CN107048381A - 一种改善睡眠的保健食品及其制备方法 - Google Patents
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Abstract
本发明公开了一种改善睡眠的保健食品及其制备方法,属于保健食品领域。所述改善睡眠的保健食品按质量份计,包括首乌藤40‑50份、百合35‑45份、茯苓25‑35份和人参 15‑20份。所述改善睡眠的保健食品的制备方法首先将各组分原料净制,然后对人参超微粉碎得人参超微粉,再对首乌藤、茯苓和百合加水煎煮、过滤,减压浓缩、减压干燥后粉碎、过筛、得干膏粉,最后将制备的人参超微粉和干膏粉混合均匀,用质量浓度为85%乙醇制软材,经制粒整粒、抛光、包装、检验即得。本发明所述一种改善睡眠的保健食品不仅改善睡眠的效果较为明显,而且药性缓和、不易产生耐药性、无毒副作用、适合长期服用。
Description
技术领域
本发明属于保健食品领域,具体涉及一种改善睡眠的保健食品及其制备方法。
背景技术
人的一生大约有1/3的时间是在睡眠中度过的。失眠是最常见的睡眠障碍,主要表现为入睡困难、早醒、精神疲劳、头晕眼花、记忆力不集中、工作效率下降等。目前在我国存在睡眠障碍的人数逐年增长,好睡眠俨然成为现代都市生活的“奢侈品”。随着生活节奏加快、工作压力增大,失眠严重的影响着人们的生活、工作与健康。
目前西医是治疗失眠的主要手段之一。市场上用于治疗失眠的药物主要有巴比妥类、褪黑素等。这类药品大多都能够缩短入睡时间,延长睡眠时间和提高睡眠质量,但用药后易产生清晨失眠、白天焦虑及机体对药物易上瘾和产生依赖等副作用,还会出现失眠反弹现象,且并不适用于所有年龄段的失眠人群。尤其褪黑素类产品最为常见,但此类产品仅适用于褪黑素分泌不足的人群服用。中医认为失眠与五脏失养、阴阳失调有关,通过宁心安神、滋阴健脾以调节机体阴阳之平衡才可改善睡眠,所以通过简单的补充褪黑素来改善睡眠并不是最佳方法。
近年来,中草药以其药性缓和、不易产生耐药性、适合长期服用等特点,越来越深受广大消费者的青睐。然而目前以纯中药提取膏粉作为内容物填充的胶囊,流动性较差,粘性高、吸湿性强,在生产过程中需要加入润滑剂或助流剂,如硬脂酸镁、二氧化硅等,或需要加入辅料:淀粉等,因为辅料的加入,要达到预期效果,服用量就会加大。而有些胶囊直接用中药材粉碎入囊,其吸收较差,服用量大,不方便。
发明内容
为了克服现有技术存在的问题,本发明提供了一种改善睡眠的保健食品,不仅改善睡眠效果好,而且药性缓和,无毒副作用、适合长期服用。
为了达到上述目的,本发明采取的技术手段如下:
一种改善睡眠的保健食品,按质量份计,包括首乌藤40-50份、百合35-45份、茯苓25-35份和人参15-20份。
进一步地,按质量份计,包括首乌藤45份、百合40份、茯苓30份和人参15份。
一种改善睡眠的保健食品的制备方法,所述制备方法包括以下步骤:
1)、将首乌藤、茯苓、百合和人参分别净制,备用,其中首乌藤、茯苓、百合和人参的质量按配方量称取;
2)、将步骤1)中的人参干燥后,经超微粉碎机粉碎,过筛,收取细粉,灭菌后备用,得人参超微粉;
3)、取步骤1)中的首乌藤、茯苓和百合加水煎煮2次,其中每次加12倍重量的水,每次1.5h,过滤,合并滤液,经减压浓缩至相对密度为1.30~1.35的清膏,再次减压干燥后粉碎,过筛,得干膏粉;
4)、将人参超微粉与干膏粉混合均匀,用体积分数为85%的乙醇制软材,16目筛制粒,55~60℃干燥,14目筛整粒,装入0号胶囊,抛光,包装,检验,即得成品,0.4g/粒。
进一步地,所述步骤2)中的干燥温度为60℃。
进一步地,所述步骤2)中过筛所用筛网为200目。
进一步地,所述步骤2)中灭菌采用5kGy剂量的60Co辐照灭菌。
进一步地,所述步骤3)中减压浓缩的压力为-0.065Mpa~-0.075Mpa,温度为75℃。
进一步地,所述步骤3)中清膏的相对密度在60℃下测定。
进一步地,所述步骤3)中再次减压干燥的压力为-0.085Mpa,温度为65℃;所述步骤3)中过筛所用筛网为80目。
有益效果:与现有技术相比,本发明提供的一种改善睡眠的保健食品的配方包括首乌藤40-50份、百合35-45份、茯苓25-35份和人参15-20份,各组分以中草药为原料,其药性缓和、不易产生耐药性、无毒副作用、适合长期服用,而且改善睡眠的效果较为明显。除此之外,本发明所述的一种改善睡眠的保健食品制备方法简单易行,而且在制备方法中将人参作为一种原料经超微粉碎后与干膏粉混合均匀,不仅可以改善纯中药提取膏粉作为内容物填充的胶囊,流动性较差,粘性高、吸湿性强的缺陷,而且具有一定的药效,使得本发明所述的一种改善睡眠的保健食品在加工时颗粒流动性强便于生产,成品纯度高,无辅料添加,吸收性好,效果好。
附图说明
图1为本发明所述的一种改善睡眠的保健食品的制备方法流程图。
具体实施方式
下面结合附图和实施例对本发明做进一步阐述。
实施例1
一种改善睡眠的保健食品,按质量份计,包括首乌藤45份、百合40份、茯苓30份和人参15份。
服用方法:每日两次,每次3粒,口服。
参考图1,一种改善睡眠的保健食品的制备方法,所述制备方法包括以下步骤:
1)、将首乌藤、茯苓、百合和人参分别净制,备用,其中首乌藤、茯苓、百合和人参的质量按实施例1中所述的配方量称取;
2)、将步骤1)中的人参在60℃下干燥后,经超微粉碎机粉碎,过200目筛,收取细粉,用5kGy剂量的60Co辐照灭菌后,备用,得人参超微粉;
3)、取步骤1)中的首乌藤、茯苓和百合加水煎煮2次,其中每次加12倍重量的水,每次1.5h,过滤,合并滤液,经减压浓缩至相对密度为1.30~1.35的清膏,其中减压浓缩的压力为-0.065Mpa~-0.075Mpa,温度为75℃,清膏的相对密度在60℃下测定;在-0.085Mpa,65℃下经再次减压干燥后碎,过80目筛,得干膏粉;
4)、将人参超微粉与干膏粉混合均匀,用体积分数为85%乙醇制软材,16目筛制粒,55~60℃干燥,14目筛整粒,装入0号胶囊,抛光,包装,检验,即得成品,0.4g/粒。
实施例2
一种改善睡眠的保健食品,按质量份计,包括首乌藤50份、百合35份、茯苓25份和人参18份。
服用方法:每日两次,每次3粒,口服。
本实施例中一种改善睡眠的保健食品的制备方法与实施例1所述的制备方法相同,除保健食品各组分的质量配比外。
实施例3
一种改善睡眠的保健食品,按质量份计,包括首乌藤40份、百合38份、茯苓32份和人参20份。
服用方法:每日两次,每次3粒,口服。
本实施例中一种改善睡眠的保健食品的制备方法与实施例1所述的制备方法相同,除保健食品各组分的质量配比外。
实施例4
一种改善睡眠的保健食品,按质量份计,包括首乌藤50份、百合45份、茯苓35份和人参18份。
服用方法:每日两次,每次3粒,口服。
本实施例中一种改善睡眠的保健食品的制备方法与实施例1所述的制备方法相同,除保健食品各组分的质量配比外。
本发明提供的一种改善睡眠的保健食品的科学依据如下:
1、首乌藤:味甘,性平,归心、肝经。具有养血安神,祛风通络之效。首乌藤主要含有蒽醌类、黄酮类等成分。药理研究表明,首乌藤具有明显的镇静催眠作用,连续服用催眠作用增,水煎液能延长自由活动大鼠总的睡眠时间。研究发现首乌藤与其它安神类药材配伍能够宁心定志,长期服用能使人睡眠安好,治疗失眠具有良好的效果。
2、百合:味甘、性微寒,归肺、心经,具有养阴清肺、清心安神之效。主要用于治疗肺热咳嗽、劳嗽咯血、虚烦惊悸、失眠多梦等症。百合的主要化学成分为百合多糖类、百合皂苷类、秋水仙碱等多种生物碱、磷脂类、微量元素、氨基酸和淀粉、蛋白质、脂肪等其它物质。研究表明,百合能够很好地缩短小鼠的入睡时间,减少其自发活动,具有很好的镇静催眠作用。
3、茯苓:味甘、淡,性平,归心、肺、脾肾经,具有健脾宁心,利水渗湿之效。茯苓主要含有茯苓聚糖、茯苓多糖、茯苓酸等成分。临床研究表明,茯苓水煎液具有较好的镇静催眠、改善睡眠的作用,临床上用于治疗心神不宁、惊悸失眠等症,且无明显的不良反应。
4、人参:、味甘、微苦,性温、平,入脾、心、肺经,具有大补元气、固脱生津、安神之效,主要用于治疗劳伤虚损、惊悸、健忘、眩晕头痛、失眠等症。人参的主要化学成分是人参皂苷、糖类、氨基酸、脂溶性成分、酯类、肽类及维生素类等。现代药理研究表明:人参皂苷Rb类有中枢镇静作用,Rb1、Rb2、Rc的混合物有安定作用。研究发现,人参皂苷能够显著增加快动眼睡眠时间和总睡眠时间,降低觉醒和睡眠/觉醒周期。
效果试验例:
采用实施例1中所述的一种改善睡眠的保健食品以SPF级雄性小鼠为试验对象来证明本发明所述保健食品具有改善睡眠的功效,并设置对照组。
1、试验动物选择
SPF级雄性小鼠144只,体重18g-22g,该试验小鼠由湖北省实验动物研究中心提供,实验动物生产许可证号:SCXK(鄂)2008—0005号。动物饲养室温度20~25℃,湿度为40~70%。
2、剂量选择与试验方法
按人群推荐日摄入量2.4g/60kgBW扩大10、20、30倍分别设置低、中、高三个剂量组,即0.4、0.8、1.2g/kg BW,共分三个实验组,每实验组包括阴性对照组(给予蒸馏水)、低、中、高剂量组,各剂量组实验动物数均为12只。实验一组进行延长戊巴比妥钠睡眠时间实验,实验二组进行戊巴比妥钠阈下剂量催眠实验,实验三组进行巴比妥钠睡眠潜伏期实验。小鼠连续灌胃30天后开始实验。
3、试验结果
3.1 延长戊巴比妥钠诱导的小鼠睡眠时间试验结果
表1 对延长戊巴比妥钠诱导小鼠睡眠时间的影响
由表1可以看出高剂量组有明显延长戊巴比妥钠诱导小鼠睡眠时间的作用,与阴性对照组相比,差异具有显著性,说明本发明能够延长睡眠时间。
3.2 戊巴比妥钠阈下剂量催眠实验结果
表2 戊巴比妥钠阈下剂量诱导小鼠睡眠发生率影响
由表2看出,高剂量组能显著提高阈下剂量戊巴比妥钠诱导的小鼠睡眠发生率,与阴性对照组相比,差异性显著,说明本发明具有催眠作用。
3.3 巴比妥钠睡眠潜伏期实验结果
表3 巴比妥钠诱导小鼠睡眠潜伏期的影响
由表3看出,高剂量组能明显减少巴比妥钠睡眠潜伏期时间,与阴性对照组比较有显著性差异,说明本发明产品能够减少睡眠潜伏期。综上所述,根据《保健食品检验与评价技术规范》对改善睡眠保健食品的判定标准可知,本发明提供的一种改善睡眠的保健食品不仅改善睡眠的效果较为明显,而且各组分以中草药为原料,其药性缓和、不易产生耐药性、无毒副作用、适合长期服用。
Claims (9)
1.一种改善睡眠的保健食品,其特征在于:按质量份计,包括首乌藤40-50份、百合35-45份、茯苓25-35份和人参 15-20份。
2.根据权利要求1所述的一种改善睡眠的保健食品,其特征在于:按质量份计,包括首乌藤45份、百合40份、茯苓30份和人参15份。
3.一种如权利要求1所述的改善睡眠的保健食品的制备方法,其特征在于:所述制备方法包括以下步骤:
1)、将首乌藤、茯苓、百合和人参分别净制,备用,其中首乌藤、茯苓、百合和人参的质量按配方量称取;
2)、将步骤1)中的人参干燥后,经超微粉碎机粉碎,过筛,收取细粉,灭菌后备用,得人参超微粉;
3)、取步骤1)中的首乌藤、茯苓和百合加水煎煮2次,其中每次加12倍重量的水,每次1.5h,过滤,合并滤液,经减压浓缩至相对密度为1.30~1.35的清膏,再次减压干燥后碎,过筛,得干膏粉;
4)、将人参超微粉与干膏粉混合均匀,用体积分数为85%的乙醇制软材,16目筛制粒,55~60℃干燥,14目筛整粒,装入0号胶囊,抛光,包装,检验,即得成品,0.4g/粒。
4.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤2)中的干燥温度为60℃。
5.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤2)中过筛所用筛网为200目。
6.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤2)中灭菌采用5kGy剂量的60Co辐照灭菌。
7.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤3)中减压浓缩的压力为-0.065Mpa~-0.075Mpa,温度为75℃。
8.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤3)中清膏的相对密度在60℃下测定。
9.根据权利要求3所述的改善睡眠的保健食品的制备方法,其特征在于:所述步骤3)中再次减压干燥的压力为-0.085 Mpa,温度为65℃;所述步骤3)中过筛所用筛网为80目。
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