CN106986916A - 全自动高效固相多肽合成仪及使用方法 - Google Patents
全自动高效固相多肽合成仪及使用方法 Download PDFInfo
- Publication number
- CN106986916A CN106986916A CN201710374202.6A CN201710374202A CN106986916A CN 106986916 A CN106986916 A CN 106986916A CN 201710374202 A CN201710374202 A CN 201710374202A CN 106986916 A CN106986916 A CN 106986916A
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- peptide synthesizer
- phase peptide
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 115
- 239000007790 solid phase Substances 0.000 title claims abstract description 88
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000007246 mechanism Effects 0.000 claims abstract description 153
- 239000007788 liquid Substances 0.000 claims abstract description 51
- 238000006243 chemical reaction Methods 0.000 claims abstract description 50
- 238000010438 heat treatment Methods 0.000 claims abstract description 43
- 150000001413 amino acids Chemical class 0.000 claims abstract description 33
- 238000005286 illumination Methods 0.000 claims abstract description 30
- 229920001184 polypeptide Polymers 0.000 claims abstract description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 18
- 239000007858 starting material Substances 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 26
- 230000001276 controlling effect Effects 0.000 claims description 25
- 238000009434 installation Methods 0.000 claims description 23
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- 230000015572 biosynthetic process Effects 0.000 claims description 15
- 230000008520 organization Effects 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- 208000006011 Stroke Diseases 0.000 claims description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 238000010511 deprotection reaction Methods 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 238000003786 synthesis reaction Methods 0.000 claims description 9
- 230000006698 induction Effects 0.000 claims description 6
- 230000033001 locomotion Effects 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 230000000712 assembly Effects 0.000 claims description 4
- 238000000429 assembly Methods 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 4
- 241000258971 Brachiopoda Species 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000002699 waste material Substances 0.000 claims description 3
- 238000010926 purge Methods 0.000 claims description 2
- 230000003760 hair shine Effects 0.000 claims 1
- 238000010276 construction Methods 0.000 description 6
- 238000007599 discharging Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000005611 electricity Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 230000005693 optoelectronics Effects 0.000 description 4
- 230000004913 activation Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 241000486679 Antitype Species 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
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- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (2)
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CN201720271364 | 2017-03-20 | ||
CN2017202713642 | 2017-03-20 |
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CN106986916A true CN106986916A (zh) | 2017-07-28 |
CN106986916B CN106986916B (zh) | 2023-10-13 |
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CN201710374202.6A Active CN106986916B (zh) | 2017-03-20 | 2017-05-24 | 全自动高效固相多肽合成仪及使用方法 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110111907A (zh) * | 2019-05-10 | 2019-08-09 | 苏州市海崴生物科技有限公司 | 智能数字多肽合成系统 |
CN110283229A (zh) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | 一种用于多肽药物的生产系统 |
CN111072750A (zh) * | 2018-10-22 | 2020-04-28 | 海南建邦制药科技有限公司 | 多肽合成仪及其控制系统 |
CN111072749A (zh) * | 2018-10-22 | 2020-04-28 | 海南建邦制药科技有限公司 | 多肽合成仪 |
CN112661806A (zh) * | 2021-03-16 | 2021-04-16 | 北京曜和生物科技有限公司 | 一种稳定型多肽制备装置 |
CN113769700A (zh) * | 2021-08-30 | 2021-12-10 | 长沙缔仑生物科技有限公司 | 一种dna/rna工业型全自动合成仪 |
CN114130346A (zh) * | 2021-02-02 | 2022-03-04 | 申联生物医药(上海)股份有限公司 | 全自动固相有机合成模块化设备 |
CN114853876A (zh) * | 2022-06-08 | 2022-08-05 | 开封明仁药业有限公司 | 一种胸腺法新原料制备用多肽合成仪 |
CN115232189A (zh) * | 2022-09-20 | 2022-10-25 | 核欣(苏州)医药科技有限公司 | 一种防污染输料的自动化多肽合成方法、仪器及系统 |
Citations (10)
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CN201343510Y (zh) * | 2009-01-08 | 2009-11-11 | 苏州中科天马肽工程中心有限公司 | 半自动多通道固相多肽合成仪 |
CN201459000U (zh) * | 2009-07-31 | 2010-05-12 | 江苏万邦生化医药股份有限公司 | 固相多肽的合成装置 |
CN102532252A (zh) * | 2012-03-09 | 2012-07-04 | 百奇生物科技(苏州)有限公司 | 高通量多肽合成的方法及其装置 |
CN202543113U (zh) * | 2012-03-28 | 2012-11-21 | 四川富正源生物科技有限公司 | 固相多肽合成仪 |
CN203212512U (zh) * | 2013-04-09 | 2013-09-25 | 苏州强耀生物科技有限公司 | 红外加热新型固相多肽合成仪 |
CN205011679U (zh) * | 2015-08-07 | 2016-02-03 | 天津赛瑞多肽科技有限公司 | 一种多通道全自动多肽合成仪 |
CN205088163U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 温度可控的多肽固相合成系统 |
CN205088164U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 便于排出废液的多肽固相合成系统 |
CN205088166U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 集成式多肽固相合成系统 |
CN106317163A (zh) * | 2016-08-23 | 2017-01-11 | 安徽天达谱申生物科技有限公司 | 一种高效自动化的多肽合成方法 |
-
2017
- 2017-05-24 CN CN201710374202.6A patent/CN106986916B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN201343510Y (zh) * | 2009-01-08 | 2009-11-11 | 苏州中科天马肽工程中心有限公司 | 半自动多通道固相多肽合成仪 |
CN201459000U (zh) * | 2009-07-31 | 2010-05-12 | 江苏万邦生化医药股份有限公司 | 固相多肽的合成装置 |
CN102532252A (zh) * | 2012-03-09 | 2012-07-04 | 百奇生物科技(苏州)有限公司 | 高通量多肽合成的方法及其装置 |
CN202543113U (zh) * | 2012-03-28 | 2012-11-21 | 四川富正源生物科技有限公司 | 固相多肽合成仪 |
CN203212512U (zh) * | 2013-04-09 | 2013-09-25 | 苏州强耀生物科技有限公司 | 红外加热新型固相多肽合成仪 |
CN205011679U (zh) * | 2015-08-07 | 2016-02-03 | 天津赛瑞多肽科技有限公司 | 一种多通道全自动多肽合成仪 |
CN205088163U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 温度可控的多肽固相合成系统 |
CN205088164U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 便于排出废液的多肽固相合成系统 |
CN205088166U (zh) * | 2015-11-06 | 2016-03-16 | 河南工程学院 | 集成式多肽固相合成系统 |
CN106317163A (zh) * | 2016-08-23 | 2017-01-11 | 安徽天达谱申生物科技有限公司 | 一种高效自动化的多肽合成方法 |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111072750B (zh) * | 2018-10-22 | 2023-04-18 | 海南建邦制药科技有限公司 | 多肽合成仪及其控制系统 |
CN111072750A (zh) * | 2018-10-22 | 2020-04-28 | 海南建邦制药科技有限公司 | 多肽合成仪及其控制系统 |
CN111072749A (zh) * | 2018-10-22 | 2020-04-28 | 海南建邦制药科技有限公司 | 多肽合成仪 |
CN111072749B (zh) * | 2018-10-22 | 2023-07-07 | 海南建邦制药科技有限公司 | 多肽合成仪 |
CN110111907A (zh) * | 2019-05-10 | 2019-08-09 | 苏州市海崴生物科技有限公司 | 智能数字多肽合成系统 |
CN110283229A (zh) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | 一种用于多肽药物的生产系统 |
CN114130346A (zh) * | 2021-02-02 | 2022-03-04 | 申联生物医药(上海)股份有限公司 | 全自动固相有机合成模块化设备 |
CN112661806A (zh) * | 2021-03-16 | 2021-04-16 | 北京曜和生物科技有限公司 | 一种稳定型多肽制备装置 |
CN112661806B (zh) * | 2021-03-16 | 2021-06-04 | 郭叶 | 一种稳定型多肽制备装置 |
CN113769700A (zh) * | 2021-08-30 | 2021-12-10 | 长沙缔仑生物科技有限公司 | 一种dna/rna工业型全自动合成仪 |
CN114853876A (zh) * | 2022-06-08 | 2022-08-05 | 开封明仁药业有限公司 | 一种胸腺法新原料制备用多肽合成仪 |
CN114853876B (zh) * | 2022-06-08 | 2024-04-26 | 开封明仁药业有限公司 | 一种胸腺法新原料制备用多肽合成仪 |
CN115232189B (zh) * | 2022-09-20 | 2023-01-17 | 核欣(苏州)医药科技有限公司 | 一种防污染输料的自动化多肽合成方法、仪器及系统 |
CN115232189A (zh) * | 2022-09-20 | 2022-10-25 | 核欣(苏州)医药科技有限公司 | 一种防污染输料的自动化多肽合成方法、仪器及系统 |
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CN106986916B (zh) | 2023-10-13 |
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Effective date of registration: 20240328 Address after: Room 1201, 12th Floor, Material Building, No. 1164 East Jiuzhou Avenue, Jida, Zhuhai City, Guangdong Province, 519015 Patentee after: Zhuhai Tianhe Chemical Co.,Ltd. Country or region after: China Address before: Zhuhai Baishirui Life Technology Co., Ltd., Room 1202, 12th Floor, Material Building, No. 1164 East Jiuzhou Avenue, Jida, Zhuhai City, Guangdong Province, 519015 Patentee before: ZHUHAI LIFE SCIENCE LTD. Country or region before: China |
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Denomination of invention: Fully automatic and efficient solid-phase peptide synthesizer and its usage method Granted publication date: 20231013 Pledgee: China Postal Savings Bank Co.,Ltd. Zhuhai Xiangzhou Branch Pledgor: Zhuhai Tianhe Chemical Co.,Ltd. Registration number: Y2024980028998 |