CA2955204A1 - Methods, compositions, and kits for analysis of structurally diverse complex lipids - Google Patents

Methods, compositions, and kits for analysis of structurally diverse complex lipids Download PDF

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Publication number
CA2955204A1
CA2955204A1 CA2955204A CA2955204A CA2955204A1 CA 2955204 A1 CA2955204 A1 CA 2955204A1 CA 2955204 A CA2955204 A CA 2955204A CA 2955204 A CA2955204 A CA 2955204A CA 2955204 A1 CA2955204 A1 CA 2955204A1
Authority
CA
Canada
Prior art keywords
lipid
sample
fatty acids
mixture
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2955204A
Other languages
English (en)
French (fr)
Inventor
Steven Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolon Inc
Original Assignee
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
Publication of CA2955204A1 publication Critical patent/CA2955204A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2955204A 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids Abandoned CA2955204A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031099P 2014-07-30 2014-07-30
US62/031,099 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Publications (1)

Publication Number Publication Date
CA2955204A1 true CA2955204A1 (en) 2016-02-04

Family

ID=55218314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2955204A Abandoned CA2955204A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Country Status (7)

Country Link
US (1) US11181535B2 (en,Table 1-8)
EP (1) EP3174991B1 (en,Table 1-8)
JP (1) JP6810023B2 (en,Table 1-8)
CN (1) CN107075539B (en,Table 1-8)
AU (1) AU2015296304B2 (en,Table 1-8)
CA (1) CA2955204A1 (en,Table 1-8)
WO (1) WO2016019140A1 (en,Table 1-8)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018183448A1 (en) * 2017-03-31 2018-10-04 Metabolon, Inc. Comprehensive and quatitative lipid and tocopherol analysis
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
AU2020287121A1 (en) * 2019-06-04 2022-01-06 Avanti Polar Lipids, Llc Universal lipid quantitative standards for use in lipidomics
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
WO2003078574A2 (en) 2002-03-11 2003-09-25 Lipomics Technologies, Inc. Novel metabolic targets and markers
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
US20070082399A1 (en) * 2003-07-11 2007-04-12 Tatiana A Egorova-Zachernyuk Compositions and method for stable isotope labelling of biological compounds
CN100567967C (zh) * 2006-08-31 2009-12-09 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
EP3059592A1 (en) * 2008-05-28 2016-08-24 Basf Se Methods for assessing liver toxicity
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
SG10201405974SA (en) * 2009-10-01 2014-10-30 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
GB201213127D0 (en) * 2012-07-24 2012-09-05 Univ Dundee Novel isotopic labelling method
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
CN103743851B (zh) * 2014-02-14 2015-06-17 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

Also Published As

Publication number Publication date
CN107075539B (zh) 2021-11-12
US11181535B2 (en) 2021-11-23
US20170192023A1 (en) 2017-07-06
EP3174991A1 (en) 2017-06-07
EP3174991B1 (en) 2024-03-20
JP6810023B2 (ja) 2021-01-06
AU2015296304B2 (en) 2019-08-29
AU2015296304A1 (en) 2017-02-02
WO2016019140A1 (en) 2016-02-04
CN107075539A (zh) 2017-08-18
JP2017524708A (ja) 2017-08-31
EP3174991A4 (en) 2018-02-14

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200508

EEER Examination request

Effective date: 20200508

FZDE Discontinued

Effective date: 20220829

FZDE Discontinued

Effective date: 20220829