CN107001266A - 用于生产艾达鲁吡啶的方法 - Google Patents

用于生产艾达鲁吡啶的方法 Download PDF

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Publication number
CN107001266A
CN107001266A CN201580065028.6A CN201580065028A CN107001266A CN 107001266 A CN107001266 A CN 107001266A CN 201580065028 A CN201580065028 A CN 201580065028A CN 107001266 A CN107001266 A CN 107001266A
Authority
CN
China
Prior art keywords
compound
fluoro
mixture
solvent
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580065028.6A
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English (en)
Chinese (zh)
Inventor
M·F·贾科布森
O·尼尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority claimed from PCT/EP2015/079209 external-priority patent/WO2016091997A1/en
Publication of CN107001266A publication Critical patent/CN107001266A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201580065028.6A 2014-12-12 2015-12-10 用于生产艾达鲁吡啶的方法 Pending CN107001266A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201400721 2014-12-12
DKPA201400721 2014-12-12
PCT/EP2015/079209 WO2016091997A1 (en) 2014-12-12 2015-12-10 A process for the manufacture of idalopirdine

Publications (1)

Publication Number Publication Date
CN107001266A true CN107001266A (zh) 2017-08-01

Family

ID=59011415

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580065028.6A Pending CN107001266A (zh) 2014-12-12 2015-12-10 用于生产艾达鲁吡啶的方法

Country Status (13)

Country Link
EP (1) EP3230265A1 (ko)
JP (1) JP2017537128A (ko)
KR (1) KR20170093821A (ko)
CN (1) CN107001266A (ko)
AU (1) AU2015359347A1 (ko)
BR (1) BR112017012021A2 (ko)
CA (1) CA2968770A1 (ko)
CL (1) CL2017001466A1 (ko)
CO (1) CO2017005357A2 (ko)
IL (1) IL252471A0 (ko)
MA (1) MA41148A (ko)
MX (1) MX2017007510A (ko)
RU (1) RU2017120216A (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015362394C1 (en) 2014-12-12 2021-01-28 Japan Tobacco Inc. Dihydropyrimidine-2-one compounds and medicinal uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) * 1962-07-03 Process of making g-fluoro tryptamine
CN101677547A (zh) * 2007-03-23 2010-03-24 史密丝克莱恩比彻姆公司 作为ikk2抑制剂的吲哚甲酰胺
CN102656146A (zh) * 2009-12-23 2012-09-05 H.隆德贝克有限公司 药物活性剂的制造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) * 1962-07-03 Process of making g-fluoro tryptamine
CN101677547A (zh) * 2007-03-23 2010-03-24 史密丝克莱恩比彻姆公司 作为ikk2抑制剂的吲哚甲酰胺
US8071584B2 (en) * 2007-03-23 2011-12-06 Glaxosmithkline Llc Indole carboxamides as IKK2 inhibitors
CN102656146A (zh) * 2009-12-23 2012-09-05 H.隆德贝克有限公司 药物活性剂的制造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADAM T. GILLMORE，等: "Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor", 《ORG. PROCESS RES. DEV.》 *
SATHISH BOINI，等: "Development of a Manufacturing Process for 1-(1-Pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A Key Intermediate for Protein Kinase C Inhibitor LY317615", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 *

Also Published As

Publication number Publication date
KR20170093821A (ko) 2017-08-16
CL2017001466A1 (es) 2018-01-05
JP2017537128A (ja) 2017-12-14
CA2968770A1 (en) 2016-06-16
RU2017120216A (ru) 2019-01-15
CO2017005357A2 (es) 2017-09-20
MX2017007510A (es) 2017-08-22
IL252471A0 (en) 2017-07-31
EP3230265A1 (en) 2017-10-18
AU2015359347A1 (en) 2017-06-08
BR112017012021A2 (pt) 2018-03-13
MA41148A (fr) 2017-10-17

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Application publication date: 20170801