CN107789562A - A kind of composition of integration of drinking and medicinal herbs is preparing the application in improving sleep-disorder or improving Memory Impairment medicine or health food - Google Patents
A kind of composition of integration of drinking and medicinal herbs is preparing the application in improving sleep-disorder or improving Memory Impairment medicine or health food Download PDFInfo
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- CN107789562A CN107789562A CN201711095136.5A CN201711095136A CN107789562A CN 107789562 A CN107789562 A CN 107789562A CN 201711095136 A CN201711095136 A CN 201711095136A CN 107789562 A CN107789562 A CN 107789562A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of composition of integration of drinking and medicinal herbs to prepare the application in improving sleep-disorder or improving Memory Impairment or treat medicine for senile dementia or health food.Composition prepared by the present invention mainly includes the bitter orange flower of integration of drinking and medicinal herbs, spina date seed, fructus alpiniae oxyphyllae, cape jasmine, the composition of above-mentioned integration of drinking and medicinal herbs plays the integrally-regulated advantage of herbal mixture, the composition of above-mentioned integration of drinking and medicinal herbs is preparing the application in improving Memory Impairment or improving sleep-disorder or treat medicine for senile dementia or health food, the composition of above-mentioned integration of drinking and medicinal herbs mainly has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness such as is calmed the nerves at traditional function curative effect, the composition of above-mentioned integration of drinking and medicinal herbs also has auxiliary improving memory function decline, improve sleep function, fatigue-relieving function, aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
Description
Technical field
The present invention relates to a kind of composition of integration of drinking and medicinal herbs prepare improve sleep-disorder or improve Memory Impairment or
The application in medicine for senile dementia or health food is treated, belongs to technical field of traditional Chinese medicine preparation.
Background technology
Bitter orange flower also known as bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower, flores aurantii, its source is mainly Rutaceae CitrusCitrus aurantiumL. and its fresh flowers of cultivars or the fresh flowers of all plants of Rutaceae Citrus, more specifically
For the drying in the shade of bud of fresh bitter orange flower, dry, the dry flower medicinal material of machine drying, more specifically preferably fresh bitter orange flower
The freeze-drying bud medicinal material of bud.Bitter orange flower is mild-natured, acrid-sweet flavor, slight bitter, enters spleen, Liver Channel, can medicine-food two-purpose.Bitter orange flower is containing more
Sugar, amino acid, trace element, pectin, adenosine, flavonoids, monoterpenes（Iridoids）, sesterterpenoids and triterpenes etc. into
Classifying type, particularly trace element, synephrine, adenosine, stachydrine, valine, tyrosine, isoleucine, N monomethyls tyrasamine,
Chlorogenic acid, method bamboo or wicker fence branch glycosides, neoeriocitrin, aurantiin, neohesperidin, aurantiamarin, hesperetin, nobiletin, limonin
Deng the nutritional value component or active component type spent for it.Bitter orange flower has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu effect.Cure mainly in the heart
Ruffian is vexed, abdominal distention, the few food of vomiting.Purify the blood, stimulate circulation, relax liver and stomach, qi-regulating, be adapted to taste imbalance and obesity
Women.There is relieving stagnant Qi row phlegm, scattered plot disappears the work(of ruffian, controls cough with dyspnea stomach wrist and has a pain and other effects.Bitter orange flower is a kind of cosmetic tea.From generation to generation
Flower is slightly a little bitter, but gives off a strong fragrance, hear make us forgetting it is tired.Can be calmed mood, and releasing is nervous, in addition, it helps slow
Diarrhoea caused by decompression force, the effect of can purify the blood, promote circulation, also fat reducing weight reducing.Modern pharmacological research has the calm heart
Feelings, release nervous function.Confirm the powder of bitter orange flower raw material components or fresh bitter orange flower freeze-drying bud early stage of the invention
End has the function curative effect for improving Memory Impairment or improves the function curative effect of sleep-disorder or treat the function of senile dementia
Curative effect.Particularly fresh bitter orange flower freeze-drying bud remains all nutritional value components or active component type, has
Larger market prospects and application value.
In summary, in order to play the optimum curative effect of bitter orange flower, the present invention is prepared for the bitter orange flower comprising integration of drinking and medicinal herbs, acid
Jujube kernel, fructus alpiniae oxyphyllae and the Chinese medicine composition of cape jasmine, the composition of above-mentioned integration of drinking and medicinal herbs play the integrally-regulated advantage of herbal mixture,
Bitter orange flower has soothing liver and harmonizing stomach, and regulating the flow of vital energy Xie Yu is monarch drug in a prescription.Fructus alpiniae oxyphyllae warming spleen and stopping diarrha can take the photograph saliva, warm up kidney contracting urine controlling nocturnal emission with astringent drugs, help bitter orange flower
Anti-vomiting, to tell dysphoria, therefore think ministerial drug.Spina date seed energy antitoxic heart-soothing and sedative, nourishing the liver, arrest sweating, help bitter orange flower liver-smoothing, qi-regulating, Xie Yu
Antitoxic heart-soothing and sedative, therefore think adjutant.It is that waste heat is strongly fragrant above-mentioned in chest diaphragm, the regretful Nang of body heat, deficiency dysphoric insomnia, chest gastral cavity ruffian if any patient
The composition of integration of drinking and medicinal herbs should add cape jasmine fruit, and cape jasmine fruit expels the heat-evil relieving restlessness, color it is red enter the heart, coordinate spina date seed and fructus alpiniae oxyphyllae to make the heart
Kidney is intersecting and reaches regulation between water and fire, and relieving restlessness antitoxic heart-soothing and sedative, therefore thinking makes medicine.If patient is fever caused by exogenous pathogenic factors, the evil strongly fragrant part of the body cavity above the diaphragm housing the heart and lungs, the heart
Chest unhappiness egersis and the heat that formed disturb mind person, and the composition of above-mentioned integration of drinking and medicinal herbs should add gardenia, gardenia purging intense heat relieving restlessness, coordinate
Spina date seed and fructus alpiniae oxyphyllae make coordination between the heart and kidney and reach regulation between water and fire, and relieving restlessness antitoxic heart-soothing and sedative, therefore thinking makes medicine.Above-mentioned integration of drinking and medicinal herbs
Composition answering in improvement sleep-disorder or improvement Memory Impairment or treatment medicine for senile dementia or health food is prepared
With mainly there is the composition of above-mentioned integration of drinking and medicinal herbs soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness to calm the nerves
Traditional function curative effect, the composition of above-mentioned integration of drinking and medicinal herbs also have auxiliary improving memory function decline, improve sleep function, be slow
Solve fatigue function, aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
The content of the invention
It is an object of the present invention to provide a kind of composition of integration of drinking and medicinal herbs to prepare improvement sleep-disorder or improve memory work(
It can decline or treat the application in medicine for senile dementia or health food.
The invention discloses a kind of composition of integration of drinking and medicinal herbs to prepare improvement sleep-disorder or improve Memory Impairment
Or the application in treatment medicine for senile dementia or health food.Composition prepared by the present invention mainly includes the generation of integration of drinking and medicinal herbs
Seville orange flower, spina date seed, fructus alpiniae oxyphyllae, the Chinese medicine composition of cape jasmine, the composition of above-mentioned integration of drinking and medicinal herbs play the integrally-regulated of herbal mixture
Advantage, bitter orange flower have soothing liver and harmonizing stomach, and regulating the flow of vital energy Xie Yu is monarch drug in a prescription.Fructus alpiniae oxyphyllae warming spleen and stopping diarrha can take the photograph saliva, warm up kidney contracting urine controlling nocturnal emission with astringent drugs, help generation
Seville orange flower anti-vomiting, to tell dysphoria, therefore think ministerial drug.Spina date seed energy antitoxic heart-soothing and sedative, nourishing the liver, arrest sweating, help bitter orange flower liver-smoothing, qi-regulating,
Strongly fragrant antitoxic heart-soothing and sedative is solved, therefore thinks adjutant.It is that waste heat is strongly fragrant in chest diaphragm if any patient, the regretful Nang of body heat, deficiency dysphoric insomnia, chest gastral cavity ruffian,
The composition of above-mentioned integration of drinking and medicinal herbs should add cape jasmine fruit, and cape jasmine fruit expels the heat-evil relieving restlessness, color it is red enter the heart, coordinate spina date seed and fructus alpiniae oxyphyllae
Make coordination between the heart and kidney and reach regulation between water and fire, and relieving restlessness antitoxic heart-soothing and sedative, therefore thinking makes medicine.If patient is fever caused by exogenous pathogenic factors, it is evil it is strongly fragrant on
Jiao, ambition unhappiness egersis and form heat and disturb mind person, the composition of above-mentioned integration of drinking and medicinal herbs should add gardenia, and gardenia purge the sthenic heart-fire removes
It is tired, coordinate spina date seed and fructus alpiniae oxyphyllae to make coordination between the heart and kidney and reach regulation between water and fire, and relieving restlessness antitoxic heart-soothing and sedative, therefore thinking makes medicine.Above-mentioned medicine
Homologous composition is eaten to prepare improvement sleep-disorder or improving Memory Impairment or treatment medicine for senile dementia or health care food
Mainly there is soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart to remove for application in product, the composition of above-mentioned integration of drinking and medicinal herbs
Tired traditional function curative effect, the composition of above-mentioned integration of drinking and medicinal herbs such as calm the nerves also has auxiliary improving memory function decline, improves and sleep
Dormancy function, fatigue-relieving function, aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
Present invention employs following technical proposals.
A kind of composition of integration of drinking and medicinal herbs is preparing improvement sleep-disorder or improvement Memory Impairment or treated old silly
Application in slow-witted medicine or health food, it is characterised in that the composition of integration of drinking and medicinal herbs by following masses percentage raw material system
Into：Bitter orange flower 20-45, spina date seed 25-40, fructus alpiniae oxyphyllae 30-40, and add appropriate medicinal filling auxiliary material.
A kind of composition of integration of drinking and medicinal herbs is preparing improvement sleep-disorder or improvement Memory Impairment or treated old silly
Application in slow-witted medicine or health food, it is characterised in that the composition of integration of drinking and medicinal herbs by following masses percentage raw material system
Into：Bitter orange flower 20-25, spina date seed 25-30, fructus alpiniae oxyphyllae 25-30, cape jasmine（Cape jasmine fruit or gardenia）20-25, and add appropriate
Medicinal filling auxiliary material.
The composition of above-mentioned integration of drinking and medicinal herbs mainly has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness peace
The traditional function curative effect of god, the composition of above-mentioned integration of drinking and medicinal herbs also have auxiliary improving memory function decline, improve sleep function,
Fatigue-relieving function, aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
Bitter orange flower in the composition of above-mentioned integration of drinking and medicinal herbs, bitter orange flower also known as bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower,
Flores aurantii, its source are mainly Rutaceae CitrusCitrus aurantiumL. and its cultivars fresh flowers or Rutaceae
The fresh flowers of all plants of Citrus, the drying in the shade, dry of the bud of specially fresh bitter orange flower, the dry flower medicine of machine drying
Material, the freeze-drying bud medicinal material of the bud of more specifically preferably fresh bitter orange flower.
Cape jasmine in the composition of above-mentioned integration of drinking and medicinal herbs, it is characterised in that cape jasmine source is mainly Rubiaceae cape jasmine platymiscium Cape jasmine
SonGardenia jasminoides Ellis fruit or flower, it is also possible to the flower of all known plants of Rubiaceae Gardenia Ellis,
It is more specifically the drying in the shade, dry of flower of bud or flower peak period of gardenia, the dry flower or flower pesticide material of machine drying, more
The freeze-drying bud medicinal material of the bud of specific preferably fresh gardenia flower.
A kind of composition of above-mentioned integration of drinking and medicinal herbs is preparing improvement sleep-disorder or is improving Memory Impairment or treatment always
Application in dementia medicine or health food, it is characterised in that the medicine of the composition of the integration of drinking and medicinal herbs or health food
Preparation formulation be oral liquid, granule, capsule, tablet, effervescent tablet, syrup, pill, paste nourishing agent, soft capsule, ointment,
Emulsion, powder, sustained release agent, controlled release agent, targeting preparation, powder-injection, liquid drugs injection, injection, Alevaire, microemulsion, gel, receive
Metric system agent.
The medicine of the composition of above-mentioned integration of drinking and medicinal herbs or the capsule of health food be hard shell capsules, soft capsule, gelatine capsule,
Plant capsule, super AMP capsule, liquid-filling capsule, natural capsule, controlled release capsule, spansule, the capsule preparations of capsulae enterosolubilis.
The medicine of the composition of above-mentioned integration of drinking and medicinal herbs or the tablet of health food be common compressed tablets, coating tablet, sugar coated tablet,
Film coated tablets, Enteric coated tablets, effervescent tablet, chewable tablets, multilayer tablet, dispersible tablet, sublingual tablet, buccal tablet, implant, solution piece, length
Imitate the tablet formulation of piece, microencapsule tablet, fast-release tablet, sustained release tablets and controlled release tablet.
The preparation method of the freeze-drying bud medicinal material of the bud of bitter orange flower is as follows：Using freeze drying process by harvesting
The bud of fresh bitter orange flower be placed in refrigerator-freezer temperature in subzero 5 DEG C ~ it is subzero 40 DEG C hardening freeze after, be placed in frozen vacuum dryer
Temperature in subzero 5 DEG C ~ it is subzero 50 DEG C, vacuum be 1 ~ 999pa under conditions of, vacuum freezedrying 6 ~ 48 hours, its moisture contains
Amount is less than 5%, obtains the bud medicinal material of the freeze-drying of the bud of fresh bitter orange flower.
The preparation method of the freeze-drying bud medicinal material of the bud of gardenia is as follows：Using freeze drying process by harvesting
Fresh gardenia flower bud be placed in refrigerator-freezer temperature in subzero 5 DEG C ~ it is subzero 40 DEG C hardening freeze after, be placed in frozen vacuum dryer
Temperature in subzero 5 DEG C ~ it is subzero 50 DEG C, vacuum be 1 ~ 999pa under conditions of, vacuum freezedrying 6 ~ 48 hours, its moisture contains
Amount is less than 5%, obtains the bud medicinal material of the freeze-drying of the bud of fresh gardenia flower.
It is an advantage of the invention that：Provide a kind of medicine of integration of drinking and medicinal herbs composition or the preparation method of health food, institute
The composition of the integration of drinking and medicinal herbs of preparation mainly has the biography that soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness are calmed the nerves
System function curative effect, the composition of prepared integration of drinking and medicinal herbs also have auxiliary improving memory function decline, improve sleep function, be slow
Solve fatigue function, aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
Provide new preparation technology and its specific new application and new effect, the particularly bitter orange flower of bitter orange flower and gardenia
Freeze-drying bud medicinal material and gardenia freeze-drying bud medicinal material, it contains the flower not influenceed by extraneous other factors
Honey, it also retains it and spends all nutritional value components or active component type.
It is found that the new medicinal part of gardenia, the bud of gardenia.
Embodiment
With reference to embodiment, the invention will be further described：
Embodiment 1
The preparation method of the freeze-drying bud of fresh bitter orange flower is as follows：It will be plucked using freeze drying process fresh after cleaning
2000 grams of the bud of bitter orange flower is placed in refrigerator-freezer temperature after subzero 30 DEG C hardening freeze, be placed in frozen vacuum dryer temperature in
Subzero 45 DEG C, under conditions of vacuum is 8pa, vacuum freezedrying 12 hours, its moisture is less than 5%, obtains fresh bitter orange flower
The bud of freeze-drying.
Embodiment 2
The bud application pulverizer that the fresh bitter orange flower obtained in example 1 is freeze-dried is beaten into powder, No. 6 sieves of pharmacopeia is crossed, obtains 100
The powder of the fresh bitter orange flower freeze-drying bud of mesh.
Embodiment 3
The preparation method of the freeze-drying bud of fresh gardenia flower is as follows：It will be plucked using freeze drying process fresh after cleaning
2000 grams of the bud of gardenia is placed in refrigerator-freezer temperature after subzero 35 DEG C hardening freeze, be placed in frozen vacuum dryer temperature in
Subzero 45 DEG C, under conditions of vacuum is 6pa, vacuum freezedrying 18 hours, its moisture is less than 5%, obtains fresh gardenia flower
The bud of freeze-drying.
Embodiment 4
The bud application pulverizer of the fresh gardenia obtained in example 3 flower freeze-drying is beaten into powder, No. 6 sieves of pharmacopeia is crossed, obtains 100
The powder of mesh fresh gardenia flower freeze-drying bud.
Embodiment 5
The fructus alpiniae oxyphyllae application pulverizer of the integration of drinking and medicinal herbs of pharmacy's purchase is beaten into powder, No. 6 sieves of pharmacopeia is crossed, obtains 100 mesh fructus alpiniae oxyphyllaes
Powder.
Embodiment 6
The spina date seed application pulverizer of the integration of drinking and medicinal herbs of pharmacy's purchase is beaten into powder, No. 6 sieves of pharmacopeia is crossed, obtains 100 mesh spina date seeds
Powder.
Embodiment 7
The cape jasmine fruit application pulverizer of the integration of drinking and medicinal herbs of pharmacy's purchase is beaten into powder, No. 6 sieves of pharmacopeia is crossed, obtains 100 mesh cape jasmine fruits
Real powder.
Embodiment 8
The present invention is from animal factor induction property and the Memory Impairment of physiological brain aging, by sleep-disorder（Sleep
Disorder, SD, it makes raw poison in brain gas network exception or disorder evil to " poison damage brain network "）It is multifactor caused with aβ protein etc.
The Memory Impairment of physiological brain aging is combined, and causes sleep-disorder and the mouse ventricles of the brain disposably to inject A β shallow lakes using sleep deprivation
Powder sample albumen makes sleep-disorder physiological brain aging Memory Impairment（Sleep Disorder-factors'
Physiological Brain Aging Memory Subside, SDPBAMS,）Model, abbreviation SDAD models.Using sleep
Obstacle physiological brain aging Memory Impairment（SDAD）The raw material components that rat model is prepared to bitter orange flower are fresh bitter orange flower
It is freeze-dried powder and its 30% ethanol water elution position, the 70% ethanol water elution position and 95% ethanol water total extract of bud
Pharmacological Activity Screening is carried out, passes through behaviouristics（Morris water mazes）Measure and the detection of measure and Physiology and biochemistry corresponding index,
Experiment confirm fresh bitter orange flower freeze-drying bud powder and its 30% ethanol water elution position, 70% ethanol water elution position and
95% ethanol water total extract can make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model shortens latent
Phase, increased platform number, extended in fourth quadrant residence time.Meanwhile the powder of fresh bitter orange flower freeze-drying bud and its
30% ethanol water elution position can make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model autonomic activities increases
Add, so as to play relieving restlessness that clears away heart-fire, delay brain aging, improve the multiple functions such as sleep, antidepression.It is to fine by sleep-disorder and A β
Silk forms the Memory Impairment of the multifactor caused sleep-disorder physiological brain aging such as aggregation（SDAD）Improve with auxiliary
Memory function, further confirm that the raw material components of bitter orange flower preparation have the function curative effect for improving Memory Impairment or improved and sleep
The function curative effect of dormancy obstacle treats the function curative effect of Alzheimer disease or treats the function curative effect of senile dementia.It is particularly new
Fresh bitter orange flower freeze-drying bud remains all nutritional value components or active component type, and pharmacologic effect is very notable,
With larger market prospects and application value.
1 material
1.1 animal SPF level healthy SD male rats, weight 300-350 g are limited up to experimental animal by Hunan Si Laike scapes
Company provides, credit number：SCXK（Hunan）2009-0004.Rearing conditions：20-22 DEG C of temperature, feed with Rat Standard feed, from
By drinking water.
The bitter orange flower raw material components that the raw material components of 1.2 bitter orange flowers are obtained with reagent by example 1 and example 2 are 100 mesh
Macroporous absorption on the powder and its 95% ethanol water total extract and 95% ethanol water totality thing of fresh bitter orange flower freeze-drying bud
30% ethanol water elution position of resin and 70% ethanol water elution position.Aβ25-35（Sigma companies, lot number 095M4775V）.
1.3 instrument ZS-B types stereotaxic apparatus, Morris water maze video analytic systems（The many real enlightening wound science and technology in Beijing
Development Co., Ltd）, Forma-86C ULT ultra low temperature freezers（U.S.'s match is silent to fly）, Allegra64R high speed refrigerated centrifuges
Machine（U.S.'s Beckman Kurt）, UV-1800 type ultraviolet-visible spectrophotometers（Japanese Shimadzu Corporation）.
2 methods
110 healthy SD male rats are randomly divided into blank group, sleep-disorder by the foundation of 2.1 animal packets and animal model
Physiological brain aging failure of memory（Sleep Disorder-factors' Physiological Brain Aging
Memory Subside, SDAD）Model group, Doneppezil Hydrochloride group, the ethanol water total extract middle dose group of bitter orange flower 95%, generation
The ethanol water total extract high dose group of seville orange flower 95%, the ethanol water elution position middle dose group of bitter orange flower 30%, the ethanol water of bitter orange flower 30%
Elute position high dose group, the ethanol water elution position middle dose group of bitter orange flower 70%, the high agent in ethanol water elution position of bitter orange flower 70%
Amount group, the powder middle dose group of fresh bitter orange flower freeze-drying bud, the powder high dose of fresh bitter orange flower freeze-drying bud
Group, totally 11 groups, every group of 10 rats.
Sleep-disorder physiological brain aging Memory Impairment（SDAD）The foundation of model：Each experimental group is more first with improveing
Platform water environment method progress sleep deprivation obtains sleep-disorder for 3 weeks and rationality brain aging Memory Impairment rat easily occurs.Afterwards, take
Rationality brain aging Memory Impairment lesion rat intracerebral injection condensed state A again easily occurs for not dead sleep-disorder in good condition
β25-35Obtain sleep-disorder physiological brain aging Memory Impairment（SDAD）Whole animal model.
Blank group is disregarded；Model group is handled by above-mentioned modeling method respectively with each administration group.Model group is in brain
Start within 14 days before interior injection operation the Tween-80 aqueous solution of gavage 2% to Post operation cut-off in 7 days to be administered, totally 21 days, 1 time a day.Respectively
Administration group starts i.e. 14 days beginning continuous gavages of operation consent on the 2nd week in sleep deprivation and is administered to Post operation cut-off administration in 7 days, gives altogether
Medicine 21 days, 1 time a day.
The injected clear water in pond makes the water surface be higher by platform 1-2 cm, water temperature control to 2.2 Morris water maze laboratories in advance
System is in 2 DEG C or so of 24 scholar.Pool inner wall scribble it is pitch-dark, every time test before appropriate black ink must be added into pond, pond is common
It is divided into 4 quadrants.Platform is placed among fourth quadrant, optionally a little put rat towards pool wall of pool in other three quadrants
Enter in water, experiment lasts 5 days, and respectively test once, tests 1 min to every morning each quadrant every time.If rat is within 1 min
Platform is not yet found, then rat is taken on platform and it is stood above 15 s, if rat finds platform within l min,
Also allow its 15 s that stood on platform, just terminate once to train, so training 4 days.At the 5th day, platform is removed, every rat trip
L min, record the time that every rat passes through original platform for the first time（Incubation period）, every rat is in l min by platform
Number, the total distance swum across and the time stayed in quadrant where original platform and other three quadrants, calculate the 4th
The time of quadrant swim（t4）Account for whole swimming time（tAlways）Percentage.
2.3 autonomic activitieses are tested：By self acting detector for small animals and MP-100 Physiological Experiment signal processing and analysis
System is connected, and puts 1 rat in each device at random, allows animal indoor in the min of device endoadaptation 5, detection before detection every time
Keep quite, prevent the activity to rat from having an impact.Record the autonomic activities number in the min of each group rat 20 and independently live
The dynamic time, and weigh the changes of weight of rat.
2.4 statistical methods use SAS software analysis, and experimental data is used±sRepresent, one-way analysis of variance experiment
Data.P＜ 0.05 is statistically significant.
3 results
3.1 bitter orange flower raw material components are to sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model Morris
The influence of water maze laboratory
Compared with blank group, model group rats prolongation of latency, the reduction of platform number, difference short in fourth quadrant residence time are crossed
Significantly（P＜ 0.01）, model group rats occur space exploration impairment, Memory Impairment, activity reduce etc. dementia symptom；
Compared with model group, administration Doneppezil Hydrochloride group, bitter orange flower raw material components each group can shorten incubation period, increase platform number,
In fourth quadrant residence time and apart from extension（P ＜ 0.05 or P ＜ 0.01）, illustrate that each administration group treatment is effective, prompt from generation to generation
Flower raw material components（The powder group of especially fresh bitter orange flower freeze-drying bud, the ethanol water elution position group of bitter orange flower 30%, generation
The ethanol water elution position group of seville orange flower 70%）Positive effect, above-mentioned each administration group have improvement rat model space exploration ability, on
Stating each administration group has the dementia symptom performance for improving rat model, and above-mentioned each administration group has the memory work(for improving rat model
The function curative effect that can decline.It the results are shown in Table 1.
Each position of the bitter orange flower of table 1 is to SDAD rat model space exploration result of the tests（±s,n=8）
Compared with blank group：﹟ ﹟ P< 0.01；Compared with SDAD model groups：* P<0.05,** P < 0.01。
3.2 bitter orange flower raw material components are to sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model is certainly
Main crawler behavior result of the test
Compared with blank group, model group rats autonomic activities number is reduced, and increased weight is slow, significant difference（P ＜ 0.01）, mould
There is sleep-disorder, had no peace of mind, the performance of the dementia symptom such as hyper somnolence in type group rat, and model group rats hair color is in disorder, behavior
Impatience simultaneously has certain aggressiveness etc. depressive symptom performance occur；Compared with model group, each position of bitter orange flower raw material components can make mould
The number of activities increase of type animal（Bitter orange flower has soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, improves sleep function, fatigue-relieving function etc.
Traditional function curative effect）, rat model hair color after administration is smooth, have a sweet temper, depressive symptom performance disappears, increased weight
Significantly（P ＜ 0.05 or P ＜ 0.01）, illustrate each position of bitter orange flower raw material group to SDAD rat model positive effects, especially newly
The powder and the ethanol water elution position group effect of bitter orange flower 30% of fresh bitter orange flower freeze-drying bud are optimal.Particularly it is fresh from generation to generation
Flower freeze-drying bud remains nutritional value component used or active component type, pharmacologic effect are very notable.It is above-mentioned to grind
Study carefully and also demonstrate that bitter orange flower has soothing liver and harmonizing stomach, traditional effect of regulating the flow of vital energy Xie Yu.Meanwhile bitter orange flower also has calm mood, solution
Except nervous modern pharmacology curative effect.See and the results are shown in Table 2 and table 3.
Each position of bitter orange flower raw material components of table 2 is to SDAD rat model autonomic activities Behavior Test results（±s,n=
8）
Compared with blank group：﹟ ﹟ P< 0.01；Compared with SDAD model groups：* P<0.05,** P < 0.01。
Each position of bitter orange flower raw material components of table 3 is to SDAD rat model changes of weight analysis results（±s,n=8）
Compared with blank group：﹟ ﹟ P< 0.01；Compared with SDAD model groups：* P<0.05,** P < 0.01。
Embodiment 9
The present invention is from animal factor induction property and the Memory Impairment of physiological brain aging, by sleep-disorder（Sleep
Disorder, SD, it makes raw poison in brain gas network exception or disorder evil to " poison damage brain network "）It is multifactor caused with aβ protein etc.
The Memory Impairment of physiological brain aging is combined, and causes sleep-disorder and the mouse ventricles of the brain disposably to inject A β shallow lakes using sleep deprivation
Powder sample albumen makes sleep-disorder physiological brain aging Memory Impairment（Sleep Disorder-factors'
Physiological Brain Aging Memory Subside, SDPBAMS,）Model, abbreviation SDAD models.Using sleep
Obstacle physiological brain aging Memory Impairment（SDAD）The raw material components that rat model is prepared to gardenia are spent for fresh gardenia
It is freeze-dried powder and its 30% ethanol water elution position, the 70% ethanol water elution position and 95% ethanol water total extract of bud
Pharmacological Activity Screening is carried out, passes through behaviouristics（Morris water mazes）Measure and the detection of measure and Physiology and biochemistry corresponding index,
Experiment confirm fresh gardenia flower freeze-drying bud powder and its 30% ethanol water elution position, 70% ethanol water elution position and
95% ethanol water total extract can make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model shortens latent
Phase, increased platform number, extended in fourth quadrant residence time.Meanwhile fresh gardenia flower freeze-drying bud powder and its
95% ethanol water total extract can make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model autonomic activities increases
Add, so as to play relieving restlessness that clears away heart-fire, delay brain aging, improve the multiple functions such as sleep, antidepression.It is to fine by sleep-disorder and A β
Silk forms the Memory Impairment of the multifactor caused sleep-disorder physiological brain aging such as aggregation（SDAD）Improve with auxiliary
The function curative effect of Memory Impairment, further confirm that raw material components prepared by gardenia have improvement sleep-disorder or improve note
Recall hypofunction function curative effect.
1 material
1.1 animal SPF level healthy SD male rats, weight 300-350 g are limited up to experimental animal by Hunan Si Laike scapes
Company provides, credit number：SCXK（Hunan）2009-0004.Rearing conditions：20-22 DEG C of temperature, feed with Rat Standard feed, from
By drinking water.
The gardenia raw material components that the raw material components of 1.2 gardenias are obtained with reagent by example 3 and example 4 are 100 mesh
Macroporous absorption on the powder and its 95% ethanol water total extract and 95% ethanol water totality thing of fresh gardenia flower freeze-drying bud
30% ethanol water elution position of resin and 70% ethanol water elution position.Aβ1-40（Sigma companies, lot number 052M4801V）.
1.3 instrument ZS-B types stereotaxic apparatus, Morris water maze video analytic systems（The many real enlightening wound science and technology in Beijing
Development Co., Ltd）, Forma-86C ULT ultra low temperature freezers（U.S.'s match is silent to fly）, Allegra64R high speed refrigerated centrifuges
Machine（U.S.'s Beckman Kurt）, UV-1800 type ultraviolet-visible spectrophotometers（Japanese Shimadzu Corporation）.
2 methods
110 healthy SD male rats are randomly divided into blank group, sleep-disorder by the foundation of 2.1 animal packets and animal model
Physiological brain aging Memory Impairment（Sleep Disorder-factors' Physiological Brain Aging
Memory Subside, SDAD）Model group, Doneppezil Hydrochloride group, the ethanol water total extract middle dose group of gardenia 95%, Cape jasmine
Son spends 95% ethanol water total extract high dose group, the ethanol water elution position middle dose group of gardenia 30%, the ethanol water of gardenia 30%
Elute position high dose group, the ethanol water elution position middle dose group of gardenia 70%, the high agent in ethanol water elution position of gardenia 70%
Amount group, the powder middle dose group of fresh gardenia flower freeze-drying bud, the powder high dose of fresh gardenia flower freeze-drying bud
Group, totally 11 groups, every group of 10 rats.
Sleep-disorder physiological brain aging Memory Impairment（SDAD）The foundation of model：Each experimental group is more first with improveing
Platform water environment method progress sleep deprivation obtains sleep-disorder for 3 weeks and rationality brain aging Memory Impairment rat easily occurs.Afterwards, take
Rationality brain aging Memory Impairment lesion rat intracerebral injection condensed state A again easily occurs for not dead sleep-disorder in good condition
β25-35Obtain sleep-disorder physiological brain aging Memory Impairment（SDAD）Whole animal model.
Blank group is disregarded；Model group is handled by above-mentioned modeling method respectively with each administration group.Model group is in brain
Start within 14 days before interior injection operation the Tween-80 aqueous solution of gavage 2% to Post operation cut-off in 7 days to be administered, totally 21 days, 1 time a day.Respectively
Administration group starts i.e. 14 days beginning continuous gavages of operation consent on the 2nd week in sleep deprivation and is administered to Post operation cut-off administration in 7 days, gives altogether
Medicine 21 days, 1 time a day.
The injected clear water in pond makes the water surface be higher by platform 1-2 cm, water temperature control to 2.2 Morris water maze laboratories in advance
System is in 2 DEG C or so of 24 scholar.Pool inner wall scribble it is pitch-dark, every time test before appropriate black ink must be added into pond, pond is common
It is divided into 4 quadrants.Platform is placed among fourth quadrant, optionally a little put rat towards pool wall of pool in other three quadrants
Enter in water, experiment lasts 5 days, and respectively test once, tests 1 min to every morning each quadrant every time.If rat is within 1 min
Platform is not yet found, then rat is taken on platform and it is stood above 15 s, if rat finds platform within l min,
Also allow its 15 s that stood on platform, just terminate once to train, so training 4 days.At the 5th day, platform is removed, every rat trip
L min, record the time that every rat passes through original platform for the first time（Incubation period）, every rat is in l min by platform
Number, the total distance swum across and the time stayed in quadrant where original platform and other three quadrants, calculate the 4th
The time of quadrant swim（t4）Account for whole swimming time（tAlways）Percentage.
2.3 autonomic activitieses are tested：By self acting detector for small animals and MP-100 Physiological Experiment signal processing and analysis
System is connected, and puts 1 rat in each device at random, allows animal indoor in the min of device endoadaptation 5, detection before detection every time
Keep quite, prevent the activity to rat from having an impact.Record the autonomic activities number in the min of each group rat 20 and independently live
The dynamic time, and weigh the changes of weight of rat.
2.4 statistical methods use SAS software analysis, and experimental data is used±sRepresent, one-way analysis of variance experiment
Data.P＜ 0.05 is statistically significant.
3 results
3.1 gardenia raw material components are to sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model Morris
The influence of water maze laboratory
Compared with blank group, model group rats prolongation of latency, the reduction of platform number, difference short in fourth quadrant residence time are crossed
Significantly（P＜ 0.01）, model group rats occur space exploration impairment, Memory Impairment, activity reduce etc. dementia symptom；
Compared with model group, administration Doneppezil Hydrochloride group, gardenia raw material components each group can shorten incubation period, increase platform number,
In fourth quadrant residence time and apart from extension（P ＜ 0.05 or P ＜ 0.01）, illustrate that each administration group treatment is effective, prompt cape jasmine
Flower raw material components（The especially ethanol water elution position group of gardenia 30%, the powder group of fresh gardenia flower freeze-drying bud, new
95% ethanol water total extract group of fresh gardenia freeze-drying bud powder）Positive effect, above-mentioned each administration group have improvement mould
Type rat space exploration ability, above-mentioned each administration group have the dementia symptom performance for improving rat model, above-mentioned each administration group tool
There is the function curative effect for the Memory Impairment for improving rat model.It the results are shown in Table 4.
Each position of gardenia raw material components of table 4 is to SDAD rat model space exploration result of the tests（±s,n=8）
Compared with model group：* P<0.05,** P < 0.01。
3.2 gardenia raw material components are to sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model is certainly
Main crawler behavior result of the test
Compared with blank group, model group rats autonomic activities number is reduced, and increased weight is slow, significant difference（P ＜ 0.01）, mould
There is sleep-disorder, had no peace of mind, the performance of the dementia symptom such as hyper somnolence in type group rat, and model group rats hair color is in disorder, behavior
Impatience simultaneously has certain aggressiveness etc. depressive symptom performance occur；Compared with model group, each position of gardenia raw material components can make mould
The number of activities increase of type animal（Gardenia has the Traditional Curative Effects such as purging intense heat relieving restlessness, liver soothing and depression relief.）, each administration group rat model
Hair color is smooth, have a sweet temper, depressive symptom performance disappears；Each administration group rat model increased weight is obvious（P ＜ 0.05 or
P ＜ 0.01）, the powder group increased weight of particularly fresh gardenia flower freeze-drying bud is very notable, fresh gardenia flower freezing
The powder of dry flower has improvement gastrointestinal function because it contains pollen（Defaecation）, particularly suitable teenager's improvement intestines and stomach work(
Energy（Apositia）And put on weight；Illustrate each position of gardenia raw material group to SDAD rat model positive effects, it is especially fresh
The powder and the ethanol total extract effect of gardenia 95% of gardenia freeze-drying bud are optimal.The studies above also demonstrate that cape jasmine
Flower has the Traditional Curative Effects such as purging intense heat relieving restlessness, liver soothing and depression relief.Meanwhile gardenia also has tranquilizing and allaying excitement, the modern pharmacology of fatigue-relieving
Curative effect.See and the results are shown in Table 5 and table 6.
Each position of gardenia raw material components of table 5 is to SDAD rat model autonomic activities Behavior Test results（±s,n=
8）
Compared with model group：* P<0.05,** P < 0.01。
Each position of gardenia raw material components of table 6 is to SDAD rat model changes of weight analysis results（±s,n=8）
The present invention of embodiment 10 is from animal factor induction property and the Memory Impairment of physiological brain aging, by sleep-disorder
（Sleep Disorder, SD, it makes raw poison in brain gas network exception or disorder evil to " poison damage brain network "）With aβ protein etc. it is more because
The Memory Impairment of physiological brain aging is combined caused by element, causes sleep-disorder and the mouse ventricles of the brain disposable using sleep deprivation
Inject A amyloid betas and make sleep-disorder physiological brain aging Memory Impairment（Sleep Disorder-factors'
Physiological Brain Aging Memory Subside, SDPBAMS,）Model, abbreviation SDAD models.Using sleep
Obstacle physiological brain aging Memory Impairment（SDAD）Rat model is bitter orange flower to integration of drinking and medicinal herbs（The bud of fresh bitter orange flower
Freeze-drying bud medicinal material）3 grams of powder, 4 grams of Spine Date Seed, composition totally 11 grams of powder of 4 grams of Sharpleaf Glangal Fruit（Referred to as
- No. 1 side of compound bitter orange flower）, integration of drinking and medicinal herbs is bitter orange flower（The freeze-drying bud medicinal material of the bud of fresh bitter orange flower）Powder 3
Gram, the composition of 4 grams of Spine Date Seed, 4 grams of Sharpleaf Glangal Fruit, 4 grams of cape jasmine fruit totally 15 grams of powder（Abbreviation compound bitter orange flower -2
Number side）, integration of drinking and medicinal herbs is bitter orange flower（The freeze-drying bud medicinal material of the bud of fresh bitter orange flower）3 grams of powder, Spine Date Seed 4
Gram, 4 grams of Sharpleaf Glangal Fruit, gardenia（（The freeze-drying bud medicinal material of the bud of fresh gardenia flower））The composition that 4 grams of powder
Totally 15 grams of powder（- No. 3 sides of abbreviation compound bitter orange flower）Pharmacological Activity Screening is carried out, passes through behaviouristics（Morris water mazes）Measure
Measure and detection with Physiology and biochemistry corresponding index, experiment confirm-No. 2-No. 1 side of compound bitter orange flower, compound bitter orange flower sides and answered
Square-No. 3 Fang Junneng of bitter orange flower make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model shortening incubation period,
Increased platform number, extended in fourth quadrant residence time.Meanwhile-No. 1 side of compound bitter orange flower ,-No. 2 sides of compound bitter orange flower and
- No. 3 Fang Junneng of compound bitter orange flower make sleep-disorder physiological brain aging Memory Impairment（SDAD）Rat model autonomic activities
Increase, so as to play relieving restlessness that clears away heart-fire, delay brain aging, improve the multiple functions such as sleep, antidepression.It is to by sleep-disorder and A β
Fibril forms the Memory Impairment of the multifactor caused sleep-disorder physiological brain aging such as aggregation（SDAD）Change with auxiliary
The function curative effect of kind Memory Impairment, further confirm compound bitter orange flower -1,2,3 prepared by the composition of above-mentioned integration of drinking and medicinal herbs
Number side has the function curative effect for improving sleep-disorder or improving Memory Impairment.
1 material
1.1 animal SPF level healthy SD male rats, weight 300-350 g are limited up to experimental animal by Hunan Si Laike scapes
Company provides, credit number：SCXK（Hunan）2009-0004.Rearing conditions：20-22 DEG C of temperature, feed with Rat Standard feed, from
By drinking water.
It is new that compound bitter orange flower -1,2, No. 3 sides and reagent prepared by the compositions of 1.2 integration of drinking and medicinal herbs by example 2 obtains 100 mesh
Powder, the example 5 that powder, the example 4 of fresh bitter orange flower freeze-drying bud obtain 100 mesh fresh gardenias flower freeze-drying bud obtain
Powder, the example 6 of 100 mesh fructus alpiniae oxyphyllaes obtain the powder of 100 mesh spina date seeds and example 7 obtains the powder of 100 mesh cape jasmine fruits, will be above-mentioned
The powder of integration of drinking and medicinal herbs is combined the composition for preparing integration of drinking and medicinal herbs ,-No. 1 side of compound bitter orange flower：The bitter orange flower of integration of drinking and medicinal herbs
（The freeze-drying bud medicinal material of the bud of fresh bitter orange flower）The combination of 3 grams of powder, 4 grams of Spine Date Seed, 4 grams of Sharpleaf Glangal Fruit
Thing totally 11 grams of powder；- No. 2 sides of compound bitter orange flower：The bitter orange flower of integration of drinking and medicinal herbs（The freeze-drying bud of the bud of fresh bitter orange flower
Medicinal material）3 grams of powder, 4 grams of Spine Date Seed, 4 grams of Sharpleaf Glangal Fruit, composition totally 15 grams of powder of 4 grams of cape jasmine fruit powder；It is multiple
Square-No. 3 sides of bitter orange flower：The bitter orange flower of integration of drinking and medicinal herbs（The freeze-drying bud medicinal material of the bud of fresh bitter orange flower）3 grams of powder, acid
4 grams of jujube kernel powder, 4 grams of Sharpleaf Glangal Fruit, gardenia（（The freeze-drying bud medicinal material of the bud of fresh gardenia flower））4 grams of powder
Composition totally 15 grams of powder.Aβ25-35（Sigma companies, lot number 095M4775V）.
1.3 instrument ZS-B types stereotaxic apparatus, Morris water maze video analytic systems（The many real enlightening wound science and technology in Beijing
Development Co., Ltd）, Forma-86C ULT ultra low temperature freezers（U.S.'s match is silent to fly）, Allegra64R high speed refrigerated centrifuges
Machine（U.S.'s Beckman Kurt）, UV-1800 type ultraviolet-visible spectrophotometers（Japanese Shimadzu Corporation）.
2 methods
90 healthy SD male rats are randomly divided into blank group by the foundation of 2.1 animal packets and animal model, sleep-disorder is given birth to
Rationality brain aging Memory Impairment（Sleep Disorder-factors' Physiological Brain Aging
Memory Subside, SDAD）Model group, Doneppezil Hydrochloride group, the square middle dose group of compound bitter orange flower-No. 1, compound are from generation to generation
- No. 1 square high dose group of flower, the square middle dose group of compound bitter orange flower-No. 2, the square high dose group of compound bitter orange flower-No. 2, compound are from generation to generation
- No. 3 square middle dose groups of flower, the square high dose group of compound bitter orange flower-No. 3, totally 9 groups, every group of 10 rats.
Sleep-disorder physiological brain aging Memory Impairment（SDAD）The foundation of model：Each experimental group is more first with improveing
Platform water environment method progress sleep deprivation obtains sleep-disorder for 3 weeks and rationality brain aging Memory Impairment rat easily occurs.Afterwards, take
Rationality brain aging Memory Impairment lesion rat intracerebral injection condensed state A again easily occurs for not dead sleep-disorder in good condition
β25-35Obtain sleep-disorder physiological brain aging Memory Impairment（SDAD）Whole animal model.
Blank group is disregarded；Model group is handled by above-mentioned modeling method respectively with each administration group.Model group is in brain
Start within 14 days before interior injection operation the Tween-80 aqueous solution of gavage 2% to Post operation cut-off in 7 days to be administered, totally 21 days, 1 time a day.Respectively
Administration group starts i.e. 14 days beginning continuous gavages of operation consent on the 2nd week in sleep deprivation and is administered to Post operation cut-off administration in 7 days, gives altogether
Medicine 21 days, 1 time a day.
The injected clear water in pond makes the water surface be higher by platform 1-2 cm, water temperature control to 2.2 Morris water maze laboratories in advance
System is in 2 DEG C or so of 24 scholar.Pool inner wall scribble it is pitch-dark, every time test before appropriate black ink must be added into pond, pond is common
It is divided into 4 quadrants.Platform is placed among fourth quadrant, optionally a little put rat towards pool wall of pool in other three quadrants
Enter in water, experiment lasts 5 days, and respectively test once, tests 1 min to every morning each quadrant every time.If rat is within 1 min
Platform is not yet found, then rat is taken on platform and it is stood above 15 s, if rat finds platform within l min,
Also allow its 15 s that stood on platform, just terminate once to train, so training 4 days.At the 5th day, platform is removed, every rat trip
L min, record the time that every rat passes through original platform for the first time（Incubation period）, every rat is in l min by platform
Number, the total distance swum across and the time stayed in quadrant where original platform and other three quadrants, calculate the 4th
The time of quadrant swim（t4）Account for whole swimming time（tAlways）Percentage.
2.3 autonomic activitieses are tested：By self acting detector for small animals and MP-100 Physiological Experiment signal processing and analysis
System is connected, and puts 1 rat in each device at random, allows animal indoor in the min of device endoadaptation 5, detection before detection every time
Keep quite, prevent the activity to rat from having an impact.Record the autonomic activities number in the min of each group rat 20 and independently live
The dynamic time, and weigh the changes of weight of rat.
2.4 statistical methods use SAS software analysis, and experimental data is used±sRepresent, one-way analysis of variance experiment
Data.P＜ 0.05 is statistically significant.
3 results
The compound bitter orange flower -1 of the composition preparation of 3.1 integration of drinking and medicinal herbs, 2, No. 3 sides are remembered to sleep-disorder physiological brain aging
Hypofunction（SDAD）The influence of rat model Morris water maze laboratories
Compared with blank group, model group rats prolongation of latency, the reduction of platform number, difference short in fourth quadrant residence time are crossed
Significantly（P＜ 0.01）, model group rats occur space exploration impairment, Memory Impairment, activity reduce etc. dementia symptom；
Compared with model group, compound bitter orange flower -1 prepared by administration Doneppezil Hydrochloride group, the composition of integration of drinking and medicinal herbs, 2, No. 3 sides are each
Administration group can shorten incubation period, increase platform number, in fourth quadrant residence time and apart from extension（P ＜ 0.05 or P ＜
0.01）, illustrate that each administration group treatment of the compound bitter orange flower -1 of the composition preparation of integration of drinking and medicinal herbs, 2, No. 3 sides is effective, its medicine food is same
The compound bitter orange flower -1 of the composition preparation in source, 2, No. 3 square effects are very notable, and the composition preparation of above-mentioned integration of drinking and medicinal herbs is answered
Square bitter orange flower -1,2, No. 3 each administration groups in side have improvement rat model space exploration ability, the composition system of above-mentioned integration of drinking and medicinal herbs
The standby dementia symptom performance of compound bitter orange flower -1,2, No. 3 each administration groups in side with improvement rat model, above-mentioned integration of drinking and medicinal herbs
The function of compound bitter orange flower -1,2, No. 3 each administration groups in side with the Memory Impairment for improving rat model prepared by composition
Curative effect.It the results are shown in Table 7.
- 1,2, No. 3 side of 7 compound bitter orange flower of table is to SDAD rat model space exploration result of the tests（±s, n=8）
Note：Compared with model group,* p﹤ 0.05,** p﹤ 0.01.
Compound bitter orange flower -1 prepared by the compositions of 3.2 integration of drinking and medicinal herbs, 2, No. 3 sides are to sleep-disorder physiological brain aging
Memory Impairment（SDAD）The influence of rat model autonomic activities Behavior Test and body weight
Compared with blank group, model group rats autonomic activities number is reduced, and increased weight is slow, significant difference（P ＜ 0.01）, mould
There is sleep-disorder, had no peace of mind, the performance of the dementia symptom such as hyper somnolence in type group rat, and model group rats hair color is in disorder, behavior
Impatience simultaneously has certain aggressiveness etc. depressive symptom performance occur；Compared with model group, the compound of the composition preparation of integration of drinking and medicinal herbs
Bitter orange flower -1,2, No. 3 each administration groups in side can increase the number of activities of animal pattern, the compound of the composition preparation of integration of drinking and medicinal herbs
Bitter orange flower -1, the rat model hair color of 2, No. 3 each administration groups in side is smooth, have a sweet temper, depressive symptom performance disappears；Medicine is eaten
The compound bitter orange flower -1 of homologous composition preparation, the rat model increased weight of 2, No. 3 each administration groups in side are obvious（P ＜ 0.05
Or P ＜ 0.01）.See and the results are shown in Table 8.
Table -1,2, No. 3 influence of the side to SDAD rat models autonomic activities and changes of weight of 8 compound bitter orange flower（±s, n
=8）
Note：Compared with model group,* p﹤ 0.05,** p﹤ 0.01.
In summary, above-mentioned integration of drinking and medicinal herbs composition prepare compound bitter orange flower -1,2, No. 3 sides be respectively provided with it is soothing the liver and
It is prepared by the traditional function curative effect that stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness are calmed the nerves, the composition of above-mentioned integration of drinking and medicinal herbs
Compound bitter orange flower -1,2, No. 3 sides also each have auxiliary improving memory function decline, improve sleep function, fatigue-relieving function,
Aid digestion function, the modern pharmacology curative effect of strengthen immunity function.
Claims (8)
1. a kind of composition of integration of drinking and medicinal herbs is preparing improvement sleep-disorder or is improving Memory Impairment or treatment senile dementia
Application in medicine or health food, it is characterised in that the composition of integration of drinking and medicinal herbs is made up of the raw material of following masses percentage：
Bitter orange flower 20-45, spina date seed 25-40, fructus alpiniae oxyphyllae 30-40, and add appropriate medicinal filling auxiliary material.
2. a kind of composition of integration of drinking and medicinal herbs is preparing improvement sleep-disorder or is improving Memory Impairment or treatment senile dementia
Application in medicine or health food, it is characterised in that the composition of integration of drinking and medicinal herbs is made up of the raw material of following masses percentage：
Bitter orange flower 20-25, spina date seed 25-30, fructus alpiniae oxyphyllae 25-30, cape jasmine 20-25, and add appropriate medicinal filling auxiliary material.
3. a kind of composition of integration of drinking and medicinal herbs according to claim any one of 1-2 is preparing improvement sleep-disorder or improvement
Application in Memory Impairment or treatment medicine for senile dementia or health food, it is characterised in that the group of above-mentioned integration of drinking and medicinal herbs
Compound mainly has the traditional function curative effect that soothing liver and harmonizing stomach, regulating the flow of vital energy Xie Yu, warm kidney contracting urine controlling nocturnal emission with astringent drugs, calming heart relieving restlessness are calmed the nerves, above-mentioned medicine
Eating homologous composition also has auxiliary improving memory function decline, improves sleep function, fatigue-relieving function, aid digestion work(
Energy, the modern pharmacology curative effect of strengthen immunity function.
4. a kind of composition of integration of drinking and medicinal herbs according to claim any one of 1-2 is preparing improvement sleep-disorder or changed
Application in kind Memory Impairment or treatment medicine for senile dementia or health food, it is characterised in that：Described bitter orange flower is again
Name bitter orange flower, the flores aurantii that turns green, bitter citrus immature flower, Fructus Aurantii flower, flores aurantii, its source is mainly Rutaceae CitrusCitrus aurantium
L. and its fresh flowers of cultivars or the fresh flowers of all plants of Rutaceae Citrus, the bud of specially fresh bitter orange flower
Dry in the shade, dry, the dry flower medicinal material of machine drying, the freeze-drying bud of the bud of more specifically preferably fresh bitter orange flower
Medicinal material.
5. remembered according to a kind of composition of integration of drinking and medicinal herbs described in claim 2 preparing to improve sleep-disorder or improve
Application in hypofunction or treatment medicine for senile dementia or health food, it is characterised in that：Cape jasmine source is mainly Rubiaceae
Cape jasmine platymiscium cape jasmineGardenia jasminoides Ellis fruit or flower, it is also possible to which Rubiaceae Gardenia Ellis is all
Know the flower of plant, more specifically for gardenia bud or flower peak period the drying in the shade of flower, dry, the dry flower of machine drying
Or flower pesticide material, more specifically preferably fresh gardenia flower bud freeze-drying bud medicinal material.
6. a kind of composition of integration of drinking and medicinal herbs according to claim any one of 1-2 is preparing improvement sleep-disorder or improvement
Application in Memory Impairment or treatment medicine for senile dementia or health food, it is characterised in that：The group of the integration of drinking and medicinal herbs
The medicine of compound or the preparation formulation of health food be oral liquid, granule, capsule, tablet, effervescent tablet, syrup, pill,
Paste nourishing agent, soft capsule, ointment, emulsion, powder, sustained release agent, controlled release agent, targeting preparation, powder-injection, liquid drugs injection, injection, mist
Agent, microemulsion, gel, nanometer formulation.
7. a kind of composition of integration of drinking and medicinal herbs according to claim 6 is preparing improvement sleep-disorder or is improving memory function
Application in decline or treatment medicine for senile dementia or health food, it is characterised in that：Described capsule is hard shell capsules, flexible glue
Capsule, gelatine capsule, plant capsule, super AMP capsule, liquid-filling capsule, natural capsule, controlled release capsule, spansule, capsulae enterosolubilis
Capsule preparations.
8. a kind of composition of integration of drinking and medicinal herbs according to claim 6 is preparing improvement sleep-disorder or is improving memory function
Application in decline or treatment medicine for senile dementia or health food, it is characterised in that：Described tablet is common compressed tablets, bag
Garment piece, sugar coated tablet, Film coated tablets, Enteric coated tablets, effervescent tablet, chewable tablets, multilayer tablet, dispersible tablet, sublingual tablet, buccal tablet, implantation
Piece, solution piece, long-acting, microencapsule tablet, fast-release tablet, the tablet formulation of sustained release tablets and controlled release tablet.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110038054A (en) * | 2019-05-13 | 2019-07-23 | 江西中医药大学 | Active component improves sleep or antidepression or improves in failure of memory drug or food and applies in preparation in gardenia and branches and leaves fruit |
| CN114668061A (en) * | 2022-04-11 | 2022-06-28 | 安徽东荣堂生物科技有限公司 | Wild jujube seed tea for soothing and relieving and preparation method thereof |
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