CN106727888A - A kind of jerusalem artichoke compound product and preparation method thereof - Google Patents
A kind of jerusalem artichoke compound product and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention discloses a kind of jerusalem artichoke compound product and preparation method thereof, it is by the Chinese herbal medicines such as jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed, Agricus blazei, royal jelly, xylo-oligosaccharide and auxiliary material, using crushing, hydrolysis, enzymolysis, CO2The series of processes such as supercritical extract purifying, filtering, concentration, spraying, drying, allotment, dry granulation, packaging are made granule.Product of the present invention carries out compatibility and is made from natural plants, has no toxic side effect, and long-term taking is conducive to adjusting physiological function, with the effect such as auxiliary hyperglycemic, reducing blood lipid；The integrated modern biotechnology extractive technique of this method, than traditional Chinese herbal medicine soaking extracting method have the advantages that extract yield it is high, rate of extraction is fast, it is nontoxic, nonflammable, using complete, free from environmental pollution, the granule nutritional ingredient being made is high, is a kind of Chinese herb compound product biological technology production method of high-efficiency environment friendly.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine granule compound product and preparation method thereof, more particularly to containing jerusalem artichoke, Cordyceps militaris,
The Chinese herbal medicines such as radix bardanae, cassia seed, a kind of preparation method of granule is made with biotechnology.
Background technology
Jerusalem artichoke (Helianthus tuberosus L.), also known as Jerusalem artichoke, Jerusalem artichoke, research find：Jerusalem artichoke extracts synanthrin,
Diabetes can be treated.It has dual regulation to blood sugar, i.e., on the one hand can reduce blood sugar in diabetic patients, on the other hand
Hypoglycemia glucose can again raised.Research display, containing a kind of non-with human pancreatic's Li Neisheng insulin structures in Jerusalem artichoke
Often approximate material, when occurring glucose in urine in urine, edible Jerusalem artichoke can control glucose in urine, illustrate to reduce blood sugar effect.When people goes out
During existing hypoglycemia, can be equally eased after edible Jerusalem artichoke.With regulation functions of intestines and stomach, enhance immunity, toxin-expelling and face nourishing, change
It is apt to lipid-metabolism, promotes mineral absorption, is conducive to vitamin to synthesize, prevent carious tooth, be suitable for diabetes patient.
Cordyceps militaris（ Cordyceps militaris）, chemical analysis：N6-[β-（Acetamide formyl）Oxygen ethyl] adenosine；
Chinese caterpillar fungus cyclic peptide A；Nucleosides；Ergosterol peroxide.Cordycepin in Cordyceps militaris, can antiviral, antibacterial, the substantially life of suppression tumour
Long, interference human body RNA and DNA synthesis.Riched Cordyceps Militaris contain cordycepic acid, and cordycepic acid can effectively prophylactic treatment cerebral thrombus, cerebral hemorrhage, kidney
MSOF, while also having diuresis.Adenosine in Cordyceps militaris, can suppress Platelet congregation preventing and treating with antiviral, antibacterial
Thrombosis, can also eliminate face spot, anti-ageing wrinkle resistant.Cordyceps sinensis polysaccharide in Cordyceps militaris, is improved immunity, and anti-aging, righting is solid
This, cardioprotection, liver, the effect of anti-convulsion.Ergosterol, superoxide dismutase in Cordyceps militaris, urge suppressing or eliminating
The superoxide radical of people's aging is formed and anticancer, health care, attenuation have good action.Cordyceps militaris is also rich in selenium, substantial amounts of science reality
Trampling proves that selenium can significantly suppress the growth of cancer cell, stimulates the generation of immunoglobulin and antibody, enhancing immunity of organism and
Oxidation resistance, with special nutritive value and obvious medical value.
Radix bardanae（Arctium lappa）Alias：Dislike real root, mouse viscous root, ox dish, Campanulales, be composite family biennial herb
Plant.Contain 4.7 grams of protein, 0.8 gram of fat, 3 grams of sugar, the kilojoule of energy 160 (38 kilocalories), crude fibre in every 100 grams of burdocks
2.4 grams, 242 milligrams of calcium, 61 milligrams of phosphorus, 7.6 milligrams of iron, 3.9 milligrams of carrotene, 5 milligrams of Catergen.Burdock is all
In dish class vegetables, string content is most, and its water soluble fiber and insoluble fibre respectively accounts for half, can make lactic acid bacteria more
Vivaciously, thoroughly playing improves effect of constipation, and lignin is one kind of the most strings contained by burdock, and it has very excellent
Different antibacterial action.Burdock has the pharmacological action quenched one's thirst, and with treatment diabetes, hypertension, high fat of blood, anticancer, insomnia, carries
The effects such as body immunity high.
Cassia seed (CatsiatoraLinn), also known as " going back pupil ", cassia seed contains anthraquinone analog compound to cassia seed, and contains
Multivitamin and abundant amino acid, fat, carbohydrate etc., its healthcare function is increasingly subject to the weight of people in recent years
Depending on.Cassia seed has the functions such as clearing away the liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight, often drinks cassia-tora tea, and blood pressure can be made normal, free movement of the bowels,
There is no blurred vision.Clinical trial certificate, drinking cassia-tora tea can clear liver and improve vision, prevent eye-blurred, lowering blood pressure and blood fat, drop blood
Sugar, reduction cholesterol etc., have good curative effect for prevention and treatment of coronary heart disease, hypertension；And cassia seed rich in vitamin A and
Zinc, can prevent and treat yctalopia and avoid zinc deficiency in children.Additionally, the function that cassia-tora tea relaxes bowel can also solve modern's stomach
And the problem of constipation, dry feces can be treated, help smooth defecation.
Agricus blazei（Agaricus blazei murrill）, with various biological functions, strengthen function of immune system, drop
Blood sugar, reducing blood lipid, regulation blood pressure, improvement liver function, antianaphylaxis etc..Its nursing role to tumor patient makes us closing especially
Note, its inhibiting cancer effect is occupied first of each medicinal fungi.Antitumor and enhancing immunologic function is essentially from polysaccharide body.Agricus blazei contains
There is various active polysaccharide, its component is higher by 5 times than ganoderma lucidum.It is currently known and kind about more than 10 is found in the mycelium of Agricus blazei
Polysaccharide.With the effect of the more various polysaccharide of zoopery, show that wherein many polysaccharide have Synergistic action, with B-D- glucans
It is most strong with the effect of protein bound complex, to S180 inhibiting rates up to 99%, and a- glucans and β galactolipin glucans
Up to more than 90%.Such as merge application with mitomycin C, up to 100%.In addition to polysaccharide, the aliphatic acid of Agricus blazei, steroids
Also it is improved immunity.Zoopery shows, in more than 10 kinds of mushrooms（Including ganoderma lucidum, umbellate pore furgus etc.）In, the work of Agricus blazei
With the most notable.
Royal jelly (royal jelly), also known as bee milk, queen bee breast, royal jelly, are the young works of cultivation larva in honeycomb
The secretion royal jelly of honeybee pharynx gland contains protein, fat, carbohydrate, vitamin A, vitamin B l, vitamin B2, abundant leaf
Acid, pantothenic acid and inositol.Also it is similar to acetylcholine sample material, and the amino acid that needs of various human bodies and bio-hormone etc..Honeybee
Royal jelly contains para-insulin, has better effects to diabetes；Royal jelly can strengthen adrenal cortex function, adjust human hormone, living
Brain cell between change, is conducive to treating climacteric disfunction and chronic prostatitis syndrome, and royal jelly contains plurality of inorganic salt, can promote liver
Sugar release, promotes metabolism, thus can eliminate speckle with beauty, and has functions that good regulation blood fat.
Xylo-oligosaccharide（Xylo-oligosaccharide）Molecular formula：（C5H10O5）2-7, molecular weight：300.28~
1050.98.Xylo-oligosaccharide is to be polymerized in carbohydrate to breed one of most strong kind of Bifidobacterium function, and the both effectiveness of it is that other gather
Close carbohydrate nearly 20 times, do not have the enzyme for hydrolyzing xylo-oligosaccharide, so it can be directly entered big enteral being preferably in human gastrointestinal tract
Bifidobacterium is utilized, and promotes Bifidobacterium propagation to produce various organic acids simultaneously.Gut pH is reduced, suppresses harmful bacteria life
It is long, probiotics is largely bred in enteron aisle, reach above-mentioned health-care efficacy, with functions of intestines and stomach imbalance, diabetes, hypertension,
Effect of the diseases such as obesity, artery sclerosis, carious tooth.
The content of the invention
It is an object of the invention to provide a kind of jerusalem artichoke compound product and preparation method thereof, overcome Chinese herbal medicine tradition and extract
The deficiency that energy consumption is big in technique, material consumption is big, impurity is more, quality is unstable, with the active component being sufficiently reserved in raw material, extracts
Purity is high, and extract yield it is high the advantages of, be that operation facility, save energy, a modern Chinese herbal medicine free from environmental pollution are new
The biological medicine technology of preparing of product.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of jerusalem artichoke compound product, its herbal raw material is counted by weight：3000 parts of jerusalem artichoke, 2000 parts of Cordyceps militaris, radix bardanae
2000 parts, 1500 parts of cassia seed, 1500 parts of Agricus blazei；Auxiliary material is based on the percentage of herbal raw material gross weight：Royal jelly dried powder
10%th, xylo-oligosaccharide 10%, maltodextrin 10%.
Preparation method：By jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed, these herbal raw materials of Agricus blazei through smash, enzymolysis,
CO2Supercritical extract purifying, filtering, concentration, spray drying, add royal jelly dried powder, xylo-oligosaccharide, maltodextrin these auxiliary materials
Uniform, granulation, packaging are allocated, granule is obtained.Comprise the following steps：
（1）Herbal raw material jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed and the Agricus blazei that will be cleaned are weighed, and are crushed, and sieving is crushed
Fineness is 30-60 mesh；
（2）Comminuted powder is soaked 1-2 hours with drinking water, solid-liquid ratio is 1：20-30, is subsequently adding herbal raw material weight 0.5-
1.0% cellulase, the amylase of 0.5-1.0%, the pectase of 0.5-1.0%, 50-60 DEG C of enzymolysis 90-120min；Described
Cellulase activity is 20000U/g, and amylase activity is 100000U/g, and pectinase activity is 30000U/g, enzyme 1-3mol/
The salt acid for adjusting pH of L is 5.0-6.5；Feed liquid is warming up to 100-110 DEG C after enzyme digestion reaction, is gone out enzyme 3-5 minutes, then by feed liquid
Using 80 mesh plate-frame filterings, filtrate must be digested standby；
（3）Enzymolysis filtrate is used into supercritical CO2Extraction equipment separating and extracting active material refined solution, extraction kettle pressure 28-
32MPa, separating still pressure 16-22MPa, rectifying column pressure 26-30MPa, CO2High pressure pump pressure 35-40MPah；
（4）Refined solution is concentrated using membrane filtration, membrane aperture is 200-300Da, operating pressure 0.8-1.0MPa, concentrate concentration
It is Brix=16.0-18.0%；
（5）Using low temperature spray drying, active material dry powder is obtained；Control parameter：Moisture evaporation rate 1000-1200ml/h, enters
100-120 DEG C of air temperature, 60-70 DEG C of leaving air temp, air compressor gas production 4.0m3/ h, operating pressure 0.6-0.7MPa；It is dry
Powder water content≤5%；
（6）Royal jelly dried powder, xylo-oligosaccharide and maltodextrin are added in active material dry powder, allotment is uniform, granulator is stirred,
Pelletizing machine whole grain；
（7）Granule is obtained using the aseptic filling and packing of particles packing machine；Packaging material are medical aluminum foil bag, packing shop air
Cleanliness factor is 100,000 grades, and temperature is 20-24 DEG C, humidity 50-55%.
Remarkable advantage of the invention is：Product of the present invention carries out compatibility and is made from natural plants, has no toxic side effect, long
Phase takes and is conducive to adjusting physiological function, with the effect such as auxiliary hyperglycemic, reducing blood lipid；The integrated modern biotechnology of this method extracts skill
Art, than traditional Chinese herbal medicine soaking extracting method have extract yield it is high, rate of extraction is fast, it is nontoxic, nonflammable, using completely,
Free from environmental pollution the advantages of, the granule nutritional ingredient being made is high, is a kind of Chinese herb compound product biological skill of high-efficiency environment friendly
Art production method.
Specific embodiment
Embodiment 1：Jerusalem artichoke compound product
Herbal raw material：Jerusalem artichoke 3000g, Cordyceps militaris 2000g, radix bardanae 2000g, cassia seed 1500g, Agricus blazei 1500g；
Auxiliary material：Royal jelly dried powder 10%, xylo-oligosaccharide 10%, maltodextrin 10%.
Preparation method：
（1）Herbal raw material jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed and the Agricus blazei that will be cleaned are weighed, and are crushed, and sieving is crushed
Fineness is 30 mesh；
（2）Comminuted powder is soaked 1 hour with drinking water, solid-liquid ratio is 1：20, it is subsequently adding the fibre of herbal raw material weight 0.5%
The plain enzyme of dimension, 0.5% amylase, 0.5% pectase, 50 DEG C of enzymolysis 90min；Described cellulase activity is 20000U/g,
Amylase activity is 100000U/g, and pectinase activity is 30000U/g, and enzyme is 5.0 with the salt acid for adjusting pH of 1mol/L；Enzymolysis is anti-
Should after feed liquid is warming up to 100 DEG C, gone out enzyme 3 minutes, and feed liquid then is used into 80 mesh plate-frame filterings, must digest filtrate standby；
（3）Enzymolysis filtrate is used into supercritical CO2Extraction equipment separating and extracting active material refined solution, extraction kettle pressure 28MPa,
Separating still pressure 16MPa, rectifying column pressure 26MPa, CO2High pressure pump pressure 35MPah；
（4）Refined solution is concentrated using membrane filtration, membrane aperture is 200Da, and operating pressure 0.8MPa, concentrate concentration is Brix=
16.0%；
（5）Using low temperature spray drying, active material dry powder is obtained；Control parameter：Moisture evaporation rate 1000ml/h, EAT
100 DEG C, 60 DEG C of leaving air temp, air compressor gas production 4.0m3/ h, operating pressure 0.6MPa；Dry powder water content≤5%；
（6）Royal jelly dried powder, xylo-oligosaccharide and maltodextrin are added in active material dry powder, allotment is uniform, granulator is stirred,
Pelletizing machine whole grain；
（7）Granule is obtained using the aseptic filling and packing of particles packing machine；Packaging material are medical aluminum foil bag, packing shop air
Cleanliness factor is 100,000 grades, and temperature is 20 DEG C, humidity 50%.
Embodiment 2：Jerusalem artichoke compound product
Herbal raw material：Jerusalem artichoke 3000g, Cordyceps militaris 2000g, radix bardanae 2000g, cassia seed 1500g, Agricus blazei 1500g；
Auxiliary material：Royal jelly dried powder 10%, xylo-oligosaccharide 10%, maltodextrin 10%.
Preparation method：
（1）Herbal raw material jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed and the Agricus blazei that will be cleaned are weighed, and are crushed, and sieving is crushed
Fineness is 60 mesh；
（2）Comminuted powder is soaked 2 hours with drinking water, solid-liquid ratio is 1：30, it is subsequently adding the fibre of herbal raw material weight 1.0%
The plain enzyme of dimension, 1.0% amylase, 1.0% pectase, 60 DEG C of enzymolysis 120min；Described cellulase activity is 20000U/g,
Amylase activity is 100000U/g, and pectinase activity is 30000U/g, and enzyme is 6.5 with the salt acid for adjusting pH of 3mol/L；Enzymolysis is anti-
Should after feed liquid is warming up to 110 DEG C, gone out enzyme 5 minutes, and feed liquid then is used into 80 mesh plate-frame filterings, must digest filtrate standby；
（3）Enzymolysis filtrate is used into supercritical CO2Extraction equipment separating and extracting active material refined solution, extraction kettle pressure 32MPa,
Separating still pressure 22MPa, rectifying column pressure 30MPa, CO2High pressure pump pressure 40MPah；
（4）Refined solution is concentrated using membrane filtration, membrane aperture is 300Da, and operating pressure 1.0MPa, concentrate concentration is Brix=
18.0%；
（5）Using low temperature spray drying, active material dry powder is obtained；Control parameter：Moisture evaporation rate 1200ml/h, EAT
120 DEG C, 70 DEG C of leaving air temp, air compressor gas production 4.0m3/ h, operating pressure 0.7MPa；Dry powder water content≤5%；
（6）Royal jelly dried powder, xylo-oligosaccharide and maltodextrin are added in active material dry powder, allotment is uniform, granulator is stirred,
Pelletizing machine whole grain；
（7）Granule is obtained using the aseptic filling and packing of particles packing machine；Packaging material are medical aluminum foil bag, packing shop air
Cleanliness factor is 100,000 grades, and temperature is 24 DEG C, humidity 55%.
Embodiment 3：Jerusalem artichoke compound product
Herbal raw material：Jerusalem artichoke 3000g, Cordyceps militaris 2000g, radix bardanae 2000g, cassia seed 1500g, Agricus blazei 1500g；
Auxiliary material：Royal jelly 10%, xylo-oligosaccharide 10%, maltodextrin 10%.
Preparation method：
（1）Herbal raw material jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed and the Agricus blazei that will be cleaned are weighed, and are crushed, and sieving is crushed
Fineness is 45 mesh；
（2）Comminuted powder is soaked 1.5 hours with drinking water, solid-liquid ratio is 1：25, it is subsequently adding herbal raw material weight 0.8%
Cellulase, 0.8% amylase, 0.8% pectase, 55 DEG C of enzymolysis 105min；Described cellulase activity is 20000U/
G, amylase activity is 100000U/g, and pectinase activity is 30000U/g, and enzyme is 6.0 with the salt acid for adjusting pH of 2mol/L；Enzymolysis
Feed liquid is warming up to 105 DEG C after reaction, go out enzyme 4 minutes, feed liquid is then used into 80 mesh plate-frame filterings, filtrate must be digested standby；
（3）Enzymolysis filtrate is used into supercritical CO2Extraction equipment separating and extracting active material refined solution, extraction kettle pressure 30MPa,
Separating still pressure 19MPa, rectifying column pressure 28MPa, CO2High pressure pump pressure 38MPah；
（4）Refined solution is concentrated using membrane filtration, membrane aperture is 250Da, and operating pressure 0.9MPa, concentrate concentration is Brix=
17.0%；
（5）Using low temperature spray drying, active material dry powder is obtained；Control parameter：Moisture evaporation rate 1100ml/h, EAT
110 DEG C, 65 DEG C of leaving air temp, air compressor gas production 4.0m3/ h, operating pressure 0.65MPa；Dry powder water content≤5%；
（6）Royal jelly dried powder, xylo-oligosaccharide and maltodextrin are added in active material dry powder, allotment is uniform, granulator is stirred,
Pelletizing machine whole grain；
（7）Granule is obtained using the aseptic filling and packing of particles packing machine；Packaging material are medical aluminum foil bag, packing shop air
Cleanliness factor is 100,000 grades, and temperature is 22 DEG C, humidity 52%.
A kind of jerusalem artichoke compound product embodiment extract powder of table 1 and nutritional ingredient
Above-mentioned main component detection method：
1st, energy：Using《National food safety standard prepackaged food nutritional labeling general rule》GB 28050-2011；
2nd, protein：Using《The measure of national food safety standard Protein in Food》GB 5009.5-2010；
3rd, fat：Using《The measure of fat in food》GB/T5009.6-2003；
4th, carbohydrate：Using《National food safety standard prepackaged food nutritional labeling general rule》GB 28050-2011；
5th, sodium：Using《The measure of potassium, sodium in food》GB/T5009.91-2003.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with
Modification, should all belong to covering scope of the invention.
Claims (3)
1. a kind of jerusalem artichoke compound product, it is characterised in that：Herbal raw material is counted by weight：3000 parts of jerusalem artichoke, Cordyceps militaris
2000 parts, 2000 parts of radix bardanae, 1500 parts of cassia seed, 1500 parts of Agricus blazei；Auxiliary material presses the percentage of herbal raw material gross weight
Meter：Royal jelly dried powder 10%, xylo-oligosaccharide 10%, maltodextrin 10%.
2. a kind of method for preparing jerusalem artichoke compound product as claimed in claim 1, it is characterised in that：By jerusalem artichoke, Cordyceps militaris, ox
These herbal raw materials of burdock root, cassia seed, Agricus blazei are through smashing, enzymolysis, CO2Supercritical extract purifying, filtering, concentration, spraying
Dry, add royal jelly dried powder, xylo-oligosaccharide, uniform maltodextrin these auxiliary materials allotment, granulation, packaging, granule is obtained.
3. method according to claim 2, it is characterised in that：Comprise the following steps：
（1）Herbal raw material jerusalem artichoke, Cordyceps militaris, radix bardanae, cassia seed and the Agricus blazei that will be cleaned are weighed, and are crushed, and sieving is crushed
Fineness is 30-60 mesh；
（2）Comminuted powder is soaked 1-2 hours with drinking water, solid-liquid ratio is 1：20-30, is subsequently adding herbal raw material weight 0.5-
1.0% cellulase, the amylase of 0.5-1.0%, the pectase of 0.5-1.0%, 50-60 DEG C of enzymolysis 90-120min；Described
Cellulase activity is 20000U/g, and amylase activity is 100000U/g, and pectinase activity is 30000U/g, enzyme 1-3mol/
The salt acid for adjusting pH of L is 5.0-6.5；Feed liquid is warming up to 100-110 DEG C after enzyme digestion reaction, is gone out enzyme 3-5 minutes, then by feed liquid
Using 80 mesh plate-frame filterings, filtrate must be digested standby；
（3）Enzymolysis filtrate is used into supercritical CO2Extraction equipment separating and extracting active material refined solution, extraction kettle pressure 28-
32MPa, separating still pressure 16-22MPa, rectifying column pressure 26-30MPa, CO2High pressure pump pressure 35-40MPah；
（4）Refined solution is concentrated using membrane filtration, membrane aperture is 200-300Da, operating pressure 0.8-1.0MPa, concentrate concentration
It is Brix=16.0-18.0%；
（5）Using low temperature spray drying, active material dry powder is obtained；Control parameter：Moisture evaporation rate 1000-1200ml/h, enters
100-120 DEG C of air temperature, 60-70 DEG C of leaving air temp, air compressor gas production 4.0m3/ h, operating pressure 0.6-0.7MPa；It is dry
Powder water content≤5%；
（6）Royal jelly dried powder, xylo-oligosaccharide and maltodextrin are added in active material dry powder, allotment is uniform, granulator is stirred,
Pelletizing machine whole grain；
（7）Granule is obtained using the aseptic filling and packing of particles packing machine；Packaging material are medical aluminum foil bag, packing shop air
Cleanliness factor is 100,000 grades, and temperature is 20-24 DEG C, humidity 50-55%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201611056001.3A CN106727888A (en) | 2016-11-26 | 2016-11-26 | A kind of jerusalem artichoke compound product and preparation method thereof |
Applications Claiming Priority (1)
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Cited By (4)
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| CN110301645A (en) * | 2019-06-18 | 2019-10-08 | 江苏碧青园海洋生物科技有限公司 | A kind of synanthrin composition and preparation method |
| TWI680762B (en) * | 2018-06-21 | 2020-01-01 | 大仁科技大學 | Peptide for inhibiting angiotensin converting enzyme, hydrolysate of cassia seeds, food composition or medical composition including the peptide and a use of the peptide thereof |
| CN111544565A (en) * | 2020-06-10 | 2020-08-18 | 福建华尔康生物科技有限公司 | Ginseng and spina date seed tablet compound product and preparation method thereof |
| CN115364138A (en) * | 2022-09-19 | 2022-11-22 | 博斯创想(上海)医疗科技有限公司 | Compound bacterial liquid for improving chemotherapy side effects and preparation method thereof |
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| CN1413673A (en) * | 2002-10-26 | 2003-04-30 | 乌兰浩特市植物保护植物检疫工作站 | Medicine for treating diabetes and its preparation method |
| CN104667021A (en) * | 2015-03-24 | 2015-06-03 | 福建天斯顿生物科技有限公司 | Compound product containing bamboo leaf flavonoid and preparation method thereof |
| CN106107375A (en) * | 2016-07-01 | 2016-11-16 | 萧方道 | Folium Bambosae flavone extracts and prepares this Folium Bambosae flavone health promoting beverage and the method for beverage |
| CN110079420A (en) * | 2019-05-07 | 2019-08-02 | 青岛大学 | A kind of preparation method of jerusalem artichoke health red rice rice wine |
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| CN1413673A (en) * | 2002-10-26 | 2003-04-30 | 乌兰浩特市植物保护植物检疫工作站 | Medicine for treating diabetes and its preparation method |
| CN104667021A (en) * | 2015-03-24 | 2015-06-03 | 福建天斯顿生物科技有限公司 | Compound product containing bamboo leaf flavonoid and preparation method thereof |
| CN106107375A (en) * | 2016-07-01 | 2016-11-16 | 萧方道 | Folium Bambosae flavone extracts and prepares this Folium Bambosae flavone health promoting beverage and the method for beverage |
| CN110079420A (en) * | 2019-05-07 | 2019-08-02 | 青岛大学 | A kind of preparation method of jerusalem artichoke health red rice rice wine |
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| TWI680762B (en) * | 2018-06-21 | 2020-01-01 | 大仁科技大學 | Peptide for inhibiting angiotensin converting enzyme, hydrolysate of cassia seeds, food composition or medical composition including the peptide and a use of the peptide thereof |
| CN110301645A (en) * | 2019-06-18 | 2019-10-08 | 江苏碧青园海洋生物科技有限公司 | A kind of synanthrin composition and preparation method |
| CN111544565A (en) * | 2020-06-10 | 2020-08-18 | 福建华尔康生物科技有限公司 | Ginseng and spina date seed tablet compound product and preparation method thereof |
| CN115364138A (en) * | 2022-09-19 | 2022-11-22 | 博斯创想(上海)医疗科技有限公司 | Compound bacterial liquid for improving chemotherapy side effects and preparation method thereof |
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Application publication date: 20170531 |