CN107019789A - Hair-loss preventing and hair-restoring Chinese medicine composition, its preparation method and application - Google Patents
Hair-loss preventing and hair-restoring Chinese medicine composition, its preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention provides a kind of hair-loss preventing and hair-restoring Chinese medicine composition, its preparation method and its application, its active component is made up of following bulk drug：Cacumen biotae, Eclipta prostrata, radix sophorae, Ligusticum wallichii root, cnidium monnieri fruit, Roots of Panax Notoginseng.The hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided has effects that to promote subcutaneous blood circulation, can rapidly permeate, promote scalp blood circulation, promote scalp nutrition supply, activate hair follicle, promotes hair health growth, and firm root of hair prevents trichomadesis.
Description
Technical field
The invention belongs to Chinese medicine and household chemicals technical field, and in particular to a kind of hair-loss preventing and hair-restoring Chinese medicine composition, its
Preparation method and application.
Background technology
The growth cycle of hair is divided into growth period, catagen and stand-down.The hair normally come off be into catagen and
The hair of stand-down, due to entering catagen with the hair into growth period constantly in dynamic equilibrium, therefore can maintain normal number
The hair of amount.Hair is abnormal or excessive coming off belongs to pathologic alopecia, is the common disease and frequently-occurring disease of dept. of dermatology.Cause pathology
Property alopecia the reason for it is a lot, have hereditary alopecia, nervous baldness, trophism alopecia, alopecia of chemical origin, physical alopecia etc..
The incidence of alopecia in recent years has the trend of rising, and social interaction and mental health of the alopecia to patient bring tremendous influence.
Hormone control or Metabolism regulation medicine are used modern alopeciaing therapeutic more：Male hormone metabolism medicine is adjusted, that such as non-hero
Amine；Antiandrogen medicine, such as estradione；Androgen receptor competitive inhibitor, such as Cimetidine；Biologically conditioning agent, such as
Minoxidil.The reason for alopecia occurs is complicated, and these medicines carry out alopeciaing therapeutic, there is no the treatment method of special efficacy, and easily cause
More adverse drug reaction, user's compliance is poor.
China's Traditional Chinese Medicine has some original understanding and method to the etiology and pathogenesis of alopecia and treatment, and Chinese medicine takes off
Hair with Mutiple Targets, take into account the advantage for the treatment of comprehensively, but there is also in-convenience in use, the problem of use feeling is poor.Existing anticreep
Send out Chinese prescription a lot, but prescription is complicated mostly, and medicinal material species is various, limits prescription answering in daily hair care product
With.
The content of the invention
Therefore, it is an object of the invention to overcome defect of the prior art to prevent there is provided a kind of external application, easy to use
It is de- to educate hair Chinese medicine composition, and said composition preparation method and application.
Before technical scheme is illustrated, term used herein is defined as follows：
" PCR refers to term：PCR.
To achieve the above object, the first aspect of the present invention provides a kind of hair-loss preventing and hair-restoring Chinese medicine composition, and its feature exists
In the Chinese medicine composition is made up of following bulk drug：Cacumen biotae, Eclipta prostrata, radix sophorae, cnidium monnieri fruit, Ligusticum wallichii root, pseudo-ginseng
Root.
Preferably, the Chinese medicine composition includes following raw materials in part by weight the effective elements of the medicine：
1~20 part of cacumen biotae, 1~20 part of Eclipta prostrata, 1~20 part of radix sophorae, cnidium monnieri fruit 1~15 part, 5~10 parts of Ligusticum wallichii root,
1~15 part of Roots of Panax Notoginseng.
It is highly preferred that 10~20 parts of cacumen biotae, 5~10 parts of sweet wine intestines, 5~10 parts of radix sophorae, cnidium monnieri fruit 5~10 parts, Ligusticum wallichii
5~10 parts of root, 0~5 part of Roots of Panax Notoginseng.
It is further preferred that 10~15 parts of cacumen biotae, 5~8 parts of sweet wine intestines, 5~8 parts of radix sophorae, cnidium monnieri fruit 5~8 parts, Ligusticum wallichii
5~8 parts of root, 0~3 part of Roots of Panax Notoginseng.
Preferably, further included in the bulk drug of the Chinese medicine composition：Kidney tea, coffee and ginger；Preferably, its is heavy
Amount number, which is matched, is：
Kidney tea, 1~20 part；
Coffee, 1~20 part；
Ginger, 1~20 part.
Second aspect of the present invention provides the preparation method of Chinese medicine composition described in first aspect, and the preparation method can be wrapped
Include following steps：
(1) each bulk drug is weighed standby；
(2) medicinal material is placed in extractor, is added ethanol, is heated to reflux, and is filtered；
(3) add ethanol again in filter residue, be heated to reflux, filter；With
(4) merging filtrate, is concentrated under reduced pressure into no alcohol taste.
Preferably, temperature is heated to reflux described in step (2) for 70~80 DEG C, the time is heated to reflux for 1~5 hour, plus
Enter amount of alcohol for 5~10 times of medicinal material amount, concentration of alcohol is 50~80%；Most preferably, the temperature that is heated to reflux is 80 DEG C, plus
Hot return time is 2 hours, and it is 5 times of medicinal material amount to add amount of alcohol, and concentration of alcohol is 75%；And/or
Temperature is heated to reflux described in step (3) for 70~80 DEG C, the time is heated to reflux for 1~5 hour, adds amount of alcohol
For 1~10 times of medicinal material amount, concentration of alcohol is 50~80%；Most preferably, the temperature that is heated to reflux is 80 DEG C, when being heated to reflux
Between be 1 hour, it is 4 times of medicinal material amount to add amount of alcohol, and concentration of alcohol is 75%.
Preferably, the control condition that is concentrated under reduced pressure described in step (4) is 0.05~0.07Mpa of vacuum, and thickening temperature is
60~65 DEG C；Preferably, the control condition that is concentrated under reduced pressure is vacuum 0.065Mpa, and thickening temperature is 65 DEG C.
The Chinese medicine composition that third aspect present invention provides first aspect present invention offer is preparing hair-loss preventing and hair-restoring product
In application.
Fourth aspect present invention provides a kind of hair-loss preventing and hair-restoring personal-care supplies or cosmetics, and the product includes this hair
The Chinese medicine composition that bright first aspect is provided；Preferably, the daily chemical products are selected from：Shampoo, hair conditioner, hair film and scalp are adjusted
Manage liquid.
Fifth aspect present invention provides a kind of hair-loss preventing and hair-restoring hair washing product, and the hair washing product is included：
Traditional Chinese medicine composition extract liquid, 0.1~5 part of thickener, 0.1~5 described in 1~60 part of claim any one of 1-3
Part conditioner, 5~40 parts of surfactants, 0.1~5 portion of preservative and 5~80 parts of solvents；
Wherein it is preferred to：
The thickener is selected from one or more of：Sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, I
Primary glue, sodium alginate,
The surfactant is selected from one or more of：Bay alcohol sulfuric ester ammonium, laureth sodium sulfovinate, coconut palm
Oleamide CAB,
The conditioner is selected from one or more of：Guar gum, polyquaternium, dimethyl silicone polymer,
The preservative is selected from one or more of：Hydroxybenzoate, methylisothiazolinone, imidazolidinyl urea,
Phenoxyethanol, sodium benzoate, and/or
The solvent is selected from one or more of：Ethanol, glycerine, propane diols, water.
Present invention also offers a kind of hair-loss preventing and hair-restoring hair products, the hair products are included：
Traditional Chinese medicine composition extract liquid, 5~80 parts of solvents, 1~10 part of breast described in 1~60 part of claim any one of 1-3
Agent, 0.1~20 portion of conditioner, 0.1~5 portion of preservative and 1~10 part of NMF；Wherein it is preferred to：
The solvent is selected from one or more of：Ethanol, glycerine, propane diols, water,
The emulsifying agent is selected from one or more of：PPG-11 tristearin alcohol ether, the different tristearin of PEG-20 anhydrosorbitols
Acid esters, stearine, alkyl trimethyl ammonium chloride, stearamidopropyl dimethylamine,
The conditioner is selected from one or more of：Cation guar gum, polyquaternium, dimethyl silicone polymer,
The preservative is selected from one or more of：Hydroxybenzoate, methylisothiazolinone, imidazolidinyl urea,
Phenoxyethanol, sodium benzoate, and/or
The NMF is selected from one or more of：Cetanol, hyaluronic acid, stearyl alcohol.
The hair-loss preventing and hair-restoring Chinese medicine composition of the present invention can have but be not limited to following beneficial effect：
1st, Chinese medicine composition of the present invention is prepared from using pure Chinese medicine.The suitable raw material of collocation, can easily be prepared into day
The scalp and hair-care care product such as shampoo, hair conditioner, conditioning liquid for often using.
2nd, it can rapidly permeate, promote scalp blood circulation, promote scalp nutrition supply, activate hair follicle, promote hair health
Growth, firm root of hair prevents trichomadesis.
3rd, have no side effect, no dependence is safe from harm to health.
4th, solve Chinese prescription in-convenience in use, the problem of use feeling is poor, application beneficial to hair-loss preventing and hair-restoring product and
Marketing.
Brief description of the drawings
Hereinafter, embodiment of the present invention is described in detail with reference to accompanying drawing, wherein：
Fig. 1 shows Chinese medicine composition alcohol extracting sample Mice Auricle microcirculation test result of the present invention.
Fig. 2 shows mRNA expression influence result of the test of the Chinese medicine composition alcohol extracting sample of the present invention on Wnt10b.
Embodiment
The present invention is further illustrated below by specific embodiment, it should be understood, however, that, these embodiments are only
It is used for specifically describing in more detail, and is not to be construed as limiting the present invention in any form.
This part carries out general description to the material and test method that are arrived used in present invention experiment.Although being
It is it is known in the art that still the present invention still uses up herein to realize many materials used in the object of the invention and operating method
It may be described in detail.It will be apparent to those skilled in the art that within a context, if not specified, material therefor of the present invention and behaviour
It is well known in the art as method.
The medicinal material and instrument used in following examples is as follows：
Medicinal material：
Cacumen biotae, Eclipta prostrata, radix sophorae, Ligusticum wallichii root, cnidium monnieri fruit, Roots of Panax Notoginseng, kidney tea, coffee, ginger is purchased from：Yunnan is to brightness
Pharmaceutcal corporation, Ltd；
Epidermal keratinocytes HEK (Human Epidermal Keratinocytes, fetal), is purchased from：Japan is spun；
Dimethyl sulfoxide (DMSO) DMSO, ethanol is purchased from：Xilong Chemical Co., Ltd；
Carbomer, laureth sodium sulfovinate, dimethyl silicone polymer, sodium benzoate, glycerine, stearamide propyl two
Methylamine, cetanol, hydroxybenzoate, chloraldurate, minoxidil is purchased from：Chemical Reagent Co., Ltd., Sinopharm Group；
RNeasy Mini kit, are purchased from：Dojindo Lab；
One Step SYBR PrimeScript RT-PCR Kit II, are purchased from：Qiagen；
Instrument：
Multi-function extractor, is purchased from：Close engineering equipment Co., Ltd in Ningbo Xiangshan three；Model：DTQ 0.2T；
Outer circulation haplo-effect concentrator, purchased from Ningbo Hua Zi pharmaceutical equipments Manufacturing Co., Ltd；Model：150-0574；
Multilocation microcirculation microscope, is purchased from：Xuzhou Xin Guang optical instruments Co., Ltd；Model：WX-6；
Real-time PCR, are purchased from：American AB I companies；Model：ABI PRISM 7900HT；
Embodiment 1
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided.
(1) each raw material is weighed by following portions by weight：14 parts of cacumen biotae, 8 parts of Eclipta prostrata, 6 parts of radix sophorae, 6 parts of Ligusticum wallichii root, snake
Bed fruit 6 parts, 2 parts of Roots of Panax Notoginseng.
(2) medicinal material is placed in extractor, adds 5 times of 75% ethanol of amount, is heated to 80 DEG C of backflow 2h, filtering；
(3) 4 times of 75% ethanol of amount are added in filter residue, 80 DEG C of backflow 1h, filtering are heated to；
(4) merging filtrate, 0.06Mpa, is concentrated under reduced pressure into no alcohol taste at 65 DEG C.
Embodiment 2
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided.
(1) each raw material is weighed by following portions by weight：10 parts of cacumen biotae, 5 parts of Eclipta prostrata, 8 parts of radix sophorae, 8 parts of Ligusticum wallichii root, snake
Bed fruit 8 parts, 1 part of Roots of Panax Notoginseng.
(2) medicinal material is placed in extractor, adds 1 times of 75% ethanol of amount, is heated to 80 DEG C of backflow 2h, filtering；
(3) 4 times of 75% ethanol of amount are added in filter residue, 80 DEG C of backflow 2h, filtering are heated to；
(4) merging filtrate, 0.06Mpa, is concentrated under reduced pressure into no alcohol taste at 60 DEG C.
Embodiment 3
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided.
(1) each raw material is weighed by following portions by weight：15 parts of cacumen biotae, 10 parts of Eclipta prostrata, 20 parts of radix sophorae, Ligusticum wallichii root 10
Part, 8 parts of cnidium monnieri fruit, 15 parts of Roots of Panax Notoginseng, 1 part of kidney tea, 1 part of coffee, 1 part of ginger.
(2) medicinal material is placed in extractor, adds 7 times of 75% ethanol of amount, is heated to 80 DEG C of backflow 2h, filtering；
(3) 2 times of 80% ethanol of amount are added in filter residue, 70 DEG C of backflow 5h, filtering are heated to；
(4) merging filtrate, 0.065Mpa, 65 DEG C be concentrated under reduced pressure into no alcohol taste.
Embodiment 4
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided.
(1) each raw material is weighed by following portions by weight：20 parts of cacumen biotae, 20 parts of Eclipta prostrata, 20 parts of radix sophorae, Ligusticum wallichii root 10
Part, 15 parts of cnidium monnieri fruit, 15 parts of Roots of Panax Notoginseng, 20 parts of kidney tea, 20 parts of coffee, 20 parts of ginger.
(2) medicinal material is placed in extractor, adds 10 times of 75% ethanol of amount, is heated to 75 DEG C of backflow 5h, filtering；
(3) 10 times of 50% ethanol of amount are added in filter residue, 80 DEG C of backflow 4h, filtering are heated to；
(4) merging filtrate, 0.06Mpa, 65 DEG C be concentrated under reduced pressure into no alcohol taste.
Embodiment 5
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring hair washing product that the present invention is provided.
Each raw material is weighed by following portions by weight：10 parts of traditional Chinese medicine composition extract liquids by the preparation of the method for embodiment 1；0.5
The carbomer of part；20 parts of laureth sodium sulfovinates；5 parts of dimethyl silicone polymers；0.3 part of sodium benzoate.
The preparation method of the present embodiment：0.5 part of carbomer is dissolved in 64.2 parts of water, adds 20 parts of laureth sulfuric acid
Ester sodium, is heated to 70~80 DEG C, stirring and dissolving is cooled to less than 45 DEG C, adds 10 parts of Chinese medicine groups prepared by the method for embodiment 1
Compound extract solution, 5 parts of dimethyl silicone polymers, 0.3 part of sodium benzoate, stir.
Embodiment 6
The present embodiment is used for the preparation method for illustrating the hair-loss preventing and hair-restoring hair products that the present invention is provided.
Each raw material is weighed by following portions by weight：10 parts of traditional Chinese medicine composition extract liquids by the preparation of the method for embodiment 1；5 parts
Glycerine；4 parts of stearamidopropyl dimethylamines；5 parts of cetanols；5 parts of dimethyl silicone polymers；0.2 part of hydroxybenzoate.
The preparation method of the present embodiment：4 parts of stearamidopropyl dimethylamines add 5 parts of glycerine, heating in 70.8 parts of water
To 70~80 DEG C, stirring and dissolving adds 5 parts of cetanols, stirred, and is cooled to less than 45 DEG C, adds 10 parts and presses the side of embodiment 1
The traditional Chinese medicine composition extract liquid of method preparation, 5 parts of dimethyl silicone polymers, 0.2 part of hydroxybenzoate, stir.
Test example 1
This test example is used to illustrate that the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided has promotion subcutaneous blood circulation
Effect.It is as follows using Mice Auricle microcirculation test：
(1) dosage and packet：KM kind mouse are taken, 18-22g, male and female half and half are divided into 3 groups, i.e., 1 group：Vehicle controls (75%
Ethanol solution) group (50 μ L/ ears)；2 groups：Minoxidil group (positive control) (50 μ L/ ears)；3 groups：The embodiment of the present invention 1 is made
Standby hair-loss preventing and hair-restoring Chinese medicine composition alcohol extract group (50 μ L/ ears).Every group 16.
KM kinds mouse is originated：Guangdong Medical Lab Animal Center's production licence number：SCXK (Guangdong) 2013-0002, hair
Demonstrate,prove unit：Science and Technology Department of Guangdong Province.C57BL/6 mouse are originated：The long-living bio tech ltd in Liaoning；Production licence number：
SCXK (the Liao Dynasty) 2015-0001, issuing unit：Science and Technology Department of Liaoning Province.Experimental animal uses credit number：SYXK (Yunnan) 2012-
0001, issuing unit：Kunming Technology Bureau.
(2) animal is handled：Fiber crops are injected intraperitoneally by 0.1mL/10g.bw dosage with 3.5% chloraldurate in mouse before experiment
Liquor-saturated, fixed mouse right ear auricle is placed under micro-circle microscope, is amplified 50 times of observations, is selected boundary clear, feature is significantly quiet
Arteries and veins is the object of observation, the image before collection administration, and after IMAQ, 50 μ L corresponding sample is smeared in each group mouse right ear auricle
Product.
(3) observation index：Mouse is observed respectively at 5min, 10min, 15min, 20min, 25min, 30min after administration
Auris dextra auricle (same position) venule, and gather image.Different time points same position after by measuring before administration and being administered
Venule blood vessel pipe diameter size, calculate the caliber difference before and after administration, and carry out statistical analysis.Venule before and after administration
Venule blood vessels caliber before venule blood vessels caliber-administration after blood vessels caliber difference DELTA Φ=administration.
As a result as shown in Figure 1：Prove that Chinese traditional medicine composition composition alcohol extracting thing has effects that to promote subcutaneous blood circulation.
Test example 2
This test example is used to illustrate that the hair-loss preventing and hair-restoring Chinese medicine composition that the present invention is provided has promotion subcutaneous blood circulation
Effect.
Wnt molecules are very clear and definite to the extremely important this point of hair tonic, and known Wnt is existing 19 kinds up to now.Its
A kind of middle Wnt10b of Wnt are the very important intercellular signal proteins matter during the generation of hair follicle.In mouse mouthful moustache hair follicle
Organ culture in, Wnt10b promotes hair shaft growth, it was demonstrated that Wnt10b is the cell propagation for playing the role of to promote hair follicle.
Experiment studies each sample to the Wnt10b tables in hair association factor using culture human epidermal keratinocyte below
The effect reached.
(1) modulation of sample：Alcohol extract sample and minoxidil are dissolved with dimethyl sulfoxide (DMSO) DMSO, the present invention implements 1 and made
Standby hair-loss preventing and hair-restoring Chinese medicine composition alcohol extract sample concentration is 0.05mg/mL, and minoxidil concentration is 0.02mg/mL, DMSO
It is used as blank control.
(2) to the influence of the hair tonic related gene expression of human epidermal cell：Broadcast in 35mm Dish (Tissue Culture Dish)
(300,000cells/dish) human epidermal keratinocyte is planted, is cultivated in 1ml human epidermal keratinocyte proliferation culture medium
1 day.5 μ l dimethyl sulfoxide (DMSO) DMSO, alcohol extract sample or minoxidil solution is added, is cultivated.After culture 3 days, use
RNA extracts Kit (RNeasy Mini kit) and extracts RNA.Use One Step SYBR PrimeScript RT-PCR Kit
II, expressed with real-time PCR (the ABI PRISM 7900HT) mRNA for determining Wnt10b.The Primer used be from
Qiagen purchases.
Wherein human epidermal keratinocyte comes from epidermal keratinocytes HEK (the Human Epidermal of culture
Keratinocytes,fetal；Japan is spun)
Chinese medicine composition alcohol extracting sample (0.05mg/L) of the present invention, minoxidil (0.2mg/mL) make Wnt10b's respectively
MRNA expression becomes 2 times, 1.5 times.N=3, average value ± standard deviation：Alcohol extracting sample P<0.05, minoxidil P<0.1.
Although present invention has been a certain degree of description, it will be apparent that, do not departing from the spirit and scope of the present invention
Under the conditions of, the appropriate change of each condition can be carried out.It is appreciated that the invention is not restricted to the embodiment, and it is attributed to right
It is required that scope, it includes the equivalent substitution of each factor.
Claims (10)
1. a kind of Chinese medicine composition for hair-loss preventing and hair-restoring, it is characterised in that the active component of the Chinese medicine composition is by wrapping
What the bulk drug containing following component was made：Cacumen biotae, Eclipta prostrata, radix sophorae, cnidium monnieri fruit, Ligusticum wallichii root, Roots of Panax Notoginseng.
2. Chinese medicine composition according to claim 1, it is characterised in that each bulk drug composition in the Chinese medicine composition
Parts by weight are matched：
1~20 part of cacumen biotae, 1~20 part of Eclipta prostrata, 1~20 part of radix sophorae, 1~15 part of cnidium monnieri fruit, 5~10 parts of Ligusticum wallichii root, pseudo-ginseng
1~15 part of root；
Preferably, 10~20 parts of cacumen biotae, 5~10 parts of sweet wine intestines, 5~10 parts of radix sophorae, cnidium monnieri fruit 5~10 parts, Ligusticum wallichii root 5~10
Part, 0~5 part of Roots of Panax Notoginseng；
It is highly preferred that 10~15 parts of cacumen biotae, 5~8 parts of sweet wine intestines, 5~8 parts of radix sophorae, cnidium monnieri fruit 5~8 parts, Ligusticum wallichii root 5~8
Part, 0~3 part of Roots of Panax Notoginseng.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that enter in the bulk drug of the Chinese medicine composition
One step is included：Kidney tea, coffee and ginger；Preferably, its parts by weight proportioning is：
Kidney tea, 1~20 part；
Coffee, 1~20 part；
Ginger, 1~20 part.
4. a kind of method for preparing any one of the claim 1-3 Chinese medicine compositions, it is characterised in that methods described bag
Include following steps：
(1) each bulk drug is weighed standby；
(2) medicinal material is placed in extractor, adds ethanol, be heated to reflux, filtered；
(3) ethanol is added in filter residue, is heated to reflux, is filtered；With
(4) merging filtrate, is concentrated under reduced pressure into no alcohol taste.
5. method according to claim 4, it is characterised in that：
Temperature is heated to reflux described in step (2) for 70~80 DEG C, the time that is heated to reflux is 1~5 hour, addition amount of alcohol is medicine
5~10 times of material amount, concentration of alcohol is 50~80%, it is preferable that the temperature that is heated to reflux is 80 DEG C, and the time that is heated to reflux is 2
Hour, it is 5 times of medicinal material amount to add amount of alcohol, and concentration of alcohol is 75%；And/or
It is 70~80 DEG C that temperature is heated to reflux described in step (3), and addition amount of alcohol is 1~10 times of medicinal material amount, when being heated to reflux
Between be 1~5 hour, concentration of alcohol is 50~80%, it is preferable that the temperature that is heated to reflux is 80 DEG C, and the time that is heated to reflux is 1
Hour, it is 4 times of medicinal material amount to add amount of alcohol, and concentration of alcohol is 75%.
6. method according to claim 4, it is characterised in that the control condition that is concentrated under reduced pressure described in step (4) is vacuum
0.05~0.07Mpa is spent, thickening temperature is 60~65 DEG C；Preferably, the control condition that is concentrated under reduced pressure is vacuum
0.065Mpa, thickening temperature is 65 DEG C.
7. according to application of any one of the claim 1-3 Chinese medicine composition in hair-loss preventing and hair-restoring product is prepared.
8. a kind of hair-loss preventing and hair-restoring personal-care supplies or cosmetics, it is characterised in that it is any that the product includes claim 1-3
Chinese medicine composition described in；Preferably, the daily chemical products are selected from：Shampoo, hair conditioner, hair film and scalp conditioning liquid.
9. a kind of hair-loss preventing and hair-restoring hair washing product, it is characterised in that the hair washing product is included：
Traditional Chinese medicine composition extract liquid, 0.1~5 part of thickener, 1~5 part of conditioning described in 1~60 part of claim any one of 1-3
Agent, 5~40 parts of surfactants, 0.1~5 portion of preservative and 5~80 parts of solvents；
Wherein it is preferred to：
The thickener is selected from one or more of：Sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, Arabic gum,
Sodium alginate,
The surfactant is selected from one or more of：Bay alcohol sulfuric ester ammonium, laureth sodium sulfovinate, cocounut oil acyl
Amine CAB,
The conditioner is selected from one or more of：Guar gum, polyquaternium, dimethyl silicone polymer,
The preservative is selected from one or more of：Hydroxybenzoate, methylisothiazolinone, imidazolidinyl urea, benzene oxygen
Ethanol, sodium benzoate, and/or
The solvent is selected from one or more of：Ethanol, glycerine, propane diols, water.
10. a kind of hair-loss preventing and hair-restoring hair products, it is characterised in that the hair products are included：
Traditional Chinese medicine composition extract liquid described in 1~60 part of claim any one of 1-3,5~80 parts of solvents, 1~10 part of emulsifying agent,
0.1~20 portion of conditioner, 0.1~5 portion of preservative and 1~10 part of NMF；
Wherein it is preferred to：
The solvent is selected from one or more of：Ethanol, glycerine, propane diols, water,
The emulsifying agent is selected from one or more of：PPG-11 tristearin alcohol ether, PEG-20 sorbitan isostearates,
Stearine, alkyl trimethyl ammonium chloride, stearamidopropyl dimethylamine,
The conditioner is selected from one or more of：Cation guar gum, polyquaternium, dimethyl silicone polymer,
The preservative is selected from one or more of：Hydroxybenzoate, methylisothiazolinone, imidazolidinyl urea, benzene oxygen
Ethanol, sodium benzoate, and/or
The NMF is selected from one or more of：Cetanol, hyaluronic acid, stearyl alcohol.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823044A (en) * | 2017-11-15 | 2018-03-23 | 陈荷芬 | A kind of Chinese medicine preparation shampoo |
| CN108272671A (en) * | 2018-03-13 | 2018-07-13 | 名臣健康用品股份有限公司 | Have effects that the Chinese medicine composition of hair-loss preventing and hair-restoring and its application |
| CN108403488A (en) * | 2018-03-11 | 2018-08-17 | 啵噜噜（广州）婴儿用品科技有限公司 | A kind of cosmetic composition suitable for keratin fiber |
| CN109549881A (en) * | 2017-09-26 | 2019-04-02 | 东莞自然衡健康科技有限公司 | A kind of preparation method of composite plant anti-shed hair growth liquid |
| CN110840754A (en) * | 2019-11-28 | 2020-02-28 | 广州市发雅丝精细化工有限公司 | Anti-dandruff oil-control shampoo and preparation method thereof |
| CN111616978A (en) * | 2020-07-16 | 2020-09-04 | 马祥全 | Application of brassinosteroids as emulsifier in cosmetics |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101546A (en) * | 1993-10-14 | 1995-04-19 | 刘大仕 | Traditional Chinese medicine shampoo |
| CN101890080A (en) * | 2010-08-02 | 2010-11-24 | 西北大学 | Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof |
| CN103550108A (en) * | 2013-11-15 | 2014-02-05 | 广州好迪集团有限公司 | Hair nourishing and damage repairing shampoo |
-
2017
- 2017-05-27 CN CN201710391672.3A patent/CN107019789B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101546A (en) * | 1993-10-14 | 1995-04-19 | 刘大仕 | Traditional Chinese medicine shampoo |
| CN101890080A (en) * | 2010-08-02 | 2010-11-24 | 西北大学 | Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof |
| CN103550108A (en) * | 2013-11-15 | 2014-02-05 | 广州好迪集团有限公司 | Hair nourishing and damage repairing shampoo |
Non-Patent Citations (2)
| Title |
|---|
| 潘会君等: "基于数据挖掘治疗脱发处方用药规律研究", 《现代中药研究与实践》 * |
| 瞿幸: "中医辨证治疗脱发八法", 《中华中医药杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549881A (en) * | 2017-09-26 | 2019-04-02 | 东莞自然衡健康科技有限公司 | A kind of preparation method of composite plant anti-shed hair growth liquid |
| CN107823044A (en) * | 2017-11-15 | 2018-03-23 | 陈荷芬 | A kind of Chinese medicine preparation shampoo |
| CN108403488A (en) * | 2018-03-11 | 2018-08-17 | 啵噜噜（广州）婴儿用品科技有限公司 | A kind of cosmetic composition suitable for keratin fiber |
| CN108272671A (en) * | 2018-03-13 | 2018-07-13 | 名臣健康用品股份有限公司 | Have effects that the Chinese medicine composition of hair-loss preventing and hair-restoring and its application |
| CN110840754A (en) * | 2019-11-28 | 2020-02-28 | 广州市发雅丝精细化工有限公司 | Anti-dandruff oil-control shampoo and preparation method thereof |
| CN111616978A (en) * | 2020-07-16 | 2020-09-04 | 马祥全 | Application of brassinosteroids as emulsifier in cosmetics |
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|---|---|
| CN107019789B (en) | 2020-09-11 |
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