CN105380963A - Cordyceps sinensis active soft capsule and production technology thereof - Google Patents
Cordyceps sinensis active soft capsule and production technology thereof Download PDFInfo
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- CN105380963A CN105380963A CN201510899186.3A CN201510899186A CN105380963A CN 105380963 A CN105380963 A CN 105380963A CN 201510899186 A CN201510899186 A CN 201510899186A CN 105380963 A CN105380963 A CN 105380963A
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- soft capsule
- cordyceps
- micropowder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a cordyceps sinensis active soft capsule and a production technology thereof. The soft capsule is composed of the following raw materials in parts by weight: 0.4 to 1.6 parts of freeze-dried cordyceps sinensis micropowder, 0.4 to 3.0 parts of lecithin, and 3.5 to 6.5 parts of capsule carrier. The provided production technology can obtain high-purity extract of fresh pilose antler through an ultrasonic condensation, the bioactive substances are maximally preserved, and thus the bioavailability is greatly improved. The utilization rate of effective components in pilose antler is increased by 30 times or so (from 2-5% to 70% or more).
Description
Technical field
The invention belongs to medical art, relate to the active soft capsule of a kind of Cordyceps and production technology thereof.
Background technology
Cordyceps has another name called Cordyceps, and be the famous and precious tonic herb of China's usual one among the people, its nutritional labeling, higher than Radix Ginseng, can be used as medicine, also edible, is superior delicacies, has very high nutritive value.Cordyceps can the immunity of enhancing body, and nourishing lung and kidney, has obvious inhibitory action to pulmonary carcinoma, hepatocarcinoma etc.Clinically to chronic cough of deficiency lung, asthma, hemoptysis of pulmonary tuberculosis, night sweat, soreness of waist and knee joint of suffering from a deficiency of the kidney, impotence and seminal emission, the red blood cell decreased after neurasthenia and chemotherapy, radiotherapy is all effective in cure.
Summary of the invention
The object of the invention is to the defect overcoming prior art existence, the active soft capsule of a kind of Cordyceps and production technology thereof are provided, make effective ingredient nearly all in Cornu Cervi Pantotrichum all become the solution state being easy to absorption of human body.Traditional Cornu Cervi Pantotrichum processing and treating method is changed with the application of " Vacuum Freezing & Drying Technology " and " the broken technology of low-temperature fine powder ", utilize fresh Cordyceps for raw material, adopt the technology of " low-temperature ultrasonic cracking " and " biological hydrolysis, enzymolysis, extraction ", by the membranolysis in Pilose Antler Tissues, intracellular nutrient substance is discharged rapidly, fully extracts effective ingredient in fresh Cornu Cervi Pantotrichum.Obtained the fresh Cornu Cervi Pantotrichum extract of higher degree by ultrasonic concentration, remain bioactive substance to greatest extent, and bioavailability is improved greatly.The utilization rate of effective ingredient in Cornu Cervi Pantotrichum can be made to rise to more than 70% by 2-5%, improve about 30 times.Processing technique improves further, fine and soft for raw material with fresh Cornu Cervi Pantotrichum or lyophilizing, extract the active ingredient (somatomedin as total in Cornu Cervi Pantotrichum of clear efficacy, the mono-product of IGF-1, NGF, EGF, TGF and joint product), active component with folk prescription or with other medical material compatibilities, exploitation improve immunity of organisms, strong health, the medicine of preventing and curing diseases or nutrient and healthcare products, fully improve Cornu Cervi Pantotrichum value-added content of product.
Its technical scheme is:
The active soft capsule of a kind of Cordyceps, is made up of the raw material of following portions by weight proportioning: lyophilizing, micropowder Cordyceps 0.4-1.6 part, lecithin 0.4-3.0 part, capsule carrier 3.5-6.5 part.
Described capsule carrier is lecithin or Semen sojae atricolor, Semen arachidis hypogaeae, Fructus Canarii albi wherein any one.
A production technology for the active soft capsule of the full matter of Cordyceps, comprises the following steps:
20-60min →-25-40 DEG C of the vacuum lyophilization of fresh Cordyceps → pretreatment →-5-20 DEG C low temperature rubbing → ultrasonic treatment, make Penis et testis cervi micropowder water content below 5% → low-temperature fine powder is broken :-5-30 DEG C is crushed to 300-800 order micropowder → add lecithin and soft capsule carrier, and mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging makes the active soft capsule of Cordyceps.
Compared with prior art, beneficial effect of the present invention is: the present invention with health product on market " soft capsule " product for sample, in the technical foundation of existing lyophilizing production line, utilize advanced in the world " Vacuum Freezing & Drying Technology ", " the broken technology of low-temperature fine powder " and " low-temperature ultrasonic cracking technique " processing fresh Cornu Cervi Pantotrichum raw material, change the processing technique that tradition falls behind, realize the function technology upgrading innovation with the deer raw produce of advanced technology processing, Improving The Quality of Products and added value, form economic advantages.Solve the bioactive ingredients and the nutrient substance that how farthest retain Cornu Cervi Pantotrichum raw material, do not lose heat-sensitive nutrition, retain the biological hologram active substance of Cornu Cervi Pantotrichum product, Crushing of Ultrafine mixes polar substances and fat-soluble solvent and makes soft gel products under cryogenic.
" ultrasonic treatment " technology of utilization extracts fresh Cornu Cervi Pantotrichum and Embryo cervi, become the liquid containing plurality of active ingredients such as a large amount of micromolecule polypeptides, bioactive ingredients can must remain very well, and separation and Extraction goes out effective ingredient wherein and makes the extraction and application rate of effective ingredient improve about 30 times (2 ~ 5% rise to more than 70%) than existing routine techniques fully.Its innovation point is: utilize ultrasonic cavitation effect, mechanical vibration, disturbance effect, high acceleration, emulsifying, spread, smash and the multistage effects such as stirring action, increase molecular motion of material frequency and speed, increase solvent penetration power, thus acceleration target component enters solvent, promote that extraction is carried out, high temperature can be avoided the destruction of target component.
Show according to the study: use seven kinds of enzyme activities in the Cornu Cervi Pantotrichum after " vacuum lyophilization " processing to be " contrast Cornu Cervi Pantotrichum " 2.5 ~ 250 times; Hydrolysis amino acid total amount " vacuum lyophilization Cornu Cervi Pantotrichum " is higher than " contrast Cornu Cervi Pantotrichum " 27.59%.
" Vacuum Freezing & Drying Technology " its know-why is: by deer product quick freezing Cheng Bing good for pretreatment, then make water constantly be sublimed into outside gas discharge system in high vacuum conditions, thus make deer product reach the object of dehydrate.Its innovation point is: under the whole process of this technology makes material remain at low temperature state, the product active ingredient processed is high, and nutrition does not run off, and processes time saving and energy saving, with high content of technology, and convenient transportation, is convenient to long term storage.
" the broken technology of low-temperature fine powder ": principle is: under deer product good for pretreatment is in low-temperature material condition, carry out Cellular Level Pulverizing.Utilize " the broken technology of low-temperature fine powder " to be pulverized under cryogenic by the raw materials such as Cornu Cervi Pantotrichum, cell wall breaking active substance is discharged, decreases processing link, maintain original nutrition and do not lose, substantially increase the bioavailability of product.The innovative point of technology is: conventional size reduction technology is carried out under normal conditions, the impact that many nutrient substance can be subject to temperature loss in various degree and destruction, process powder particle size simultaneously and be only 80 ~ 100 orders, and " freeze grinding technology " can make fine powder reach 200 ~ 1000 orders, the particle diameter of powder body is made to reach 1-0.3 μm, crushing biological cells rate reaches more than 95%, improves the bioavailability of product, makes its active component more easily for human body absorbs.
The active substance contained in solid-state intermediate conveniently grinding mode is pulverized, the temperature damage active component produced during owing to pulverizing, and the conventional granularity pulverized is larger, mix with soft capsule carrier (mostly being lipid material), easily occur that the immiscible layering of profit mixes uneven phenomenon, therefore we are by consideration application " low-temperature fine powder is broken " technology, solid-state intermediate is crushed to the microgranule of more than 300-800 order by plan, it is made to be easy to be blended in soft capsule carrier, form uniform suspension, make product content even.The determination of soft capsule carrier components, raw material and soft capsule carrier prescription proportioning will be research emphasis.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described further.
Embodiment 1:
Get fresh Cordyceps 5kg, pretreatment → low temperature rub (-5 DEG C) → ultrasonic treatment (30 minutes) → vacuum lyophilization (-35 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-15 DEG C are crushed to 300 order micropowders) → by Penis et testis cervi micropowder 0.4kg, lecithin l.0kg and vegetable oil 3.5kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging to make Cordyceps activity soft capsule.0.5g/ ball.
Embodiment 2:
Get fresh Cordyceps 5kg, pretreatment → low temperature rub (10 DEG C) → ultrasonic treatment (35 minutes) → vacuum lyophilization (-40 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-10 DEG C are crushed to 400 order micropowders) → by Penis et testis cervi micropowder 1.0kg, lecithin l.0kg and vegetable oil 3kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging to make Cordyceps activity soft capsule.0.5g/ ball.
Embodiment 3:
Get fresh Cordyceps 5kg, (15 DEG C) → ultrasonic treatment (40 minutes) → vacuum lyophilization (-35 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-20 DEG C are crushed to 500 order micropowders) → Penis et testis cervi micropowder 1kg, lecithin 0.4kg and vegetable oil 3.5kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging is made Cordyceps activity soft capsule is rubbed in pretreatment → low temperature.0.5g/ ball.
Embodiment 4:
Get fresh Cordyceps 10kg, (20 DEG C) → ultrasonic treatment (50 minutes) → vacuum lyophilization (-35 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-20 DEG C are crushed to 600 order micropowders) → Penis et testis cervi micropowder 2kg, lecithin 1kg and vegetable oil 7kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging is made Cordyceps activity soft capsule is rubbed in pretreatment → low temperature.0.5g/ ball.
Embodiment 5
Get fresh Cordyceps 10kg, (20 DEG C) → ultrasonic treatment (50 minutes) → vacuum lyophilization (-35 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-25 DEG C are crushed to 600 order micropowders) → Penis et testis cervi micropowder 2kg, lecithin 2kg and vegetable oil 6kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging is made Cordyceps activity soft capsule is rubbed in pretreatment → low temperature.0.6g/ ball.
Embodiment 6:
Get fresh Cordyceps 10kg, (10 DEG C) → ultrasonic treatment (60 minutes) → vacuum lyophilization (-35 DEG C, make Penis et testis cervi micropowder water content below 5%) → low-temperature fine powder broken (-25 DEG C are crushed to 600 order micropowders) → Penis et testis cervi micropowder 1.6kg, lecithin 2kg and vegetable oil 6.5kg mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging is made Cordyceps activity soft capsule is rubbed in pretreatment → low temperature.0.6g/ ball.
The above; be only the present invention's preferably detailed description of the invention; protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art; in the technical scope that the present invention discloses, the simple transformation of the technical scheme that can obtain apparently or equivalence are replaced and are all fallen within the scope of protection of the present invention.
Claims (3)
1. the active soft capsule of Cordyceps, is characterized in that, be made up of the raw material of following portions by weight proportioning: lyophilizing, micropowder Cordyceps 0.4-1.6 part, lecithin 0.4-3.0 part, capsule carrier 3.5-6.5 part.
2. the active soft capsule of Cordyceps according to claim 1, is characterized in that, described capsule carrier is lecithin or Semen sojae atricolor, Semen arachidis hypogaeae, Fructus Canarii albi wherein any one.
3. a production technology for the active soft capsule of the full matter of Cordyceps according to claim 1, is characterized in that, comprise the following steps:
20-60min →-25-40 DEG C of the vacuum lyophilization of fresh Cordyceps → pretreatment →-5-20 DEG C low temperature rubbing → ultrasonic treatment, make Penis et testis cervi micropowder water content below 5% → low-temperature fine powder is broken :-5-30 DEG C is crushed to 300-800 order micropowder → add lecithin and soft capsule carrier, and mixing and stirring → soft capsule fill pelleting → wash ball → dry → sterilizing → inspection → packaging makes the active soft capsule of Cordyceps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510899186.3A CN105380963A (en) | 2015-12-09 | 2015-12-09 | Cordyceps sinensis active soft capsule and production technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510899186.3A CN105380963A (en) | 2015-12-09 | 2015-12-09 | Cordyceps sinensis active soft capsule and production technology thereof |
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| Publication Number | Publication Date |
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| CN105380963A true CN105380963A (en) | 2016-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510899186.3A Pending CN105380963A (en) | 2015-12-09 | 2015-12-09 | Cordyceps sinensis active soft capsule and production technology thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420844A (en) * | 2016-11-09 | 2017-02-22 | 广东东阳光药业有限公司 | Fresh Cordyceps extract with anti-melanoma activity |
| CN107019206A (en) * | 2017-03-29 | 2017-08-08 | 炎黄（固安）生物科技有限公司 | A kind of Cordyceps militaris composite reactive small peptide soft capsule |
-
2015
- 2015-12-09 CN CN201510899186.3A patent/CN105380963A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420844A (en) * | 2016-11-09 | 2017-02-22 | 广东东阳光药业有限公司 | Fresh Cordyceps extract with anti-melanoma activity |
| CN106420844B (en) * | 2016-11-09 | 2019-11-12 | 广东东阳光药业有限公司 | One kind having the active fresh Cordyceps extract of melanoma |
| CN107019206A (en) * | 2017-03-29 | 2017-08-08 | 炎黄（固安）生物科技有限公司 | A kind of Cordyceps militaris composite reactive small peptide soft capsule |
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Application publication date: 20160309 |