CN107110873B - 检测血红蛋白中异常的方法 - Google Patents

检测血红蛋白中异常的方法 Download PDF

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CN107110873B
CN107110873B CN201580059324.5A CN201580059324A CN107110873B CN 107110873 B CN107110873 B CN 107110873B CN 201580059324 A CN201580059324 A CN 201580059324A CN 107110873 B CN107110873 B CN 107110873B
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sample
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mass
spectrum
globulin
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CN107110873A (zh
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R·K·埃尔斯
J·K·埃尔斯
T·阿邦
S·M·E·多彻蒂
M·纳瑟
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Map Diagnostics Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
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  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201580059324.5A 2014-08-29 2015-08-27 检测血红蛋白中异常的方法 Active CN107110873B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1415367.0 2014-08-29
GBGB1415367.0A GB201415367D0 (en) 2014-08-29 2014-08-29 Methods for detecting abnormalities in haemoglobin
PCT/GB2015/052491 WO2016030688A1 (en) 2014-08-29 2015-08-27 Method for detecting abnormalities in hemoglobin

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CN107110873A CN107110873A (zh) 2017-08-29
CN107110873B true CN107110873B (zh) 2019-07-05

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US (1) US10359431B2 (enExample)
EP (1) EP3186640B1 (enExample)
JP (1) JP2017525971A (enExample)
CN (1) CN107110873B (enExample)
CY (1) CY1122239T1 (enExample)
DK (1) DK3186640T3 (enExample)
ES (1) ES2751480T3 (enExample)
GB (1) GB201415367D0 (enExample)
PT (1) PT3186640T (enExample)
WO (1) WO2016030688A1 (enExample)

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EP3555631A4 (en) * 2016-12-19 2020-08-12 The UAB Research Foundation MASS SPECTROMETRY STANDARDS FOR HEMOGLOBIN BETA AND HEMOGLOBIN BETA SICKLE CELL DISEASE AND THEIR USES
WO2019022189A1 (ja) * 2017-07-27 2019-01-31 国立大学法人九州大学 グロビンタイピングペプチド
CN108062977A (zh) * 2017-12-18 2018-05-22 广东祥岳生物技术有限公司 一种新生儿地中海贫血筛查结果自动判断系统
CN110658252A (zh) * 2019-10-01 2020-01-07 长沙湘华质谱医学科技有限公司 用于质谱诊断地中海贫血症的特征蛋白质谱模型及其用途
CN110658251A (zh) * 2019-10-01 2020-01-07 长沙湘华质谱医学科技有限公司 表征地中海贫血症的特征蛋白组合物或质谱模型的用途
CN110632326A (zh) * 2019-10-01 2019-12-31 北京毅新博创生物科技有限公司 用于质谱诊断地中海贫血症的特征蛋白标记组合物及其诊断产品
CN111638261B (zh) * 2020-04-17 2023-04-07 融智生物科技（青岛）有限公司 一种计算设备、存储介质和地中海贫血筛查装置及系统
CN111948404B (zh) * 2020-08-03 2023-04-07 融智生物科技（青岛）有限公司 用于筛查地中海贫血的特征蛋白标记组合物、质谱模型及其应用
CN116203143B (zh) * 2022-05-11 2024-01-05 重庆医科大学附属儿童医院 血红蛋白病的标志物组合物及其筛查试剂与应用

Citations (4)

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WO2003002757A1 (en) * 2001-06-28 2003-01-09 Monash University Method for kidney disease detection by protein profiling
CN1882840A (zh) * 2003-09-23 2006-12-20 沃拉克有限公司 用于新生儿筛选的血红蛋白检定
CN101128739A (zh) * 2005-02-01 2008-02-20 伦敦国王学院 一种筛选方法
CN103278574A (zh) * 2013-04-26 2013-09-04 首都医科大学附属北京朝阳医院 利用液相色谱串联三重四级杆质谱仪检测糖化血红蛋白的方法

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US3492095A (en) * 1967-10-05 1970-01-27 Harold B Tillen Product for and method of testing blood for the presence of hemoglobin s
US4847209A (en) 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
FR2821428B1 (fr) * 2001-02-23 2004-08-06 Abx Sa Reactif et procede pour l'identification et le comptage de cellules biologiques
US20040171026A1 (en) 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
EP1533617A1 (en) * 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005116607A1 (en) * 2004-05-27 2005-12-08 Monash University A method for the rapid analysis of polypeptides
WO2007117794A2 (en) 2006-03-06 2007-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Glycated peptides and methods of use
JP2007263896A (ja) * 2006-03-29 2007-10-11 Univ Nagoya 肺癌患者の術後予後予測のための生物マーカー及びその方法
WO2008011158A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Method of detecting and/ or measuring hepcidin in a sample
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WO2003002757A1 (en) * 2001-06-28 2003-01-09 Monash University Method for kidney disease detection by protein profiling
CN1882840A (zh) * 2003-09-23 2006-12-20 沃拉克有限公司 用于新生儿筛选的血红蛋白检定
CN101128739A (zh) * 2005-02-01 2008-02-20 伦敦国王学院 一种筛选方法
CN103278574A (zh) * 2013-04-26 2013-09-04 首都医科大学附属北京朝阳医院 利用液相色谱串联三重四级杆质谱仪检测糖化血红蛋白的方法

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Publication number Publication date
DK3186640T3 (da) 2019-10-21
GB201415367D0 (en) 2014-10-15
EP3186640A1 (en) 2017-07-05
ES2751480T3 (es) 2020-03-31
US20180224462A1 (en) 2018-08-09
JP2017525971A (ja) 2017-09-07
US10359431B2 (en) 2019-07-23
WO2016030688A1 (en) 2016-03-03
CN107110873A (zh) 2017-08-29
EP3186640B1 (en) 2019-07-24
PT3186640T (pt) 2019-10-30
CY1122239T1 (el) 2020-11-25

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