AU2015296304B2 - Methods, compositions, and kits for analysis of structurally diverse complex lipids - Google Patents

Methods, compositions, and kits for analysis of structurally diverse complex lipids Download PDF

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Publication number
AU2015296304B2
AU2015296304B2 AU2015296304A AU2015296304A AU2015296304B2 AU 2015296304 B2 AU2015296304 B2 AU 2015296304B2 AU 2015296304 A AU2015296304 A AU 2015296304A AU 2015296304 A AU2015296304 A AU 2015296304A AU 2015296304 B2 AU2015296304 B2 AU 2015296304B2
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Australia
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lipid
mixture
fatty acids
separate
present
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AU2015296304A1 (en
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Steven Watkins
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Metabolon Inc
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Metabolon Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
AU2015296304A 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids Active AU2015296304B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031099P 2014-07-30 2014-07-30
US62/031,099 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Publications (2)

Publication Number Publication Date
AU2015296304A1 AU2015296304A1 (en) 2017-02-02
AU2015296304B2 true AU2015296304B2 (en) 2019-08-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015296304A Active AU2015296304B2 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Country Status (7)

Country Link
US (1) US11181535B2 (en,Table 1-8)
EP (1) EP3174991B1 (en,Table 1-8)
JP (1) JP6810023B2 (en,Table 1-8)
CN (1) CN107075539B (en,Table 1-8)
AU (1) AU2015296304B2 (en,Table 1-8)
CA (1) CA2955204A1 (en,Table 1-8)
WO (1) WO2016019140A1 (en,Table 1-8)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018183448A1 (en) * 2017-03-31 2018-10-04 Metabolon, Inc. Comprehensive and quatitative lipid and tocopherol analysis
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
AU2020287121A1 (en) * 2019-06-04 2022-01-06 Avanti Polar Lipids, Llc Universal lipid quantitative standards for use in lipidomics
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法

Citations (3)

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US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins

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US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
WO2003078574A2 (en) 2002-03-11 2003-09-25 Lipomics Technologies, Inc. Novel metabolic targets and markers
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
WO2005005616A2 (en) * 2003-07-11 2005-01-20 Egorova-Zachernyuk Tatiana A Compositions and methods for stable isotope labelling of biological compounds
CN100567967C (zh) * 2006-08-31 2009-12-09 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
EP2286236B1 (en) * 2008-05-28 2016-04-20 Basf Se Methods for assessing liver toxicity
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
SG179122A1 (en) * 2009-10-01 2012-05-30 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
CN103743851B (zh) * 2014-02-14 2015-06-17 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins

Non-Patent Citations (5)

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Title
Daren Stephens, "Fatty Acid Mass Spectrometry Protocol Updated 10/11/2007 By Daren Stephens", (2007-10-11), URL: http://www.lipidmaps.org/protocols/PP0000003800.pdf, (2017-11-17) *
Ekroos K et al, Anal. Chem. 2002, 74, p941-949 *
Khalil M B et al, Mass Spectrometry Reviews, 2010, 29, pp 877– 929 *
MOORE JEFF D ET AL, "Quantitation and standardization of lipid internal standards for mass spectroscopy", METHODS IN ENZYMO, ACADEMIC PRESS, US, (2007-01-01), vol. 432, ISSN 0076-6879, pages 351 - 367 *
MURPHY et al., "Mass Spectrometric Analysis of Long-Chain Lipids.", Mass Spectrometry Review, vol. 30, no. 4, (2011-07), (2015-09-25) *

Also Published As

Publication number Publication date
CA2955204A1 (en) 2016-02-04
WO2016019140A1 (en) 2016-02-04
AU2015296304A1 (en) 2017-02-02
EP3174991A4 (en) 2018-02-14
CN107075539B (zh) 2021-11-12
US11181535B2 (en) 2021-11-23
JP2017524708A (ja) 2017-08-31
CN107075539A (zh) 2017-08-18
EP3174991A1 (en) 2017-06-07
JP6810023B2 (ja) 2021-01-06
US20170192023A1 (en) 2017-07-06
EP3174991B1 (en) 2024-03-20

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