CN107019206A - A kind of Cordyceps militaris composite reactive small peptide soft capsule - Google Patents
A kind of Cordyceps militaris composite reactive small peptide soft capsule Download PDFInfo
- Publication number
- CN107019206A CN107019206A CN201710193975.4A CN201710193975A CN107019206A CN 107019206 A CN107019206 A CN 107019206A CN 201710193975 A CN201710193975 A CN 201710193975A CN 107019206 A CN107019206 A CN 107019206A
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- CN
- China
- Prior art keywords
- cordyceps militaris
- soft capsule
- small peptide
- composite reactive
- micro
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 30
- 239000007901 soft capsule Substances 0.000 title claims abstract description 21
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 16
- 239000002131 composite material Substances 0.000 title claims abstract description 11
- 238000001471 micro-filtration Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000005516 engineering process Methods 0.000 claims abstract description 7
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 7
- 238000005119 centrifugation Methods 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims abstract description 6
- 238000011049 filling Methods 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000012141 concentrate Substances 0.000 claims abstract description 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 230000005684 electric field Effects 0.000 claims description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims 1
- 241000382353 Pupa Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 230000036449 good health Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 208000033065 inborn errors of immunity Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000003792 Metallothionein Human genes 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940001501 fibrinolysin Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of manufacturing technology scheme of Cordyceps militaris composite reactive small peptide soft capsule, including：Using heat backflow or ultrasonic wave or microwave means, the soluble component of Cordyceps militaris is extracted with pure water, then with membrane technology methods such as centrifugation, micro-filtration, ultrafiltration, the materials such as the high molecular weight protein class more than 10000Da are removed in separation, then cryogenic vacuum is concentrated into the 1% of original volume, then reconcile filling into soft capsule food, every capsule contains above-mentioned concentrate 0.4ml.By the above method, technique is simple, with clearly defined objective, easily implements；Good health care effect, extracts and separates from edible Cordyceps militaris, be free from side effects, and is promoted and practical value with preferable.
Description
Technical field
The present invention relates to the health food of healthcare field, more particularly to a kind of conditioning of human-body sub-health.
Background technology
Good health and a long life are the targets that the mankind pursue forever, and health food is because of its effect in terms of health conditioning,
Indispensable part in through being lived as people.Modern technologies process how is used, Traditional health care food resource is improved
Validity and wholesomeness, are one of major subjects of current health food research and development.
Cordyceps militaris is new raw-food material, in China's traditional edible medicinal history and more than ten years modern functions among the people for having a many decades
Food processing course, there is its unique effect in terms of nourishing and health preserving regulating sub-health of human body.Traditional eating method, mainly
Baoshang, it is soaked, steep in wine, it is impossible to give full play to effect of Cordyceps militaris active ingredient.Modern functions food-processing method, substantially exists
Crush or ultramicro grinding is recorded capsule or addition auxiliary material tabletting or extracted and is re-dubbed oral liquid, beverage, for the work(of product
All there is the problem of design is not enough in effect property and specific aim.
The content of the invention
The present invention solves the technical problem of provide in a kind of being directed to by main contents of Cordyceps militaris bioactive peptide
Old age has the soft capsule food of health-care efficacy.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of Cordyceps militaris composite reactive small peptide is provided
Soft capsule, it is characterised in that：A certain amount of Cordyceps militaris, is made 60~120 mesh Cordyceps militaris powder, adds 5~15 times of pure water, adopts
With heat backflow or ultrasonic wave or microwave means, the soluble component of Cordyceps militaris is extracted, then with centrifugation, micro-filtration, ultrafiltration etc.
The high molecular weight protein class material more than 10000Da is removed in membrane technology method, separation, and then cryogenic vacuum is concentrated into original volume
1%, then reconcile filling into soft capsule food, every capsule contains above-mentioned concentrate 0.4ml.
In a preferred embodiment of the invention, the mesh of Cordyceps militaris powder particles size 60~120, feed liquid mass ratio is 1：5
~15,45~55 DEG C of Extracting temperature, vacuum is maintained at -0.05~-0.08MPA, and extraction time is 20~40min, extracts three
It is secondary, it is then that extract solution is admixed together.
In a preferred embodiment of the invention, the mesh of Cordyceps militaris powder particles size 60~120, solid-liquid ratio is 1：5~
15, ultrasonic frequency is 20~40kHz, and intensity is 0.012~0.025 W/cm3, and extraction time is 20~40min.
In a preferred embodiment of the invention, the mesh of Cordyceps militaris powder particles size 60~120, solid-liquid ratio is 1：5~
15, microwave frequency is 10000~20000MHz, and electric-field intensity is 1 × 104~1 × 106V/M, extraction time is 20~60s.
In a preferred embodiment of the invention, centrifugation, micro-filtration, ultrafiltration order are：4500r/min is centrifuged
5min, separates supernatant, then with 0.45um micro-filtrations, 0.22um micro-filtrations, 10000Da ultrafiltration, collects filtrate.
The beneficial effects of the invention are as follows：The present invention uses pure water extraction using heat backflow or ultrasonic wave or microwave means
The soluble component of Cordyceps militaris is taken, then with membrane technology methods such as centrifugation, micro-filtration, ultrafiltration, separation removes big more than 10000Da
Molecule protein class material, then cryogenic vacuum concentration, reconciles filling into soft capsule food.Improve active in product small point
The relative amount of the small peptide of son, these micromolecule active polypeptides maintain the bioactivity and specificity of peptide, with preventing and treating blood
The function such as bolt, anti-aging, regulation be immune (for example can be with the fibrinolysin of antithrombotic, superoxide dismutase (SOD), gluathione
Peptide peroxidase, metallothionein etc.), so as to strengthen the both effectiveness of product.
The present invention provides a kind of preparation method of Cordyceps militaris composite reactive small peptide soft capsule, with clearly defined objective, and technique is simple, holds
Easily implement；Good health care effect, extracts and separates from edible Cordyceps militaris, be free from side effects, and is promoted and practical with preferable
Value.
Embodiment：
A kind of preparation method of Cordyceps militaris composite reactive small peptide soft capsule, 100 grams of raw material Cordyceps militaris, less than 55 DEG C crushing cross 80
Mesh sieve, is added in ultrasonic extraction tank, and add water 1000ml, set extraction conditions as：55 DEG C of temperature, ultrasonic frequency is
40kHz, intensity is 0.025W/cm3, and extraction time is 30min, and leaching liquor 4500r/min then is centrifuged into 5min, separates supernatant
Liquid, then filters supernatant with 0.45um microfiltration membranes, 0.22um microfiltration membranes, 10000Da milipore filters step by step, collects filtrate, dense
10ml is reduced to, the filling soft capsule of mediation, every soft capsule contains above-mentioned concentrate 0.4ml.
Typical use-case is as follows：
Use-case 1：Zhang, man 44 years old, often has the powerless symptom of shortness of breath uncomfortable in chest, pain of the heart area, action, is shakiness through hospital diagnosis
Sizing angina pectoris, with high fat of blood, hypertension, it is proposed that do cardiac stent.Take soft capsule of the present invention each 1,2 of morning and evening daily
Symptom significantly mitigates after month.
Use-case 2：Slowly certain, female, 46 years old, hospital diagnosis was diabetes, daily insulin injection twice, 28 units every time,
With lassitude and weak, move weak, spiritual difference.Fatigue symptom after soft capsule of the present invention each 1,1 month of the morning and evening daily is taken to show
Write and mitigate, insulin dosage is down to daily insulin injection twice after 3 months, every time 20 units.
Use-case 3：Mr. Wang, male, 49 years old, spiritlessness and weakness was easily tired, hypoimmunity, when climate change, susceptible outer
Heresy, flu is continuous throughout the year, and the course of disease is longer.Hypoimmunity after soft capsule of the present invention each 1,2 months of the morning and evening daily is taken to ask
Topic significantly mitigates.
Claims (5)
1. a kind of Cordyceps militaris composite reactive small peptide soft capsule, it is characterised in that：A certain amount of Cordyceps militaris, is made 60~120 mesh pupas
Cordyceps sinensis powder, adds 5~15 times of pure water, using heat backflow or ultrasonic wave or microwave means, extracts the solubility of Cordyceps militaris
Composition, then with membrane technology methods such as centrifugation, micro-filtration, ultrafiltration, the high molecular weight protein class material more than 10000Da is removed in separation,
Then cryogenic vacuum is concentrated into the 1% of original volume, then reconciles filling into soft capsule food, and every capsule contains above-mentioned concentrate
0.4ml。
2. a kind of Cordyceps militaris composite reactive small peptide soft capsule according to claim 1, it is characterised in that：Cordyceps militaris powder particles are big
Small 60~120 mesh, feed liquid mass ratio is 1：5~15,45~55 DEG C of Extracting temperature, vacuum is maintained at -0.05~-0.08MPA,
Extraction time is 20~40min, is extracted three times, then that extract solution is admixed together.
3. a kind of Cordyceps militaris composite reactive small peptide soft capsule according to claim 1, it is characterised in that：Cordyceps militaris powder particles are big
Small 60~120 mesh, solid-liquid ratio is 1：5~15, ultrasonic frequency is 20~40kHz, and intensity is 0.012~0.025W/cm3, is carried
It is 20~40min to take the time.
4. a kind of Cordyceps militaris composite reactive small peptide soft capsule according to claim 1, it is characterised in that：Cordyceps militaris powder particles are big
Small 60~120 mesh, solid-liquid ratio is 1：5~15, microwave frequency is 10000~20000MHz, and electric-field intensity is 1 × 104~1 ×
106V/M, extraction time is 20~60s.
5. a kind of Cordyceps militaris composite reactive small peptide soft capsule according to claim 1, it is characterised in that：Centrifugation, micro-filtration, ultrafiltration
Operation order is：4500r/min centrifuges 5min, separates supernatant, is then surpassed with 0.45um micro-filtrations, 0.22um micro-filtrations, 10000Da
Filter, collects filtrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710193975.4A CN107019206A (en) | 2017-03-29 | 2017-03-29 | A kind of Cordyceps militaris composite reactive small peptide soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710193975.4A CN107019206A (en) | 2017-03-29 | 2017-03-29 | A kind of Cordyceps militaris composite reactive small peptide soft capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107019206A true CN107019206A (en) | 2017-08-08 |
Family
ID=59525338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710193975.4A Pending CN107019206A (en) | 2017-03-29 | 2017-03-29 | A kind of Cordyceps militaris composite reactive small peptide soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107019206A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380963A (en) * | 2015-12-09 | 2016-03-09 | 郑州莉迪亚医药科技有限公司 | Cordyceps sinensis active soft capsule and production technology thereof |
-
2017
- 2017-03-29 CN CN201710193975.4A patent/CN107019206A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380963A (en) * | 2015-12-09 | 2016-03-09 | 郑州莉迪亚医药科技有限公司 | Cordyceps sinensis active soft capsule and production technology thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张楠: "蛹虫草多肽通过PI3K/Akt/mTOR通路增强胃癌细胞株SGC-7901对氟尿嘧啶化疗敏感性的研究", 《中国博士学位论文全文数据库-医药卫生科技辑》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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Application publication date: 20170808 |