CN107115424B - Change acidic constitution and protect calcium and clearing heat and detoxicating Chinese medicine composition and preparation method - Google Patents
Change acidic constitution and protect calcium and clearing heat and detoxicating Chinese medicine composition and preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
The present invention relates to a kind of change acidic constitutions to protect calcium and clearing heat and detoxicating Chinese medicine composition and preparation method.The pharmaceutical composition is after Chinese medical extract and bone collagen are dissolved in ocean basic ion water, to be sprayed on the particle or powdered inert carrier of blank, be dried to obtain；The Chinese medical extract is made by honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis.The constituent of the pharmaceutical composition is few, can effectively prevent calcium loss, and has effects that clearing heat and detoxicating, the acid system of change, can alleviate and improve the symptom of osteoporosis.
Description
Technical field
The invention belongs to field of medicaments, and calcium and clearing heat and detoxicating Chinese traditional medicine composition are protected more particularly to a kind of change acidic constitution
Object and preparation method.
Background technology
Osteoporosis is since bone amount is reduced, and bone micro-structure destroys, so that the brittleness of bone increases and fracture risk increases
A kind of whole body osteopathy added.There are many reason for causing osteoporosis：(1) inherent cause.Sclerotin may be multigenic disease, this
A little genes may participate in the regulation and control of acquisition and the bone conversion of bone amount, there is apparent racial difference；(2) trophic factor.Calcium is in sclerotin
Most basic mineral composition, calcium insufficiency of intake, malabsorption can cause osteoporosis, and with advancing age, people
Intake, the absorption of calcium are reduced body and outdoor activity is reduced, vitamin D synthesis deficiency etc., can all promote the hair of osteoporosis
It is raw.(3), hormonal change.Into after old age, great changes will take place for human endocrine, thyroid hormone rise, calcitonin and life
Long hormone reduces, and the bone resorption and absorption of osteoclast significantly increase, and osteocyte osteogenic ability declines.In addition osteoporosis is also
Related with the influence of habits and customs and drug, inactive people is easier than the people of activity to occur osteoporosis, and the elderly is often
Muscle does not get enough athletic exercise, in bone blood circulation slow down, metabolic function reduce, promote the generation of osteoporosis.It is in addition, long-term use of
Glucocorticoid on kidney, antiepileptic, are carried out containing aluminum antacid, diuretics, thyroid hormone etc. and cancer patient at anti-coagulants
Chemotherapy can influence calcium uptake and metabolism, cause osteoporosis.
The clinical manifestation of osteoporosis is mainly that whole body ostalgia is powerless, using the small of the back and fracture site rest pain as
Main, activity is considerably restricted.As social population is increasingly aging, the incidence of osteoporosis increasingly increases, to patient
Huge pain is brought, white elephant is also resulted in family and society, becomes a serious social concern.Osteoporosis
Preventing and controlling have become one of important public hygiene problem and the most popular research field of medical field of social concerns.
Domestic and international medical field unanimously think the long-term calcium deficiency of human body be cause osteoporosis, osteoproliferation, rickets it is main
Reason, it is main at present to be prevented and treated using the method for replenishing the calcium for this disease.Pre- preventing bone rarefaction will possess comprehensive benefit
Skeleton nutrition is filled, promotes calcium absorption, promotes collagen generation, prevents the comprehensive functions such as calcium loss in bone, bone could be prevented
The loose generation of matter, to ensure that bone is strong strong.The product of pre- preventing bone rarefaction is mostly few using simple supplement calcium or addition
Amount nutriment is major product, does not solve the problems, such as to prevent and repair osteoporosis very well methodically.It is domestic existing
Active calcium, that is, the ionized calcium of calcium-supplementing preparation, calcium gluconate, calcium lactate, calcium carbonate etc., but the main ingredient of some calcium preparations
For calcium oxide, calcium hydroxide and a small amount of calcium carbonate, these inorganic calciums are not easy to be absorbed by the body, and its toxicity is larger.
The name of disease of osteoporosis is had no in China's traditional Chinese medicine, but similar symptom and etiology and pathogenesis exist《Yellow Emperor, a legendary ruler
Interior warp》In just have related record.Chinese medicine and compound Chinese medicinal preparation are had become for anti-curing osteoporosis as the world of medicine in recent years
One of research hotspot.It is now recognized that the effective single medicinal material of osteoporosis up to hundreds of, these Chinese medicines have anti-sclerotin
The mechanism of fluffing action is had been generally acknowledged that including following several：With estrogen-like effect, directly act on osteocyte, influence carefully
The secretion of intracellular cytokine and other.Osteoporosis is treated on tcm clinical practice mostly from kidney tonifying to set about, and coordinates invigorating the spleen promoting the circulation of qi and promoting blood circulation and removing blood stasis,
Improve the symptom of patient.But the complicated component of Chinese medicine compound prescription, prescription are owed to simplify, the compatibility of all kinds of Chinese medicines is also required to deeply grind
Study carefully.Therefore, there is still a need for exploitation formula is simple, and calcium loss can be safely, effectively prevented, so as to the medicine of anti-curing osteoporosis
Object.
The content of the invention
The purpose of the present invention is to meet the needs of social majority of populations, provide a kind of can effectively prevent osteoporosis
Calcium and preparation method thereof.The constituent of the pharmaceutical composition is few, and preparation process is simple, easy to operate, reproducible, can effectively prevent
Only calcium loss, and there is clearing heat and detoxicating, change acidic constitution, so as to alleviate and improve the symptom of osteoporosis.
In order to reach object above, the present invention is carried out by following technical solution.
In the first aspect of the present invention, provide a kind of change acidic constitution and protect calcium and clearing heat and detoxicating Chinese medicine composition,
It is that the particle of blank or powdered inertia load are sprayed on after Chinese medical extract and bone collagen are dissolved in ocean basic ion water
On body, it is dried to obtain；The Chinese medical extract is made by honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis.
Preferably, the Chinese medical extract is by honeysuckle 10-30 parts by weight, chrysanthemum 10-30 parts by weight, Poria cocos 10-
25 parts by weight, rhizoma alismatis 2-8 parts by weight are made；It is preferred that by honeysuckle 15-25 parts by weight, chrysanthemum 10-15 parts by weight, Poria cocos 12-18
Parts by weight, rhizoma alismatis 3-7 parts by weight are made.
The source and effect of each bulk pharmaceutical chemicals or ingredient are as follows in pharmaceutical composition of the present invention：
Honeysuckle is caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera
Hypoglauca Miq., Honeysuckle flower (hair calyx honeysuckle) Lonicera confusa DC. or hair style honeysuckle Lonicera
The dry flower of dasystyla Rehd. or with the flower just opened.Property it is sweet, tremble with fear.With clearing heat and detoxicating, the effect of wind-heat dissipating.It is main
Control carbuncle swells furunculosis, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.
Chrysanthemum is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor
It is sweet, bitter, it is slightly cold.With relieve heat heat-clearing, the effect of flat liver improving eyesight.Cure mainly anemopyretic cold, dizziness of having a headache, red eye, swell pain, eyes dusk
Flower.
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, put down.
With clearing damp and promoting diuresis, the effect of invigorating the spleen calming heart.Oedema oliguria is cured mainly, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea is confused and worried,
Insomnia of palpitating with fear.
Rhizoma alismatis is the dry tuber of Notes On Alism At Aceae rhizoma alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet,
It is cold.With diuresis, the effect of clearing away damp-heat.Cure mainly difficult urination, oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, puckery pain of heat gonorrhea；
Hyperlipidemia.
Bone collagen, also referred to as ossein, are a kind of fibrous proteins in bone, content can account for bone organic matter
90%, it is that a kind of biological polymer substance is the important substance for maintaining bone toughness and providing skeleton nutrition.Bone collagen
In rich in elastin, for improving cutis laxa, the effect of anti-aging can become apparent from.
Alkali ion water refers to directly be taken either by alkali ion water treating apparatus (also referred to as alkali ion generation machine)
The water of the display alkalescence of making, that is, one kind of general described electrolysis water belong to one kind of functional water.At present, it is commercially available
Alkali ion water has such as ocean alkali ion water.It is generally believed that weakly alkaline water quality can moderately adjust the acid body of body
Matter, and ocean alkali ion water contains the marine natural minerals of needed by human body, can supplement the elements such as calcium, magnesium, potassium, sodium, help
In health.
In the pharmaceutical composition of the present invention, the weight ratio of Chinese medical extract and bone collagen is (2-7):1, be preferably
(2-4):1.The particle of the blank or powdered inert carrier can known in the art can be used as inert carrier in preparation
Those substances or ingredient, such as in lactose, starch, microcrystalline cellulose, dextran, glucose, sucrose, xylitol
It is one or more.
The preparation method of the Chinese medical extract is：Honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 1-3
Secondary, each amount of water is 3-8 times of volume, and heating temperature is 80-100 DEG C, and when extraction time is 1-3 small, filtering merges filter
Liquid, be spray dried to powder to get.
Applicant by honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis in the course of the research it was unexpectedly observed that carry out compatibility with heat-clearing
The effect of removing toxic substances, strengthening the spleen and stomach kidney-nourishing, and its water extract has certain collaboration after being combined with bone collagen with special ratios
Synergistic effect can significantly improve the effect of prevention osteoporosis.
In the second aspect of the present invention, provide a kind of change acidic constitution and protect calcium and clearing heat and detoxicating Chinese medicine composition system
Agent, it includes above-mentioned pharmaceutical compositions and pharmaceutically acceptable auxiliary material.Common Chinese medicine preparation and its applicable auxiliary material are at this
Field is known.The pharmaceutical preparation of the present invention is preferably aqua, tablet, capsule, granule or powder.
On the other hand, the present invention also provides the preparation method of aforementioned pharmaceutical compositions, comprise the following steps：
(1), honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 1-3 times, each amount of water is 3-8 times of body
Product, heating temperature are 80-100 DEG C, and when extraction time is 1-3 small, filtering, merging filtrate is spray dried to powder, spare；
(2), Chinese medical extract powder obtained by step (1) is dissolved in the basic ion water of ocean, adds in bone collagen, stirring
Uniformly, be then sprayed on the particle or powdered inert carrier of blank, it is dry to get.
Conventional formulation method is that active ingredient and auxiliary material are put together to be stirred, and in the present invention, it is by
Medicament extract and bone collagen are sprayed at the particle or powdered lazy of blank through spray pattern with after the basic ion water dissolution of ocean
On property carrier, powder is then spray dried to.The pharmaceutical composition prepared with ad hoc approach of the present invention has the following advantages that：⑴
Active Chinese drug component extract and bone collagen are sprayed on blank granules or powdered inert carrier surface with spray pattern to have
Beneficial to the dissolving and absorption of active ingredient, so as to improve drug effect；(2) dissolve, be conducive to anti-by the use of ocean basic ion water as solvent
The effect of natural mineral matter is only supplemented while calcium loss, and plays improvement acidic constitution, it is certain so as to have to health
Help effect.(3) efficiency can be improved using sprinkling and spray drying technology, remove the toxicity of Chinese medicine, be also prevented from thermal sensitivity
Active ingredient loss and raising solubility etc..
On the other hand, the pharmaceutical composition and pharmaceutical preparation for additionally providing the present invention are preparing the medicine for the treatment of osteoporosis
Application in object.
Specific embodiment
The present invention provides the following examples to further illustrate, but protection scope of the present invention is not limited to these implementations
Example.
Embodiment 1
Raw material forms：Honeysuckle 18g, chrysanthemum 12g, Poria cocos 15g, rhizoma alismatis 5g, bone collagen 20g, ocean basic ion water
In right amount.
Preparation method：Honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 2 times, each amount of water is 6 times
Volume, heating temperature are 100 DEG C, and when extraction time is 2.5 small, filtering, merging filtrate is spray dried to powder, spare；By institute
It obtains Chinese medical extract powder to be dissolved in the basic ion water of ocean, adds in bone collagen, stir evenly, be then sprayed on blank crystallite
It is dry on cellulose grain, appropriate magnesium stearate is added in, is uniformly mixed, it is tabletted.
Embodiment 2
Raw material forms：Honeysuckle 25g, chrysanthemum 12g, Poria cocos 13g, rhizoma alismatis 6g, bone collagen 28g, ocean basic ion water
In right amount.
Preparation method：Honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 3 times, each amount of water is 4 times
Volume, heating temperature are 90 DEG C, and when extraction time is 3 small, filtering, merging filtrate is spray dried to powder, spare；By gained
Chinese medical extract powder is dissolved in the basic ion water of ocean, is added in bone collagen, is stirred evenly, be then sprayed on blank lactose
It is dry on grain, appropriate talcum powder is added in, is fitted into capsule shells to get capsule.
Embodiment 3
Raw material forms：Honeysuckle 15g, chrysanthemum 15g, Poria cocos 18g, rhizoma alismatis 4g, bone collagen 13g, ocean basic ion water
In right amount.
Preparation method：Honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 3 times, each amount of water is 5 times
Volume, heating temperature are 80 DEG C, and when extraction time is 1.5 small, filtering, merging filtrate is spray dried to powder, spare；By institute
It obtains Chinese medical extract powder to be dissolved in the basic ion water of ocean, adds in bone collagen, stir evenly, be then sprayed on blank starch
On, it is dry, appropriate talcum powder is added in, is fitted into capsule shells to get capsule.
Test example 1：Effect to osteoporosis models in ovariectomized rats
1st, experimental animal：Female sd inbred rats, weight 200-230g.
2nd, the foundation of osteoporosis models in ovariectomized rats：With the amobarbital intraperitoneal injection of anesthesia of 20mg/kg weight, abdomen
Portion's routine disinfection aseptically, takes ventral approach center operative incision to open abdominal cavity, cuts off both sides ovary.Thoroughly hemostasis
Afterwards, two layers peritoneal suture, muscle and skin successively are divided, it is postoperative to give penicillin intraperitoneal injection (80,000 U/kg).Sham-operated control group
It opens and is sutured after cutting off a little adipose tissue after abdomen, the weight of cut-out is substantially identical with two ovary weights, remaining operation is same as above.
Two groups of rat feedings are administered after 6 weeks.
3rd, sample and administering mode is administered：
Of the present invention group：The tablet that according to embodiments of the present invention 1 raw material composition and method is prepared.Tablet is dissolved in water
Afterwards, three times, dosage 120mg/kg's daily gavage is administered continuously 2 months.
Control group 1：By honeysuckle 18g, chrysanthemum 12g, Poria cocos 15g, rhizoma alismatis 5g, ocean basic ion appropriate amount of water as raw material,
The tablet that according to embodiments of the present invention 1 method is prepared.After tablet is dissolved in water, daily gavage three times, dosage
120mg/kg is administered continuously 2 months.
Control group 2：By honeysuckle 18g, chrysanthemum 27g, rhizoma alismatis 5g, bone collagen 20g, ocean basic ion appropriate amount of water conduct
Raw material, the tablet that according to embodiments of the present invention 1 method is prepared.After tablet is dissolved in water, daily gavage three times, dosage
120mg/kg is administered continuously 2 months.
Control group 3：By honeysuckle 18g, chrysanthemum 17g, Poria cocos 15g, bone collagen 20g, ocean basic ion appropriate amount of water is made
For raw material, tablet that according to embodiments of the present invention 1 method is prepared.After tablet is dissolved in water, daily gavage three times, to medicament
120mg/kg is measured, is administered continuously 2 months.
Model control group：Physiological saline, daily gavage three times, are persistently given 2 months.
Sham-operated control group：Physiological saline, daily gavage three times, are persistently given 2 months.
4th, result of the test：
(1), to the influence of rat osteoprotegerin, 1 the results are shown in Table.
Influence result of 1 each group of table to rat osteoprotegerin
The result shows that compared with model control group, of the present invention group, the rat osteoprotegerin concentration of control group 1-3 have it is aobvious
Sex differernce is write, but the of the present invention group of concentration compared with control group 1-3 for osteoprotegerin has significantly more improvement effect.
(2) to the influence of rat femur structural parameters, 2 be the results are shown in Table.
2 each group of table is to the influence result (n=5) to rat femur structural parameters
The result shows that compared with model control group, of the present invention group, the diaphysis fraction of control group 1-3, bone trabecula number,
Bone trabecula thickness substantially increases, and bone trabecula gap is obviously reduced.But of the present invention group effect is more compared with control group 1-3
To be notable.
Claims (7)
1. a kind of Chinese medicine composition for preventing osteoporosis, it is characterised in that be that Chinese medical extract and bone collagen are dissolved in sea
After soap ionized water, it is sprayed on graininess or powdered inert carrier, is dried to obtain；Wherein,
The Chinese medical extract is by honeysuckle 10-30 parts by weight, chrysanthemum 10-30 parts by weight, Poria cocos 10-25 parts by weight, rhizoma alismatis
2-8 parts by weight are made；The preparation method of the Chinese medical extract is：Honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, is heated after adding water
Extraction 1-3 times, each amount of water are 3-8 times of volume, and heating temperature is 80-100 DEG C, when extraction time is 1-3 small, filtering,
Merging filtrate, be spray dried to powder to get；
The weight ratio of Chinese medical extract and bone collagen is (2-7):1；
The graininess or powdered inert carrier be selected from lactose, starch, microcrystalline cellulose, dextran, glucose, sucrose,
One or more in xylitol.
2. Chinese medicine composition as described in claim 1, it is characterised in that the Chinese medical extract is by honeysuckle 15-25 weight
Part, chrysanthemum 10-15 parts by weight, Poria cocos 12-18 parts by weight, rhizoma alismatis 3-7 parts by weight are made.
3. Chinese medicine composition as described in claim 1, it is characterised in that the weight ratio of Chinese medical extract and bone collagen is
(2-4):1。
4. a kind of Chinese medicine preparation for preventing osteoporosis, it is characterised in that as the Chinese traditional medicine composition as described in one of claim 1-3
Object and pharmaceutically acceptable auxiliary material are made.
5. Chinese medicine preparation as claimed in claim 4, it is characterised in that the dosage form of the preparation is tablet, capsule, granule
Or powder.
6. the preparation method of the Chinese medicine composition as described in one of claim 1-3, it is characterised in that comprise the following steps：
(1), honeysuckle, chrysanthemum, Poria cocos, rhizoma alismatis are weighed, adds water heating extracting 1-3 times, each amount of water is 3-8 times of volume,
Heating temperature is 80-100 DEG C, and when extraction time is 1-3 small, filtering, merging filtrate is spray dried to powder, spare；
(2), Chinese medical extract powder obtained by step (1) is dissolved in the basic ion water of ocean, adds in bone collagen, stirring is equal
It is even, be then sprayed on graininess or powdered inert carrier, it is dry to get.
7. the Chinese medicine composition as described in one of claim 1-3 or the Chinese medicine preparation as described in one of claim 4-5 are being made
Application in the drug of standby prevention osteoporosis.
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|---|---|---|---|---|
| CN1056418A (en) * | 1990-05-15 | 1991-11-27 | 刘汉旭 | A kind of manufacture method of bath fluid for lowering obesity and defatting |
| CN102218089A (en) * | 2011-06-08 | 2011-10-19 | 华夏先葆(北京)中药研究院有限公司 | Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia |
| CN105412569A (en) * | 2015-12-24 | 2016-03-23 | 福和寿（武汉）健康管理有限公司 | Composition for increasing bone mineral density and preparation and preparation method thereof |
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