CN107106635B - 肺炎球菌溶血素突变体及其使用方法 - Google Patents

肺炎球菌溶血素突变体及其使用方法 Download PDF

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CN107106635B
CN107106635B CN201580071394.2A CN201580071394A CN107106635B CN 107106635 B CN107106635 B CN 107106635B CN 201580071394 A CN201580071394 A CN 201580071394A CN 107106635 B CN107106635 B CN 107106635B
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CN107106635A (zh
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R·K·特温坦
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University of Oklahoma
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
CN201580071394.2A 2014-11-21 2015-11-20 肺炎球菌溶血素突变体及其使用方法 Active CN107106635B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462082848P 2014-11-21 2014-11-21
US62/082,848 2014-11-21
PCT/US2015/061859 WO2016081839A1 (en) 2014-11-21 2015-11-20 Pneumolysin mutants and methods of use thereof

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CN107106635A CN107106635A (zh) 2017-08-29
CN107106635B true CN107106635B (zh) 2021-10-08

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9181308B2 (en) 2011-03-28 2015-11-10 St. Jude Children's Research Hospital Methods and compositions employing immunogenic fusion proteins
WO2018124959A2 (en) 2016-12-28 2018-07-05 Henriques Normark Birgitta Microparticles from streptococcus pneumoniae as vaccine antigens
CN110967482B (zh) * 2018-09-30 2023-04-07 重庆市畜牧科学院 一种山羊化脓隐秘杆菌感染检测试剂盒及其检测方法
CN113264999B (zh) * 2021-04-29 2023-02-28 星济生物(苏州)有限公司 中和肺炎链球菌溶血素蛋白的抗原结合蛋白及其用途
WO2023039223A1 (en) * 2021-09-09 2023-03-16 Affinivax, Inc. Multivalent pneumococcal vaccines
WO2023092090A1 (en) 2021-11-18 2023-05-25 Matrivax, Inc. Immunogenic fusion protein compositions and methods of use thereof
CN115927420A (zh) * 2022-05-27 2023-04-07 贵州省畜牧兽医研究所 一种溶血素重组表达及间接elisa检测方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101018863A (zh) * 2004-05-07 2007-08-15 利-安·柯卡姆 突变体肺炎链球菌溶血素蛋白质
US8128939B2 (en) * 2007-04-13 2012-03-06 The Board Of Regents Of The University Of Oklahoma Mutants of cholesterol-dependent cytolysins and uses thereof
CN102939105A (zh) * 2009-12-22 2013-02-20 赛诺菲巴斯德有限公司 免疫原性组合物和相关的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686102A (en) 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof
JP3237842B2 (ja) 1988-12-16 2001-12-10 オランダ国 ニューモリシンミュータント及びそれから製造されたニューモコッカルワクチン
US6716432B1 (en) 1988-12-16 2004-04-06 James Cleland Paton Pneumolysin mutants and pneumococcal vaccines made therefrom
US5854416A (en) 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
ATE291625T1 (de) 1995-06-07 2005-04-15 Univ Minnesota Streptococcus toxinmutanten und verfahren zu deren anwendung
EP0998557A2 (en) 1997-07-21 2000-05-10 North American Vaccine, Inc. Modified immunogenic pneumolysin, compositions and their use as vaccines
US6224880B1 (en) 1997-09-24 2001-05-01 Merck & Co., Inc. Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines
US6903184B1 (en) 1998-03-02 2005-06-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multiple antigenic peptides immunogenic against Streptococcus pneumonia
PL204863B1 (pl) 1998-07-22 2010-02-26 Stichting Dienst Landbouwkundi Zastosowanie mutanta Streptococcus, szczepionka i sposoby kontrolowania lub eliminowania choroby paciorkowcowej w populacji
PT1140157E (pt) 1998-12-21 2009-05-06 Medimmune Inc Proteínas de streptococcus pneumoniae e fragmentos imunogénicos para vacinas
US6887480B1 (en) 1999-06-10 2005-05-03 Medimmune, Inc. Streptococcus pneumoniae proteins and vaccines
US7262024B2 (en) 2001-12-20 2007-08-28 Id Biomedical Corporation Streptococcus antigens
WO2004043376A2 (en) 2002-11-07 2004-05-27 Synergy America, Inc. Compositions and methods for treating or preventing pneumococcal infection
CA2555803A1 (en) 2004-02-13 2005-08-27 Sanofi Pasteur Limited Pneumolysin derivatives
WO2005108419A1 (en) 2004-05-07 2005-11-17 Lea-Ann Kirkham Mutant cholesterol-binding cytolysin proteins
WO2007144647A2 (en) 2006-06-15 2007-12-21 Timothy John Mitchell Adjuvant compositions
CN106008679A (zh) * 2008-12-24 2016-10-12 荷兰王国卫生福利和运动部国家公共卫生和环境研究所 修饰的肺炎链球菌溶血素(ply)多肽
CL2010001216A1 (es) * 2010-11-08 2011-01-28 New Tech Copper S P A Sistema para confinar el espacio sobre el electrolito en una celda de electro obtencion y evacuar los aerosoles generados, que comprende un confinador insertado en cada anodo, con un par de proyecciones flexibles y un par de perfiles en angulo, y ductos longitudinales con perforaciones sobre el nivel del electrolito.
US9181308B2 (en) 2011-03-28 2015-11-10 St. Jude Children's Research Hospital Methods and compositions employing immunogenic fusion proteins
JP6397805B2 (ja) 2015-08-28 2018-09-26 東芝メモリ株式会社 半導体製造装置およびその運転方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101018863A (zh) * 2004-05-07 2007-08-15 利-安·柯卡姆 突变体肺炎链球菌溶血素蛋白质
US8128939B2 (en) * 2007-04-13 2012-03-06 The Board Of Regents Of The University Of Oklahoma Mutants of cholesterol-dependent cytolysins and uses thereof
CN102939105A (zh) * 2009-12-22 2013-02-20 赛诺菲巴斯德有限公司 免疫原性组合物和相关的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Molecular Cloning, Characterization, and Complete Nucleotide Sequence of the Gene for Pneumolysin, the Sulfhydryl-Activated Toxin of Streptococcus Pneumoniae;J A Walker等;《Infection and immunity》;19870531;第55卷(第5期);1184-1189 *
The Impact of Pneumolysin on the Macrophage Response to Streptococcus Pneumoniae Is Strain-Dependent;Richard M Harvey等;《PloS one》;20140808;第9卷(第8期);1-9 *
肺炎链球菌溶血素Ply蛋白疫苗及BLP技术应用的研究;侯宏嘉;《中国优秀硕士论文全文数据库 医药卫生科技辑》;20140930(第9期);E059-72 *

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BR112017010696A2 (pt) 2017-12-26
LT3220937T (lt) 2024-12-27
JP2017536124A (ja) 2017-12-07
US10562941B2 (en) 2020-02-18
SMT202400482T1 (it) 2025-01-14
PT3220937T (pt) 2024-11-18
EP3220937A4 (en) 2018-05-30
HUE069200T2 (hu) 2025-02-28
ES2993430T3 (en) 2024-12-30
MX2017006625A (es) 2018-01-15
DK3220937T3 (da) 2024-12-02
US20180312552A1 (en) 2018-11-01
EP3220937B1 (en) 2024-09-04
JP6734274B2 (ja) 2020-08-05
SI3220937T1 (sl) 2025-03-31
EP3220937A1 (en) 2017-09-27
KR20170083635A (ko) 2017-07-18
CN107106635A (zh) 2017-08-29
EP4501949A2 (en) 2025-02-05
KR102304828B1 (ko) 2021-09-27
EP4501949A3 (en) 2025-04-30
HRP20241627T1 (hr) 2025-02-14
MX381872B (es) 2025-03-13
FI3220937T3 (fi) 2024-11-29
PL3220937T3 (pl) 2025-01-27
CA2968398A1 (en) 2016-05-26
AU2015349787B2 (en) 2021-07-29
AU2015349787A1 (en) 2017-06-22
RS66221B1 (sr) 2024-12-31
WO2016081839A1 (en) 2016-05-26
ZA201703881B (en) 2021-10-27

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