CN107050055A - A kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method - Google Patents
A kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method Download PDFInfo
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- CN107050055A CN107050055A CN201710262560.8A CN201710262560A CN107050055A CN 107050055 A CN107050055 A CN 107050055A CN 201710262560 A CN201710262560 A CN 201710262560A CN 107050055 A CN107050055 A CN 107050055A
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- Prior art keywords
- donkey
- hide gelatin
- dermalaxia
- film
- microcapsules
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Abstract
The invention belongs to the field of Chinese medicines, specifically related to a kind of donkey-hide gelatin microcapsules dermalaxia film, include the air-permeable layer of non-woven fabrics material, adhere to donkey-hide gelatin microcapsule granule on non-woven fabrics fiber, the donkey-hide gelatin microcapsule granule includes donkey-hide gelatin, surfactant, anionic polymer emulsion stabilizer, glycerine and olive oil.After donkey-hide gelatin is by low-temperature setting, it is ground into small diameter particles and is mixed with lipid solution, is dispersed in the dispersion liquid that donkey-hide gelatin microcapsules are obtained in distilled water, effectively realizes the dispersed of donkey-hide gelatin, overcome common donkey-hide gelatin block viscosity big, be unfavorable for the shortcomings of active principle penetrates into human body in donkey-hide gelatin.Microcapsules are combined with non-woven fabrics, improve the gas permeability of donkey-hide gelatin microcapsules dermalaxia film, it is to avoid the sweat that human body is discharged during attaching nourishes anaerobic bacteria, produces peculiar smell, and side effect is produced to skin.Subsequent experimental shows that donkey-hide gelatin microcapsules dermalaxia film provided by the present invention can be effectively improved skin keratin phenomenon, with certain application value.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method.
Background technology
Donkey-hide gelatin clinically has a wide range of applications as Chinese three great traditions tonic, extensively using with enriching yin of enriching blood,
The effect of moisturizing, stop blooding.In nineteen ninety version, nineteen ninety-five version, version, version, version in 2010 in 2005 in 2000《The People's Republic of China (PRC)
Pharmacopeia》The solid gum boiled using donkey hide is provided as donkey-hide gelatin certified products, it is relevant that current State Food and Drug Administration announces
The medicine of donkey-hide gelatin has 203 kinds, and Chinese medicine protection kind has 9 kinds, and the health food based on donkey-hide gelatin has 127 kinds.Traditionally donkey-hide gelatin
Instructions of taking, one kind is that block donkey-hide gelatin molten is made by traditional processing technology or takes after boiling, this method addition rock sugar etc.
Improve taste, have the disadvantage to take mouthfeel not good, and some alimentary canal classes parasitism germ, heavy metal element in donkey-hide gelatin process
Also by oral, had undesirable effect into human body.
Donkey-hide gelatin product is by orally, macro-molecular protein, small molecule peptide chain are also by the digestion of protease, hydrolysis, conversion
Into amino acid molecular, the medical value of small-molecular peptides is lost.It is sticky airtight because donkey-hide gelatin outward appearance is black Gelatinous plate, directly
Connect cause skin surface anoxic, sweat excessively to soak donkey-hide gelatin external application, donkey-hide gelatin as culture medium breed bacteria, be unfavorable for skin be good for
Health.And donkey-hide gelatin viscosity is larger, the active principle in donkey-hide gelatin can not efficiently act on skin by diffusion, cause donkey-hide gelatin
Utilization rate is low.
Skin keratin is a kind of common skin sub-health state, is mainly shown as and dries decortication, chap.Table in the winter time
Existing even more serious, severe shows as oozing of blood breach occur, annoyings people's routine work and life.And treated at this stage using hormone
Method can only respite skin keratin degree, hormone therapy stop after easily recurring, therapeutic effect is not obvious.Frequently with it is sweet
The skin care item such as oil can only temporarily improve chapped skin by moistening effect, can not also effect a radical cure skin keratin.
The content of the invention
The present invention provides a kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method, and donkey-hide gelatin is dispersed into microencapsulation
It is dispersed in non-woven fabrics fiber, the keratinization phenomenon for improving skin.
Technical solution of the present invention is：A kind of donkey-hide gelatin microcapsules dermalaxia film, includes the air-permeable layer of non-woven fabrics material, in nothing
Spin and adhere to donkey-hide gelatin microcapsule granule on measuring fiber, the donkey-hide gelatin microcapsule granule includes donkey-hide gelatin, surfactant, anion high score
Sub- emulsion stabilizer, glycerine and olive oil.
Further, the donkey-hide gelatin, surfactant, anionic polymer emulsion stabilizer, glycerine and Quality of Olive Oil Produced ratio
For:1：0.05~0.2：0.02~0.16:0.3~1.2:0.5~1.8.
Further, the anionic polymer emulsion stabilizer is selected from sodium carboxymethylcellulose.
A kind of donkey-hide gelatin microcapsules dermalaxia film, preparation process includes：
(1) donkey-hide gelatin is cooled to -50~-60 DEG C using dry ice, by the donkey-hide gelatin after cooling with etc. after quality dry ice mixes, it is low
Particle 0.1~0.5mm sizes are crushed in fast pulverizer.
(2) fast-crushing 1min after the low temperature donkey-hide gelatin powder after crushing is mixed with the dry ice of three times quality, obtains donkey-hide gelatin
With the mixed-powder of dry ice.
(3) surfactant, anionic polymer emulsion stabilizer (sodium carboxymethylcellulose) and glycerine are dissolved in olive
In oil, lipid solution is configured to, is added to by way of spraying in the mixed-powder of stirring, obtain core powder.
(4) core powder is added portionwise in degerming distilled water, stirring 3h is opened in adition process, and control temperature 20
Between~35 DEG C, emulsion is obtained.
(5) citric acid of 1wt% concentration is added into emulsion system, emulsion pH to 4.5 is adjusted, then 40~60
8~10h is stirred at DEG C, pH=7 is adjusted by the sodium bicarbonate solution of 1wt% concentration, micro-capsule dispersion liquid is obtained.
(6) 2~5mm polypropylene non-woven fabric is soaked in micro-capsule dispersion liquid, donkey-hide gelatin microcapsules skin is obtained after taking-up
Skin softens film.
Lipid solution quality is the 3~20% of donkey-hide gelatin quality in the step (3)；Surface-active in the lipid solution
Agent, anionic polymer emulsion stabilizer, glycerine, Quality of Olive Oil Produced ratio are 1：0.2~0.4:3~6:5~9, preferably 1:
0.25~0.35:4~5:6~8；The mass ratio of core and distilled water is 1 in the step (4):8~12, preferably 1:9~
10。
The beneficial effects of the present invention are after low-temperature setting donkey-hide gelatin, be effectively ground into small diameter particles, with fat by it
Property solution mixing after, be dispersed in the dispersion liquid that microcapsules are obtained in distilled water.Donkey-hide gelatin is effectively realized by this processing mode
It is dispersed, it is to avoid common donkey-hide gelatin block viscosity is big, is unfavorable for the infiltration of active principle.And pass through microcapsules and non-woven fabrics
Combination, be effectively ensured the gas permeability of donkey-hide gelatin microcapsules dermalaxia film, it is to avoid the sweat that human body is discharged during attaching
Anaerobic bacteria is nourished, causes corruption to produce peculiar smell, side effect is produced to skin.
The invention provides the application method of infrared activated, this method ensure that donkey-hide gelatin microcapsules dermalaxia film in work
Before changing in the packed microcapsules of active ingredient, it is to avoid pathogen contamination, active ingredient are lost in, moisture evaporation brings donkey-hide gelatin dry and cracked
Failure.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.
Technical scheme is illustrated below in conjunction with specific embodiment.
The preparation (one) of the donkey-hide gelatin microcapsules dermalaxia film of embodiment 1
(1) the donkey-hide gelatin original 10.0g of Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov.'s production is weighed, is placed in dry ice particles and freezes
30min, until donkey-hide gelatin deblocking temperature is down to after subzero 50 DEG C, is pulverized block donkey-hide gelatin using mortar, then adds 5g dry ice particles
After continue after being ground, add 5g solid dry ice particles, added in the lump in small particle pulverizer after mixing, 1800r/
3min is stirred under min rotating speeds, 0.2mm or so pulverized particles are obtained.
(2) small particle pulverizer is added after mixing the pulverized particles in step (1) and 30g dry ice particles,
1min is stirred under 1000r/min rotating speeds, mixed-powder is obtained.And mixed-powder is temporarily stored in after hermetic bag, it is embedded in dry ice
In keep in.
(3) the common 70mg of polysorbate40, anionic polymer emulsion stabilizer 20mg, glycerine 210mg, olive oil 350mg are weighed,
After mixing, lipid solution is obtained.The mode that lipid solution is sprayed sprays into the mixed-powder obtained in step (2), and stirs equal
It is even, obtain core powder.
(4) core powder is added portionwise in 320mL sterile purified waters, stirs 3h at 25 DEG C, obtain emulsion.
(5) 1wt% aqueous citric acid solutions are added dropwise in the emulsion obtained to step (4), and open stirring, until breast
Change liquid pH=4.5.Adjust after pH stabilizations, continue to stir 8h.Then pH is adjusted to neutrality using 1wt% sodium acid carbonates, obtains micro-
Capsule dispersant liquid.
(6) polypropylene non-woven of 2mm thickness is arranged in 1min in micro-capsule dispersion liquid, after taking-up 50% humidity,
5h is dried under 30min, donkey-hide gelatin microcapsules dermalaxia film is obtained.
The preparation (two) of the donkey-hide gelatin microcapsules dermalaxia film of embodiment 2
(1) the donkey-hide gelatin original 20.0g of Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov.'s production is weighed, is placed in dry ice particles and freezes
30min, until donkey-hide gelatin deblocking temperature is down to after subzero 65 DEG C, is pulverized block donkey-hide gelatin using mortar, then adds 8g dry ice particles
After continue after being ground, add 12g solid dry ice particles, added in the lump in small particle pulverizer after mixing, 1800r/
2min is stirred under min rotating speeds, 0.5mm pulverized particles are obtained.
(2) small particle pulverizer is added after mixing the pulverized particles in step (1) and 60g dry ice particles,
1min is stirred under 1000r/min rotating speeds, mixed-powder is obtained.And mixed-powder is temporarily stored in after hermetic bag, it is embedded in dry ice
In keep in.
(3) the common 140mg of polysorbate40, anionic polymer emulsion stabilizer 80mg, glycerine 840mg, olive oil are weighed
900mg, after mixing, obtains lipid solution.The mode that lipid solution is sprayed sprays into the mixed-powder obtained in step (2), and
Stir, obtain core powder.
(4) core powder is added portionwise in 660mL sterile purified waters, stirs 2h at 35 DEG C, obtain emulsion.
(5) 1% aqueous citric acid solution is added dropwise in the emulsion obtained to step (4), and opens stirring, until emulsification
Liquid pH=4.5.Adjust after pH stabilizations, continue to stir 10h.Then pH is adjusted to neutrality using 1% sodium acid carbonate, obtains microcapsules
Dispersion liquid.
(6) polypropylene non-woven of 3mm thickness is arranged in 0.8min in micro-capsule dispersion liquid, after taking-up 50% humidity,
5h is dried under 30min, donkey-hide gelatin microcapsules dermalaxia film is obtained.
The blank assay of embodiment 3
(1) edible gelatin 10.0g is weighed, is placed in dry ice particles and freezes 30min, until donkey-hide gelatin deblocking temperature is down to subzero 50
After DEG C, block donkey-hide gelatin is pulverized using mortar, continued after then adding 5g dry ice particles after being ground, 5g solid-states is added and does
Ice particle, is added in small particle pulverizer in the lump after mixing, and 3min is stirred under 1800r/min rotating speeds, obtains 0.2mm crushing
Particle.
(2) small particle pulverizer is added after mixing the pulverized particles in step (1) and 30g dry ice particles,
1min is stirred under 1000r/min rotating speeds, mixed-powder is obtained.And mixed-powder is temporarily stored in after hermetic bag, it is embedded in dry ice
In keep in.
(3) the common 70mg of polysorbate40, anionic polymer emulsion stabilizer 20mg, glycerine 210mg, olive oil 350mg are weighed,
After mixing, lipid solution is obtained.The mode that lipid solution is sprayed sprays into the mixed-powder obtained in step (2), and stirs equal
It is even, obtain core powder.
(4) core powder is added portionwise in 320mL sterile purified waters, stirs 3h at 25 DEG C, obtain emulsion.
(5) 1% aqueous citric acid solution is added dropwise in the emulsion obtained to step (4), and opens stirring, until emulsification
Liquid pH=4.5.Adjust after pH stabilizations, continue to stir 8h.Then pH is adjusted to neutrality using 1% sodium acid carbonate, obtains microcapsules
Dispersion liquid.
(6) polypropylene non-woven of 2mm thickness is arranged in 1min in micro-capsule dispersion liquid, after taking-up 50% humidity,
5h is dried under 30min, the microcapsules dermalaxia film of blank control group is obtained.
The rabbit skin keratinization of embodiment 4 is tested
6 months monthly ages rabbit 5 is bought by Jinan Jin Feng laboratory animals Co., Ltd, rabbit rabbit top layer fine, soft fur is scraped
Remove, and put hermetic bag, the thionyl chloride steam 10mL of 1% content is injected in the hermetic bag of two ears of rabbit or so, is adopted
With thionyl chloride steam induction rabbit rabbit skin dehydration keratinization 30mim.
Experimental point 10 is respectively randomly selected in 5 rabbit or so two ears, each experimental point area 0.5cm*0.5cm will
Donkey-hide gelatin microcapsules dermalaxia film prepared by embodiment (1) is attached on the left ear experimental point of rabbit, then using 1.5w/cm2It is red
Outside line heating gun carries out heat-activated 1min to donkey-hide gelatin microcapsules dermalaxia film.Attached in fact in the auris dextra experimental point of rabbit simultaneously
The microcapsules dermalaxia film of the blank control group of the preparation of example 3 is applied, then using 1.5w/cm2Infrared heating rifle is micro- to donkey-hide gelatin
Capsule dermalaxia film carries out heat-activated 1min.Rabbit left-right ear microcapsules dermalaxia film, distillation washing are removed after 5h
Hot blast drying 10min, exposes keratinization cortex after net.Then skin keratin on the experimental point of the ear of same rabbit or so two is contrasted
Change the order of severity, experimental data is shown in Table 1：
Table 1：Rabbit skin keratin experimental results
| Group | Effective (X/10) | Effectively (X/10) | Invalid (X/10) | Total effective rate/% |
| Rabbit 1 | 4/10 | 5/10 | 1/10 | 90 |
| Rabbit 2 | 8/10 | 2/10 | 0/10 | 100 |
| Rabbit 3 | 7/10 | 3/10 | 0/10 | 100 |
| Rabbit 4 | 1/10 | 7/10 | 2/10 | 80 |
| Rabbit 5 | 2/10 | 7/10 | 1/10 | 90 |
As can be seen from Table 1, the donkey-hide gelatin microcapsules dermalaxia film that prepared by the present invention is to the effective of rabbit keratinized skin
Rate reaches 62%, and effective percentage reaches 45%, and total effective rate reaches 92%, and inefficiency is 8%, can effectively alleviate skin keratin
Change the order of severity, improve skin dehydration keratinization phenomenon.And be not added with the control group of donkey-hide gelatin composition, then have no rabbit skin keratin
Change phenomenon to be significantly improved, water washing control group man rabbit skin to be distilled and after drying, rabbit skin keratinization layer shows again
Out.
The human skin keratinocyteization of embodiment 5 is tested
The people of skin of palm of hand keratinization patient 12 is randomly selected as experimenter, it is each random on experimenter's keratinized skin surface
Choose experimental point 2, each experimental point area 0.5cm*0.5cm, donkey-hide gelatin microcapsules dermalaxia film prepared by embodiment (1)
It is attached on the left ear experimental point of experimenter, then using 1.5w/cm2Infrared heating rifle enters to donkey-hide gelatin microcapsules dermalaxia film
Row heat-activated 2min.Experimenter's microcapsules dermalaxia film is removed after 4h, hot blast drying 10min after distilled water is cleaned, exposure
Go out keratinization cortex.Observation finds that cuticula keratinization phenomenon is obviously improved.After continuous medication one week, there are 8 patient's realities
The skin keratin phenomenon tested a little disappears, and skin recovers the normal other four experimenter's keratinization phenomenons of compared to non-medication
Region, is also obviously improved, and cuticula softening, keratinization scale skin is reduced, and skin color turns to ruddy, serious drying slight crack
Disappear.
The respective embodiments described above are to realize the specific embodiment of the present invention, it will be understood by those skilled in the art that
And in actual applications, can to it, various changes can be made in the form and details, without departing from the spirit and scope of the present invention.
Claims (9)
1. a kind of donkey-hide gelatin microcapsules dermalaxia film, it is characterised in that：Include the air-permeable layer of non-woven fabrics material, in the fibre of air-permeable layer
Adhere to donkey-hide gelatin microcapsule granule in dimension, the donkey-hide gelatin microcapsule granule includes donkey-hide gelatin, surfactant, anionic polymer emulsion
Stabilizer, glycerine and olive oil.
2. donkey-hide gelatin microcapsules dermalaxia film as claimed in claim 1, it is characterised in that：The donkey-hide gelatin, surfactant, the moon
Ion macromolecule emulsion stabilizer, glycerine and Quality of Olive Oil Produced ratio are:1：0.05~0.2：0.02~0.16：0.3~1.2：0.5
~1.8.
3. donkey-hide gelatin microcapsules dermalaxia film as claimed in claim 1, it is characterised in that：The anionic polymer emulsion is steady
Determine agent and be selected from sodium carboxymethylcellulose.
4. donkey-hide gelatin microcapsules dermalaxia film as claimed in claim 1, it is characterised in that：The air-permeable layer of the non-woven fabrics material
For polypropylene fiber nonwoven cloth, thickness is 2~5mm.
5. a kind of method for preparing donkey-hide gelatin microcapsules dermalaxia film described in Claims 1 to 4, it is characterised in that step includes：
(1) donkey-hide gelatin is cooled to -50~-60 DEG C using dry ice, by the donkey-hide gelatin after cooling with etc. after quality dry ice mixes, low speed powder
Particle 0.1~0.5mm sizes are crushed in broken machine；
(2) fast-crushing 1min after the low temperature donkey-hide gelatin powder after crushing is mixed with the dry ice of three times quality, obtains donkey-hide gelatin with doing
The mixed-powder of ice；
(3) surfactant, anionic polymer emulsion stabilizer and glycerine are dissolved in olive oil, are configured to lipid solution,
And be added in the mixed-powder of step (2), obtain core powder；
(4) the core powder of step (3) is added portionwise in degerming distilled water, control temperature stirs 3h between 20~35 DEG C,
Obtain emulsion；
(5) citric acid of 1wt% concentration is added into the emulsion of step (4), emulsion pH to 4.5 is adjusted, then 40~
8~10h is stirred at 60 DEG C, pH=7 is adjusted finally by the sodium bicarbonate solution of 1wt% concentration, obtains micro-capsule dispersion liquid；
(6) 2~5mm polypropylene non-woven fabric is soaked in micro-capsule dispersion liquid, donkey-hide gelatin microcapsules skin is obtained after taking-up soft
Change film.
6. the method as claimed in claim 5 for preparing donkey-hide gelatin microcapsules dermalaxia film, it is characterised in that：The lipid solution
Quality is 3wt%~20wt% of donkey-hide gelatin quality.
7. the method as claimed in claim 5 for preparing donkey-hide gelatin microcapsules dermalaxia film, it is characterised in that：The lipid solution
Middle surfactant, anionic polymer emulsion stabilizer, glycerine, Quality of Olive Oil Produced ratio are 1:0.25~0.35:4~5:6~
8。
8. the method as claimed in claim 5 for preparing donkey-hide gelatin microcapsules dermalaxia film, it is characterised in that：The step (4)
The mass ratio of middle core powder and distilled water is 1:8~12.
9. the method as claimed in claim 5 for preparing donkey-hide gelatin microcapsules dermalaxia film, it is characterised in that：The step (4)
The mass ratio of middle core powder and distilled water is 1:9~10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710262560.8A CN107050055A (en) | 2017-04-20 | 2017-04-20 | A kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710262560.8A CN107050055A (en) | 2017-04-20 | 2017-04-20 | A kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method |
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| CN107050055A true CN107050055A (en) | 2017-08-18 |
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ID=59599945
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| CN201710262560.8A Pending CN107050055A (en) | 2017-04-20 | 2017-04-20 | A kind of donkey-hide gelatin microcapsules dermalaxia film and preparation method |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102031691A (en) * | 2010-11-08 | 2011-04-27 | 东华大学 | Microcapsule finishing agent of multi-functional core material with high dispersivity and stability as well as preparation method and applications thereof |
| CN103393599A (en) * | 2013-08-05 | 2013-11-20 | 四川金岁方药业有限公司 | Preparation method of traditional Chinese medicine fine powder |
| CN103462871A (en) * | 2013-09-24 | 2013-12-25 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatin essence hydrating mask and preparation method thereof |
| CN105560156A (en) * | 2014-10-10 | 2016-05-11 | 九芝堂股份有限公司 | Mask and preparation method thereof |
-
2017
- 2017-04-20 CN CN201710262560.8A patent/CN107050055A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102031691A (en) * | 2010-11-08 | 2011-04-27 | 东华大学 | Microcapsule finishing agent of multi-functional core material with high dispersivity and stability as well as preparation method and applications thereof |
| CN103393599A (en) * | 2013-08-05 | 2013-11-20 | 四川金岁方药业有限公司 | Preparation method of traditional Chinese medicine fine powder |
| CN103462871A (en) * | 2013-09-24 | 2013-12-25 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatin essence hydrating mask and preparation method thereof |
| CN105560156A (en) * | 2014-10-10 | 2016-05-11 | 九芝堂股份有限公司 | Mask and preparation method thereof |
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