ATE291625T1 - Streptococcus toxinmutanten und verfahren zu deren anwendung - Google Patents
Streptococcus toxinmutanten und verfahren zu deren anwendungInfo
- Publication number
- ATE291625T1 ATE291625T1 AT96921589T AT96921589T ATE291625T1 AT E291625 T1 ATE291625 T1 AT E291625T1 AT 96921589 T AT96921589 T AT 96921589T AT 96921589 T AT96921589 T AT 96921589T AT E291625 T1 ATE291625 T1 AT E291625T1
- Authority
- AT
- Austria
- Prior art keywords
- spe
- toxin
- vaccine
- toxins
- wild type
- Prior art date
Links
- 239000003053 toxin Substances 0.000 title abstract 6
- 231100000765 toxin Toxicity 0.000 title abstract 6
- 241000194017 Streptococcus Species 0.000 title 1
- 108700012359 toxins Proteins 0.000 abstract 5
- 229960005486 vaccine Drugs 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100001160 nonlethal Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48026195A | 1995-06-07 | 1995-06-07 | |
PCT/US1996/010252 WO1996040930A1 (en) | 1995-06-07 | 1996-06-07 | Mutants of streptococcal toxin a and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE291625T1 true ATE291625T1 (de) | 2005-04-15 |
Family
ID=23907283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96921589T ATE291625T1 (de) | 1995-06-07 | 1996-06-07 | Streptococcus toxinmutanten und verfahren zu deren anwendung |
Country Status (12)
Country | Link |
---|---|
US (3) | US6632441B2 (de) |
EP (2) | EP0832241B1 (de) |
JP (1) | JPH11514844A (de) |
KR (1) | KR100456594B1 (de) |
AT (1) | ATE291625T1 (de) |
AU (1) | AU723116B2 (de) |
CA (1) | CA2221480A1 (de) |
DE (1) | DE69634510T2 (de) |
DK (1) | DK0832241T3 (de) |
ES (1) | ES2239332T3 (de) |
PT (1) | PT832241E (de) |
WO (1) | WO1996040930A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW517061B (en) * | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
CN1211487C (zh) * | 1996-12-06 | 2005-07-20 | 明尼苏达大学董事会 | 链球菌毒素a突变体及其使用方法 |
US6774218B2 (en) | 1996-12-06 | 2004-08-10 | Regents Of The University Of Minnesota | Mutants of streptococcal toxin C and methods of use |
DK0946730T3 (da) | 1996-12-06 | 2006-07-10 | Univ Minnesota | Mutanter af streptokok-toksin C og fremgangsmåder til anvendelse |
US6075119A (en) | 1997-04-07 | 2000-06-13 | The Rockefeller University | Peptides useful for reducing symptoms of toxic shock syndrome |
US7087235B2 (en) * | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
US6872394B1 (en) | 1997-12-02 | 2005-03-29 | Idaho Research Foundation, Inc. | Non-toxic immune stimulating enterotoxin compositions |
EP1127132A1 (de) * | 1998-10-07 | 2001-08-29 | The Rockefeller University | Geeignete peptide zur reduzierung des toxischen schock syndroms und von septischem schock |
US20040236082A1 (en) * | 2001-04-13 | 2004-11-25 | Marshall Matthew J. | Modified staphylococcal enterotoxins and expression systems therefore |
SE0102327D0 (sv) * | 2001-06-28 | 2001-06-28 | Active Biotech Ab | A novel engineered superantigen for human therapy |
US20070178113A1 (en) * | 2005-11-22 | 2007-08-02 | Backstrom B T | Superantigen conjugate |
EP2147015A4 (de) | 2007-04-13 | 2011-01-26 | Univ Oklahoma State | Mutanten von cholesterinabhängigen cytolysinen und verwendungen davon |
JP2017521654A (ja) | 2014-06-27 | 2017-08-03 | アボット・ラボラトリーズAbbott Laboratories | ヒトペギウイルス2(HPgV−2)を検出するための組成物および方法 |
EP3220937A4 (de) | 2014-11-21 | 2018-05-30 | The Board of Regents of the University of Oklahoma | Pneumolysinmutanten und verfahren zur verwendung davon |
AU2017206656B2 (en) | 2016-01-10 | 2024-02-01 | Neotx Therapeutics Ltd. | Immunopotentiator enhanced superantigen mediated cancer immunotherapy |
MX2021013908A (es) | 2019-05-15 | 2022-03-11 | Neotx Therapeutics Ltd | Tratamiento para el cáncer. |
CN115484978A (zh) | 2020-03-05 | 2022-12-16 | 尼奥克斯医疗有限公司 | 使用免疫细胞治疗癌症的方法和组合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784948A (en) * | 1983-08-10 | 1988-11-15 | The Rockefeller University | Production of streptococcal m protein immunogens and molecular probes |
US5336598A (en) | 1989-11-15 | 1994-08-09 | National Jewish Center For Immunology And Respiratory Medicine | Method for diagnosing a superantigen caused pathologial condition via assay of T-cells |
US5298396A (en) | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
WO1993014634A1 (en) | 1992-01-28 | 1993-08-05 | National Jewish Center For Immunology And Respiratory Medicine | Protective effects of mutated superantigens |
-
1996
- 1996-06-07 PT PT96921589T patent/PT832241E/pt unknown
- 1996-06-07 JP JP9502265A patent/JPH11514844A/ja not_active Ceased
- 1996-06-07 EP EP96921589A patent/EP0832241B1/de not_active Expired - Lifetime
- 1996-06-07 EP EP05075021A patent/EP1538208A3/de not_active Withdrawn
- 1996-06-07 AT AT96921589T patent/ATE291625T1/de not_active IP Right Cessation
- 1996-06-07 AU AU62782/96A patent/AU723116B2/en not_active Ceased
- 1996-06-07 ES ES96921589T patent/ES2239332T3/es not_active Expired - Lifetime
- 1996-06-07 DK DK96921589T patent/DK0832241T3/da active
- 1996-06-07 KR KR1019970709192A patent/KR100456594B1/ko not_active IP Right Cessation
- 1996-06-07 WO PCT/US1996/010252 patent/WO1996040930A1/en active IP Right Grant
- 1996-06-07 US US08/973,391 patent/US6632441B2/en not_active Expired - Fee Related
- 1996-06-07 CA CA002221480A patent/CA2221480A1/en not_active Abandoned
- 1996-06-07 DE DE69634510T patent/DE69634510T2/de not_active Expired - Fee Related
-
2003
- 2003-07-22 US US10/625,221 patent/US6870042B1/en not_active Expired - Fee Related
-
2005
- 2005-03-21 US US11/085,466 patent/US20060039925A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69634510D1 (de) | 2005-04-28 |
US20020054887A1 (en) | 2002-05-09 |
EP1538208A2 (de) | 2005-06-08 |
EP0832241B1 (de) | 2005-03-23 |
DK0832241T3 (da) | 2005-08-01 |
EP1538208A3 (de) | 2007-05-23 |
JPH11514844A (ja) | 1999-12-21 |
DE69634510T2 (de) | 2006-01-26 |
AU6278296A (en) | 1996-12-30 |
KR100456594B1 (ko) | 2005-06-17 |
KR19990022750A (ko) | 1999-03-25 |
EP0832241A1 (de) | 1998-04-01 |
US20060039925A1 (en) | 2006-02-23 |
US6870042B1 (en) | 2005-03-22 |
CA2221480A1 (en) | 1996-12-19 |
WO1996040930A1 (en) | 1996-12-19 |
AU723116B2 (en) | 2000-08-17 |
PT832241E (pt) | 2005-08-31 |
US6632441B2 (en) | 2003-10-14 |
ES2239332T3 (es) | 2005-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0832241 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |