CN106999591A - 一种抗pd‑1抗体制剂及其在医药上的应用 - Google Patents

一种抗pd‑1抗体制剂及其在医药上的应用 Download PDF

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CN106999591A
CN106999591A CN201680003949.4A CN201680003949A CN106999591A CN 106999591 A CN106999591 A CN 106999591A CN 201680003949 A CN201680003949 A CN 201680003949A CN 106999591 A CN106999591 A CN 106999591A
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antibody
cancer
pharmaceutical preparation
polysorbate
trehalose dihydrate
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CN106999591B (zh
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李�杰
颜贞
王萍萍
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陶维康
张连山
孙飘扬
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Suzhou Rich Biological Medicine Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Abstract

一种稳定的抗PD‑1抗体药物制剂及其在医药上的应用。该抗PD‑1抗体药物制剂含有抗PD‑1抗体、缓冲剂，还可以含有至少一种稳定剂，任选的还可以含有表面活性剂。本发明的抗PD‑1抗体药物制剂可以有效地抑制抗体的聚集和脱酰胺作用，从而阻止抗体产品的降解，得到稳定的注射药物制剂。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN201680003949.4A 2015-09-28 2016-09-14 一种抗pd-1抗体制剂及其在医药上的应用 Active CN106999591B (zh)

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CN201510629020X 2015-09-28
CN201510629020 2015-09-28
PCT/CN2016/098982 WO2017054646A1 (zh) 2015-09-28 2016-09-14 一种抗pd-1抗体制剂及其在医药上的应用

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EP (1) EP3357508A4 (zh)
JP (1) JP6921062B2 (zh)
KR (1) KR20180054791A (zh)
CN (1) CN106999591B (zh)
AU (1) AU2016329960A1 (zh)
BR (1) BR112018005349A2 (zh)
CA (1) CA2999079A1 (zh)
MX (1) MX2018003306A (zh)
RU (1) RU2731418C2 (zh)
TW (1) TWI721020B (zh)
UA (1) UA124259C2 (zh)
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WO2021143767A1 (zh) * 2020-01-15 2021-07-22 信达生物制药(苏州)有限公司 结合pd-1和pd-l1的双特异性抗体的制剂及其用途
WO2021203769A1 (zh) * 2020-04-10 2021-10-14 江苏恒瑞医药股份有限公司 一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途
CN114632150A (zh) * 2017-11-02 2022-06-17 正大天晴药业集团股份有限公司 一种抗pd-l1人源化单克隆抗体的药物组合物

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