CN107137464A - A kind of Chinese medicine composition for being exclusively used in environmental sheldrake - Google Patents
A kind of Chinese medicine composition for being exclusively used in environmental sheldrake Download PDFInfo
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- CN107137464A CN107137464A CN201710335625.7A CN201710335625A CN107137464A CN 107137464 A CN107137464 A CN 107137464A CN 201710335625 A CN201710335625 A CN 201710335625A CN 107137464 A CN107137464 A CN 107137464A
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- beach wormwood
- sheldrake
- chinese medicine
- false beach
- medicine composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The present invention relates to a kind of Chinese medicine composition for being exclusively used in environmental sheldrake, it is made up of false beach wormwood and pilose bushclover herb, the weight ratio of false beach wormwood and pilose bushclover herb is 1:1‑1:5.The present invention is also claimed to expect to mix the application fed by above-mentioned Chinese medicine composition with other feedings.Proved through experimental study, false beach wormwood is used in combination with pilose bushclover herb with specific part by weight, synergy is obvious, and evident in efficacy, cost is low；The purpose that prevention and control duck plague and ETEC catch can be achieved using antibiotic need not be reused after the present invention.
Description
Technical field
The invention belongs to sheldrake breeding technology field, more particularly to a kind of Chinese medicine composition for being exclusively used in environmental sheldrake,
For treating sheldrake disease caused by ETEC infection, and anti-duck plague.
Background technology
After sheldrake is infected by ETEC, easily trigger the multi-sections such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis
Position treating severe infectious diseases, huge economic loss is caused to sheldrake cultivation.The antibiotic such as Norfloxacin, Florfenicol are to prevent and treat this
The conventional Western medicine of class disease, as medication is more and more spread unchecked, its antibody-resistant bacterium is more and more more, and drug cost is also increasing, but
It is that therapeutic effect and resistance situation are not taken a turn for the better, goes from bad to worse on the contrary.
People, which begin look for some Chinese herbal medicines, to be used to reverse the drug resistance of antibiotic Western medicine, or attempt to filter out can be straight
Connect prevention or suppress the Chinese herbal medicine of ETEC.
Duck plague, also known as duck viral enteritis, are the urgency of a kind of duck as caused by duck plague virus, goose and a variety of Anseriformes birds
Raw, hot and septic deadly infectious disease.At present in addition to vaccine control, medicine there is no to treat.
False beach wormwood is Piperaceae platymiscium, is mainly distributed on the provinces such as China Guangdong, Guangxi, Hainan, happiness be born in mountain valley thick forest,
Moist shady place by rubber forest Zhong Huo villages.There are some researches show false beach wormwood has antipyretic-antalgic, anti-inflammatory, oxidation resistant effect, and its
Preferable broad-spectrum insecticidal activity is shown to the various plants such as aphid, prodenia litura, Brontispa longissima insect.On false beach wormwood to poultry
Fowl ETEC catches or the research of virus infection is not disclosed.
Pilose bushclover herb is the whole herb with root of legume pilose bushclover herb, with benefiting qi for tranquillization, promoting blood circulation and stopping pain, inducing diuresis to remove edema, removing toxic substances
The effect of dissipating bind.Fever due to deficiency of vital energy is cured mainly, is had a sleepless night, acute filthy disease stomachache, arthralgia pain due to rheumatism, oedema, scrofula, swollen ulcer drug.
Through retrieval, not inquiring to combine pilose bushclover herb and false beach wormwood is used to treat sheldrake and be infected by ETEC to cause
Disease relevant report, do not inquire yet be united and applied in prevention duck plague relevant report.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for being exclusively used in environmental sheldrake, it, which is cooperateed with, makees
With obvious, it is not necessary to reuse the purpose that prevention and control duck plague and ETEC infectious disease can be achieved in antibiotic.
To solve above technical problem, the present invention uses following technical scheme：A kind of Chinese medicine for being exclusively used in environmental sheldrake
Composition, is made up of false beach wormwood and pilose bushclover herb, and the weight ratio of false beach wormwood and pilose bushclover herb is 1:1-1:5.
Described weight ratio is fresh weight ratio.
The present invention is also claimed to expect to mix the application fed by above-mentioned Chinese medicine composition with other feedings.
The beneficial effect that the present invention possesses is：Proved through experimental study, false beach wormwood is joined with pilose bushclover herb with specific part by weight
Conjunction is used, and synergy is obvious, and evident in efficacy, cost is low.
Embodiment
Technical scheme and beneficial effect are described further with reference to specific embodiment, this embodiment
The false beach wormwood used is the blade and spray of false beach wormwood, and pilose bushclover herb is the blade and spray of pilose bushclover herb, and following part by weight is fresh weight
Than.
First, pilose bushclover herb and measure of the false beach wormwood to ETEC synergy
1. test medicine：
(1) false beach wormwood is smashed and takes juice, obtain false beach wormwood Normal juice；
(2) pilose bushclover herb is smashed and takes juice, obtain pilose bushclover herb Normal juice；
(3) false beach wormwood and pilose bushclover herb are first according to fresh weight 3:1 mixing, then smash and take juice, obtain mixed juice 1#；
(4) false beach wormwood and pilose bushclover herb are first according to fresh weight 2:1 mixing, then smash and take juice, obtain mixed juice 2#；
(5) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:1 mixing, then smash and take juice, obtain mixed juice 3#；
(6) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:2 mixing, then smash and take juice, obtain mixed juice 4#；
(7) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:3 mixing, then smash and take juice, obtain mixed juice 5#；
(8) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:4 mixing, then smash and take juice, obtain mixed juice 6#；
(9) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:5 mixing, then smash and take juice, obtain mixed juice 7#；
(10) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:6 mixing, then smash and take juice, obtain mixed juice 8#；
(11) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:7 mixing, then smash and take juice, obtain mixed juice 9#；
(12) false beach wormwood and pilose bushclover herb are first according to fresh weight 1:8 mixing, then smash and take juice, obtain mixed juice 10#.
(13) concentration is 10mg/g Amoxicillin decoction.
2. subjects：The ETEC of sheldrake infection.
3. test method：
MIC of each medicament to ETEC is determined using liquid coubling dilution.
Above-mentioned 13 kinds of medicaments, every kind of medicament takes 7 test tubes respectively, numbering 1-7, and every loads 1ml broth bouillons.
Be separately added into above-mentioned test medicine to each No. 1 test tube so that false beach wormwood Normal juice, pilose bushclover herb Normal juice and mixed juice 1#-10# just
Beginning concentration is 200mg/ml, and the initial concentration of Amoxicillin is 5mg/ml；After No. 1 test tube is well mixed, 1ml mixed liquors are taken extremely
No. 2 test tubes, draw 1ml mixed liquors to No. 6 test tubes by that analogy and cast out, complete doubling dilution；No. 7 test tubes are the blank of not dosing
Control.
It is 10 to add bacteria containing amount in the cultured E bacteria suspensions of 0.1ml, suspension to every test tube5CFU/ml。
Whole test tubes are placed in 37 DEG C, 24h are cultivated on 120r/min shaking table, the least concentration for not occurring muddiness is the medicament to big
The MIC of intestines Escherichia.
4. result of the test
MIC measurement result of each medicament to ETEC
Note："+" represents that long bacterium is muddy in upper table；"-" represents that not long bacterium does not occur muddiness.
As seen from the above table, false beach wormwood Normal juice and pilose bushclover herb Normal juice are 200mg/ml to the MIC of ETEC.And mixed
In juice, mix juice 1#, mixed juice 8# MIC and be more than 200mg/ml, illustrate that false beach wormwood compares 3 with pilose bushclover herb according to weight:1 and 1:6 mixing, table
It is now antagonism；Mixed juice 2#, mixed juice 10# MIC are 200mg/ml, illustrate that the two compares 2 according to weight:1 and 1:8 mixing interactions
Not substantially, it is showed only as summation action；(weight compares 1 to mixed juice 9#:7) MIC is reduced to 100mg/ml, shows certain collaboration and makees
With.
The MIC that mixed juice 3#- mixes juice 7# is reduced to 12.5mg/ml, shows obvious synergy；With Western medicine Amoxicillin
1.25mg/ml effect is suitable.
2nd, the experiment in vitro that false beach wormwood and pilose bushclover herb are used in combination
According to weight ratio it is 1 by false beach wormwood and pilose bushclover herb:2 mixing are used as test group；Separately set false beach wormwood single dose and pilose bushclover herb single dose
As a control group 1 and control group 2；Three groups of choppings are handled.
1. treat the experiment of duck E bacterial diseases
Subjects：Make a definite diagnosis the sheldrake group for having infected duck E bacterial diseases.
Test method：Morbidity duck group is divided into 3 groups, test group is mixed according to the feeding material addition 50g choppings of per kilogram coarse food grain
Thing is fed；Control group 1 is crushed false beach wormwood single dose according to per kilogram coarse food grain feeding material addition 50g and fed；Control group 2 according to
Per kilogram coarse food grain feeding material addition 50g crushes pilose bushclover herb single dose and fed；Coarse food grain feeding material is corn flour, green vegetables it is mixed
Compound；Each group is persistently fed 7 days.
Result of the test：The sick duck feed intake of test group increased, no death, all be fully recovered using duck group after 7 days；Control
The most of still wans of duck group of group 1, have 5% sick duck dead；It is also still wan that duck group of control group 2 is most of, there is 3%
Sick duck it is dead.
2. treat duck plague experiment
Fed according to per kilogram coarse food grain feeding material addition 50g chopping mixtures, monthly at least 1 time, duck plague epizootic modeling
Monthly feeding rises to 5-7 times；So far the method for breeding is implemented 5 years, never occurs duck plague.
Claims (3)
1. a kind of Chinese medicine composition for being exclusively used in environmental sheldrake, it is characterised in that be made up of false beach wormwood and pilose bushclover herb, false beach wormwood and iron
The weight ratio of horsewhip is 1:1-1:5.
2. the Chinese medicine composition according to claim 1 for being exclusively used in environmental sheldrake, it is characterised in that described weight ratio
For fresh weight ratio.
3. the Chinese medicine composition described in claim 1 or 2 mixes the application fed with other feeding material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710335625.7A CN107137464A (en) | 2017-05-12 | 2017-05-12 | A kind of Chinese medicine composition for being exclusively used in environmental sheldrake |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710335625.7A CN107137464A (en) | 2017-05-12 | 2017-05-12 | A kind of Chinese medicine composition for being exclusively used in environmental sheldrake |
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| CN107137464A true CN107137464A (en) | 2017-09-08 |
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| CN201710335625.7A Pending CN107137464A (en) | 2017-05-12 | 2017-05-12 | A kind of Chinese medicine composition for being exclusively used in environmental sheldrake |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107568495A (en) * | 2017-10-24 | 2018-01-12 | 天峨县平昌生态农业有限公司 | A kind of chicken feed addictive |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641493A (en) * | 2014-11-13 | 2016-06-08 | 天津市中敖饲料有限公司 | Duck plague treating traditional Chinese medicine composition and preparation method thereof |
-
2017
- 2017-05-12 CN CN201710335625.7A patent/CN107137464A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641493A (en) * | 2014-11-13 | 2016-06-08 | 天津市中敖饲料有限公司 | Duck plague treating traditional Chinese medicine composition and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107568495A (en) * | 2017-10-24 | 2018-01-12 | 天峨县平昌生态农业有限公司 | A kind of chicken feed addictive |
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Application publication date: 20170908 |
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