CN107002029A - 用于干细胞培养和治疗的诱导培养基和方法 - Google Patents

用于干细胞培养和治疗的诱导培养基和方法 Download PDF

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CN107002029A
CN107002029A CN201580065072.7A CN201580065072A CN107002029A CN 107002029 A CN107002029 A CN 107002029A CN 201580065072 A CN201580065072 A CN 201580065072A CN 107002029 A CN107002029 A CN 107002029A
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stem cell
mescenchymal stem
cell colony
inducing culture
handled
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阿林·贝当古
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Cibo
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Commons Bio
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CN201580065072.7A 2014-10-01 2015-09-24 用于干细胞培养和治疗的诱导培养基和方法 Pending CN107002029A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/504,399 US20160095885A1 (en) 2014-10-01 2014-10-01 Induction Medium & Methods for Stem Cell Culture & Therapy
US14/504,399 2014-10-01
PCT/US2015/052029 WO2016053758A1 (en) 2014-10-01 2015-09-24 Induction medium and methods for stem cell culture and therapy

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CN107002029A true CN107002029A (zh) 2017-08-01

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US (6) US20160095885A1 (enIt.pdf)
EP (2) EP3201318B1 (enIt.pdf)
JP (3) JP6890538B2 (enIt.pdf)
KR (9) KR102636786B1 (enIt.pdf)
CN (1) CN107002029A (enIt.pdf)
AU (3) AU2015324241B2 (enIt.pdf)
CA (2) CA3000334A1 (enIt.pdf)
ES (1) ES2961691T3 (enIt.pdf)
MX (1) MX2017004288A (enIt.pdf)
RU (1) RU2717983C2 (enIt.pdf)
WO (1) WO2016053758A1 (enIt.pdf)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110121553A (zh) * 2016-10-27 2019-08-13 纽约哥伦比亚大学董事会 免疫抑制性间充质细胞及其形成方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160095885A1 (en) 2014-10-01 2016-04-07 WibiWorks Therapeutics, Inc. Induction Medium & Methods for Stem Cell Culture & Therapy
EP3386521A1 (en) 2015-12-07 2018-10-17 Colorado State University Research Foundation Activated stem cells and systemic treatment methods for infected wounds
KR102674158B1 (ko) * 2016-03-31 2024-06-10 샌바이오, 인크. 줄기 세포 배양 및 치료를 위한 배지, 방법, 세포 및 분비 인자
CN110177868A (zh) * 2016-10-06 2019-08-27 转基因纳米生物技术公司 用于癌症干细胞(csc)扩增的方法
EP3560527B1 (en) * 2016-12-16 2024-01-31 Regene Pharm Co., Ltd. Tissue healing agent
JP7430914B2 (ja) * 2018-08-29 2024-02-14 株式会社Regene Pharm がんの治療のための医薬組成物
KR102424237B1 (ko) 2018-10-30 2022-07-21 비타볼러스 인크. 치료용 포유동물 세포의 경구 전달
KR102460408B1 (ko) * 2020-07-23 2022-10-28 포항공과대학교 산학협력단 줄기세포 시트를 제조하는 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050265980A1 (en) * 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
CN101407790A (zh) * 2008-10-30 2009-04-15 浙江大学 一种增强人骨髓间充质干细胞旁分泌能力的处理方法
US20100008992A1 (en) * 2006-05-19 2010-01-14 Medistem Laboratories, Inc. Treatment of disc degenerative disease and compositions for same
US20140017787A1 (en) * 2010-10-11 2014-01-16 Aline M. Betancourt Mesenchymal stem cells and related therapies

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298863B1 (en) 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
US20110044958A1 (en) 2008-03-14 2011-02-24 The Board Of Trustees Of The University Of Illinois Activated mesenchymal stem cells for the prevention and repair of inflammatory states
DK2620493T3 (da) 2008-05-28 2019-07-01 Univ Ramot Mesenkymale stamceller til behandling af CNS-sygdomme
US8703487B2 (en) * 2009-12-01 2014-04-22 The Regents Of The University Of California Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
CN106692193B (zh) 2011-04-06 2021-01-05 桑比欧公司 用于调节外周免疫功能的方法和组合物
WO2012150707A1 (ja) 2011-05-02 2012-11-08 国立大学法人熊本大学 幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法
WO2013082543A1 (en) * 2011-11-30 2013-06-06 Advanced Cell Technology, Inc. Mesenchymal stromal cells and uses related thereto
US9725698B2 (en) * 2012-07-11 2017-08-08 Imstem Biotechnology, Inc. Trophoblast-derived mesenchymal stem cells (T-MSCs) produced from human embryonic stem cells, methods and uses thereof
US20160095885A1 (en) 2014-10-01 2016-04-07 WibiWorks Therapeutics, Inc. Induction Medium & Methods for Stem Cell Culture & Therapy
CN104845933A (zh) * 2015-05-15 2015-08-19 大连理工大学 一种增强脂肪间充质干细胞免疫学性能和迁移能力的方法
KR102674158B1 (ko) 2016-03-31 2024-06-10 샌바이오, 인크. 줄기 세포 배양 및 치료를 위한 배지, 방법, 세포 및 분비 인자

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050265980A1 (en) * 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
US20100008992A1 (en) * 2006-05-19 2010-01-14 Medistem Laboratories, Inc. Treatment of disc degenerative disease and compositions for same
CN101407790A (zh) * 2008-10-30 2009-04-15 浙江大学 一种增强人骨髓间充质干细胞旁分泌能力的处理方法
US20140017787A1 (en) * 2010-10-11 2014-01-16 Aline M. Betancourt Mesenchymal stem cells and related therapies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEON等: ""Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a"", 《BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110121553A (zh) * 2016-10-27 2019-08-13 纽约哥伦比亚大学董事会 免疫抑制性间充质细胞及其形成方法

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