CN107002052B - 流感a病毒变体 - Google Patents

流感a病毒变体 Download PDF

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Publication number
CN107002052B
CN107002052B CN201580063468.8A CN201580063468A CN107002052B CN 107002052 B CN107002052 B CN 107002052B CN 201580063468 A CN201580063468 A CN 201580063468A CN 107002052 B CN107002052 B CN 107002052B
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influenza
virus
polymerase
amino acid
compound
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Expired - Fee Related
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CN201580063468.8A
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Chinese (zh)
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CN107002052A (zh
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J·R·里曼
R·伯恩
H·B·本奈特
D·J·巴特尔斯
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N9/10—Transferases (2.)
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    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07048—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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CN201580063468.8A 2014-10-02 2015-10-01 流感a病毒变体 Expired - Fee Related CN107002052B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462058945P 2014-10-02 2014-10-02
US62/058,945 2014-10-02
PCT/US2015/053393 WO2016054312A1 (en) 2014-10-02 2015-10-01 Influenza a virus variants

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CN107002052A CN107002052A (zh) 2017-08-01
CN107002052B true CN107002052B (zh) 2021-10-15

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US (1) US10801077B2 (enExample)
EP (1) EP3201221A1 (enExample)
JP (1) JP6953307B2 (enExample)
CN (1) CN107002052B (enExample)
CA (1) CA2963076A1 (enExample)
MA (1) MA40773A (enExample)
WO (1) WO2016054312A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3068782B1 (en) 2013-11-13 2018-05-23 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
ES2741444T3 (es) 2013-11-13 2020-02-11 Vertex Pharma Inhibidores de la replicación de virus de la gripe
MA40772A (fr) * 2014-10-02 2017-08-08 Vertex Pharma Variants du virus de la grippe a
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
CN106929482A (zh) * 2015-12-31 2017-07-07 北京大学 定点突变的流感病毒、其活疫苗及其制备方法和应用

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MA40772A (fr) 2014-10-02 2017-08-08 Vertex Pharma Variants du virus de la grippe a
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Publication number Publication date
CN107002052A (zh) 2017-08-01
JP6953307B2 (ja) 2021-10-27
MA40773A (fr) 2017-08-08
US20170204479A1 (en) 2017-07-20
US10801077B2 (en) 2020-10-13
WO2016054312A1 (en) 2016-04-07
JP2017537605A (ja) 2017-12-21
CA2963076A1 (en) 2016-04-07
EP3201221A1 (en) 2017-08-09

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