CN107049861B - 一种润肤美白的膏霜 - Google Patents
一种润肤美白的膏霜 Download PDFInfo
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- CN107049861B CN107049861B CN201710281622.XA CN201710281622A CN107049861B CN 107049861 B CN107049861 B CN 107049861B CN 201710281622 A CN201710281622 A CN 201710281622A CN 107049861 B CN107049861 B CN 107049861B
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- whitening agent
- lipid carrier
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Abstract
一种润肤美白的膏霜及其制备方法，润肤美白的膏霜包括：复合美白剂纳米结构脂质载体、沙棘油、玉米胚芽油、芝麻油、月见草油、甜扁桃油、角鲨烷、透明质酸、硬脂酸异辛酯、山梨醇、尼泊金乙酯、醋酸锌、丁二酸二异辛酯硫酸钠、对羟基苯甲酸甲酯、珍珠粉和去离子水；制备时，先将复合美白剂纳米结构脂质载体之外组分加热搅拌均匀后，乳化均质，消泡后降温后，再加入上述复合美白剂纳米结构脂质载体，搅拌均匀即可。
Description
技术领域
本发明涉及一种复合美白剂纳米结构脂质载体以及使用该复合美白剂纳米结构脂质载体的润肤美白的膏霜，以及它们的制备方法。
背景技术
黄芩为一种常用的中草药，其提取物含多种化学活性成分，如黄酮及其苷类、木脂素及其苷类、酚苷和醇苷，具有抗氧化、抗菌、抗炎、免疫调节以及镇热解痛等药理作用。
光果甘草为多年生草本植物，主要分布于新疆北部、青海、甘肃等省区，且具有抗寒、抗盐碱、耐热、耐旱等优良特性，其根提取物具有抗氧化、美白抗炎和防止黑色素生成的功能，广泛用于化妆品和医用护理品行业。
原花青素是自然界中广泛存在的聚多酚类混合物，该类化合物具有多种生物活性，以其高效、低毒、高生物利用度而著称。原花青素是目前国际上公认的清除人体内自由基的天然抗氧化剂，其抗氧化、清除自由基的能力是VE(生育酚，维生素E)的50倍、VC(抗坏血酸，维生素C)的20倍。将原花青素开发成功能性化妆品，用以美白、保湿、预防皮肤衰老已成为研究热点。原花青素具有优良的性质和功效，但其稳定性较差，易受外界条件影响，易氧化，对光热值敏感等。如何在有效保护原花青素的同时提高其稳定性，具有重要的现实意义。
纳米结构脂质载体NLC是将固体脂质和空间上不相容的液体脂质在一定温度下混合制备得到的纳米粒给药载体。NLC通过形成一些含纳米隔室的脂质骨架,增加了晶体的混乱程度，提高了药物载药量,避免储存过程中药物被排挤,与传统载体系统(如脂质体、微球等)相比其具有更高的载药能力及降低储藏过程包封药物泄漏的问题，而且NLC能改变药物释放曲线，因而是一种更为理想的载体，同时适用于化妆品和食品领域等。
市面上可供选择的美白霜的品种不计其数，以植物草本为特色的美白霜也很多，但其稳定性、美白效果等存在不足。
发明内容
本发明的目的在于，提供一种润肤美白的膏霜，克服了现有技术中美白霜中的抗氧化性能不足，美白成分不稳定、易分解，从而影响美白效果的缺陷，并且具有提高的抗氧化性能和美白等效果。
为了达到上述目的，本发明采用的技术方案是：
1.一种复合美白剂纳米结构脂质载体，其特征在于：纳米结构脂质载体内各成分的重量份为：
复合美白剂：7-20；NLC复合脂质材料：10-40份；乳化剂：10-25份以及适量的去离子水；
所述复合美白剂每100重量份中，包括以下重量份的三种活性成分：光果甘草根提取物10-30份、黄芩提取物20-50份、原花青素10-30份。
2.上述1所述的复合美白剂纳米结构脂质载体，其特征在于：纳米结构脂质载体内各成分的重量份为：复合美白剂：10-15；NLC复合脂质材料：15-30份；乳化剂：10-15份以及适量的去离子水。
3.一种润肤美白的膏霜，其特征在于：包括：上述1所述的复合美白剂纳米结构脂质载体、沙棘油、玉米胚芽油、芝麻油、月见草油、甜扁桃油、角鲨烷、透明质酸、硬脂酸异辛酯、山梨醇、尼泊金乙酯、醋酸锌、丁二酸二异辛酯硫酸钠、对羟基苯甲酸甲酯、珍珠粉和去离子水。
4.上述3所述的润肤美白的膏霜，其特征在于：包括如下重量份的各组分：上述1所述的复合美白剂纳米结构脂质载体5-20、沙棘油1-5、玉米胚芽油1-5、芝麻油1-5、月见草油1-5、甜扁桃油1-5、角鲨烷2-10、透明质酸4-10、硬脂酸异辛酯5-10、山梨醇3-8、尼泊金乙酯1-4、醋酸锌1-4、丁二酸二异辛酯硫酸钠1-5、对羟基苯甲酸甲酯0.1-1、珍珠粉4-10和去离子水40-80。
5.上述3-4所述的润肤美白的膏霜的制备方法，其特征在于：先将复合美白剂纳米结构脂质载体之外组分加热至70-90℃，搅拌均匀后，乳化均质5-20分钟，消泡后降温至30-60℃，再加入上述复合美白剂纳米结构脂质载体，搅拌均匀即可。
本发明采用的纳米结构脂质载体NLC复合脂质材料和乳化剂将复合美白剂制作为纳米结构脂质载体，提高了其水溶性和稳定性。本发明的复合脂质材料可以采用NLC的任意可用载体材料，优选为三种以上脂质材料的复合，所述脂质材料包括以下化合物：单硬脂酸甘油酯、维生素E醋酸酯、癸二酸二乙酯、芦巴胶油、辛癸酸三甘油酯、蓖麻油。乳化剂也可以采用NLC的任意可用材料，优选包括以下物质中的一种或几种：O-1000(鲸蜡硬脂基橄榄油酯/山梨醇橄榄油酯)、Tween20(聚氧乙烯山梨醇酐单月桂酸酯)、聚氧乙烯-700硬脂酸酯复合物、泊洛沙姆407、聚硬脂酸-40-烃氧酯、六聚甘油单硬脂酸酯、聚氧乙烯-21-硬脂酸酯。
本发明的复合美白剂纳米结构脂质载体，NLC复合脂质材料和乳化剂的用量可以根据其具体材料的性质来确定，当采用上述优选材料时，可使用的含量为：NLC复合脂质材料的含量为重量百分比的5-30％，乳化剂的含量为重量百分比的5-20％，其余为去离子水。
本发明所述的纳米结构脂质载体内各成分的重量份为：复合美白剂：7-20；NLC复合脂质材料：10-40份；乳化剂：10-25份以及适量的去离子水。
本发明所述的纳米结构脂质载体，粒径小于400nm，在皮肤上可以形成很好的闭合体系,可增强皮肤的水合作用，应用于护肤产品中可提高产品的保湿性能。
进一步的，本发明提供一种制备上述复合美白剂纳米结构脂质载体的方法，包括以下几个步骤：
(1)称取乳化剂和去离子水作为水相，称取复合脂质材料作为油相，水相和油相分别在同温水浴中搅拌融化；
(2)称取复合美白剂加入到融化的油相中，搅拌融化得到均一体系；
(3)在水浴条件下将融化的水相和油相混合后搅拌至完全乳化；
(4)将乳化后的样品进行高压均质，冷却后得到复合美白剂纳米结构脂质载体。
其中所述步骤(1)中所使用的水浴温度为50℃-80℃。
其中所述步骤(2)中使用的水浴温度为50℃-80℃。
其中所述步骤(3)中所述的油相和水相混合时采用的加入顺序是将水相加入到油相中，水浴温度是50℃-80℃。
其中所述步骤(3)中所述的高压均质工艺参数为：均质温度50℃-80℃，均质压力30MPa-120MPa，均质循环3-10次。
本发明的优点在于：
(1)提出了全新的复合美白剂的成分和组分关系，并结合NLC技术，提供一种能够提高美白剂稳定性、美白效果和抗氧化性能的方案，通过其成分之间的相互协同增效作用达到更好、光稳定性更强、水溶性更高的具有美白肌肤效果的产品。
(2)本发明中的NLC载体技术提高了活性物质光果甘草根提取物、黄芩提取物、原花青素的稳定性，促进活性物质对皮肤细胞酪氨酸酶活性的抑制作用，有利于充分发挥其美白功效性。本发明制备的复合美白剂-NLC稳定性好，具有良好的水溶解性。
(3)本发明制备的复合美白剂-NLC粒径小于400nm，在皮肤上可以形成很好的闭合体系,可增强皮肤的水合作用,应用于护肤产品中可提高了产品的保湿性能。
(4)本发明制备的复合美白剂-NLC与皮肤角质层有很好的亲和性,能有效地将活性组分输送并渗透进角质层,使得活性组分有效地作用于皮肤的深层细胞，使其有效地发挥美白功效性。
(5)本发明中的复合美白剂采用了光果甘草根提取物、黄芩提取物、原花青素的组合，三者之间形成了协调增强作为，有效提高了美白、去皱抗氧化效果。
具体实施方式
为进一步说明本发明，结合以下实施例具体说明：
这些实施例用于说明本发明而不限于本发明的范围。实施例中采用的实施条件可以根据具体厂家的条件做进一步调整，未注明的实施条件通常为常规试验中的条件。
实施例1：复合美白剂纳米结构脂质载体的制备
1、称取单硬脂酸甘油酯9g,维生素E醋酸酯5g，芦巴胶油4g，称好后放入150mL烧杯中，置于65℃水浴中400r/min搅拌至融化，作为油相；同时开启高压均质机并用65℃去离子水预热；
2、称取泊洛沙姆407 3g，六聚甘油单硬脂酸酯9g，去离子水60g，称好后放入100mL带塞锥形瓶中，置于70℃水浴中，作为水相；
3、称取10g复合美白剂加入到融化的油相中，400r/min搅拌至完全融化，其中光果甘草根提取物3g、黄芩提取物5g、原花青素2g；
4、将水相一次性倒入油相中，700r/min搅拌至完全乳化；
5、将乳化好的高温乳液体系注入高压均质机，调节均质压力为60MPa,在此压力下循环2次；
6、冷却至室温得复合美白剂纳米结构脂质载体，用去离子水1000倍稀释后得到水分散液，该分散液通过光子相关光谱(PCS)测得其粒径为210nm。
对比例1：复合美白剂纳米结构脂质载体的制备
1、称取单硬脂酸甘油酯9g,维生素E醋酸酯5g，芦巴胶油4g，称好后放入150mL烧杯中，置于65℃水浴中400r/min搅拌至融化，作为油相；同时开启高压均质机并用65℃去离子水预热；
2、称取泊洛沙姆407 3g，六聚甘油单硬脂酸酯9g，去离子水60g，称好后放入100mL带塞锥形瓶中，置于70℃水浴中，作为水相；
3、称取10g复合美白剂加入到融化的油相中，400r/min搅拌至完全融化，其中光果甘草根提取物6g、原花青素4g；
4、将水相一次性倒入油相中，700r/min搅拌至完全乳化；
5、将乳化好的高温乳液体系注入高压均质机，调节均质压力为60MPa,在此压力下循环2次；
6、冷却至室温得复合美白剂纳米结构脂质载体，用去离子水1000倍稀释后得到水分散液，该分散液通过光子相关光谱(PCS)测得其粒径为200nm。
对比例2：复合美白剂纳米结构脂质载体的制备
1、称取单硬脂酸甘油酯9g,维生素E醋酸酯5g，芦巴胶油4g，称好后放入150mL烧杯中，置于65℃水浴中400r/min搅拌至融化，作为油相；同时开启高压均质机并用65℃去离子水预热；
2、称取泊洛沙姆407 3g，六聚甘油单硬脂酸酯9g，去离子水60g，称好后放入100mL带塞锥形瓶中，置于70℃水浴中，作为水相；
3、称取10g复合美白剂加入到融化的油相中，400r/min搅拌至完全融化，其中黄芩提取物6g、原花青素4g；
4、将水相一次性倒入油相中，700r/min搅拌至完全乳化；
5、将乳化好的高温乳液体系注入高压均质机，调节均质压力为60MPa,在此压力下循环2次；
6、冷却至室温得复合美白剂纳米结构脂质载体，用去离子水1000倍稀释后得到水分散液，该分散液通过光子相关光谱(PCS)测得其粒径为195nm。
实施例2：润肤美白膏霜(各组分用量为重量份)
实施例1制得的复合美白剂纳米结构脂质载体10；
沙棘油2、玉米胚芽油2、芝麻油3、月见草油1、甜扁桃油2、角鲨烷4、透明质酸5、硬脂酸异辛酯5、山梨醇4、尼泊金乙酯2、醋酸锌2、丁二酸二异辛酯硫酸钠3、对羟基苯甲酸甲酯0.5、珍珠粉5和去离子水50。
制备时，先将除实施例1制得的复合美白剂纳米结构脂质载体之外组分加热至80℃，搅拌均匀后，乳化均质10分钟，消泡后降温至50℃，加入实施例1制得的复合美白剂纳米结构脂质载体，搅拌均匀即可。
实施例3：润肤美白膏霜(各组分用量为重量份)
实施例1制得的复合美白剂纳米结构脂质载体15；
沙棘油3、玉米胚芽油2、芝麻油3、月见草油2、甜扁桃油2、角鲨烷5、透明质酸5、硬脂酸异辛酯6、山梨醇3、尼泊金乙酯2、醋酸锌2、丁二酸二异辛酯硫酸钠2、对羟基苯甲酸甲酯0.6、珍珠粉5和去离子水60。
制备时，先将除实施例1制得的复合美白剂纳米结构脂质载体之外组分将热至85℃，搅拌均匀后，乳化均质10分钟，消泡后降温至50℃，加入实施例1制得的复合美白剂纳米结构脂质载体，搅拌均匀即可。
对比例3：润肤美白膏霜(各组分用量为重量份)
对比例1制得的复合美白剂纳米结构脂质载体10；
沙棘油2、玉米胚芽油2、芝麻油3、月见草油1、甜扁桃油2、角鲨烷4、透明质酸5、硬脂酸异辛酯5、山梨醇4、尼泊金乙酯2、醋酸锌2、丁二酸二异辛酯硫酸钠3、对羟基苯甲酸甲酯0.5、珍珠粉5和去离子水50。
制备时，先将除对比例1制得的复合美白剂纳米结构脂质载体之外组分加热至80℃，搅拌均匀后，乳化均质10分钟，消泡后降温至50℃，加入对比例1制得的复合美白剂纳米结构脂质载体，搅拌均匀即可。
对比例4：润肤美白膏霜(各组分用量为重量份)
对比例2制得的复合美白剂纳米结构脂质载体10；
沙棘油2、玉米胚芽油2、芝麻油3、月见草油1、甜扁桃油2、角鲨烷4、透明质酸5、硬脂酸异辛酯5、山梨醇4、尼泊金乙酯2、醋酸锌2、丁二酸二异辛酯硫酸钠3、对羟基苯甲酸甲酯0.5、珍珠粉5和去离子水50。
制备时，先将除对比例2制得的复合美白剂纳米结构脂质载体之外组分加热至80℃，搅拌均匀后，乳化均质10分钟，消泡后降温至50℃，加入对比例2制得的复合美白剂纳米结构脂质载体，搅拌均匀即可。
对比例5：润肤美白膏霜(各组分用量为重量份)
光果甘草根提取物3、黄芩提取物5、原花青素2；沙棘油2、玉米胚芽油2、芝麻油3、月见草油1、甜扁桃油2、角鲨烷4、透明质酸5、硬脂酸异辛酯5、山梨醇4、尼泊金乙酯2、醋酸锌2、丁二酸二异辛酯硫酸钠3、对羟基苯甲酸甲酯0.5、珍珠粉5和去离子水50。
制备时，先将除光果甘草根提取物、黄芩提取物、原花青素之外组分加热至80℃，搅拌均匀后，乳化均质10分钟，消泡后降温至50℃，加入光果甘草根提取物、黄芩提取物、原花青素，搅拌均匀即可。
表1：实施例2-3和对比例3-5产品的存储稳定性测试表
实施2-3和对比例3-4产品的美白和去皱纹抗氧化效果测试：
试用人员每天早晚净面后，面部涂抹并按摩10-15分钟上述产品，试用2周后，评估结果，
表2：实施2-3和对比例3-4产品的美白和去皱纹抗氧化效果测试结果
| 美白祛斑 | 去皱抗氧化 | |
| 实施例2 | 色斑明显减弱 | 脸部皱纹有明显消减 |
| 实施例3 | 色斑明显减弱 | 脸部皱纹有明显消减 |
| 对比例3 | 色斑变化不明显 | 脸部皱纹消减不明显 |
| 对比例4 | 色斑变化不明显 | 脸部皱纹消减不明显 |
通过以上试验数据可知，本发明的润肤美白膏霜具有保存稳定，美白和抗氧化效果明显，而非本发明范围内的产品，保存稳定性不佳，美白和和抗氧化效果不明显。
本发明的范围不受所述具体实施方案的限制，所述实施方案只作为阐明本发明各个方面的单个例子，本发明范围内还包括功能等同的方法和组分。实际上，除了本文所述的内容外，本领域技术人员参照上文的描述可以容易地掌握对本发明的多种改进。所述改进也落入所附权利要求书的范围之内。上文提及的每篇参考文献皆全文列入本文作为参考。
Claims (5)
1.一种复合美白剂纳米结构脂质载体，其特征在于：纳米结构脂质载体内各成分的重量份为：
复合美白剂：7-20份；纳米结构脂质载体NLC复合脂质材料：10-40份；乳化剂：10-25份以及适量的去离子水；
所述复合美白剂每100重量份中，包括以下重量份的三种活性成分：光果甘草根提取物10-30份、黄芩提取物20-50份、原花青素10-30份；
制备所述复合美白剂纳米结构脂质载体的方法，包括以下几个步骤：
(1)称取乳化剂和去离子水作为水相，称取复合脂质材料作为油相，水相和油相分别在同温水浴中搅拌融化；
(2)称取复合美白剂加入到融化的油相中，搅拌融化得到均一体系；
(3)在水浴条件下将融化的水相和油相混合后搅拌至完全乳化；
(4)将乳化后的样品进行高压均质，冷却后得到复合美白剂纳米结构脂质载体；
其中所述步骤(1)中所使用的水浴温度为50℃-80℃；
其中所述步骤(2)中使用的水浴温度为50℃-80℃；
其中所述步骤(3)中所述的油相和水相混合时采用的加入顺序是将水相加入到油相中，水浴温度是50℃-80℃；
其中所述步骤(4)中所述的高压均质工艺参数为：均质温度50℃-80℃，均质压力30MPa-120MPa，均质循环3-10次。
2.权利要求1所述的复合美白剂纳米结构脂质载体，其特征在于：纳米结构脂质载体内各成分的重量份为：复合美白剂：10-15份；纳米结构脂质载体NLC复合脂质材料：15-30份；乳化剂：10-15份以及适量的去离子水。
3.一种润肤美白的膏霜，其特征在于：包括：权利要求1所述的复合美白剂纳米结构脂质载体、沙棘油、玉米胚芽油、芝麻油、月见草油、甜扁桃油、角鲨烷、透明质酸、硬脂酸异辛酯、山梨醇、尼泊金乙酯、醋酸锌、丁二酸二异辛酯硫酸钠、对羟基苯甲酸甲酯、珍珠粉和去离子水。
4.权利要求3所述的润肤美白的膏霜，其特征在于：包括如下重量份的各组分：权利要求1所述的复合美白剂纳米结构脂质载体5-20、沙棘油1-5、玉米胚芽油1-5、芝麻油1-5、月见草油1-5、甜扁桃油1-5、角鲨烷2-10、透明质酸4-10、硬脂酸异辛酯5-10、山梨醇3-8、尼泊金乙酯1-4、醋酸锌1-4、丁二酸二异辛酯硫酸钠1-5、对羟基苯甲酸甲酯0.1-1、珍珠粉4-10和去离子水40-80。
5.权利要求3-4所述的润肤美白的膏霜的制备方法，其特征在于：先将复合美白剂纳米结构脂质载体之外组分加热至70-90℃，搅拌均匀后，乳化均质5-20分钟，消泡后降温至30-60℃，再加入上述复合美白剂纳米结构脂质载体，搅拌均匀即可。
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