CN107109700A - 用于推导对pd‑1拮抗剂的反应的基因特征生物标志物的系统和方法 - Google Patents
用于推导对pd‑1拮抗剂的反应的基因特征生物标志物的系统和方法 Download PDFInfo
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- CN107109700A CN107109700A CN201580072918.XA CN201580072918A CN107109700A CN 107109700 A CN107109700 A CN 107109700A CN 201580072918 A CN201580072918 A CN 201580072918A CN 107109700 A CN107109700 A CN 107109700A
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Data Mining & Analysis (AREA)
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- General Engineering & Computer Science (AREA)
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- Artificial Intelligence (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462089538P | 2014-12-09 | 2014-12-09 | |
| US62/089538 | 2014-12-09 | ||
| US201562160284P | 2015-05-12 | 2015-05-12 | |
| US62/160284 | 2015-05-12 | ||
| PCT/US2015/064445 WO2016094377A1 (en) | 2014-12-09 | 2015-12-08 | System and methods for deriving gene signature biomarkers of response to pd-1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107109700A true CN107109700A (zh) | 2017-08-29 |
Family
ID=56108044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580072918.XA Pending CN107109700A (zh) | 2014-12-09 | 2015-12-08 | 用于推导对pd‑1拮抗剂的反应的基因特征生物标志物的系统和方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11377693B2 (enExample) |
| EP (1) | EP3230498B1 (enExample) |
| JP (1) | JP2018505658A (enExample) |
| KR (1) | KR20170086661A (enExample) |
| CN (1) | CN107109700A (enExample) |
| AU (2) | AU2015360736A1 (enExample) |
| BR (1) | BR112017012222A2 (enExample) |
| CA (1) | CA2968406A1 (enExample) |
| MX (1) | MX2017007535A (enExample) |
| RU (1) | RU2017123117A (enExample) |
| WO (1) | WO2016094377A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111088360A (zh) * | 2020-01-17 | 2020-05-01 | 暨南大学 | Pd1-ctla4和/或pdl2-ctla4在制备预测aml预后试剂盒中的应用 |
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| SG176468A1 (en) | 2005-12-02 | 2011-12-29 | Sinai School Medicine | Chimeric viruses presenting non-native surface proteins and uses thereof |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| JP6596411B2 (ja) | 2013-03-14 | 2019-10-23 | アイカーン スクール オブ メディシン アット マウント サイナイ | ニューカッスル病ウイルス及びその使用 |
| CR20160319A (es) | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
| KR102407019B1 (ko) | 2014-02-27 | 2022-06-08 | 머크 샤프 앤드 돔 코포레이션 | 암의 치료를 위한 결합 방법 |
| JP6767096B2 (ja) * | 2014-12-11 | 2020-10-14 | リティックス バイオファーマ エイエス | 免疫チェックポイント阻害剤の組み合わせ |
| EP3839510A3 (en) | 2015-04-17 | 2021-08-25 | Merck Sharp & Dohme Corp. | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| CA3019394A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| US10438699B2 (en) * | 2016-05-10 | 2019-10-08 | Macau University Of Science And Technology | Method and system for determining an association of biological features with a medical condition |
| US11515008B2 (en) | 2016-10-07 | 2022-11-29 | Omniseq, Inc. | Methods and systems for determining personalized t'herapies |
| WO2018097166A1 (ja) * | 2016-11-24 | 2018-05-31 | 第一三共株式会社 | Pd-1免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法 |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| JP2021521439A (ja) * | 2018-04-13 | 2021-08-26 | エックス4 ファーマシューティカルズ, インコーポレイテッド | がん血清バイオマーカーおよびその使用方法 |
| WO2019213478A1 (en) | 2018-05-04 | 2019-11-07 | Nanostring Technologies, Inc. | Gene expression assay for measurement of dna mismatch repair deficiency |
| EP3793557A1 (en) | 2018-05-14 | 2021-03-24 | Merck Sharp & Dohme Corp. | Biomarkers for a combination therapy comprising lenvatinib and a pd-1 antagonist |
| JP2021524744A (ja) * | 2018-05-21 | 2021-09-16 | ナノストリング テクノロジーズ,インコーポレイティド | 分子遺伝子シグネチャーとその使用方法 |
| WO2020005068A2 (en) * | 2018-06-29 | 2020-01-02 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Gene signatures and method for predicting response to pd-1 antagonists and ctla-4 antagonists, and combination thereof |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| EP4198057A1 (en) * | 2018-12-05 | 2023-06-21 | F. Hoffmann-La Roche AG | Diagnostic methods and compositions for cancer immunotherapy |
| WO2020243568A1 (en) * | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| EP4010022A4 (en) * | 2019-08-09 | 2024-01-17 | The Regents of University of California | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BLADDER CANCER |
| AU2020356455A1 (en) | 2019-09-24 | 2022-04-14 | Mirati Therapeutics, Inc. | Combination therapies |
| US20220380854A1 (en) * | 2019-11-04 | 2022-12-01 | Merck Sharp & Dohme Corp. | ANGIOGENESIS AND mMDSC GENE EXPRESSION BASED BIOMARKER OF TUMOR RESPONSE TO PD-1 ANTAGONISTS |
| WO2021110927A1 (en) * | 2019-12-04 | 2021-06-10 | Servicio Andaluz De Salud | Method to predict the response to cancer treatment with anti-pd1 immunotherapy |
| CA3171250A1 (en) | 2020-03-10 | 2021-09-16 | E. Lynne KELLEY | Methods for treating neutropenia |
| WO2022074648A1 (en) * | 2020-10-05 | 2022-04-14 | 4C Biomed Limited | Marker for response to pd-1/pd-l1 immunotherapy |
| WO2022135402A1 (zh) * | 2020-12-24 | 2022-06-30 | 信达生物制药(苏州)有限公司 | Pd-l1和/或mhc-2生物标记物在预测肺癌患者治疗疗效中的用途 |
| CN117940586A (zh) * | 2021-07-22 | 2024-04-26 | 阿西利亚诊断公司 | 用于免疫疗法后的疗法应答的生物标志物 |
| JP2025501311A (ja) | 2022-01-03 | 2025-01-17 | チェックメイト ファーマシューティカルズ, インコーポレイテッド | 自然免疫活性化因子に応答するための転写バイオマーカー |
| WO2023244632A1 (en) * | 2022-06-17 | 2023-12-21 | Merck Sharp & Dohme Llc | Genome wide tumor derived gene expression based signatures associated with poor prognosis for melanoma patients with early stage disease |
| WO2024083867A1 (en) | 2022-10-17 | 2024-04-25 | Ultimovacs Asa | Biomarker |
| EP4623092A1 (en) * | 2022-11-21 | 2025-10-01 | Merck Sharp & Dohme LLC | Genome wide tumor derived gene expression based signatures associated with poor prognosis for melanoma patients with early stage disease |
| WO2024225488A1 (ja) * | 2023-04-27 | 2024-10-31 | 株式会社リプロセル | 抗pd-1抗体療法に応答性である候補がん患者を同定する方法 |
| WO2025034883A1 (en) | 2023-08-08 | 2025-02-13 | Quanta Therapeutics, Inc. | Combination therapies with kras modulators |
| WO2025106905A1 (en) | 2023-11-17 | 2025-05-22 | Quanta Therapeutics, Inc. | Combination therapies with a kras modulator and an immunomodulator inhibitor |
| WO2025136845A1 (en) * | 2023-12-19 | 2025-06-26 | Merck Sharp & Dohme Llc | Methods of treating a patient with a pd-1 antagonist |
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- 2015-12-08 BR BR112017012222A patent/BR112017012222A2/pt not_active Application Discontinuation
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- 2015-12-08 US US15/533,769 patent/US11377693B2/en active Active
- 2015-12-08 RU RU2017123117A patent/RU2017123117A/ru not_active Application Discontinuation
- 2015-12-08 JP JP2017530266A patent/JP2018505658A/ja active Pending
- 2015-12-08 KR KR1020177018558A patent/KR20170086661A/ko not_active Withdrawn
- 2015-12-08 CA CA2968406A patent/CA2968406A1/en not_active Abandoned
- 2015-12-08 EP EP15868101.5A patent/EP3230498B1/en active Active
- 2015-12-08 WO PCT/US2015/064445 patent/WO2016094377A1/en not_active Ceased
- 2015-12-08 MX MX2017007535A patent/MX2017007535A/es unknown
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2020
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|---|---|
| BR112017012222A2 (pt) | 2018-01-30 |
| EP3230498A4 (en) | 2018-08-01 |
| WO2016094377A1 (en) | 2016-06-16 |
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| RU2017123117A3 (enExample) | 2019-07-17 |
| CA2968406A1 (en) | 2016-06-16 |
| EP3230498A1 (en) | 2017-10-18 |
| MX2017007535A (es) | 2017-08-10 |
| KR20170086661A (ko) | 2017-07-26 |
| AU2015360736A1 (en) | 2017-06-01 |
| RU2017123117A (ru) | 2019-01-10 |
| EP3230498B1 (en) | 2023-01-18 |
| US11377693B2 (en) | 2022-07-05 |
| AU2020204557A1 (en) | 2020-07-30 |
| US20180327848A1 (en) | 2018-11-15 |
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