CN107001310B - 麦芽酚铁的结晶形式 - Google Patents

麦芽酚铁的结晶形式 Download PDF

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Publication number
CN107001310B
CN107001310B CN201580052331.2A CN201580052331A CN107001310B CN 107001310 B CN107001310 B CN 107001310B CN 201580052331 A CN201580052331 A CN 201580052331A CN 107001310 B CN107001310 B CN 107001310B
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China
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degrees
polymorph
maltol
ferric
ferric maltol
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Chinese (zh)
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CN107001310A (zh
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D·P·蔡尔兹
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Medical Research Council
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Medical Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
CN201580052331.2A 2014-10-28 2015-10-23 麦芽酚铁的结晶形式 Active CN107001310B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1419174.6A GB2531742B (en) 2014-10-28 2014-10-28 Polymorphs of ferric maltol
GB1419174.6 2014-10-28
PCT/EP2015/074653 WO2016066555A1 (en) 2014-10-28 2015-10-23 Crystalline forms of ferric maltol

Publications (2)

Publication Number Publication Date
CN107001310A CN107001310A (zh) 2017-08-01
CN107001310B true CN107001310B (zh) 2020-05-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580052331.2A Active CN107001310B (zh) 2014-10-28 2015-10-23 麦芽酚铁的结晶形式

Country Status (18)

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US (1) US9802973B2 (enExample)
EP (1) EP3160951B1 (enExample)
JP (2) JP6404358B2 (enExample)
KR (1) KR102576930B1 (enExample)
CN (1) CN107001310B (enExample)
AU (1) AU2015340825B2 (enExample)
CA (1) CA2944210C (enExample)
CL (1) CL2017001030A1 (enExample)
EA (1) EA033323B1 (enExample)
ES (1) ES2661944T3 (enExample)
GB (1) GB2531742B (enExample)
IL (1) IL251863A0 (enExample)
MX (1) MX370730B (enExample)
PL (1) PL3160951T3 (enExample)
SA (1) SA517381406B1 (enExample)
SG (1) SG11201702639RA (enExample)
WO (1) WO2016066555A1 (enExample)
ZA (1) ZA201702136B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2531742B (en) 2014-10-28 2016-10-05 Iron Therapeutics Holdings Ag Polymorphs of ferric maltol
CN112574158B (zh) * 2020-12-29 2022-08-02 南京百泽医药科技有限公司 一种麦芽酚铁晶型ii及其制备方法
IT202100018578A1 (it) 2021-07-14 2023-01-14 Indena Spa Dispersione amorfa di maltolo ferrico e relativo processo di preparazione
WO2023047195A1 (en) * 2021-09-21 2023-03-30 Rk Pharma Inc. An improved process for the preparation of ferric maltol
CN119638662B (zh) * 2024-12-09 2025-11-14 金陵药业股份有限公司 一种麦芽酚铁-草酸共晶及其制备方法
CN119638661B (zh) * 2024-12-09 2025-11-14 金陵药业股份有限公司 一种麦芽酚铁-槲皮素共晶及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107458A1 (en) * 1982-10-22 1984-05-02 National Research Development Corporation Pharmaceutical compositions
US5028411A (en) * 1984-04-19 1991-07-02 National Research Development Corporation Pharmaceutical compositions
WO2003097627A1 (en) * 2002-05-18 2003-11-27 Vitra Pharmaceuticals Limited Method of forming iron hydroxypyrone compounds
CN103443091A (zh) * 2011-01-27 2013-12-11 阿文斯若皮帝克斯控股股份公司 方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE37534E1 (en) 1982-10-22 2002-01-29 Btg International Limited Pharmaceutical compositions
WO2014165607A2 (en) 2013-04-02 2014-10-09 Stealth Peptides International, Inc. Aromatic-cationic peptide formulations, compositions and methods of use
GB2531742B (en) 2014-10-28 2016-10-05 Iron Therapeutics Holdings Ag Polymorphs of ferric maltol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107458A1 (en) * 1982-10-22 1984-05-02 National Research Development Corporation Pharmaceutical compositions
US5028411A (en) * 1984-04-19 1991-07-02 National Research Development Corporation Pharmaceutical compositions
WO2003097627A1 (en) * 2002-05-18 2003-11-27 Vitra Pharmaceuticals Limited Method of forming iron hydroxypyrone compounds
CN103443091A (zh) * 2011-01-27 2013-12-11 阿文斯若皮帝克斯控股股份公司 方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis and Properties of Tri(3-hydroxy-2-methyl-4-pyronato) Complexes of Chromium(III), Manganese(III) and Iron(III);Hideyoshi MORITA et al.;《Chemistry Letters》;19751231(第4期);第339-342页 *

Also Published As

Publication number Publication date
BR112017008903A2 (pt) 2017-12-19
JP2017535510A (ja) 2017-11-30
US9802973B2 (en) 2017-10-31
CA2944210A1 (en) 2016-05-06
GB201419174D0 (en) 2014-12-10
PL3160951T3 (pl) 2018-07-31
CA2944210C (en) 2017-06-20
EP3160951A1 (en) 2017-05-03
CN107001310A (zh) 2017-08-01
IL251863A0 (en) 2017-06-29
GB2531742A (en) 2016-05-04
SA517381406B1 (ar) 2021-03-15
AU2015340825B2 (en) 2016-11-24
CL2017001030A1 (es) 2018-01-19
AU2015340825A1 (en) 2016-08-25
MX2017005413A (es) 2017-10-04
JP6678711B2 (ja) 2020-04-08
GB2531742B (en) 2016-10-05
US20170260222A1 (en) 2017-09-14
SG11201702639RA (en) 2017-05-30
WO2016066555A1 (en) 2016-05-06
JP6404358B2 (ja) 2018-10-10
EA201790667A1 (ru) 2017-08-31
JP2018197268A (ja) 2018-12-13
ES2661944T3 (es) 2018-04-04
EP3160951B1 (en) 2017-12-06
KR102576930B1 (ko) 2023-09-12
ZA201702136B (en) 2018-11-28
MX370730B (es) 2019-12-20
KR20170071446A (ko) 2017-06-23
EA033323B1 (ru) 2019-09-30

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Application publication date: 20170801

Assignee: JIANGSU AOSAIKANG PHARMACEUTICAL Co.,Ltd.

Assignor: MEDICAL RESEARCH COUNCIL

Contract record no.: X2022990000590

Denomination of invention: Crystalline form of iron maltol

Granted publication date: 20200522

License type: Exclusive License

Record date: 20220901