CN107108520B - 合成麦角硫因及相关化合物的方法 - Google Patents

合成麦角硫因及相关化合物的方法 Download PDF

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Publication number
CN107108520B
CN107108520B CN201580062451.0A CN201580062451A CN107108520B CN 107108520 B CN107108520 B CN 107108520B CN 201580062451 A CN201580062451 A CN 201580062451A CN 107108520 B CN107108520 B CN 107108520B
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formula
compound
sulfoxide
ergothioneine
benzyl
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Chinese (zh)
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CN107108520A (zh
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M·A·加尔迪内
L·P·孔德
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University of Cape Town
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University of Cape Town
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580062451.0A 2014-09-22 2015-09-22 合成麦角硫因及相关化合物的方法 Active CN107108520B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1416678.9 2014-09-22
GBGB1416678.9A GB201416678D0 (en) 2014-09-22 2014-09-22 Process For Synthesizing Ergothioneine And Its Intermediates
PCT/IB2015/001668 WO2016046618A1 (en) 2014-09-22 2015-09-22 Process for synthesizing ergothioneine and related compounds

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CN107108520A CN107108520A (zh) 2017-08-29
CN107108520B true CN107108520B (zh) 2018-11-02

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Country Link
US (1) US9908854B2 (https=)
EP (1) EP3197874B1 (https=)
JP (1) JP6483250B2 (https=)
CN (1) CN107108520B (https=)
GB (1) GB201416678D0 (https=)
WO (1) WO2016046618A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105949130B (zh) * 2016-04-29 2018-10-19 华南农业大学 一种利用超声-微波辅助结合真空冷冻干燥提取食用菌麦角硫因的方法
CN111170945B (zh) * 2020-01-15 2022-03-29 中国科学院西北高原生物研究所 黄蘑菇中天然抗氧化氨基酸衍生物的分离工艺及其应用
JP6864131B1 (ja) * 2020-03-04 2021-04-28 長瀬産業株式会社 Ｌ−エルゴチオネイン含有組成物
CN111574458B (zh) * 2020-06-11 2023-04-07 上海克琴科技有限公司 一种麦角硫因的合成方法
CN114409608B (zh) * 2022-01-24 2022-09-02 广州金娜宝生物科技有限公司 一种麦角硫因的合成方法
CN119032084A (zh) * 2022-04-22 2024-11-26 南京纽邦生物科技有限公司 麦角硫因的化学合成方法和使用方法
CN116102502A (zh) * 2022-11-28 2023-05-12 南京艾希帝生物科技有限公司 一种麦角硫因的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120136159A1 (en) * 2009-10-06 2012-05-31 Tertrahedron The method of synthesizing ergothioneine and analogs
WO2014100752A1 (en) * 2012-12-21 2014-06-26 Liu Pinghua Ergothioneine production through metabolic engineering

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120136159A1 (en) * 2009-10-06 2012-05-31 Tertrahedron The method of synthesizing ergothioneine and analogs
WO2014100752A1 (en) * 2012-12-21 2014-06-26 Liu Pinghua Ergothioneine production through metabolic engineering

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Irene Erdelmeier et al..Cysteine as sustainable sulfur-reagent for the protecting-group-free synthesis of sulfur-containing amino acids:Biomimetic synthesis of L-ergothioneine in water.《GREEN CHEMISTRY》.2012,第14卷(第8期),2256-2265. *

Also Published As

Publication number Publication date
JP2017536086A (ja) 2017-12-07
US20170305865A1 (en) 2017-10-26
WO2016046618A1 (en) 2016-03-31
EP3197874B1 (en) 2019-04-24
JP6483250B2 (ja) 2019-03-13
GB201416678D0 (en) 2014-11-05
EP3197874A1 (en) 2017-08-02
US9908854B2 (en) 2018-03-06
CN107108520A (zh) 2017-08-29

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