CN106999537B - 新颖α4β7肽单体和二聚体拮抗剂 - Google Patents

新颖α4β7肽单体和二聚体拮抗剂 Download PDF

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CN106999537B
CN106999537B CN201580064273.5A CN201580064273A CN106999537B CN 106999537 B CN106999537 B CN 106999537B CN 201580064273 A CN201580064273 A CN 201580064273A CN 106999537 B CN106999537 B CN 106999537B
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CN106999537A (zh
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艾少克·伯翰德瑞
迪奈施·V·帕特尔
吉尼特·泽梅德
莱瑞·C·马赛艾克斯
刘永鸿
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Protagonist Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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CN201580064273.5A 2014-10-01 2015-10-01 新颖α4β7肽单体和二聚体拮抗剂 Active CN106999537B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462058506P 2014-10-01 2014-10-01
US201462058510P 2014-10-01 2014-10-01
US62/058,510 2014-10-01
US62/058,506 2014-10-01
US201562149257P 2015-04-17 2015-04-17
US62/149,257 2015-04-17
US201562192934P 2015-07-15 2015-07-15
US62/192,934 2015-07-15
PCT/US2015/053558 WO2016054411A1 (en) 2014-10-01 2015-10-01 NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS

Publications (2)

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CN106999537A CN106999537A (zh) 2017-08-01
CN106999537B true CN106999537B (zh) 2020-01-31

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US (5) US9809623B2 (OSRAM)
EP (1) EP3200812B8 (OSRAM)
JP (1) JP2017535527A (OSRAM)
KR (1) KR20170108936A (OSRAM)
CN (1) CN106999537B (OSRAM)
AU (1) AU2015328002A1 (OSRAM)
BR (1) BR112017006826A2 (OSRAM)
CA (1) CA2962642A1 (OSRAM)
IL (1) IL251260A0 (OSRAM)
MX (1) MX391184B (OSRAM)
RU (1) RU2017114414A (OSRAM)
SG (1) SG11201702553RA (OSRAM)
WO (1) WO2016054411A1 (OSRAM)

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CN113621027A (zh) 2014-05-16 2021-11-09 领导医疗有限公司 α4β7整联蛋白硫醚肽拮抗剂
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AU2021205415A1 (en) * 2020-01-10 2022-07-21 Protagonist Therapeutics, Inc. Methods for treating inflammatory bowel diseases with α4β7 integrin antagonists
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