CN107132345A - A kind of biological chip reading apparatus - Google Patents
A kind of biological chip reading apparatus Download PDFInfo
- Publication number
- CN107132345A CN107132345A CN201710479474.2A CN201710479474A CN107132345A CN 107132345 A CN107132345 A CN 107132345A CN 201710479474 A CN201710479474 A CN 201710479474A CN 107132345 A CN107132345 A CN 107132345A
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- China
- Prior art keywords
- cleaning
- chip
- along
- reading apparatus
- drive mechanism
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
Abstract
The invention discloses a kind of biological chip reading apparatus, including support, liquid-transfering gun, first drive mechanism, material component, reagent refrigerating device, it is arranged at the material component and multiple chip incubating devices at the reagent refrigerating device rear, with the multiple chip incubating device is disposed adjacent washes needle device, it is set up in the multiple chip incubating device and the device for cleaning chip and its signal supervisory instrument washed above needle device, the second drive mechanism for driving the device for cleaning chip and the signal supervisory instrument back and forth movement, and it is arranged at the syringe needle collection device and waste collecting device of work top bottom.With this structure design, under driving effect by the first drive mechanism and the second drive mechanism, the a series of activities such as making, incubation, test and the cleaning of chip sample can be automatically performed, chip testing efficiency is greatly improved, effectively reduces test job amount.
Description
Technical field
The present invention relates to biochip technical field of measurement and test, more particularly to a kind of biological chip reading apparatus.
Background technology
Biological chip testing technology, is fixed on bio-chip substrate using fluorescence, biotin or other method mark
Biomolecule (such as DNA, RNA, protein molecular, antigen, antibody) target, and will be marked by building some special detection means
Note signal changes into the view data for being available for analyzing and processing, to obtain and analyze the life of the biomolecule on biochip
The various information such as thing, physics, chemistry, the time of day of diagnostic biomolecule.
Biochip test equipment is widely used in the fields such as scientific research, medicine, health, is to be used to catch and handle biological core
The instrument of piece image, traditional biochip supplies analysis has the following disadvantages：(1) automaticities are low, so that surveying
Examination is less efficient.(2) lacks necessary chip incubating device and cleaning device, it is impossible to be efficiently incubated, after use
Device is fast and effectively cleaned, so that cleaning efficiency is not high and not clean enough, and then to cause when reusing
Test result produces error.
The content of the invention
High, the time saving and energy saving biological chip reading apparatus it is an object of the invention to provide a kind of automaticity.
For up to this purpose, the present invention uses following technical scheme：
A kind of biological chip reading apparatus, including support, erection are with the liquid-transfering gun above the support, for driving the shifting
The first multi-shaft interlocked drive mechanism of liquid rifle, be arranged at the support work top material component, with the material component
The reagent refrigerating device that is disposed adjacent, it is arranged at the material component and multiple chips at the reagent refrigerating device rear are incubated
Device, be disposed adjacent with the multiple chip incubating device wash needle device, be set up in the multiple chip incubating device and wash
Device for cleaning chip and its signal supervisory instrument above needle device, for driving the device for cleaning chip and the signal to examine
Survey the second drive mechanism of device back and forth movement and be arranged at the syringe needle collection device and waste collection of work top bottom
Device.
Wherein, the material component include sample loading device, be arranged at the sample loading device side dilution position,
And the syringe needle box of dilution position side is arranged at, the side of the syringe needle box is provided with reagent refrigerating device.
Wherein, first drive mechanism includes first slide rail and institute of the parallel shelf located at the support two lateral walls
The first slide rail is stated to slide the second slide rail set and come and go the liquid-transfering gun slided along the second slide rail length direction,
First slide rail is set along the support Y direction, and second slide rail is set along the support X-direction.
Wherein, second drive device includes threeth cunning of the parallel shelf located at the multiple chip incubating device two ends
Rail, and the portal frame being slidably matched with the 3rd slide rail, the device for cleaning chip and signal supervisory instrument difference
It is arranged at the both sides of the crossbeam of the portal frame.
Wherein, the cross rail top of the portal frame is provided with first for driving the device for cleaning chip up and down motion
Motor, and the second motor for driving the signal supervisory instrument to move up and down.
Wherein, the device for cleaning chip includes being connected with first motor fixed mount, along the fixation
Frame one side short transverse slides up and down the wiper mechanism of setting and is arranged between the wiper mechanism and the fixed mount
Bolster；The wiper mechanism includes purge block, and is arranged at the purge block bottom surface and along the cleaning block length
The uniform cleaning needle in direction and waste liquid pin, the cleaning needle and the cleaning chamber insertion set along the purge block length direction insertion
Set, the waste liquid pin is set with the waste liquid chamber insertion set along the purge block length direction insertion, the cleaning chamber and institute
State waste liquid chamber to connect with corresponding external pump body phase, the two ends of the fixed mount one side are respectively along the fixed mount height side
To guide pillar is provided with, the purge block is slided with the guide pillar and set, and the bolster is set to spring, and the bolster is arranged
It is inconsistent in one end of the guide pillar and upper side with the purge block and/or downside.
Wherein, the signal supervisory instrument includes the test bracket fastened with second motor, and is set up in
Test probe assembly in the cavity of the test bracket；A test bracket at least cavity wall can with the test bracket
Offer and visited for adjusting the test along the test bracket length direction at the top of dismounting connection, the cavity of the test bracket
The elongated slot of needle assemblies installation site；The test probe assembly includes two probe fixed plates that parallel interval is set up and down, set
Support column between two probe fixed plate, along the uniform probe of the two probe fixed plates length direction and level
It is arranged at the limiting plate of multiple probe bottoms；The support column is arranged in pairs two in two probe fixed plate respectively
End, and it is located at the probe fixed plate of the top and the screw rod being arranged in elongated slot fastening.
Wherein, the chip incubating device includes being incubated platform, the heating plate for being embedded in the incubation platform bottom and temperature spy
Head, the 3rd drive mechanism for being arranged at described incubation platform one end, and be connected with the drive shaft of the 3rd drive mechanism
Lid is incubated, incubation platform length direction described in the incubation cover rim, which comes and goes to slide, to be set；3rd drive mechanism includes being anchored on
The supporting plate for being incubated you portion, the guide rail set along the supporting plate length direction, the supporting plate is arranged at away from institute
The one end for stating incubation platform is provided with stepper motor and comes and goes the silk braid that slip is set along the drive screw of the stepper motor,
The silk braid is fastened with the end for being incubated lid, and the lid that is incubated is fastened with the sliding block that the guide rail is slidably matched.
Wherein, the reagent refrigerating device includes refrigerating box, the refrigeration lid being arranged at the top of the refrigerating box, is arranged at institute
Stating refrigerating box side is used for the 4th drive mechanism of the refrigeration lid automatic open-close and is arranged at the system of the refrigerating box bottom
Cold structure, the side wall of the refrigeration lid and the refrigerating box is hinged；The refrigerating box is provided with multiple refrigeration cavitys, described
Refrigerate and be provided through osculum between the bottom of cavity and the side wall of the refrigerating box；The refrigeration mechanism includes being brought into close contact
Cooling piece in the refrigerating box bottom surface, the fin being arranged at below the cooling piece and it is arranged at the fin
The fan of lower section.
Wherein, the needle device of washing includes cleaning block body, giving up along the cleaning Block body length direction insertion setting
Sap cavity and water-injecting cavity and multiple clean-out openings along the cleaning Block body length direction uniformly, the clean-out opening are arranged at institute
The top of cleaning block body is stated, the multiple clean-out opening is set with the waste liquid chamber and water-injecting cavity insertion, the clean-out opening bag
Include along the first clean-out opening for being vertically arranged of cleaning block body, and be arranged at the first clean-out opening bottom hole and with the waste liquid chamber
The second clean-out opening that insertion is set, the diameter of first clean-out opening is more than the diameter of second clean-out opening, and described first is clear
The bottom hole of hole flushing is provided with being sheathed on the sphere that the bulb stopper of waste liquid pin periphery is engaged.
Beneficial effects of the present invention：The present invention is including support, erection with the liquid-transfering gun above the support, for driving
State the first multi-shaft interlocked drive mechanism of liquid-transfering gun, be arranged at the support work top material component, with the material
Reagent refrigerating device that component is disposed adjacent, the multiple chips for being arranged at the material component and the reagent refrigerating device rear
Incubating device, be disposed adjacent with the multiple chip incubating device wash needle device, be set up in the multiple chip incubating device
And wash above needle device device for cleaning chip and its signal supervisory instrument, for driving the device for cleaning chip and the letter
Second drive mechanism of number detection means back and forth movement and the syringe needle collection device and waste liquid for being arranged at work top bottom
Collection device.With this structure design, under the driving effect by the first drive mechanism and the second drive mechanism, it can be automatically performed
The a series of activities such as making, incubation, test and the cleaning of chip sample, are greatly improved chip testing efficiency, effectively drop
Low test job amount.
Brief description of the drawings
Fig. 1 is a kind of axonometric drawing of biological chip reading apparatus of the invention.
Fig. 2 is the axonometric drawing of the second drive mechanism in Fig. 1.
Fig. 3 is the axonometric drawing of Fig. 1 chips cleaning devices.
Fig. 4 is the axonometric drawing of signal supervisory instrument in Fig. 1.
Fig. 5 is the axonometric drawing of Fig. 1 chips incubating devices.
Fig. 6 is the axonometric drawing of reagent cold storage plant in Fig. 1.
Fig. 7 is the front view that needle device is washed in Fig. 1.
Fig. 8 is the sectional view in AA sections in Fig. 7.
Fig. 9 is the axonometric drawing that needle device is washed in Fig. 1.
Figure 10 is the axonometric drawing of waste collecting device in Fig. 1.
Embodiment
Further illustrate technical scheme below in conjunction with the accompanying drawings and by embodiment.
As shown in Figure 1 to Figure 2, a kind of biological chip reading apparatus in the present embodiment, including support 1, erection and the support 1
The liquid-transfering gun 2 of top, the work for driving the first multi-shaft interlocked drive mechanism 3 of the liquid-transfering gun 2, being arranged at the support 1
The material component of making table top, the reagent refrigerating device 4 being disposed adjacent with the material component, it is arranged at the material component and institute
State the rear of reagent refrigerating device 4 multiple chip incubating devices 5, with the multiple chip incubating device 5 is disposed adjacent washes pin
Device 6, the device for cleaning chip 8 for being set up in the multiple chip incubating device 5 and washing the top of needle device 6 and its signal detection dress
Put 7, the second drive mechanism 9 for driving the device for cleaning chip 8 and the back and forth movement of the signal supervisory instrument 7 and
It is arranged at the syringe needle collection device 11 and waste collecting device 12 of work top bottom.
Specifically, the material component includes sample loading device 13, is arranged at the side of sample loading device 13
Dilution position 14 and the syringe needle box 15 for being arranged at dilution position side, the side of the syringe needle box 15 is provided with reagent refrigerating
Device 4.
In the present embodiment, as shown in figure 1, first drive mechanism 3, which includes parallel shelf, is located at the opposite sides of support 1
First slide rail 31 of wall, the second slide rail 32 for setting is slided with first slide rail 31 and along the length of the second slide rail 32
Direction comes and goes the liquid-transfering gun 2 slided, and Y direction of first slide rail 31 along the support 1 is set, second slide rail
32 are set along the X-direction of the support 1, afterwards with reference to the up and down motion of liquid-transfering gun, realize liquid-transfering gun above support table top
Three-shaft linkage.
With reference to shown in Fig. 2, second drive device includes parallel shelf located at the multiple two ends of chip incubating device 5
3rd slide rail 91, and the portal frame 92 being slidably matched with the 3rd slide rail, device for cleaning chip 8 and the signal inspection
The both sides that device 7 is respectively arranged at the crossbeam of the portal frame are surveyed, further, the cross rail top of the portal frame 92 is provided with
For the first motor 93 for driving the device for cleaning chip 8 to move up and down, and for driving the signal detection to fill
Put the second motor 94 of 7 up and down motions.In the present embodiment, the side relative with the 3rd slide rail 91 is provided with for portal frame
The guide rod 95 slided is come and gone, the effect for the timing belt that portal frame is driven by the 3rd motor 97 of driving is past along the 3rd slide rail
Return motion.The setting of first motor 93 and the second motor 94, realizes device for cleaning chip 8 and signal detection respectively
The up and down motion of device 7.It will not be described here.
With reference to shown in Fig. 3, the device for cleaning chip 8 include be connected with first motor fixed mount 81,
The wiper mechanism 82 of setting is slided up and down along the one side short transverse of fixed mount 81 and is arranged at the wiper mechanism 82
Bolster 83 between the fixed mount；The wiper mechanism 82 includes purge block 821, and is arranged at the purge block
821 bottom surfaces and along the length direction of purge block 821 uniform cleaning needle 822 and waste liquid pin 823, the cleaning needle 822 with
Set along the insertion of cleaning chamber 824 that the length direction insertion of purge block 821 is set, the waste liquid pin 823 with along the cleaning
The length direction insertion of block 821 set the insertion of waste liquid chamber 825 set, it is described cleaning chamber 824 and the waste liquid chamber 825 with it is corresponding
External pump body phase connection, the two ends of the one side of fixed mount 81 are provided with guide pillar along the fixed mount short transverse respectively
84, the purge block 821 is slided with the guide pillar 84 and set, and the bolster 83 is set to spring, and the bolster 83 is arranged
In one end of the guide pillar and inconsistent with the upper side of the purge block 821.
With reference to shown in Fig. 4, the signal supervisory instrument 7 includes the test bracket 71 fastened with second motor,
And it is set up in the test probe assembly 72 in the cavity of the test bracket 71；The test bracket 71 has a cavity wall and institute
State test bracket 71 to be detachably connected, offered at the top of the cavity of the test bracket 71 along the length direction of test bracket 71
Elongated slot 711 for adjusting the test installation site of probe assembly 72；The test probe assembly 72 includes parallel up and down
Two probe fixed plates 721 every setting, the support column 722 being arranged between two probe fixed plate 721, along two probe
The uniform probe 723 of the length direction of fixed plate 721 and the limiting plate 724 for being horizontally placed on multiple probe bottoms；Institute
Support column 722 is stated to be arranged in pairs respectively in the two ends of two probe fixed plate 721, and positioned at the probe fixed plate of the top
721 screw rod with being arranged in the elongated slot 711 is fastened.With the signal supervisory instrument of this structure design, pass through test bracket
Set, good shield effectiveness can be played to test probe assembly 72, can effectively strengthen test accuracy, meanwhile, test
The setting of elongated slot in support, easily test probe assembly can be adjusted.
With reference to shown in Fig. 5 and Fig. 6, the chip incubating device 5 includes being incubated platform 51, is embedded in incubation platform 51 bottom
Heating plate and temp probe, the 3rd drive mechanism 52 for being arranged at described incubation platform 51 one end, and with the described 3rd driving
The incubation lid 53 that the drive shaft of mechanism 52 is connected, the incubation lid 53 comes and goes slip along incubation platform 51 length direction and set
Put；3rd drive mechanism 52 includes being anchored on the supporting plate 521 of incubation platform 51 end, grown along the supporting plate 521
Degree direction set guide rail 522, be arranged at the supporting plate 521 away from it is described incubation platform 51 one end be provided with stepper motor
523 and along the stepper motor 523 drive screw 524 come and go slide set silk braid 525, the silk braid 525 with it is described
The end fastening of lid 53 is incubated, the sliding block 526 that the incubation lid 53 is slidably matched with the guide rail 522 is fastened.Set with this structure
Meter, chip to be tested is positioned over after incubation platform, you can by being incubated the movement of lid, chip to be tested is in a relative closure
Cavity in, so as to accelerate the incubation efficiency of biochip to be measured.
With reference to shown in Fig. 6, the reagent refrigerating device 4 includes refrigerating box 41, is arranged at the cold of the top of refrigerating box 41
Hide lid 42, be arranged at the side of refrigerating box 41 for the 4th drive mechanism 43 for refrigerating the automatic open-close of lid 42, Yi Jishe
The refrigeration mechanism 44 of the bottom of refrigerating box 41 is placed in, the side wall of the refrigeration lid 42 and the refrigerating box 41 is hinged；Institute
State refrigerating box 41 and be provided with multiple refrigeration cavitys, run through setting between the bottom of the refrigeration cavity and the side wall of the refrigerating box 41
It is equipped with osculum；The refrigeration mechanism 44 includes being brought into close contact cooling piece 441 in the bottom surface of refrigerating box 41, is arranged at institute
State the fin 442 of the lower section of cooling piece 441 and be arranged at the fan 443 of the lower section of fin 442.In present embodiment,
4th drive mechanism drives timing belt, and then the folding for driving the mode of the jointed shaft of refrigeration lid to drive refrigeration to cover using motor,
It will not be described here.In present embodiment, osculum can be connected with external pump body phase, accelerate condensate liquid to outflow with this, prevent from tiring out
Sewage or ice slag are formed after poly- in refrigeration chamber.
With reference to shown in Fig. 7 to Fig. 9, the needle device 6 of washing includes cleaning block body 61, cleans the length of block body 61 along described
Waste liquid chamber 62 and water-injecting cavity 63 that direction insertion is set and multiple cleanings along cleaning block body 61 length direction uniformly
Hole, the clean-out opening be arranged at it is described cleaning block body 61 top, the multiple clean-out opening with the waste liquid chamber 62 and note
The insertion of water cavity 63 is set, further, and the clean-out opening includes the first clean-out opening 64 being vertically arranged along cleaning block body 61, with
And the bottom hole of the first clean-out opening 64 and the second clean-out opening 65 set with the insertion of waste liquid chamber 62 are arranged at, described first is clear
The diameter of hole flushing 64 is more than the diameter of second clean-out opening 65, and the bottom hole of first clean-out opening 64 is provided with and be sheathed on useless
The sphere 641 that the bulb stopper of liquid pin periphery is engaged, is flowed into waste water chamber for the ease of the water in water-injecting cavity, in the first clean-out opening 64
It is provided with side wall between water-injecting cavity 63 in through hole 66, the present embodiment, waste liquid chamber 62 and water-injecting cavity 63 are respectively arranged with water
Multiple waste liquid pins, with this structure design, when being cleaned to waste liquid pin, first can be inserted corresponding first clean-out opening 64 by pump
It is interior, and the bulb stopper and the sphere 641 of the bottom of the first clean-out opening 64 of shank periphery are brought into close contact, by being produced in waste liquid chamber 62
Negative pressure the waste liquid in waste liquid pin is emptied, afterwards, then by the through hole 66 on the side wall of the first clean-out opening 64 to the first clean-out opening
Injected clear water in 64, is cleaned with this to the outer surface of waste liquid pin.
With reference to shown in Figure 10, in order to prevent from washing needle device 6, chip incubating device 5 and its device for cleaning chip 8 in cleaning
During sewage outflow to ground, washing needle device 6, multiple chip incubating devices 5 and its device for cleaning chip being arranged side by side
8 bottom sets waste collecting device 12, and the waste collecting device is set to the container that bottom surface is inclined to set, to cause sewage
Flow, and discharged by bottom discharge mouthful 121 to relatively low one end.
The technical principle of the present invention is described above in association with specific embodiment.These descriptions are intended merely to explain the present invention's
Principle, and limiting the scope of the invention can not be construed in any way.Based on explanation herein, the technology of this area
Personnel, which would not require any inventive effort, can associate other embodiments of the present invention, and these modes are fallen within
Within protection scope of the present invention.
Claims (10)
1. a kind of biological chip reading apparatus, it is characterised in that：Including support, erection and the liquid-transfering gun above the support, it is used for
Drive the first multi-shaft interlocked drive mechanism of the liquid-transfering gun, be arranged at the support work top material component and institute
State reagent refrigerating device that material component is disposed adjacent, be arranged at the material component and the reagent refrigerating device rear it is many
Individual chip incubating device, be disposed adjacent with the multiple chip incubating device wash needle device, be set up in the multiple chip and incubate
Educate device and wash above needle device device for cleaning chip and its signal supervisory instrument, for drive the device for cleaning chip and
Second drive mechanism of the signal supervisory instrument back and forth movement and be arranged at the syringe needle collection device of work top bottom with
And waste collecting device.
2. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：The material component adds including sample
Carry the dilution position for putting, being arranged at the sample loading device side and the syringe needle box for being arranged at dilution position side, institute
The side for stating syringe needle box is provided with reagent refrigerating device.
3. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：First drive mechanism includes flat
Row is set up in the first slide rail of the support two lateral walls, slides the second slide rail set, Yi Jiyan with first slide rail
The second slide rail length direction comes and goes the liquid-transfering gun slided, and first slide rail is set along the support Y direction, institute
The second slide rail is stated to set along the support X-direction.
4. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：Second drive device includes flat
Row is set up in the 3rd slide rail at the multiple chip incubating device two ends, and the gantry being slidably matched with the 3rd slide rail
Frame, the device for cleaning chip and the signal supervisory instrument are respectively arranged at the both sides of the crossbeam of the portal frame.
5. a kind of biological chip reading apparatus according to claim 4, it is characterised in that：The cross rail top of the portal frame is set
The first motor for driving the device for cleaning chip to move up and down is equipped with, and for driving the signal detection to fill
Put the second motor of up and down motion.
6. a kind of biological chip reading apparatus according to claim 5, it is characterised in that：The device for cleaning chip include with
Fixed mount that first motor is connected, the cleaning machine for sliding up and down along the fixed mount one side short transverse setting
Structure and the bolster being arranged between the wiper mechanism and the fixed mount；The wiper mechanism includes purge block, and
Be arranged at the purge block bottom surface and along the purge block length direction uniform cleaning needle and waste liquid pin, the cleaning needle with
Set along the cleaning chamber insertion that the purge block length direction insertion is set, the waste liquid pin with along the purge block length direction
The waste liquid chamber insertion that insertion is set is set, and the cleaning chamber and the waste liquid chamber are connected with corresponding external pump body phase, described
The two ends of fixed mount one side are provided with guide pillar along the fixed mount short transverse respectively, and the purge block is slided with the guide pillar
Set, the bolster is set to spring, the bolster be sheathed on one end of the guide pillar and with the upside of the purge block
Face and/or downside are inconsistent.
7. a kind of biological chip reading apparatus according to claim 5, it is characterised in that：The signal supervisory instrument include with
The test bracket of the second motor fastening, and the test probe assembly being set up in the cavity of the test bracket；
A test bracket at least cavity wall is detachably connected with the test bracket, along institute at the top of the cavity of the test bracket
Test bracket length direction is stated to offer for adjusting the elongated slot for testing probe assembly installation site；The test probe groups
Part includes two probe fixed plates that parallel interval is set up and down, the support column being arranged between two probe fixed plate, along institute
State the uniform probe of two probe fixed plate length directions and be horizontally placed on the limiting plate of multiple probe bottoms；Institute
State support column to be arranged in pairs respectively in the two ends of two probe fixed plate, and be located at the probe fixed plate of the top with being arranged at
Screw rod fastening in the elongated slot.
8. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：The chip incubating device includes incubating
The heating plate and temp probe that educate platform, are embedded in the incubation platform bottom, the 3rd driving machine for being arranged at described incubation platform one end
Structure, and the incubation lid being connected with the drive shaft of the 3rd drive mechanism, incubation platform length side described in the incubation cover rim
Set to round slide；3rd drive mechanism includes being anchored on the supporting plate in the incubation you portion, along the supporting plate
Length direction set guide rail, be arranged at the supporting plate away from it is described incubation platform one end be provided with stepper motor, Yi Jiyan
The drive screw of the stepper motor comes and goes the silk braid for sliding and setting, and the silk braid is fastened with the end for being incubated lid, described
Lid is incubated to fasten with the sliding block that the guide rail is slidably matched.
9. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：The reagent refrigerating device includes cold
Hide case, the refrigeration lid being arranged at the top of the refrigerating box, be arranged at the refrigerating box side for the refrigeration lid automatic open-close
The 4th drive mechanism and be arranged at the refrigeration mechanism of the refrigerating box bottom, the refrigeration lid and the one of the refrigerating box
Side wall is hinged；The refrigerating box is provided with multiple refrigeration cavitys, the bottom of the refrigeration cavity and the side wall of the refrigerating box
Between be provided through osculum；The refrigeration mechanism includes being brought into close contact cooling piece in the refrigerating box bottom surface, set
Fin below the cooling piece and the fan being arranged at below the fin.
10. a kind of biological chip reading apparatus according to claim 1, it is characterised in that：The needle device of washing includes cleaning
Block body, the waste liquid chamber and water-injecting cavity that are set along the cleaning Block body length direction insertion and along the cleaning block body
The uniform multiple clean-out openings of length direction, the clean-out opening is arranged at the top of the cleaning block body, the multiple clean-out opening
Set with the waste liquid chamber and water-injecting cavity insertion, the clean-out opening includes the first cleaning being vertically arranged along cleaning block body
Hole, and the first clean-out opening bottom hole and the second clean-out opening set with the waste liquid chamber insertion are arranged at, described first is clear
The diameter of hole flushing is more than the diameter of second clean-out opening, and the bottom hole of first clean-out opening is provided with and is sheathed on outside waste liquid pin
The sphere that the bulb stopper enclosed is engaged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710479474.2A CN107132345B (en) | 2017-06-22 | 2017-06-22 | A kind of biological chip reading apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710479474.2A CN107132345B (en) | 2017-06-22 | 2017-06-22 | A kind of biological chip reading apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107132345A true CN107132345A (en) | 2017-09-05 |
| CN107132345B CN107132345B (en) | 2019-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710479474.2A Active CN107132345B (en) | 2017-06-22 | 2017-06-22 | A kind of biological chip reading apparatus |
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| CN (1) | CN107132345B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110142262A (en) * | 2019-05-24 | 2019-08-20 | 中国科学院苏州生物医学工程技术研究所 | Liquid distributes needle cleaning device |
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