CN107075539B - 用于分析结构不同的复杂脂质的方法、组合物和试剂盒 - Google Patents

用于分析结构不同的复杂脂质的方法、组合物和试剂盒 Download PDF

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CN107075539B
CN107075539B CN201580040519.5A CN201580040519A CN107075539B CN 107075539 B CN107075539 B CN 107075539B CN 201580040519 A CN201580040519 A CN 201580040519A CN 107075539 B CN107075539 B CN 107075539B
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lipid
site
fatty acids
mixture
backbone
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CN107075539A (zh
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史蒂文·沃特金斯
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Metabolon Inc
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Metabolon Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
CN201580040519.5A 2014-07-30 2015-07-30 用于分析结构不同的复杂脂质的方法、组合物和试剂盒 Active CN107075539B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031099P 2014-07-30 2014-07-30
US62/031099 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

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CN107075539A CN107075539A (zh) 2017-08-18
CN107075539B true CN107075539B (zh) 2021-11-12

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US (1) US11181535B2 (en,Table 1-8)
EP (1) EP3174991B1 (en,Table 1-8)
JP (1) JP6810023B2 (en,Table 1-8)
CN (1) CN107075539B (en,Table 1-8)
AU (1) AU2015296304B2 (en,Table 1-8)
CA (1) CA2955204A1 (en,Table 1-8)
WO (1) WO2016019140A1 (en,Table 1-8)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
WO2018183448A1 (en) * 2017-03-31 2018-10-04 Metabolon, Inc. Comprehensive and quatitative lipid and tocopherol analysis
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
AU2020287121A1 (en) * 2019-06-04 2022-01-06 Avanti Polar Lipids, Llc Universal lipid quantitative standards for use in lipidomics
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法

Citations (4)

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CN1952650A (zh) * 2006-08-31 2007-04-25 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins
CN103743851A (zh) * 2014-02-14 2014-04-23 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

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US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
WO2003078574A2 (en) 2002-03-11 2003-09-25 Lipomics Technologies, Inc. Novel metabolic targets and markers
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
US20070082399A1 (en) * 2003-07-11 2007-04-12 Tatiana A Egorova-Zachernyuk Compositions and method for stable isotope labelling of biological compounds
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
SG10201405974SA (en) * 2009-10-01 2014-10-30 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry

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CN1952650A (zh) * 2006-08-31 2007-04-25 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins
CN103743851A (zh) * 2014-02-14 2014-04-23 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

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Publication number Publication date
US11181535B2 (en) 2021-11-23
US20170192023A1 (en) 2017-07-06
EP3174991A1 (en) 2017-06-07
EP3174991B1 (en) 2024-03-20
JP6810023B2 (ja) 2021-01-06
AU2015296304B2 (en) 2019-08-29
AU2015296304A1 (en) 2017-02-02
WO2016019140A1 (en) 2016-02-04
CA2955204A1 (en) 2016-02-04
CN107075539A (zh) 2017-08-18
JP2017524708A (ja) 2017-08-31
EP3174991A4 (en) 2018-02-14

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