，4％的多缩戊糖，20.91％的灰分，并含有亮氨酸、缬氨酸、酪氨酸、脯氨酸、丙氨酸、苏氨酸、精氨酸、赖氨酸、谷氨酸、天门冬氨酸等10种氨基酸。这些氨基酸对治疗疾病有着不可低估的药用价值。然而，现有技术中，关于白蚁巢的应用并不多。
发明内容
发明目的：本发明针对现有技术中的不足，提供了一种抗骨关节炎的复方白蚁巢颗粒。
技术方案：本发明公开了一种抗骨关节炎的复方白蚁巢颗粒，所述的白蚁巢颗粒的配方为：白蚁巢提取物、薄荷、菊花、陈皮、甘草、党参、黄芪、红糖、麦芽糊精。
所述的白蚁巢颗粒的配方为：白蚁巢提取物5～20份、薄荷3～4份、菊花2～5份、麦芽糊精5～6份、红糖1～3份、陈皮2～5份、甘草6～7份、党参2～3份、黄芪1～3份。
所述的复方白蚁巢颗粒通过如下方法得到：将白蚁巢提取物，与薄荷、菊花、陈皮、甘草、党参、黄芪一起煎煮，再进行浓缩，得到浓缩液，向浓缩液中加入红糖搅拌均匀后再加入麦芽糊精，造粒，得到复方白蚁巢颗粒。
所述的白蚁巢提取物通过如下方法获得：将白蚁巢进行预处理，得到药液，将甘草浸湿，冷冻12小时后微波解冻，再重复冷冻解冻一次；二次解冻后，用70％的乙醇浸泡24小时，经过过滤，得到提取物。
所述的白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷3份、菊花2份、麦芽糊精5份、红糖1份、陈皮2份、甘草6份、党参2份、黄芪1份。
所述的白蚁巢颗粒的配方为：白蚁巢提取物20份、薄荷4份、菊花5份、麦芽糊精6份、红糖3份、陈皮5份、甘草7份、党参3份、黄芪3份。
7所述的白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷4份、菊花2份、麦芽糊精6份、红糖1份、陈皮5份、甘草6份、党参2份、黄芪1份。
有益效果：本发明所提供的制备方法所得到的白蚁巢颗粒，可以增进饮食，恢复体力，提高机体应激能力和机体免疫能力，有效的抗骨关节炎。
具体实施方式：
实施例1
白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷3份、菊花2份、麦芽糊精5份、红糖1份、陈皮2份、甘草6份、党参2份、黄芪1份。
将白蚁巢进行预处理，得到药液，将甘草浸湿，冷冻12小时后微波解冻，再重复冷冻解冻一次；二次解冻后，用70％的乙醇浸泡24小时，经过过滤，得到提取物。
将白蚁巢提取物，与薄荷、菊花、陈皮、甘草、党参、黄芪一起煎煮，再进行浓缩，得到浓缩液，向浓缩液中加入红糖搅拌均匀后再加入麦芽糊精，造粒，得到复方白蚁巢颗粒。
实施例2
白蚁巢颗粒的配方为：白蚁巢提取物20份、薄荷4份、菊花5份、麦芽糊精6份、红糖3份、陈皮5份、甘草7份、党参3份、黄芪3份。
将白蚁巢进行预处理，得到药液，将甘草浸湿，冷冻12小时后微波解冻，再重复冷冻解冻一次；二次解冻后，用70％的乙醇浸泡24小时，经过过滤，得到提取物。
将白蚁巢提取物，与薄荷、菊花、陈皮、甘草、党参、黄芪一起煎煮，再进行浓缩，得到浓缩液，向浓缩液中加入红糖搅拌均匀后再加入麦芽糊精，造粒，得到复方白蚁巢颗粒。
实施例3
白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷4份、菊花2份、麦芽糊精6份、红糖1份、陈皮5份、甘草6份、党参2份、黄芪1份。
将白蚁巢进行预处理，得到药液，将甘草浸湿，冷冻12小时后微波解冻，再重复冷冻解冻一次；二次解冻后，用70％的乙醇浸泡24小时，经过过滤，得到提取物。
将白蚁巢提取物，与薄荷、菊花、陈皮、甘草、党参、黄芪一起煎煮，再进行浓缩，得到浓缩液，向浓缩液中加入红糖搅拌均匀后再加入麦芽糊精，造粒，得到复方白蚁巢颗粒。
实验例
对大鼠关节炎的防治作用试验
取体重200-250g的大鼠，随机分配成空白组，云南白药膏的对照药物组，和本发明药物组(实施例1～实施例3)。对各组试验动物的左后足跖皮内注射0.05mlFreund’s的完全佐剂，致炎后第8天分别进行试验，连续给药4天进行贴敷。分别于致炎后第8天，第10天，第12天测左、后足容积，与正常值之差为肿胀度，对并大鼠的全身症状，如前肢、尾部、耳部的病变程度进行评分。
评分标准：0分为无红肿，1分为小趾关节肿胀，2分为趾关节和足跖肿胀；3分为踝关节以下足肿胀；4分为包括踝关节在内的全部足肿胀。
第12天后的试验结果如下表所示：
| 试验 | 肿胀度 |
| 空白组 | 2.41 |
| 对照药物组 | 1.71 |
| 实施例1 | 0.75 |
| 实施例2 | 0.81 |
| 实施例3 | 0.79 |
表明本发明的药物可以明显抑制大鼠关节炎，与空白组相比具有显著的差异性。
Claims (7)
1.一种抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢颗粒的配方中含有：白蚁巢提取物、薄荷、菊花、陈皮、甘草、党参、黄芪、红糖、麦芽糊精。
2.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢颗粒的配方为：白蚁巢提取物5～20份、薄荷3～4份、菊花2～5份、麦芽糊精5～6份、红糖1～3份、陈皮2～5份、甘草6～7份、党参2～3份、黄芪1～3份。
3.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的复方白蚁巢颗粒通过如下方法得到：将白蚁巢提取物，与薄荷、菊花、陈皮、甘草、党参、黄芪一起煎煮，再进行浓缩，得到浓缩液，向浓缩液中加入红糖搅拌均匀后再加入麦芽糊精，造粒，得到复方白蚁巢颗粒。
4.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢提取物通过如下方法获得：将白蚁巢进行预处理，得到药液，将甘草浸湿，冷冻12小时后微波解冻，再重复冷冻解冻一次；二次解冻后，用70％的乙醇浸泡24小时，经过过滤，得到提取物。
5.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷3份、菊花2份、麦芽糊精5份、红糖1份、陈皮2份、甘草6份、党参2份、黄芪1份。
6.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢颗粒的配方为：白蚁巢提取物20份、薄荷4份、菊花5份、麦芽糊精6份、红糖3份、陈皮5份、甘草7份、党参3份、黄芪3份。
7.根据权利要求1所述的抗骨关节炎的复方白蚁巢颗粒，其特征在于所述的白蚁巢颗粒的配方为：白蚁巢提取物5份、薄荷4份、菊花2份、麦芽糊精6份、红糖1份、陈皮5份、甘草6份、党参2份、黄芪1份。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310016A (zh) * | 2018-05-07 | 2018-07-24 | 胡彬 | 一种用于关节疼痛的外敷膏的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139553A (zh) * | 1995-06-30 | 1997-01-08 | 中国林业科学研究院森林保护研究所 | 包含白蚁种群及其主巢菌圃的药物组合物的应用 |
| CN102293825A (zh) * | 2011-08-29 | 2011-12-28 | 江苏苏南药业实业有限公司 | 一种复方白蚁巢及其制备方法 |
-
2017
- 2017-05-27 CN CN201710388385.7A patent/CN107137488A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1139553A (zh) * | 1995-06-30 | 1997-01-08 | 中国林业科学研究院森林保护研究所 | 包含白蚁种群及其主巢菌圃的药物组合物的应用 |
| CN102293825A (zh) * | 2011-08-29 | 2011-12-28 | 江苏苏南药业实业有限公司 | 一种复方白蚁巢及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 胡乔生；等: "白蚁菌圃有效药用成分的提取与应用研究", 《江西化工》 * |
| 高宁阳；等: "中药治疗骨关节炎的处方用药研究", 《中国中医骨伤科杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310016A (zh) * | 2018-05-07 | 2018-07-24 | 胡彬 | 一种用于关节疼痛的外敷膏的制备方法 |
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