CN107080253A - Gardenia and bitter orange spend prepared raw material components to be applied in all kinds of health foods are prepared - Google Patents
Gardenia and bitter orange spend prepared raw material components to be applied in all kinds of health foods are prepared Download PDFInfo
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- CN107080253A CN107080253A CN201710263334.1A CN201710263334A CN107080253A CN 107080253 A CN107080253 A CN 107080253A CN 201710263334 A CN201710263334 A CN 201710263334A CN 107080253 A CN107080253 A CN 107080253A
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- bitter orange
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- 235000007716 Citrus aurantium Nutrition 0.000 title claims abstract description 219
- 239000002994 raw material Substances 0.000 title claims abstract description 157
- 235000013402 health food Nutrition 0.000 title claims abstract description 66
- 240000001972 Gardenia jasminoides Species 0.000 title claims 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 63
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- GIKVSFNAEBQLGB-UHFFFAOYSA-N 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one Chemical compound C=1C(OC)=CC(OC)=C(C(C=2)=O)C=1OC=2C1=CC(OC)=C(OC)C(OC)=C1 GIKVSFNAEBQLGB-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
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- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
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- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
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- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 description 1
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- XJMPAUZQVRGFRE-SCHFUKFYSA-N Gardenoside Natural products O=C(OC)C=1[C@H]2[C@H]([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)[C@@](O)(CO)C=C2 XJMPAUZQVRGFRE-SCHFUKFYSA-N 0.000 description 1
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- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 description 1
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- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 1
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- XJMPAUZQVRGFRE-AYDWLWLASA-N methyl (1s,4as,7s,7as)-7-hydroxy-7-(hydroxymethyl)-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,7a-dihydro-1h-cyclopenta[c]pyran-4-carboxylate Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1[C@](C=C2)(O)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O XJMPAUZQVRGFRE-AYDWLWLASA-N 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
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- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Prepared raw material components are spent to be applied in all kinds of health foods are prepared the present invention relates to gardenia and bitter orange.Gardenia and bitter orange spend prepared raw material components to be the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself using prepared raw material components in all kinds of health foods are prepared, or the alcohol extract for the being freeze-dried flower powder composition concentration dry cream that fresh gardenia flower and fresh bitter orange are spent, or the aqueous extract freeze dried powder for being freeze-dried flower powder composition that fresh gardenia flower and fresh bitter orange are spent, or fresh gardenia flower and fresh bitter orange flower alcohol extract concentration dry cream, or fresh gardenia flower and fresh bitter orange flower pressure extracting juice freeze dried powder, or dry gardenia and dry bitter orange flower alcohol extract concentration dry cream, or dry gardenia and dry bitter orange flower Clean water withdraw liquid concentration dry cream, or the volatile oil that gardenia and bitter orange flower extraction by steam distillation are obtained, or gardenia and bitter orange flower supercritical fluid extraction extract obtained volatile oil.Above-mentioned raw materials component mainly has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function in all kinds of health foods are prepared using it.
Description
Technical field
Spend prepared raw material components to be applied in all kinds of health foods are prepared the present invention relates to gardenia and bitter orange, belong to
Eat medicine flowers food or health food preparing technical field.
Background technology
Gardenia source be mainly Rubiaceae cape jasmine platymiscium cape jasmine Gardenia jasminoides Ellis. flower or
The flower of all known plants of Rubiaceae Gardenia Ellis, more specifically bud stage spend or flower peak period flower fresh flower freeze-drying flower, fresh flower,
Dry flower.Gardenia sweet-bitter flavor cold in nature, enters lung, Liver Channel, can medicine eat it is dual-purpose.Gardenia contains flavones, monoterpene, diterpene, triterpene, fruit
The component types such as glue, tannin, amino acid, trace element, particularly flavonoids, monoterpenes, Diterpenes and triterpene are the battalion of its flower
Value composition or active component type are supported, such as contains crocin, Gardenoside, sour (gradenlicacid) A, gardenia acid B, benzyl acetate, second
Sour virtue camphor tree ester, particularly 5,7-dihydroxyl-3 ', 4 ' of flavone compound, 5 '-trimethoxyflavone, 5,7,4 '-
Trihydroxyl-6-methoxyflav one, 5,7,4 '-trihydroxyl-8-methoxyflavone, 5,7,3 '-
Trihydroxyl-8,4 ', 5 '-trimeth oxyflavone, 5-hydroxyl-6,7,3 ', 4 ', 5 '-
Pentamethoxyflavone, 5,3 '-dihydroxyl-7,4 ', 5 '-trimethoxyflavone, 5-hydroxyl-7,
3 ', 4 ', 5 '-tetramethoxyflavone, 3,5,6,4 '-tetrahydroxy-3 ', 5 '-dimethoxyflavone, 5,
7,3 ', 4 ', 5 '-pentame-thoxyflavone etc..Gardenia has purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body effect.It is existing
There is tranquilizing and allaying excitement, fatigue-relieving function for pharmacological research.Gardenia is medicine-food two-purpose, turns into delicious good on dining table after processing
Meat and fish dishes.People brew up fresh gardenia flower with water or fried when vegetables and eat, also have gardenia and rice in cape jasmine season of flowers
Cook congee and eat together.The fresh soup of gardenia, gardenia fry bamboo shoots, gardenia and fry the dish such as leek not only delicious flavour, rather good to rise
To clearing heat and cooling blood, preventing phlegm from forming and stopping coughing, wide intestines defaecation effect.Gardenia medical value and health-care effect have been recognized, but make tea,
The traditional handicraft cape jasmine Huadu such as quick-fried, decoction is to cook nutritional ingredient by high temperature by high temperature, volatility nutritive value into
Partial volume is easy to run off.Cape jasmine is Jiangxi genunie medicinal materials, and it spends perfect using further system research is needed in health food, will have
Help the development of local economy.
Bitter orange is spent also known as bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower, flores aurantii, and it is mainly Rutaceae Citrus that it, which is originated,
The flower of the flower or all plants of Rutaceae Citrus of bitter orange Citrus aurantium L. and its cultivars, more specifically spends
Flower bud phase is spent and the fresh flower of flower peak period flower is freeze-dried flower, fresh flower, dries flower.Bitter orange spends sweet slight bitter neutral in nature and sweet in taste, enters spleen, Liver Channel,
Can medicine-food two-purpose.Bitter orange flower is containing component type, particularly monoterpene, amino such as monoterpene, amino acid, trace element, pectin, tannins
Acid, trace element are the nutritional value component or active component type of its flower, such as neohesperidin, aurantiamarin, asparagine, network ammonia
Acid, valine, alanine etc..Bitter orange flower has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu effect.Modern pharmacological research have calm mood,
Release nervous function.Bitter orange flower is medicine-food two-purpose, turns into the delicious food on dining table after processing.People are bloomed season in bitter orange
Section, brews up fresh bitter orange flower with water or is fried when vegetables and eat.Bitter orange spends fresh soup, bitter orange flower to fry the dish such as bamboo shoots not only taste
Deliciousness, it is rather good to play a part of regulating spleen and stomach, regulating the flow of vital energy Xie Yu, wide intestines defaecation.Bitter orange has spent medical value and health-care effect
Be recognized, but make tea, quick-fried, the traditional handicraft bitter orange Huadu such as decoction are to cook nutritional ingredient by high temperature by high temperature,
Volatility nutritional value component is easily lost in.The dried immature fruit of citron orange and Fructus Aurantii are Jiangxi genunie medicinal materials, and it, which spends to apply in health food, needs
Further system research is perfect, it will help the development of local economy.
Prepared raw material components are spent to be applied in all kinds of health foods are prepared the present invention relates to gardenia and bitter orange, it is special
Levy and be that prepared raw material components are the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself, or
The aqueous extract freeze dried powder for the freeze-drying flower powder composition that fresh gardenia is spent and fresh bitter orange is spent, or fresh gardenia
The alcohol extract concentration dry cream for the freeze-drying flower powder composition that flower and fresh bitter orange are spent, or fresh gardenia flower and fresh acid
Flores aurantii squeezing juice freeze dried powder, or fresh gardenia flower and fresh bitter orange flower alcohol extract concentration dry cream, or dry gardenia and
Bitter orange flower aqueous extract concentration dry cream is dried, or dries gardenia and dries bitter orange flower alcohol extract concentration dry cream, or gardenia
The volatile oil that extraction by steam distillation is obtained, or gardenia and bitter orange flower supercritical fluid extraction is spent to extract and obtain with bitter orange
Volatile oil.The studies above is not yet reported that we confirm prepared by above-mentioned raw materials component first by the experimental study of system
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary in all kinds of health foods using it
Improve memory function, improve sleep function, fatigue-relieving function.
The content of the invention
Gardenia and bitter orange spend prepared raw material components to be applied in all kinds of health foods are prepared.
Present invention employs following technical proposals.
Gardenia and bitter orange spend prepared raw material components to be applied in all kinds of health foods are prepared, it is characterised in that made
Standby raw material components are that fresh gardenia spends the freeze-drying flower powder composition spent with fresh bitter orange, or fresh gardenia flower in itself
The aqueous extract freeze dried powder for the freeze-drying flower powder composition spent with fresh bitter orange, or fresh gardenia flower and fresh acid
The alcohol extract concentration dry cream of the freeze-drying flower powder composition of flores aurantii, or fresh gardenia flower and fresh bitter orange spend squeezing juice
Freeze dried powder, or fresh gardenia flower and fresh bitter orange flower alcohol extract concentration dry cream, or dry gardenia and dry bitter orange flower
Aqueous extract concentrates dry cream, or dries gardenia and dry bitter orange flower alcohol extract concentration dry cream, or gardenia and sour aqua aurantii florum
Steam distillation method extracts obtained volatile oil, or gardenia and bitter orange flower supercritical fluid extraction extract obtained volatile oil.
Above-mentioned raw materials component mainly has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, increasing in all kinds of health foods are prepared using it
Strong immunity function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
Gardenia according to claim 1 and bitter orange spend prepared raw material components in all kinds of health foods are prepared
It is the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself using prepared raw material components, it is special
Levy and be：
(1) using freeze drying process by the fresh gardenia of harvesting flower be placed in refrigerator-freezer temperature in subzero 15 DEG C~it is subzero 20 DEG C
After hardening freezes, be placed in frozen vacuum dryer temperature in subzero 25 DEG C~it is subzero 40 DEG C, vacuum is 60~140pa bar
Under part, vacuum freezedrying 8~24 hours obtains fresh gardenia and spends lyophilized dried flower, and its moisture is less than 5%, by fresh gardenia
Lyophilized dried flower is spent to be ground into the mesh of the mesh of powder 40~100.
(2) using freeze drying process by the fresh bitter orange of harvesting flower be placed in refrigerator-freezer temperature in subzero 15 DEG C~it is subzero 20 DEG C
After hardening freezes, be placed in frozen vacuum dryer temperature in subzero 25 DEG C~it is subzero 40 DEG C, vacuum is 60~140pa bar
Under part, vacuum freezedrying 8~24 hours obtains fresh bitter orange and spends lyophilized dried flower, and its moisture is less than 5%, by fresh bitter orange
Lyophilized dried flower is spent to be ground into the mesh of the mesh of powder 40~100.
(3) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 100%~0%：0%~100%.
(4) raw material components be fresh gardenia spend and fresh bitter orange spend freeze-drying flower powder composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Gardenia and bitter orange according to claim 1 and 2 spend prepared raw material components preparing all kinds of health care foods
It is the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself that prepared raw material components are applied in product
Aqueous extract freeze dried powder, it is characterised in that：
(1) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 100%~0%：0%~100%, its above-mentioned blending ingredients aqueous extract freeze dried powder, specifically
With 10~30 DEG C of 3~6 times of raw material blending ingredients of warm water ultrasonic extraction 2~3 times, 20~30 minutes every time, to merge and extracting
Liquid be placed in frozen vacuum dryer temperature in subzero 25 DEG C~it is subzero 40 DEG C, under conditions of vacuum is 60~140pa, freezing
Vacuum drying 8~24 hours, obtains the freeze-drying flower powder composition that raw material components are spent for fresh gardenia and fresh bitter orange is spent
Aqueous extract freeze dried powder.
(2) raw material components are that the freeze-drying flower powder composition aqueous extract that fresh gardenia is spent and fresh bitter orange is spent is cold
Freeze xeraphium using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, enhancing to exempt from all kinds of health foods are prepared
Epidemic disease power function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
Gardenia and bitter orange according to claim 1 and 2 spend prepared raw material components preparing all kinds of health care foods
It is the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself that prepared raw material components are applied in product
Alcohol extract concentrates dry cream, it is characterised in that：
(1) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 100%~0%：0%~100%, the alcohol extract concentration dry cream of its above-mentioned blending ingredients, specifically
With the refluxing extraction 2~4 times of 50~100% ethanol waters of 6~12 times of raw material blending ingredients, 30~90 minutes every time, to merge
Extract solution is recovered under reduced pressure at 45~60 DEG C, obtains the freeze-drying flower powder that raw material components are spent for fresh gardenia and fresh bitter orange is spent
Component alcohol extract concentrates dry cream.
(2) raw material components are the freeze-drying flower powder alcohol extract concentration dry cream that fresh gardenia is spent and fresh bitter orange is spent
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity work(using it in all kinds of health foods are prepared
Energy, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
Gardenia according to claim 1 and bitter orange spend prepared raw material components in all kinds of health foods are prepared
It is the squeezing juice freeze dried powder of fresh gardenia flower and fresh bitter orange flower composition in itself using prepared raw material components, it is special
Levy and be：
(1) raw material components prepared by are that the weight/mass percentage composition of fresh gardenia flower and fresh bitter orange flower composition is in itself
100%~0%：0%~100%, its above-mentioned blending ingredients pressure extracting juice merges pressed liquor and is placed in temperature in frozen vacuum dryer
Spend in subzero 25 DEG C~it is subzero 40 DEG C, vacuum be 60~140pa under conditions of, vacuum freezedrying 8~24 hours obtains raw material
Component is the squeezing juice freeze dried powder of fresh gardenia flower and bitter orange flower composition.
(2) raw material components are that fresh gardenia is spent and the squeezing juice freeze dried powder of bitter orange flower composition is preparing all kinds of health cares
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
Gardenia according to claim 1 and bitter orange spend prepared raw material components in all kinds of health foods are prepared
It is the alcohol extract concentration dry cream of fresh gardenia flower and fresh bitter orange flower composition in itself using prepared raw material components, it is special
Levy and be：
(1) raw material components prepared by are that the weight/mass percentage composition of fresh gardenia flower and fresh bitter orange flower composition is in itself
99%~1%：1%~99%, the alcohol extract of its above-mentioned blending ingredients concentration dry cream, specially with raw material blending ingredients 6~
The refluxing extraction of 12 times of 50~100% ethanol waters 2~4 times, 30~90 minutes every time, merges extract solution in 45~60 DEG C of decompressions
Reclaim, obtain raw material components and spend the alcohol extract with bitter orange flower composition to concentrate dry cream for fresh gardenia.
(2) raw material components be fresh gardenia spend and fresh bitter orange flower composition alcohol extract concentration dry cream prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Gardenia according to claim 1 and bitter orange spend prepared raw material components in all kinds of health foods are prepared
It is the aqueous extract concentration dry cream of dry gardenia and dry bitter orange flower composition in itself using prepared raw material components, it is special
Levy and be：
(1) raw material components prepared by are dry gardenia in itself and dry the weight/mass percentage composition of bitter orange flower composition
99%~1%：1%~99%, the aqueous extract of its above-mentioned blending ingredients concentration dry cream, specially with raw material blending ingredients 6~
10 times of boiling water boiling and extraction 2~4 times, 30~60 minutes every time, merging extract solution was placed in 50 DEG C~60 DEG C and is recovered under reduced pressure, and obtains former
It is the aqueous extract concentration dry cream dried gardenia and dry bitter orange flower composition to expect component.
(2) raw material components be dry gardenia and dry the aqueous extract concentration dry cream of bitter orange flower composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Gardenia according to claim 1 and bitter orange spend prepared raw material components in all kinds of health foods are prepared
It is the alcohol extract concentration dry cream of dry gardenia and dry bitter orange flower composition in itself using prepared raw material components, it is special
Levy and be：
(1) raw material components prepared by are dry gardenia in itself and dry the weight/mass percentage composition of bitter orange flower composition
99%~1%：1%~99%, the alcohol extract of its above-mentioned blending ingredients concentration dry cream, specially with raw material blending ingredients 6~
The refluxing extraction of 12 times of 50~95% ethanol waters 2~4 times, 30~90 minutes every time, merges extract solution in 45~60 DEG C of decompressions
Reclaim, it is the alcohol extract concentration dry cream dried gardenia and dry bitter orange flower composition to obtain raw material components.
(2) raw material components be dry gardenia and dry the alcohol extract concentration dry cream of bitter orange flower composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Gardenia according to claims 1 to 8 and bitter orange spend prepared raw material components preparing all kinds of health foods
Middle application, it is characterised in that：Gardenia source is mainly Rubiaceae cape jasmine platymiscium cape jasmine Gardenia jasminoides
Ellis. flower or the flower of all known plants of Rubiaceae Gardenia Ellis, more specifically bud stage are spent or the fresh flower of flower peak period flower is freezed
Dry flower, fresh flower, dry flower；Bitter orange is spent also known as bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower, flores aurantii, and its source is mainly
The flower or all plants of Rutaceae Citrus of Rutaceae Citrus bitter orange Citrus aurantium L. and its cultivars
The fresh flower of flower, more specifically bud stage flower and flower peak period flower is freeze-dried flower, fresh flower, dries flower.
Gardenia and bitter orange spend prepared raw material components preparing all kinds of health foods according to claim 1 and 9
Raw material components prepared by middle application are the volatile oil for the gardenia and bitter orange flower originated described in claim 9, its feature in itself
It is：
(1) raw material components prepared by are the matter for the gardenia and bitter orange flower composition originated described in claim 9 in itself
It is 99%~1% to measure percentage composition：1%~99%, the volatile oil of the extraction by steam distillation of its above-mentioned blending ingredients, specifically
With the extraction by steam distillation 1 time of 8~12 times of raw material blending ingredients, 4~6 hours extraction times, to obtain raw material components for Cape jasmine
The volatile oil of sub- flower and bitter orange flower composition.
(2) raw material components prepared by are the matter for the gardenia and bitter orange flower composition originated described in claim 9 in itself
It is 99%~1% to measure percentage composition：1%~99%, its above-mentioned blending ingredients is extracted with supercritical fluid extraction, obtains raw material group
It is divided into the volatile oil of gardenia and bitter orange flower composition.
(3) raw material components be application of the volatile oil of gardenia and bitter orange flower composition in all kinds of health foods are prepared its
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improving memory function, improvement sleep
Function, fatigue-relieving function.
Embodiment
With reference to embodiment, the invention will be further described：
Embodiment 1
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Divide the freeze-drying flower powder composition for being in itself fresh gardenia flower and fresh bitter orange flower, its preparation method is as follows：
(1) 2000 grams are spent to be placed in refrigerator-freezer temperature in subzero 20 DEG C hardening the fresh gardenia of harvesting using freeze drying process
After icing, temperature is placed in frozen vacuum dryer in subzero 40 DEG C, under conditions of vacuum is 100pa, vacuum freezedrying
20 hours, obtain fresh gardenia and spend lyophilized dried flower, its moisture is less than 5%, spends lyophilized dried flower to be ground into 100 mesh fresh gardenia
Powder.
(2) 2000 grams are spent to be placed in refrigerator-freezer temperature in subzero 20 DEG C hardening the fresh bitter orange of harvesting using freeze drying process
After icing, temperature is placed in frozen vacuum dryer in subzero 40 DEG C, under conditions of vacuum is 100pa, vacuum freezedrying
20 hours, obtain fresh bitter orange and spend lyophilized dried flower, its moisture is less than 5%, spends lyophilized dried flower to be ground into 100 mesh fresh bitter orange
Powder.
(3) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 100%~0%：0%~100%.
(4) raw material components be fresh gardenia spend and fresh bitter orange spend freeze-drying flower powder composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Embodiment 2
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Divide the aqueous extract freeze dried powder for the freeze-drying flower powder composition for being fresh gardenia flower and fresh bitter orange flower in itself, its
Preparation method is as follows：
(1) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 50%：50%, the freeze-drying flower for taking the flower of fresh gardenia described in example 1 and fresh bitter orange to spend
Each 60 grams of blending ingredients aqueous extract freeze dried powder of powder, specially 20 DEG C with 120 grams of raw material blending ingredients in 500ml
Warm water ultrasonic extraction 2 times, 25 minutes every time, merges extract solution and is placed in frozen vacuum dryer temperature in subzero 40 DEG C, vacuum
Spend under conditions of 100pa, vacuum freezedrying 24 hours obtains the freezing that raw material components are spent for fresh gardenia and fresh bitter orange is spent
Dry flower powder composition aqueous extract freeze dried powder.
(2) raw material components are that the freeze-drying flower powder composition aqueous extract that fresh gardenia is spent and fresh bitter orange is spent is cold
Freeze xeraphium using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, enhancing to exempt from all kinds of health foods are prepared
Epidemic disease power function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
Embodiment 3
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
It is that the freeze-drying flower powder composition alcohol extract that fresh gardenia flower and fresh bitter orange are spent concentrates dry cream in itself to divide, its preparation
Method is as follows：
(1) raw material components prepared by are the freeze-drying flower powder combinations that fresh gardenia flower and fresh bitter orange are spent in itself
The weight/mass percentage composition of thing is 50%：50%, the freeze-drying flower for taking the flower of fresh gardenia described in example 1 and fresh bitter orange to spend
Each 60 grams of blending ingredients alcohol extractings concentration dry cream of powder, specially with 120 grams of 95% ethanol in 1200ml of raw material blending ingredients
The refluxing extraction of water 3 times, 60 minutes every time, merge extract solution be recovered under reduced pressure at 50 DEG C, obtain raw material components for fresh gardenia flower and
The freeze-drying flower powdery components alcohol extract concentration dry cream of fresh bitter orange flower.
(2) raw material components are the freeze-drying flower powder alcohol extract concentration dry cream that fresh gardenia is spent and fresh bitter orange is spent
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity work(using it in all kinds of health foods are prepared
Energy, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
Embodiment 4
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Point it is the squeezing juice freeze dried powder of fresh gardenia flower and fresh bitter orange flower composition in itself, its preparation method is as follows：
(1) raw material components prepared by are that the weight/mass percentage composition of fresh gardenia flower and fresh bitter orange flower composition is in itself
50%：50%, take fresh gardenia flower and fresh bitter orange to spend each 500 grams of blending ingredients pressure extracting juice, merge pressed liquor and be placed in freezing
Built-in temperature is dried in vacuo in subzero 40 DEG C, vacuum is under conditions of 100pa, vacuum freezedrying 20 hours obtains raw material group
It is divided into the squeezing juice freeze dried powder of fresh gardenia flower and bitter orange flower composition.
(2) raw material components are that fresh gardenia is spent and the squeezing juice freeze dried powder of bitter orange flower composition is preparing all kinds of health cares
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
Embodiment 5
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
It is that fresh gardenia is spent and the alcohol extract of fresh bitter orange flower composition concentrates dry cream in itself to divide, and its preparation method is as follows：
(1) raw material components prepared by are that the weight/mass percentage composition of fresh gardenia flower and fresh bitter orange flower composition is in itself
99%~1%：1%~99%, the alcohol extracting concentration dry cream of its above-mentioned blending ingredients specially takes fresh gardenia flower and fresh acid
The refluxing extraction of 95% ethanol water of each 500 grams of blending ingredients of flores aurantii in 5000ml 3 times, 60 minutes every time, merges extract solution and exists
50 DEG C are recovered under reduced pressure, and obtain raw material components and spend the alcohol extract with bitter orange flower composition to concentrate dry cream for fresh gardenia.
(2) raw material components be fresh gardenia spend and fresh bitter orange flower composition alcohol extract concentration dry cream prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Embodiment 6
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Divide the aqueous extract concentration dry cream for being in itself dry gardenia and drying bitter orange flower composition, its preparation method is as follows：
(1) raw material components prepared by are dry gardenia in itself and dry the weight/mass percentage composition of bitter orange flower composition
50%：50%, the aqueous extract concentration dry cream of its above-mentioned blending ingredients specially takes dry gardenia and dries bitter orange and spends respectively
100 grams of blending ingredients decoct extraction 3 times in 1600ml times of boiling water, 30 minutes every time, merge extract solution and are placed in 60 DEG C of decompressions
Reclaim, it is the aqueous extract concentration dry cream dried gardenia and dry bitter orange flower composition to obtain raw material components.
(2) raw material components be dry gardenia and dry the aqueous extract concentration dry cream of bitter orange flower composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Embodiment 7
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Divide the alcohol extract concentration dry cream for being in itself dry gardenia and drying bitter orange flower composition, its preparation method is as follows：
(1) raw material components prepared by are dry gardenia in itself and dry the weight/mass percentage composition of bitter orange flower composition
50%：50%, the alcohol extract concentration dry cream of its above-mentioned blending ingredients specially takes dry gardenia and dries bitter orange and spends respectively
95% ethanol water refluxing extraction 3 time of 100 grams of blending ingredients at 1600ml times, 60 minutes every time, merges extract solution and is placed in 50 DEG C
It is recovered under reduced pressure, it is the alcohol extract concentration dry cream dried gardenia and dry bitter orange flower composition to obtain raw material components.
(2) raw material components be dry gardenia and dry the alcohol extract concentration dry cream of bitter orange flower composition prepare it is all kinds of
Using it mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary to improve in health food
Memory function, improvement sleep function, fatigue-relieving function.
Embodiment 8
Gardenia and bitter orange spend prepared raw material components to apply prepared raw material group in all kinds of health foods are prepared
Divide the volatile oil for being in itself gardenia and bitter orange flower, its preparation method is as follows：
(1) raw material components prepared by are the matter for the gardenia and bitter orange flower composition originated described in claim 9 in itself
It is 50% to measure percentage composition：50%, its above-mentioned gardenia and bitter orange spend each 60 grams, use extraction by steam distillation volatile oil, tool
Body is to use 120 grams of raw material blending ingredients to use extraction by steam distillation in 1200ml distilled water 1 time, 5 hours extraction times, is obtained
Raw material components are the volatile oil of gardenia and bitter orange flower composition.
(2) raw material components be application of the volatile oil of gardenia and bitter orange flower composition in all kinds of health foods are prepared its
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improving memory function, improvement sleep
Function, fatigue-relieving function.
Embodiment 9
The present invention is from animal factor induction property and sleep-disorder physiological brain memory power decline, by sleep-disorder, U.S.
Plus bright medicine and aβ protein etc. it is multifactor caused by the decline of sleep-disorder physiological brain memory power or withrawal symptom cause to have no peace of mind,
Anxiety and tense uneasiness etc. is combined, and causing sleep-disorder and the mouse ventricles of the brain disposably to inject using sleep deprivation, (half causes senile dementia
Or the A amyloid betas of AD disease dosage cause failure of memory) (half causes to give up disease for A amyloid betas and mecamylamine medicine
The mecamylamine of shape disease dosage can cause to have no peace of mind, anxiety and tense is uneasy) mixing be incubated thing and make sleep-disorder inferior health shape
State illness model, mainly show failure of memory, have no peace of mind, anxiety and tense it is uneasy.Because of fresh gardenia flower and fresh bitter orange flower
Freeze-drying flower powder composition be gardenia used and bitter orange spends prepared raw material components to be most basal nutrient value
The aqueous extract freeze-drying for the freeze-drying flower powder composition spent with active component, such as fresh gardenia flower and fresh bitter orange
Powder, or the alcohol extract for the being freeze-dried flower powder composition concentration dry cream that fresh gardenia flower and fresh bitter orange are spent, or it is fresh
Gardenia and fresh bitter orange flower pressure extracting juice freeze dried powder, or fresh gardenia flower and fresh bitter orange spend alcohol extract concentration dry
Cream, or dry gardenia and dry bitter orange flower aqueous extract concentration dry cream, or dry gardenia and dry bitter orange flower alcohol extract
Dry cream, or the volatile oil that gardenia and bitter orange flower extraction by steam distillation are obtained are concentrated, or gardenia and bitter orange spend overcritical
Fluids extraction extracts obtained volatile oil.Therefore this experimental applications sleep-disorder sub-health state illness rat model is to fresh Cape jasmine
The related preparing raw material component for the freeze-drying flower powder composition that son flower is spent to fresh bitter orange carries out relevant healthcare food work(
Effect research, determined by behaviouristics (Morris water mazes), the measure of autonomic activities tester and Physiology and biochemistry corresponding index with
Detection, gardenia and bitter orange spend the freeze-drying flower powder that the fresh gardenia of prepared raw material components is spent and fresh bitter orange is spent
Composition can make sleep-disorder sub-health state illness rat model shorten incubation period, increase platform number of times, extend in four-quadrant
Residence time is limited, the vitality restoration of TAC T-AOC in serum can be made, TchE contents are reduced, free radical is removed in enhancing
Ability, antagonism oxidation reaction, at the same make sleep-disorder sub-health state illness rat model autonomic activities reduce, so as to play
Relieving restlessness that clears away heart-fire, delays brain aging, improves and sleeps, a variety of functions such as antidepression.Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, help and disappear
Change function, strengthen immunity function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
1 material
1.1 SPF grades of animal healthy SD male rats, weight 260-300g, by Hunan, Si Laike scapes have up to experimental animal
Limit company provides, credit number：SCXK (Hunan) 2014-0005.Rearing conditions：20-22 DEG C of temperature, feeds with Rat Standard feed,
Free water.
1.2 medicines voluntarily prepare the freeze-drying flower powder group of fresh gardenia flower and fresh bitter orange flower with reagent laboratory
Compound (gardenia：Bitter orange flower is 1:1) freeze-drying of mixed-powder (referring to example 1), fresh gardenia flower and fresh bitter orange flower
Flower powder composition (gardenia：Bitter orange flower is 1:1) water extract freeze-dried powder (referring to example 2), fresh gardenia are spent and fresh
The freeze-drying flower powder composition (gardenia of bitter orange flower：Bitter orange flower is 1:1) 95% ethanol extract concentration dry cream is (in detail
See example 3).Aβ1-40(Sigma companies, lot number 052M4801V), mecamylamine (Sigma companies, lot number 123M4115V).T-
AOC, TChE and GSH-Px detection kit (Bioengineering Research Institute, lot number 20151012 are built up in Nanjing).
1.3 instrument ZS-B types stereotaxic apparatus, Morris water mazes video analytic system (many real enlightening wound science and technology hairs in Beijing
Open up Co., Ltd), Forma-86C ULT ultra low temperature freezers (U.S.'s match is silent to fly), Allegra64R high speed freezing centrifuges
(U.S.'s Beckman Kurt), UV-1800 types ultraviolet-visible spectrophotometer (Japanese Shimadzu Corporation).
2 methods
The preparation fresh gardenia flower of 2.1 medicines：Fresh bitter orange flower (1:1) freeze-drying flower mixed-powder (refers to example
1)-freeze mixed-powder.Fresh gardenia is spent：Fresh bitter orange flower (1:1) it is freeze-dried flower mixed-powder aqueous extract freeze-dried powder
(referring to example 2)-lyophilized mixed-powder water extraction freeze-dried powder.Fresh gardenia is spent：Fresh bitter orange flower (1:1) freeze-drying flower mixing
The ethanol water refluxing extraction of powder 95% concentration dry cream (referring to the example 3)-lyophilized ethanol extract dry cream of mixed-powder 95%, it is standby
With.
96 healthy SD male rats are randomly divided into blank group, sleep and hindered by the foundation of 2.2 animal packets and animal model
Hinder sub-health state illness model group, lyophilized mixed-powder high dose group, lyophilized mixed-powder middle dose group, lyophilized mixed-powder
Water extraction freeze-dried powder high dose group, freezes mixed-powder water extraction freeze-dried powder middle dose group, freezes the ethanol extract of mixed-powder 95%
Dry cream high dose group, freezes the ethanol extract dry cream middle dose group of mixed-powder 95%, totally 8 groups, every group of 12 rats.
The foundation of sleep-disorder sub-health state illness model：Each experimental group is slept using multi-platform water environment method is improved
Dormancy deprive 3 weeks (totally 21 days) sleep-disorder is easily gone crazy lesion rat.Afterwards, take not dead sleep-disorder in good condition easy
Intracerebral injection mecamylamine is incubated condensed state A β to lesion of going crazy rat again1-40(2 μ 1) obtains induction property sleep-disorder sub-health state
Illness model.
Blank group is disregarded；Model group is handled by above-mentioned modeling method respectively with administration group；Model group is in intracerebral
Start the Tween-80 aqueous solution of gavage 2% totally 14 days within 10 days before injection operation, 1 time a day.Each administration group operation consent starts to connect for 10 days
Continuous gastric infusion totally 14 days, 1 time a day.
2.3 Behavior test
Morris water maze laboratories：Injected clear water makes the water surface be higher by platform 1-2cm in pond in advance, and water temperature is controlled 24
2 DEG C or so of scholar.Pool inner wall scribble it is pitch-dark, every time test before appropriate black ink must be added into pond, pond is divided into 4
Quadrant.Platform is placed in the middle of fourth quadrant, optionally some rat is put into water towards pool wall of pool in other three quadrants,
Experiment lasts 5 days, and respectively test once, tests 1min to every morning each quadrant every time.If rat is not yet found within 1min
Platform, then take rat on platform and it is stood above 15s, if rat finds platform within l min, also allows it flat
Stand 15s on platform, just terminates once to train, so training 4 days.At the 5th day, platform is removed, every rat swims l min, record
Every rat for the first time by the time (incubation period) of original platform, every rat in l min by the number of times of platform, swim across
Total distance and the time stayed in quadrant where original platform and other three quadrants, calculate when fourth quadrant is swum
Between (t4) account for whole swimming time (tAlways) percentage.
The autonomic activities test of sleep-disorder sub-health state illness model：By self acting detector for small animals with
MP-100 Physiological Experiment signal processing and analysis system is connected, and puts 1 rat in each device at random, allows animal before detection every time
In device endoadaptation 5min, detection interior is kept quite, and prevents the activity on rat from producing influence.Record each group rat 20min
Interior autonomic activities number of times and autonomic activities time, and weigh the changes of weight of rat.2.4 spectrophotometry T-AOC,
After TChE and GSH-Px content rat behavior detection, after every group of rat is anaesthetized with chloraldurate (300mg/kg), quickly open
Chest, row Culling heart blood, 3500r/min centrifugations 10min takes serum, is placed in -70 DEG C of Cord bloods.It is ultraviolet by kit specification
Spectrophotometry T-AOC, TChE and GSH-Px content.
2.5 statistical methods use SAS software analysis, and experimental data is usedRepresent, the number of one-way analysis of variance experiment
According to.P ＜ 0.05 are statistically significant.
3 results
3.1 each experiment health food groups are to sleep-disorder sub-health state illness rat model Morris water maze laboratories
Influence
Compared with blank group, model group rats prolongation of latency, excessively platform number of times are reduced, short in fourth quadrant residence time,
Significant difference (P ＜ 0.01)；Compared with model group, incubation period can be shortened to health food group, increase platform number of times by respectively testing,
Fourth quadrant residence time extends (P ＜ 0.05 or P ＜ 0.01), illustrates each test to health food group to sleep-disorder inferior health
State illness rat model effect substantially, as a result points out fresh gardenia flower：Fresh bitter orange flower (1:1) it is freeze-dried flower mixed powder
Last (referring to example 1)-lyophilized mixed-powder group plays improvement sleep-disorder to improving sleep-disorder failure of memory effect substantially
Or auxiliary improving memory function.It the results are shown in Table 1.
Each experimental group of table 1 to sleep-disorder sub-health state illness rat model spatial memory capacity influence (n
=10)
Note：Compared with model group, * P<0.05, * * P<0.01
3.2 each experiment health food groups influence on sleep-disorder sub-health state illness rat model autonomic activities behaviouristics
Compared with blank group, the increase of model group rats autonomic activities number of times (sleep-disorder, have no peace of mind, anxiety and tense it is uneasy, Hair of Rat
Color is in disorder, behavior is impatient and has certain aggressiveness), increased weight is slow, significant difference (P ＜ 0.01)；Compared with model group, respectively
Test to health food group can make the number of activities of animal pattern reduce (soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, improve sleep function, it is slow
Fatigue function is solved, the Hair of Rat color after administration is smooth, have a sweet temper), increased weight is obvious (P ＜ 0.05 or P ＜ 0.01),
Illustrate it is each test to health food group to sleep-disorder sub-health state illness rat model effect substantially, especially fresh gardenia
Flower：Fresh bitter orange flower (1:1) freeze-drying flower mixed-powder (referring to example 1)-lyophilized mixed-powder group effect is optimal.As a result
It is shown in Table 2.
Each experimental group of table 2 to sleep-disorder sub-health state illness rat model autonomic activities Behavior Test result (N=10)
Note：Compared with model group, * P<0.05, * * P<0.01
3.3 each experiment health food groups are to each index content in sleep-disorder sub-health state illness rat model serum
Influence
Compared with blank group, T-AOC, GSH-P in model group rats serumXContent is substantially reduced (P ＜ 0.01), and TChE lives
Power strengthens (P ＜ 0.01)；Each experiment health food group can improve T-AOC content, make GSH-PXSubstantially rise (P ＜ 0.05 or P
＜ 0.01), TChE vigor is reduced, there is significant difference (P ＜ 0.05 or P ＜ 0.01) compared with model group, illustrates that each experiment is protected
Health food group effect substantially, especially spend by fresh gardenia：Fresh bitter orange flower (1:1) freeze-drying flower mixed-powder (refers to reality
Example 1)-lyophilized mixed-powder group effect is optimal.T-AOC, GSH-P in rat model serum can be madeXVitality restoration, reduce TChE
The ability of free radical is removed in content, enhancing, while preventing the reduction of neurotransmitter, plays improvement sleep or auxiliary improvement of memory work(
Effect.It the results are shown in Table 3.
Each experimental group of table 3 is to T-AOC, TChE, GSH-P in sleep-disorder sub-health state illness rat model serumXContain
Amount influence (N=10)
Note：Compared with model group, * P<0.05, * * P<0.01.
Claims (10)
1. gardenia and bitter orange spend prepared raw material components to be applied in all kinds of health foods are prepared, it is characterised in that：It is made
Standby raw material components are that fresh gardenia spends the freeze-drying flower powder composition spent with fresh bitter orange, or fresh gardenia flower in itself
The aqueous extract freeze dried powder for the freeze-drying flower powder composition spent with fresh bitter orange, or fresh gardenia flower and fresh acid
The alcohol extract concentration dry cream of the freeze-drying flower powder composition of flores aurantii, or fresh gardenia flower and the flower squeezing of fresh bitter orange take
Juice freeze dried powder, or fresh gardenia flower and fresh bitter orange flower alcohol extract concentration dry cream, or dry gardenia and dry bitter orange
Flower aqueous extract concentration dry cream, or dry gardenia and dry bitter orange flower alcohol extract concentration dry cream, or gardenia and bitter orange flower
The volatile oil that extraction by steam distillation is obtained, or gardenia and bitter orange flower supercritical fluid extraction extract obtained volatilization
Oil；Above-mentioned raw materials component is applied in all kinds of health foods are prepared, and above-mentioned raw materials component mainly has soothing liver and harmonizing stomach, qi-regulating
Xie Yu, aid digestion function, strengthen immunity function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
2. gardenia according to claim 1 and bitter orange spend prepared raw material components should in all kinds of health foods are prepared
It is the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent, its feature in itself with prepared raw material components
It is：
（1）The fresh gardenia flower of harvesting is placed in into refrigerator-freezer temperature using freeze drying process to harden in subzero 15 DEG C ~ subzero 20 DEG C
After icing, be placed in frozen vacuum dryer temperature in subzero 25 DEG C ~ it is subzero 40 DEG C, under conditions of vacuum is 60 ~ 140pa,
Vacuum freezedrying 8 ~ 24 hours, obtains fresh gardenia and spends lyophilized dried flower, and its moisture is less than 5%, and fresh gardenia is spent into lyophilized dry
Pollen is broken into the mesh of the mesh of powder 40 ~ 100；
（2）The fresh bitter orange flower of harvesting is placed in into refrigerator-freezer temperature using freeze drying process to harden in subzero 15 DEG C ~ subzero 20 DEG C
After icing, be placed in frozen vacuum dryer temperature in subzero 25 DEG C ~ it is subzero 40 DEG C, under conditions of vacuum is 60 ~ 140pa,
Vacuum freezedrying 8 ~ 24 hours, obtains fresh bitter orange and spends lyophilized dried flower, and its moisture is less than 5%, and fresh bitter orange is spent into lyophilized dry
Pollen is broken into the mesh of the mesh of powder 40 ~ 100；
（3）Prepared raw material components are the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself
Weight/mass percentage composition is 100% ~ 0%：0%~100%；
（4）Raw material components are that the freeze-drying flower powder composition that fresh gardenia is spent and fresh bitter orange is spent is preparing all kinds of health cares
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
3. the gardenia and bitter orange according to claim 1 and 2 spend prepared raw material components preparing all kinds of health foods
Raw material components prepared by middle application are the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself
Aqueous extract freeze dried powder, it is characterised in that：
（1）Prepared raw material components are the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself
Weight/mass percentage composition is 100% ~ 0%：0% ~ 100%, its above-mentioned blending ingredients aqueous extract freeze dried powder is specially mixed with raw material
The warm water ultrasonic extraction of 10 ~ 30 DEG C of charge-coupled point 3 ~ 6 times 2 ~ 3 times, 20 ~ 30 minutes every time, merges extract solution and is placed in freezing vacuum
Dry built-in temperature in subzero 25 DEG C ~ it is subzero 40 DEG C, vacuum be 60 ~ 140pa under conditions of, vacuum freezedrying 8 ~ 24 is small
When, obtain the freeze-drying flower powder composition aqueous extract freeze-drying that raw material components are spent for fresh gardenia and fresh bitter orange is spent
Powder；
（2）Raw material components are that the freeze-drying flower powder composition aqueous extract freezing that fresh gardenia is spent and fresh bitter orange is spent is dry
Dry powder mainly has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity in all kinds of health foods are prepared using it
Function, auxiliary improving memory function, improvement sleep function, fatigue-relieving function.
4. the gardenia and bitter orange according to claim 1 and 2 spend prepared raw material components preparing all kinds of health foods
Raw material components prepared by middle application are the freeze-drying flower powder composition alcohol that fresh gardenia flower and fresh bitter orange are spent in itself
Extract solution concentrates dry cream, it is characterised in that：
（1）Prepared raw material components are the freeze-drying flower powder composition that fresh gardenia flower and fresh bitter orange are spent in itself
Weight/mass percentage composition is 100% ~ 0%：0% ~ 100%, the alcohol extract concentration dry cream of its above-mentioned blending ingredients, is specially mixed with raw material
The refluxing extraction of charge-coupled point 6 ~ 12 times of 50 ~ 100% ethanol waters 2 ~ 4 times, 30 ~ 90 minutes every time, merges extract solution at 45 ~ 60 DEG C
It is recovered under reduced pressure, obtains the freeze-drying flower powdery components alcohol extract concentration that raw material components are spent for fresh gardenia and fresh bitter orange is spent
Dry cream；
（2）Raw material components are that the freeze-drying flower powder alcohol extract that fresh gardenia is spent and fresh bitter orange is spent concentrates dry cream in system
Mainly there is using it soothing liver and harmonizing stomach in standby all kinds of health foods, it is regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary
Help improvement memory function, improve sleep function, fatigue-relieving function.
5. gardenia according to claim 1 and bitter orange spend prepared raw material components should in all kinds of health foods are prepared
It is the pressure extracting juice freeze dried powder of fresh gardenia flower and fresh bitter orange flower composition in itself with prepared raw material components, it is special
Levy and be：
（1）Prepared raw material components are that fresh gardenia is spent and the weight/mass percentage composition of fresh bitter orange flower composition is 100% in itself
~0%：0% ~ 100%, its above-mentioned blending ingredients pressure extracting juice merges squeezing juice and is placed in frozen vacuum dryer temperature in subzero 25
DEG C ~ subzero 40 DEG C, vacuum is under conditions of 60 ~ 140pa, vacuum freezedrying 8 ~ 24 hours obtains raw material components for fresh Cape jasmine
The squeezing juice freeze dried powder of sub- flower and bitter orange flower composition；
（2）Raw material components are that fresh gardenia is spent and the squeezing juice freeze dried powder of bitter orange flower composition is preparing all kinds of health foods
It is middle application its mainly have soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improving memory function,
Improve sleep function, fatigue-relieving function.
6. gardenia according to claim 1 and bitter orange spend prepared raw material components should in all kinds of health foods are prepared
It is the alcohol extract concentration dry cream of fresh gardenia flower and fresh bitter orange flower composition, its feature in itself with prepared raw material components
It is：
（1）Prepared raw material components be in itself fresh gardenia flower and fresh bitter orange flower composition weight/mass percentage composition for 99% ~
1%：1% ~ 99%, the alcohol extract of its above-mentioned blending ingredients concentration dry cream, specially with the 50 of 6 ~ 12 times of raw material blending ingredients ~
The refluxing extraction of 100% ethanol water 2 ~ 4 times, 30 ~ 90 minutes every time, merges extract solution and is recovered under reduced pressure at 45 ~ 60 DEG C, obtain raw material group
It is divided into the alcohol extract concentration dry cream of fresh gardenia flower and bitter orange flower composition；
（2）Raw material components are that fresh gardenia is spent and the alcohol extract concentration dry cream of fresh bitter orange flower composition is preparing all kinds of health cares
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
7. gardenia according to claim 1 and bitter orange spend prepared raw material components should in all kinds of health foods are prepared
It is the aqueous extract concentration dry cream of dry gardenia and dry bitter orange flower composition, its feature in itself with prepared raw material components
It is：
（1）Prepared raw material components be in itself dry gardenia and dry the weight/mass percentage composition of bitter orange flower composition for 99% ~
1%：1% ~ 99%, the aqueous extract of its above-mentioned blending ingredients concentration dry cream is specially decocted with the boiling water of 6 ~ 10 times of raw material blending ingredients
Extraction 2 ~ 4 times is boiled, 30 ~ 60 minutes every time, merging extract solution was placed in 50 DEG C ~ 60 DEG C and is recovered under reduced pressure, and it is to dry Cape jasmine to obtain raw material components
Son flower and the aqueous extract concentration dry cream for drying bitter orange flower composition；
（2）Raw material components are to dry gardenia to prepare all kinds of health cares with the aqueous extract concentration dry cream for drying bitter orange flower composition
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
8. gardenia according to claim 1 and bitter orange spend prepared raw material components should in all kinds of health foods are prepared
It is the alcohol extract concentration dry cream of dry gardenia and dry bitter orange flower composition, its feature in itself with prepared raw material components
It is：
（1）Prepared raw material components be in itself dry gardenia and dry the weight/mass percentage composition of bitter orange flower composition for 99% ~
1%：1% ~ 99%, the alcohol extract of its above-mentioned blending ingredients, specially with 50 ~ 95% ethanol waters of 6 ~ 12 times of raw material blending ingredients
Refluxing extraction 2 ~ 4 times, 30 ~ 90 minutes every time, merges extract solution and is recovered under reduced pressure at 45 ~ 60 DEG C, it is to dry cape jasmine to obtain raw material components
Flower and the alcohol extract concentration dry cream for drying bitter orange flower composition；
（2）Raw material components are to dry gardenia to prepare all kinds of health cares with the alcohol extract concentration dry cream for drying bitter orange flower composition
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, aid digestion function, strengthen immunity function, auxiliary improvement of memory using it in food
Function, improvement sleep function, fatigue-relieving function.
9. gardenia and bitter orange according to claim 1 ~ 8 spend prepared raw material components should in all kinds of health foods are prepared
With, it is characterised in that：Gardenia source is mainly Rubiaceae cape jasmine platymiscium cape jasmineGardenia jasminoides Ellis.
Flower or all known plants of Rubiaceae Gardenia Ellis flower, more specifically bud stage flower or flower peak period flower fresh flower freeze-drying
Flower, fresh flower, dry flower；Bitter orange is spent also known as bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower, flores aurantii, and it is mainly rue that it, which is originated,
Section's Citrus bitter orangeCitrus aurantiumL. and its cultivars flower or the flower of all plants of Rutaceae Citrus, more
The fresh flower of specially bud stage flower and flower peak period flower is freeze-dried flower, fresh flower, dries flower.
10. gardenia and bitter orange spend prepared raw material components in all kinds of health foods are prepared according to claim 1 and 9
It is the volatile oil for the gardenia and bitter orange flower originated described in claim 9 in itself using prepared raw material components, its feature exists
In：
（1）Prepared raw material components are the quality hundred for the gardenia and bitter orange flower composition originated described in claim 9 in itself
It is 99% ~ 1% to divide content：1% ~ 99%, the volatile oil of the extraction by steam distillation of its above-mentioned blending ingredients is specially mixed with raw material
Charge-coupled point 8 ~ 12 times of extraction by steam distillation 1 time, 4 ~ 6 hours extraction times, it is that gardenia and bitter orange are spent to obtain raw material components
The volatile oil of composition；
（2）Prepared raw material components are the quality hundred for the gardenia and bitter orange flower composition originated described in claim 9 in itself
It is 99% ~ 1% to divide content：1% ~ 99%, its above-mentioned blending ingredients is extracted with supercritical fluid extraction, obtains raw material components for gardenia
With the volatile oil of bitter orange flower composition.
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Cited By (7)
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| CN107595990A (en) * | 2017-11-02 | 2018-01-19 | 张忠立 | A kind of different concentration ethanol water elution position based on gardenia and bitter orange flower and wherein active ingredient combinations medicine and purposes |
| CN107648349A (en) * | 2017-10-30 | 2018-02-02 | 江西中医药大学 | Bitter orange flower is preparing the application in improving sleep-disorder or improving failure of memory or treat Alzheimer disease drugs or health food |
| CN107789562A (en) * | 2017-11-09 | 2018-03-13 | 江西中医药大学 | A kind of composition of integration of drinking and medicinal herbs is preparing the application in improving sleep-disorder or improving Memory Impairment medicine or health food |
| CN107823295A (en) * | 2017-11-28 | 2018-03-23 | 江西中医药大学 | Gardenia is applied in preparing improvement sleep-disorder or improving failure of memory or defaecation or raising immunity medicine or health food |
| CN107927765A (en) * | 2017-11-30 | 2018-04-20 | 江西中医药大学 | Raw material prepared by fresh flower of kudzuvine and combinations thereof is applied in all kinds of tea product or beverage or health food are prepared |
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| CN115721616A (en) * | 2022-12-08 | 2023-03-03 | 北京康仁堂药业有限公司 | Preparation method and quality control method of bitter orange formula granules |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648349A (en) * | 2017-10-30 | 2018-02-02 | 江西中医药大学 | Bitter orange flower is preparing the application in improving sleep-disorder or improving failure of memory or treat Alzheimer disease drugs or health food |
| CN107595990A (en) * | 2017-11-02 | 2018-01-19 | 张忠立 | A kind of different concentration ethanol water elution position based on gardenia and bitter orange flower and wherein active ingredient combinations medicine and purposes |
| CN107789562A (en) * | 2017-11-09 | 2018-03-13 | 江西中医药大学 | A kind of composition of integration of drinking and medicinal herbs is preparing the application in improving sleep-disorder or improving Memory Impairment medicine or health food |
| CN107823295A (en) * | 2017-11-28 | 2018-03-23 | 江西中医药大学 | Gardenia is applied in preparing improvement sleep-disorder or improving failure of memory or defaecation or raising immunity medicine or health food |
| CN107927765A (en) * | 2017-11-30 | 2018-04-20 | 江西中医药大学 | Raw material prepared by fresh flower of kudzuvine and combinations thereof is applied in all kinds of tea product or beverage or health food are prepared |
| CN109363026A (en) * | 2018-10-17 | 2019-02-22 | 江西中医药大学 | Raw material prepared by roselle and folium cortex eucommiae and combinations thereof improves the application in sub-health state drug or health functional beverage in preparation |
| CN115721616A (en) * | 2022-12-08 | 2023-03-03 | 北京康仁堂药业有限公司 | Preparation method and quality control method of bitter orange formula granules |
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