CN107106692B - 磷脂组合物和微囊及使用磷脂组合物和微囊形成的乳剂 - Google Patents

磷脂组合物和微囊及使用磷脂组合物和微囊形成的乳剂 Download PDF

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CN107106692B
CN107106692B CN201580038940.2A CN201580038940A CN107106692B CN 107106692 B CN107106692 B CN 107106692B CN 201580038940 A CN201580038940 A CN 201580038940A CN 107106692 B CN107106692 B CN 107106692B
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polyethylene glycol
mole percent
phosphatidylethanolamine
dipalmitoylphosphatidylethanolamine
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CN107106692A (zh
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埃文·C·昂格尔
丹尼尔·C·埃文斯
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
CN201580038940.2A 2014-06-12 2015-06-12 磷脂组合物和微囊及使用磷脂组合物和微囊形成的乳剂 Active CN107106692B (zh)

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US201462011469P 2014-06-12 2014-06-12
US62/011,469 2014-06-12
PCT/US2015/035681 WO2015192093A1 (en) 2014-06-12 2015-06-12 Phospholipid composition and microbubbles and emulsions formed using same

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CN107106692A CN107106692A (zh) 2017-08-29
CN107106692B true CN107106692B (zh) 2021-01-05

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US (3) US9801959B2 (https=)
EP (1) EP3154591B1 (https=)
JP (1) JP6594909B2 (https=)
KR (1) KR102379534B1 (https=)
CN (1) CN107106692B (https=)
AU (1) AU2015274259B2 (https=)
CA (1) CA2951922C (https=)
WO (1) WO2015192093A1 (https=)

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EP3240579B1 (en) 2014-12-31 2022-07-27 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
BR112018012618A2 (pt) * 2015-12-21 2018-12-04 C Unger Evan composições da nano emulsão de fluorocarbonos e métodos de preparação e uso dos mesmos
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
MX2018013409A (es) 2016-05-04 2019-07-08 Lantheus Medical Imaging Inc Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3530266A1 (en) * 2018-02-27 2019-08-28 LipoCoat B.V. A lipid-based coating composition, and an object having a lipid-based coating
EP3773500A4 (en) * 2018-03-29 2022-03-16 Microvascular Therapeutics LLC COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE
WO2019191557A1 (en) * 2018-03-29 2019-10-03 Case Wester Reserve University Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
GB201908352D0 (en) * 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
WO2021096951A1 (en) * 2019-11-11 2021-05-20 Washington University Liposome compositions and methods of treatment targeted to tumor endothelium
CN111729094B (zh) * 2020-07-23 2021-07-02 四川大学华西医院 类磷脂两亲性嵌段共聚物基超声造影剂及其制备方法
EP4267203A1 (en) * 2020-12-27 2023-11-01 Solstice Pharmaceuticals B.V. A cartridge for mixing a phospholipid composition intended for intracorporeal use
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
NL2027237B1 (en) 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
TW202342111A (zh) * 2022-02-09 2023-11-01 美商藍瑟斯醫學影像公司 氣體奈米/微泡組合物及其用途

Citations (1)

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US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

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US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PL323931A1 (en) * 1995-06-07 1998-04-27 Alliance Pharma Compositions of reversed emulsion of fluorine derivatives of hydrocarbons for use as drug delivering carriers
WO1998010798A1 (en) * 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator
US6572840B1 (en) 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
JP2008509890A (ja) * 2004-08-05 2008-04-03 ベイラー・リサーチ・インスチチユート 遺伝子または薬剤送達系
EP2253308A1 (en) * 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

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EP3154591A4 (en) 2018-02-14
EP3154591B1 (en) 2023-10-11
EP3154591A1 (en) 2017-04-19
US11160885B2 (en) 2021-11-02
US20160000943A1 (en) 2016-01-07
CA2951922C (en) 2023-02-28
JP2017517533A (ja) 2017-06-29
CA2951922A1 (en) 2015-12-17
KR20170016462A (ko) 2017-02-13
EP3154591C0 (en) 2023-10-11
US9801959B2 (en) 2017-10-31
KR102379534B1 (ko) 2022-03-25
AU2015274259A1 (en) 2017-01-05
AU2015274259B2 (en) 2019-04-18
JP6594909B2 (ja) 2019-10-23
WO2015192093A1 (en) 2015-12-17
CN107106692A (zh) 2017-08-29
US10493173B2 (en) 2019-12-03
US20190184038A1 (en) 2019-06-20
US20180092995A1 (en) 2018-04-05

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