CN106983725A - A kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol - Google Patents
A kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol Download PDFInfo
- Publication number
- CN106983725A CN106983725A CN201710236594.XA CN201710236594A CN106983725A CN 106983725 A CN106983725 A CN 106983725A CN 201710236594 A CN201710236594 A CN 201710236594A CN 106983725 A CN106983725 A CN 106983725A
- Authority
- CN
- China
- Prior art keywords
- extract
- pvpp
- weight
- granule
- dry granulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol, belongs to technical field of traditional Chinese medicine preparation.The method for the molten extract content of raising Chinese medicinal granule alcohol that the present invention is provided is to add PVPP to the Chinese medicinal granule for treating dry granulation, and the Chinese medicinal granule is the traditional Chinese medicine extraction composition granule or Chinese medicinal granule rich in volatile oil component, rich in ter penoidses, rich in carbohydrate content.The inventive method effectively prevents the problem of molten extract of alcohol is significantly reduced in the dry granulation of Chinese medicinal granule, and simple to operate, and cost is low, it is easy to easy to spread for the receiving at heart of user.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to using pharmaceutic adjuvant improve traditional Chinese medicine extraction composition granule or in
The method of the molten extract content of medicine composition particle alcohol.
Background technology
Chinese medicinal granule is using traditional Chinese medicine medicine materical crude slice as raw material, by extracting and developing, concentration, drying, granulation, packaging
Etc. production technology, a kind of unified specification being processed into, unitized dose amounts, the new formulation medication of unified mass standard.
Current Chinese medicinal granule mainly uses dry granulation, and simultaneously containing compositions such as volatile oil, terpene, polysaccharides
In two or more composition Chinese medicinal granule extract, there is dry method system in such as rhizoma cyperi, the bighead atractylodes rhizome, rattletop kind
The problem of molten extract of alcohol is remarkably decreased after grain.The molten extract of alcohol in the dry granulation of Chinese medicinal granule is prevented significantly to drop at present
Low method is using adjusting process parameter mostly or adds a large amount of auxiliary materials, and dry granulation is prevented by adjusting process parameter
The middle significantly reduced mode complex operation of the molten extract of alcohol, cost is high, should not promote, and prevents to do by adding a large amount of auxiliary materials
The significantly reduced mode of the molten extract of alcohol in method granulation, such as adds 50-80% maltodextrin, due to containing substantial amounts of auxiliary material shadow
Ring the actual effectiveness of medicine and the acceptance level at heart of user.The two result is unsatisfactory.Therefore, it is badly in need of a kind of behaviour
Make simple, and Chinese medicinal granule extract dry method can be significantly improved to make pellet the method for the molten extract content of alcohol.
The content of the invention
Therefore, the technical problem to be solved in the present invention is to overcome of the prior art for the dry of prevention Chinese medicinal granule
The molten extract of alcohol is that, using adjusting process parameter because of complex operation, cost is high mostly the problem of significantly reduce in method granulation,
Should not promote, or a large amount of auxiliary materials of addition and cause the acceptance level at heart of the actual effectiveness and user that influences medicine
Defect, so as to provide a kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol.
Therefore, the present invention provides you following technical scheme：
A kind of method for improving the molten extract content of Chinese medicinal granule alcohol, crosslinking is added into the Chinese medicinal granule for treat dry granulation
PVP, the Chinese medicinal granule for rich in volatile oil component, rich in ter penoidses, rich in carbohydrate content Chinese medical extract or in
Medicine composition particle.
The addition of the PVPP is Chinese medical extract or the 3%-7% of Chinese medicinal granule extract weight.
The particle diameter of the PVPP is 30 μm -150 μm.
The particle diameter of the PVPP of the PVPP is 90-100 μm.
The PVPP that parts by weight are added into Chinese medical extract or Chinese medicinal granule extract is comprised the concrete steps that, is mixed
Close and pelletized in uniform rearmounted dry granulating machine.
The reduction of the molten extract of alcohol in the new application of PVPP, the dry granulation to prevent Chinese medicinal granule.
PVPP is added into the Chinese medical extract or Chinese medicinal granule for treating dry granulation.
The addition of the PVPP is Chinese medical extract or the 3%-7% of Chinese medicinal granule extract weight.
The particle diameter of the PVPP of the PVPP is 30 μm -150 μm.
Specific addition manner is the crosslinking that weight is added into Chinese medical extract or Chinese medicinal granule extract
PVP, is well mixed in rearmounted dry granulating machine and pelletizes.
Compared with prior art, tool has the advantage that the method for the present invention：
1st, the method for the raising molten extract content of Chinese medicinal granule alcohol that the present invention is provided, technique is simple, it is only necessary in dry method
A small amount of PVPP is added before granulation into Chinese medical extract or Chinese medicinal granule extract to be well mixed, operation letter
It is single.
2nd, the PVPP that is added in the method for the molten extract content of raising Chinese medicinal granule alcohol that the present invention is provided
Particle diameter is 30 μm -150 μm, compared with the PVPP of other particle diameters, and the PVPP particle of particle diameter of the present invention is being improved
Effect in terms of the molten extract content of Chinese medicinal granule alcohol is obvious.
The addition of the PVPP is Chinese medical extract or the 3%-7% of Chinese medicinal granule extract weight.
3rd, the pharmaceutic adjuvant that the method for the molten extract content of raising Chinese medicinal granule alcohol that the present invention is provided is added only has one kind
That is PVPP, and the supplementary product consumption added only has 3%-7%, production cost is reduced, while the molten extract content energy of alcohol
Improve 5%-15%.
4th, pharmaceutic adjuvant crosslinking used in the method for the raising molten extract content of Chinese medicinal granule alcohol that the present invention is provided is poly-
It is conventional auxiliary material to tie up ketone, non-toxic and adverse reaction after taking.
Embodiment
Following embodiments is provided it is preferably to further understand the present invention, it is not limited to the optimal embodiment party
Formula, is not construed as limiting to present disclosure and protection domain, anyone the present invention enlightenment under or by the present invention and its
The feature of his prior art be combined and draw it is any with the present invention it is same or like as product, all fall within the present invention
Within protection domain.
Unreceipted specific experiment step or condition person in embodiment, according to the normal experiment described by document in the art
The operation of step or condition can be carried out.Agents useful for same or the unreceipted production firm person of instrument, are that can be obtained by purchased in market
Conventional reagent product.
Explanation：
Embodiment 1-7 is the experiment of the granule kind rich in volatile oil component；Embodiment 8-10 be rich in terpene into
The experiment for the granule kind divided；Embodiment 11-18 is the granule kind rich in carbohydrate content (carbohydrate)
Experiment.
Embodiment 3 by the rhizoma cyperi granule extract to dry granulation add particle diameter be 20,30,35,50,90,
100th, 150,160 μm of 5% PVPP further demonstrates the PVPP of different-grain diameter and rhizoma cyperi granule is carried
The influence of the molten extract content of alcohol in thing is taken, inventor has also done identical to the Chinese medicinal granule of other embodiment before the applying date
Contrast experiment, effect and embodiment 3 quite, are herein no longer tired out one by one to be stated.
Reagent source：
Particle diameter is 30 μm of PVPP：Source businessman and model：The XL-10 types of ISP companies；
Particle diameter is 100 μm of PVPP：Source businessman and model：The XL types of ISP companies；
Particle diameter is 150 μm of PVPP：Source businessman and model：German BASF kollidon CL, PVPP
XL；
Particle diameter is 160 μm of PVPP：Originate Anhui Shanhe Medical Accessary Material Co., Ltd. of businessman, and specifications and models are super
Thick level PVPP；
Particle diameter is 20 μm of PVPP：Originate businessman BASF, and specifications and models are ultra-fine level PVPPs；
Particle diameter is 50 μm of PVPP：Source businessman and model：German BASF kollidon CL, PVPP
XL-F；
Particle diameter is 35 μm of PVPP：Source businessman and model：Dongguan City Hua Yuekeming trade Co., Ltds, rule
Lattice model PVPP-F；
Particle diameter is 90 μm of PVPP：Source businessman and model：Dongguan City Hua Yuekeming trade Co., Ltds, rule
Lattice model PVPP-R.
Embodiment 1：White atractylodes rhizome dispensing granule extract dry granulation
The preparation of white atractylodes rhizome dispensing granule
White atractylodes rhizome dispensing granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take white atractylodes rhizome dispensing granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take white atractylodes rhizome dispensing granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take white atractylodes rhizome dispensing granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take white atractylodes rhizome dispensing granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：20rpm；Disk roller speed：4rpm；Disk roller pressure：10MPa
The white atractylodes rhizome dispensing granule extract dry granulation extract content of table 1
Test result indicates that：The extract content for adding white atractylodes rhizome dispensing granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 2：Rhizoma cyperi granule extract dry granulation
Rhizoma cyperi granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take rhizoma cyperi granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take rhizoma cyperi granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take rhizoma cyperi granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, mix well mixed
Dry granulation, is made sample IV afterwards.
Take rhizoma cyperi granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：15rpm；Disk roller speed：4rpm；Disk roller pressure：9MPa
The rhizoma cyperi granule extract dry granulation extract content of table 2
Test result indicates that：The extract content for adding rhizoma cyperi granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 3：Rhizoma cyperi granule extract dry granulation
Rhizoma cyperi granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP (30 μm of particle diameter) is added, is mixed
Uniform rear dry granulation is closed, sample II is made.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP (50 μm of particle diameter) is added, is mixed
Uniform rear dry granulation is closed, sample III is made.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition (100 μm of particle diameter),
Well mixed rear dry granulation is mixed, sample IV is made.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition (150 μm of particle diameter),
Dry granulation after well mixed, is made sample V.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP (20 μm of particle diameter) is added, is mixed
Uniform rear dry granulation is closed, sample VI is made.
Rhizoma cyperi granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition (160 μm of particle diameter),
Dry granulation after well mixed, is made sample VI.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：15rpm；Disk roller speed：4rpm；Disk roller pressure：9MPa
The rhizoma cyperi granule extract dry granulation extract content of table 2
Test result indicates that：It is rhizoma cyperi granule extract dry granulation particle after 30 μm of -150 μm of auxiliary materials to add particle diameter
Extract content significantly improve, and it is rhizoma cyperi granule extract dry granulation after 100 μm of -150 μm of auxiliary materials to add particle diameter
The extract content of particle improves more obvious.
Embodiment 4：Pogostemon cablin granule extract dry granulation
Pogostemon cablin granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Pogostemon cablin granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Pogostemon cablin granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Pogostemon cablin granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP is added, mixing is mixed equal
Even rear dry granulation, is made sample IV.
Pogostemon cablin granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：25rpm；Disk roller speed：4rpm；Disk roller pressure：7.5MPa
The Pogostemon cablin granule extract dry granulation extract content of table 3
Test result indicates that：The extract content for adding Pogostemon cablin granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 5：Grass-leaved sweetflag granule extract dry granulation
Grass-leaved sweetflag granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Grass-leaved sweetflag granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Grass-leaved sweetflag granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Grass-leaved sweetflag granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP is added, mixing is mixed equal
Even rear dry granulation, is made sample IV.
Grass-leaved sweetflag granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：25rpm；Disk roller speed：4rpm；Disk roller pressure：7MPa
The grass-leaved sweetflag granule extract dry granulation extract content of table 4
Test result indicates that：The extract content for adding grass-leaved sweetflag granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 6：Lianqiao Extracts extract dry granulation
Lianqiao Extracts extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take Lianqiao Extracts extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take Lianqiao Extracts extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take Lianqiao Extracts extract (crossing 80 mesh sieves), by weight 5% PVPP is added, mix well mixed
Dry granulation, is made sample IV afterwards.
Take Lianqiao Extracts extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：17rpm；Disk roller speed：4.5rpm；Disk roller pressure：7.5MPa
The Lianqiao Extracts extract dry granulation extract content of table 5
Test result indicates that：The extract content for adding Lianqiao Extracts extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 7：Peppermint prescription particle extract dry granulation
Peppermint prescription particle extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take peppermint prescription particle extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take peppermint prescription particle extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take peppermint prescription particle extract (crossing 80 mesh sieves), by weight 5% PVPP is added, mix well mixed
Dry granulation, is made sample IV afterwards.
Take peppermint prescription particle extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：17rpm；Disk roller speed：4rpm；Disk roller pressure：7MPa
The peppermint prescription particle extract dry granulation extract content of table 6
Test result indicates that：The extract content for adding peppermint prescription particle extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 8：Rhizoma cimicifugae formula granules extract dry granulation
Rhizoma cimicifugae formula granules extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take Rhizoma cimicifugae formula granules extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take Rhizoma cimicifugae formula granules extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take Rhizoma cimicifugae formula granules extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take Rhizoma cimicifugae formula granules extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：60rpm；Disk roller speed：3.5rpm；Disk roller pressure：6MPa
The Rhizoma cimicifugae formula granules extract dry granulation extract content of table 8
Test result indicates that：The extract content for adding Rhizoma cimicifugae formula granules extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 9：Rhizoma alismatis granule extract dry granulation
Rhizoma alismatis granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take rhizoma alismatis granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take rhizoma alismatis granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take rhizoma alismatis granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take rhizoma alismatis granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：60rpm；Disk roller speed：3.5rpm；Disk roller pressure：6MPa
The rhizoma alismatis granule extract dry granulation extract content of table 9
Test result indicates that：The extract content for adding rhizoma alismatis granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 10：Fructus gardenia dispensing granule extract dry granulation
Fructus gardenia dispensing granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take fructus gardenia dispensing granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take fructus gardenia dispensing granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take fructus gardenia dispensing granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take fructus gardenia dispensing granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：40rpm；Disk roller speed：3rpm；Disk roller pressure：8MPa
The fructus gardenia dispensing granule extract dry granulation extract content of table 10
Test result indicates that：The extract content for adding fructus gardenia dispensing granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 11：Radix scrophulariae granule extract dry granulation
Radix scrophulariae granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take radix scrophulariae granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take radix scrophulariae granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take radix scrophulariae granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take radix scrophulariae granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：30rpm；Disk roller speed：6rpm；Disk roller pressure：7.5MPa
The radix scrophulariae granule extract dry granulation extract content of table 11
Test result indicates that：The extract content for adding radix scrophulariae granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 12：Asparagus formulation Particulate Extract dry granulation
Asparagus formulation Particulate Extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take asparagus formulation Particulate Extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take asparagus formulation Particulate Extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take asparagus formulation Particulate Extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take asparagus formulation Particulate Extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：60rpm；Disk roller speed：3.5rpm；Disk roller pressure：6MPa
The asparagus formulation Particulate Extract dry granulation extract content of table 12
Test result indicates that：The extract content for adding asparagus fern granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 13：Reed rhizome granule extract dry granulation
Reed rhizome granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take reed rhizome granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take reed rhizome granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take reed rhizome granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take reed rhizome granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：60rpm；Disk roller speed：3.5rpm；Disk roller pressure：6MPa
The reed rhizome granule extract dry granulation extract content of table 13
Test result indicates that：The extract content for adding reed rhizome granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 14：Smilax granule extract dry granulation
Fetch earth Poria cocos granule extract (crossing 80 mesh sieves) directly dry granulation, and sample I is made.
Fetch earth Poria cocos granule extract (crossing 80 mesh sieves), by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Fetch earth Poria cocos granule extract (crossing 80 mesh sieves), by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Fetch earth Poria cocos granule extract (crossing 80 mesh sieves), by weight 5% PVPP of addition, after being well mixed
Dry granulation, is made sample IV.
Fetch earth Poria cocos granule extract (crossing 80 mesh sieves), by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：30rpm；Disk roller speed：4rpm；Disk roller pressure：6.5MPa
The smilax granule extract dry granulation extract content of table 14
Test result indicates that：The extract content for adding smilax granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 15：Root bark of shaggy-fruited dittany granule extract dry granulation
Root bark of shaggy-fruited dittany granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Root bark of shaggy-fruited dittany granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Root bark of shaggy-fruited dittany granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Root bark of shaggy-fruited dittany granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition, after being well mixed
Dry granulation, is made sample IV.
Root bark of shaggy-fruited dittany granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：30rpm；Disk roller speed：4rpm；Disk roller pressure：7.5MPa
The root bark of shaggy-fruited dittany granule extract dry granulation extract content of table 15
Test result indicates that：The extract content for adding root bark of shaggy-fruited dittany granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 16：Sealwort granule extract dry granulation
Sealwort granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Take sealwort granule extract (crossing 80 mesh sieves), by weight 1% PVPP is added, done after being well mixed
Method is pelletized, and sample II is made.
Take sealwort granule extract (crossing 80 mesh sieves), by weight 3% PVPP is added, done after being well mixed
Method is pelletized, and sample III is made.
Take sealwort granule extract (crossing 80 mesh sieves), by weight 5% PVPP is added, done after being well mixed
Method is pelletized, and sample IV is made.
Take sealwort granule extract (crossing 80 mesh sieves), by weight 7% PVPP is added, done after being well mixed
Method is pelletized, and sample V is made.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：17rpm；Disk roller speed：6.5rpm；Disk roller pressure：8MPa
The sealwort granule extract dry granulation extract content of table 16
Test result indicates that：The extract content for adding sealwort granule extract dry granulation particle after auxiliary material is notable
Improve.
Embodiment 17：Medlar dispensing granule extract dry granulation
Medlar dispensing granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Medlar dispensing granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Medlar dispensing granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Medlar dispensing granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition, after being well mixed
Dry granulation, is made sample IV.
Medlar dispensing granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：17rpm；Disk roller speed：5rpm；Disk roller pressure：7MPa
The medlar dispensing granule extract dry granulation extract content of table 17
Test result indicates that：The extract content for adding medlar dispensing granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 18：Radix Isatidis granule extract dry granulation
Radix Isatidis granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Radix Isatidis granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Radix Isatidis granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Radix Isatidis granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition, after being well mixed
Dry granulation, is made sample IV.
Radix Isatidis granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：20rpm；Disk roller speed：4.5rpm；Disk roller pressure：7.5MPa
The Radix Isatidis granule extract dry granulation extract content of table 18
Test result indicates that：The extract content for adding Radix Isatidis granule extract dry granulation particle after auxiliary material shows
Write and improve.
Embodiment 19：Morinda officinalis granule extract dry granulation
Morinda officinalis granule extract (crossing 80 mesh sieves) directly dry granulation is taken, sample I is made.
Morinda officinalis granule extract (crossing 80 mesh sieves) is taken, by weight 1% PVPP of addition, after being well mixed
Dry granulation, is made sample II.
Morinda officinalis granule extract (crossing 80 mesh sieves) is taken, by weight 3% PVPP of addition, after being well mixed
Dry granulation, is made sample III.
Morinda officinalis granule extract (crossing 80 mesh sieves) is taken, by weight 5% PVPP of addition, after being well mixed
Dry granulation, is made sample IV.
Morinda officinalis granule extract (crossing 80 mesh sieves) is taken, by weight 7% PVPP of addition, after being well mixed
Dry granulation, is made sample V.
The foundation of granulation eveluatin index：
Extract content (%)：Take above-mentioned particle appropriate, it is finely ground, about 2g is taken, it is accurately weighed, put in 250ml conical flask,
Precision adds ethanol 100ml, and close plug, weighed weight after standing 1 hour, connects reflux condensing tube, is heated to boiling, and keep
Micro-boiling 1 hour.After letting cool, conical flask, close plug, then weighed weight are removed, weightlessness is supplied with ethanol, shakes up, filtered with filter is dried
Cross, precision measures filtrate 25ml, put dry into the evaporating dish of constant weight, be evaporated in water-bath after, in 105 DEG C dry 3 hours,
Put in drier and cool down 30 minutes, rapid accurately weighed weight.[extract content (%)=the molten extract dry cream weight of alcohol/takes
Sample particle weight × 100%]
Dry granulation process parameter：Charging rate：20rpm；Disk roller speed：4rpm；Disk roller pressure：7.5MPa
The Morinda officinalis granule extract dry granulation extract content of table 19
Test result indicates that：The extract content for adding Morinda officinalis granule extract dry granulation particle after auxiliary material shows
Write and improve.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of change or
Change.There is no necessity and possibility to exhaust all the enbodiments.And the obvious change thus extended out or
Among changing still in the protection domain of the invention.
Claims (9)
1. a kind of method for improving the molten extract content of Chinese medicinal granule alcohol, it is characterised in that to the Chinese medicinal granule for treating dry granulation
PVPP is added, the Chinese medicinal granule carries for the Chinese medicine rich in volatile oil component, rich in ter penoidses, rich in carbohydrate content
Take composition granule or Chinese medicinal granule.
2. method according to claim 2, it is characterised in that the addition of the PVPP be Chinese medical extract or
The 3%-7% of Chinese medicinal granule extract weight.
3. method according to claim 3, it is characterised in that the particle diameter of the PVPP is 30 μm -150 μm.
4. method according to claim 4, it is characterised in that the particle diameter of the PVPP is 90-100 μm.
5. method according to claim 5, it is characterised in that comprise the concrete steps that to Chinese medical extract or Chinese medicinal granule
The PVPP of parts by weight is added in extract, is well mixed in rearmounted dry granulating machine and pelletizes.
6. the new application of PVPP, it is characterised in that the drop of the molten extract of alcohol in the dry granulation to prevent Chinese medicinal granule
It is low.
7. new application according to claim 7, it is characterised in that into Chinese medical extract or Chinese medicinal granule extract
The PVPP of parts by weight is added, is well mixed in rearmounted dry granulating machine and pelletizes.
8. new application according to claim 8, it is characterised in that the addition of the PVPP is Chinese medical extract
Or the 3%-7% of Chinese medicinal granule extract weight.
9. new application according to claim 8, it is characterised in that the particle diameter of the PVPP is 90 μm -100 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710236594.XA CN106983725B (en) | 2017-04-12 | 2017-04-12 | Method for improving content of alcohol-soluble extract of traditional Chinese medicine particles and new application of crospovidone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710236594.XA CN106983725B (en) | 2017-04-12 | 2017-04-12 | Method for improving content of alcohol-soluble extract of traditional Chinese medicine particles and new application of crospovidone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106983725A true CN106983725A (en) | 2017-07-28 |
| CN106983725B CN106983725B (en) | 2020-12-29 |
Family
ID=59416408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710236594.XA Active CN106983725B (en) | 2017-04-12 | 2017-04-12 | Method for improving content of alcohol-soluble extract of traditional Chinese medicine particles and new application of crospovidone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106983725B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116832124A (en) * | 2023-02-23 | 2023-10-03 | 华润三九现代中药制药有限公司 | Method for preparing glabrous greenbrier rhizome extract |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939349A (en) * | 2006-09-29 | 2007-04-04 | 谭登平 | Improvement of pelletization in Chinese medicine prescription by dry method |
| CN101214271A (en) * | 2007-12-27 | 2008-07-09 | 深圳海王药业有限公司 | Blumea balsamifera total flavones dispersible tablet and preparation thereof |
| CN101259145A (en) * | 2007-03-08 | 2008-09-10 | 宁波立华制药有限公司 | Moistureproof and preparation technique for Chinese medicine extract |
| CN101897727A (en) * | 2010-06-18 | 2010-12-01 | 贵州信邦制药股份有限公司 | Method for preparing traditional Chinese medicine tablets |
| CN102813628A (en) * | 2012-08-23 | 2012-12-12 | 江阴天江药业有限公司 | Method for improving dissolubility of phlegm-contained traditional Chinese medicine formula granule |
| CN104208037A (en) * | 2013-05-30 | 2014-12-17 | 北京长城制药厂 | Method for preventing traditional Chinese medicine capsule from absorbing moisture |
| CN104352523A (en) * | 2014-10-14 | 2015-02-18 | 磐安县道地磐药中药研究所 | Human placenta pure powder superfine decoction pieces and preparation method thereof |
-
2017
- 2017-04-12 CN CN201710236594.XA patent/CN106983725B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939349A (en) * | 2006-09-29 | 2007-04-04 | 谭登平 | Improvement of pelletization in Chinese medicine prescription by dry method |
| CN101259145A (en) * | 2007-03-08 | 2008-09-10 | 宁波立华制药有限公司 | Moistureproof and preparation technique for Chinese medicine extract |
| CN101214271A (en) * | 2007-12-27 | 2008-07-09 | 深圳海王药业有限公司 | Blumea balsamifera total flavones dispersible tablet and preparation thereof |
| CN101897727A (en) * | 2010-06-18 | 2010-12-01 | 贵州信邦制药股份有限公司 | Method for preparing traditional Chinese medicine tablets |
| CN102813628A (en) * | 2012-08-23 | 2012-12-12 | 江阴天江药业有限公司 | Method for improving dissolubility of phlegm-contained traditional Chinese medicine formula granule |
| CN104208037A (en) * | 2013-05-30 | 2014-12-17 | 北京长城制药厂 | Method for preventing traditional Chinese medicine capsule from absorbing moisture |
| CN104352523A (en) * | 2014-10-14 | 2015-02-18 | 磐安县道地磐药中药研究所 | Human placenta pure powder superfine decoction pieces and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郑少杰等: ""药用辅料交联聚维酮的应用进展"", 《中国药房》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116832124A (en) * | 2023-02-23 | 2023-10-03 | 华润三九现代中药制药有限公司 | Method for preparing glabrous greenbrier rhizome extract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106983725B (en) | 2020-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106983725A (en) | A kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol | |
| CN104910112A (en) | Preparation method, drug preparation and clinical application of high purity traditional Chinese medicine salvia miltiorrhiza active ingredient salvianolic acid B | |
| CN102258094B (en) | Tea drink containing natural plants or natural plant extracts, and preparation method and application thereof | |
| CN111281853B (en) | Preparation method of traditional Chinese medicine concentrated pill | |
| CN1436563A (en) | Skin-cleaning and itch-stopping tincture as externally applied medicine for treating skin pruritus | |
| CN103099788A (en) | Traditional Chinese medicine composite decoration from powder, preparation and decoction methods and dosage relation thereof | |
| CN103040760A (en) | Granules of solid traditional Chinese medicine particles and preparation method of granules | |
| CN1298372C (en) | Chinese traditional medicine for treating common cold | |
| CN103565686A (en) | Permanent plant hair dye and preparation method thereof | |
| CN112220859B (en) | Preparation process of compound traditional Chinese medicine preparation | |
| CN103638483B (en) | Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof | |
| CN1698855A (en) | Powder with ass-hide glue and Chinese angelica root and its preparation method | |
| CN1733206A (en) | Chinese traditional medicine preparation for curing mastoplasia | |
| CN103566318A (en) | Preparation method of Huoxiangzhengqi capsule | |
| CN1698708A (en) | Leucorrhea disease treatment capsule and its preparation method | |
| CN1733141A (en) | New preparation for curing chloasma and acne | |
| CN1759867A (en) | Granules of Chinese traditional medicine for treating women's irregular menses | |
| CN115501271B (en) | Preparation method of Qiqingbaidu granules | |
| CN115590921B (en) | Stable cicada itching-relieving particles and preparation method thereof | |
| CN113197947B (en) | Composition for clearing and activating channels and collaterals and dredging blood vessels and preparation method thereof | |
| CN102920905A (en) | Extracting method for effective component of kouyanqing capsule | |
| CN116509948A (en) | Method for improving transfer rate of berberine hydrochloride in Shuangshitongli capsules | |
| CN103341003A (en) | Scutellaria baicalensis-containing traditional Chinese medicine and preparation method thereof | |
| CN1947779A (en) | Traditional Chinese medicine granules for treating infantile cough and its prepn. method | |
| CN1660187A (en) | 'Kangfuyan' tablet and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221202 Address after: No.199 Nan'an Road, Huicheng District, Huizhou City, Guangdong Province 516000 Patentee after: China Resources Sanjiu modern traditional Chinese Medicine Pharmaceutical Co.,Ltd. Address before: No.1 Guanqing Road, Guanlan high tech park, Longhua New District, Shenzhen, Guangdong 518110 Patentee before: CHINA RESOURCES SANJIU MEDICAL & PHARMACEUTICAL Co.,Ltd. |
|
| TR01 | Transfer of patent right |