CN103040760A - Granules of solid traditional Chinese medicine particles and preparation method of granules - Google Patents
Granules of solid traditional Chinese medicine particles and preparation method of granules Download PDFInfo
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Abstract
The invention relates to granules of solid traditional Chinese medicine particles and the preparation method of the granules. The granules of solid traditional Chinese medicine particles are prepared by split charging and bagging solid particles. The solid particles are prepared by mixing the following ingredients according to weight percentage: 2 to 10 percent of Chinese medicine volatile oil, 10 to 40 percent of one or more of the Chinese medicine raw powder and zymophyte mycelium powder, 10 to 40 percent of Chinese medicine dry extract, and 10 to 75 percent of other pharmaceutical adjuncts; the Chinese medicine volatile oil and Beta-cyclodextrin are in clathration by adopting the method of saturated aqueous solution, and then solid-liquid separation is performed on clathrate compound after clathration; and the solid particles are made by firstly mixing the clathration compound and then pelletizing. The invention has the following advantages: a volatile oil clathrate compound drying procedure in which more disadvantages exist is eliminated, the loss content of the volatile oil is reduced, the process time is shortened greatly, the retention rate of the volatile oil in finished products of the preparation of Chinese medicine is improved, and the quality and the effectiveness of medicine are ensured.
Description
Technical field
The present invention relates to field of traditional Chinese, relate in particular to granule of a kind of Chinese medicine solid particle that contains volatile oil and preparation method thereof.
Background technology
The application of traditional medicine volatile oil has long history, and the effectiveness of many traditional medicine volatile oils early is known to the ancients.According to the chemical research of modern Chinese medicine, contain the Chinese crude drug One's name is legion of volatile oil, relate to the Chinese medicine of nearly all effect classification, such as Herba Menthae, Radix Bupleuri, Herba Pogostemonis, Rhizoma Curcumae, Rhizoma Chuanxiong, Folium Perillae volatilization wet goods.The nature difference of traditional medicine volatile oil is larger, is liquid at normal temperatures, and is more volatile, and character is unstable.The high solid preparation of oil content can be selected soft capsule or special hard capsule at present, but complicated process of preparation, the product storage life is short, then is difficult to adopt take dry extract as the main volatile oil preparation that contains.
The prior art scheme: first the volatile oil that extracts in the medical material is carried out enclose with beta-schardinger dextrin--water, solid-liquid separation becomes moisture volatile oil clathrate compound; This moisture volatile oil clathrate compound adopted the method for drying or 50 ℃ of following Oven Method dry 8-12 hour, powdered or granule; Mix with the former powder of medical material, dry extract etc. again, granulate; After again carrying out drying, further make the solid preparations such as tablet, capsule.
(application number: 200510003035.1 applyings date: 2005-03-28) disclose a kind of Chinese medicine preparation and preparation method thereof of nourishing qi and blood, it mainly is prepared from by the medical materials such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong and adjuvant Chinese invention patent application.This patent disclosure Radix Angelicae Sinensis, Rhizoma Chuanxiong prepare first ethereal oil, adopt beta-cyclodextrin inclusion compound, mix with dry extract again.Although whether dry behind the undeclared employing beta-cyclodextrin inclusion compound of this patent, mix with dry extract behind the enclose, Benexate Hydrochloride obviously needs drying, otherwise, can't effectively mix after the dry extract moisture absorption.
Chinese invention patent application (application number: the 201110121569.X applying date: 2011-05-12) disclose a kind of Chinese medicine preparation for the treatment of flu and preparation method thereof, made by 600～900 parts of Fructus Forsythiaes, 600～900 parts of Radix Bupleuri, 300～450 portions of Herba Ephedraes, 200～300 parts of Herba Pogostemonis, 200～300 portions of Cortex Cinnamomis and 200～300 parts of Radix Platycodoniss by described Chinese medicine preparation.Its preparation method is Fructus Forsythiae, Herba Pogostemonis, Cortex Cinnamomi to be extracted respectively volatile oil make mixture A; Fructus Forsythiae is extracted last medicinal residues and Herba Ephedrae behind the volatile oil, Radix Bupleuri, the active ingredient of Radix Platycodonis medical material united extraction, spray drying is made powder B again; Then with mixture A and beta-cyclodextrin inclusion compound, make volatile oil pressed powder C; At last powder B and powder C mixing are packed in the softgel shell and get final product.This patent is clearly also, and volatile oil pressed powder C need to carry out cold drying.
(application number: 201010011610.3 applyings date: 2010-01-06) disclose a kind of series of Chinese and preparation technology and quality control method for the treatment of infantile common cold, they are to be prepared from by Chinese medicine Folium Isatidis, Radix Bupleuri, Radix Scutellariae, Herba Schizonepetae, Radix Platycodonis, Radix Glycyrrhizae and pharmaceutic adjuvant to Chinese invention patent application.This patent Radix Bupleuri volatile oil becomes clathrate with beta-cyclodextrin inclusion compound, add again Radix Platycodonis fine powder and volatile oil clathrate compound then making the Chinese medicine clear paste, mixing, namely get extraction extractum, add and to be selected from a kind of of dextrin, lactose, sucrose or two kinds or three kinds as the granulation adjuvant, carry out one-step palletizing, mixing namely gets children's and separates the sense granule.Also clear and definite clathrate need to be dry under 50,60 ℃ condition in description for this patent.
(application number is Chinese invention patent application: 200410081462.7) disclose a kind of pharmaceutical preparation that contains volatile oil and preparation method thereof, the pharmaceutic adjuvant that it contains volatile oil and volatile oil can be solidified, wherein pharmaceutic adjuvant is that mean molecule quantity is at the Polyethylene Glycol more than 2500.The medicine key quality factors such as the content of volatile oil and utilization rate are not estimated in the preparation method.
(application number: 200910100513.9 applyings date: 2009-07-09) disclose the pharmaceutical composition for the treatment of prostatitis, prostatic hyperplasia, this pharmaceutical composition is prepared by the raw material of Chinese medicine that comprises the following weight parts proportioning Chinese invention patent application of applicant's application: 60～100 parts of powdered Wuling mycelia in combinations, 20～80 parts of Rhizoma Curcumae, 20～80 parts of Bulbus Fritillariae Thunbergiis, 20～40 parts of Rhizoma Alismatis.This patent Rhizoma Curcumae extracts the volatile oil beta-cyclodextrin inclusion compound, the preparation volatile oil clathrate compound; The medicinal residues of Rhizoma Curcumae and Bulbus Fritillariae Thunbergii, Rhizoma Alismatis merge, and extract, and extracting liquid filtering is evaporated to clear paste, then adds ethanol, and hold over night filters, and filtrate decompression is concentrated, and drying makes the medical material dried cream powder; Get above-mentioned WULINGJUN Fen ﹑ medical material dried cream powder, volatile oil clathrate compound, mixing namely gets described pharmaceutical composition.The volatile oil clathrate compound that this patent relates to directly mixes with the medical material dried cream powder, and it also is to carry out drying.
All there is following shortcoming in each above-mentioned patent:
1, after the clathrate of making behind the inclusion essential oil need be dried to first fine powder or granule, granulates after mixing with other extracts again or further processing.Inclusion essential oil water content of matter after the dehydration high (40-60%), the drying process temperature can not surpass 50 ℃, need to be for up to 8-12 hours;
2, volatile oil clathrate compound dry run has part volatile oil to overflow and partial loss, and volatile oil reservation amount reduces, and causes certain contamination, and operator are uncomfortable;
If 3 more further processing, the operations such as granulation, particle drying are made the solid preparations such as tablet, capsule, and then the volatile oil in these solid preparations keeps and can further reduce, and only has about 50%, affects medicine effectiveness and quality.
Summary of the invention
In order to solve above-mentioned technical problem, an object of the present invention is to provide a kind of granule of Chinese medicine solid particle, said composition has reduced the loss of volatile oil content, can greatly shorten the process time, improve the retention rate of volatile oil in the Chinese medicine preparation finished product, guaranteed drug quality and effectiveness.Another object of the present invention provides a kind of preparation method that adopts the granule of above-mentioned Chinese medicine solid particle.
In order to realize first above-mentioned purpose, the present invention has adopted following technical scheme:
A kind of granule of Chinese medicine solid particle, the granule of this Chinese medicine solid particle is prepared by solid particle packing pack, and described solid particle is by comprising that following percentage by weight composition mixing granulation obtains:
Chinese crude drug volatile oil 2%～10%
In the former powder of Chinese crude drug and the fermentation mycelium powder one or more 10%～40%
Chinese crude drug dry extract 10%～40%
Other pharmaceutical adjuncts 10%～75%;
Described Chinese crude drug volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Chinese crude drug volatile oil and β – cyclodextrin mass ratio are 1:4～7, the clathrate solid-liquid separation behind the enclose, and drying not, moisture is 35%～50%; Described clathrate with one or more mix rear the granulation in the former powder of Chinese crude drug and the fermentation mycelium, makes described solid particle with described Chinese crude drug dry extract, other pharmaceutical adjunct mixing granulation dryings first again.
As preferably, above-mentioned solid particle is obtained by following percentage by weight composition mixing granulation:
Chinese crude drug volatile oil 3%～10%
In the former powder of Chinese crude drug and the fermentation mycelium powder one or more 15%～35%
Chinese crude drug dry extract 10%～40%
Other pharmaceutical adjuncts 10%～60%.
As further improvement, described Chinese crude drug volatile oil is Yu the clathrate of β – cyclodextrin adopts the saturated water solution method preparation, Chinese crude drug volatile oil, β – cyclodextrin, water are than being 1:4～7:15～30, the enclose temperature is controlled at 25～50 ℃, 60～120 rev/mins of mixing speeds, 2～5 hours response time.
As preferably, above-mentioned Chinese medicine solid particle composition adopts the preparation of fermentation mycelium powder.
As preferably, above-mentioned Chinese crude drug volatile oil is selected from one or more combinations in Rhizoma Curcumae, Radix Bupleuri, Rhizoma Chuanxiong, Herba Pogostemonis and the Folium Perillae volatile oil.
As preferably, the former powder of above-mentioned Chinese crude drug is selected from one or more combinations in Radix Ginseng, Radix Panacis Quinquefolii, Cordyceps and the Radix Notoginseng.
As preferably, above-mentioned fermentation mycelium is selected from one or more combinations in ganoderma lucidum powder, fermented Cordyceps powder, powdered Wuling mycelia in combination or the Coriolous Dersicolor (Fr.) Quel mycopowder.
As preferably, other above-mentioned pharmaceutical adjuncts are selected from one or more combinations in filler, binding agent, disintegrating agent and the lubricant.As preferred again, other above-mentioned pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and the polyvidone.
In order to realize second above-mentioned purpose, the present invention has adopted following technical scheme:
A kind of method for preparing the granule of above-mentioned Chinese medicine solid particle, the method comprises the steps:
1) Chinese crude drug is prepared into Chinese crude drug volatile oil and Chinese crude drug dry extract;
2) Chinese crude drug volatile oil is carried out enclose with beta-schardinger dextrin--water, described Chinese crude drug volatile oil is Yu β – cyclodextrin mass ratio is 1:3～10, and by the Chinese crude drug volatile oil clathrate compound that solid-liquid separation obtains wetting, its moisture is 35%～50%;
3) with moisture be one or more usefulness oscillating granulator premixs granulations of 35%～50% Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug and fermentation mycelium powder body;
4) above-mentioned pre-mixed granule, Chinese crude drug dry extract and other adjuvants put granulator granulation drying, get granule, oven dry finishing control moisture 4.0%～9.0% makes described solid particle;
5) with above-mentioned solid particle packing pack, become granule.
As further improvement, described Chinese crude drug volatile oil clathrate compound adopts the saturated water solution method preparation, and volatile oil, β – cyclodextrin, water are than being 1:4～7:15～30, and the enclose temperature is controlled at 25～50 ℃, 60～120 rev/mins of mixing speeds, 2～5 hours response time.
As further improvement, the solid-liquid separating method of described Chinese crude drug volatile oil clathrate compound is centrifugal filtration, filter press or decompress filter, the moist material that obtains.
As further improvement, described Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug or fermentation mycelium premix are granulated 1～3 time, stainless steel mesh 10～30 orders.
As further improvement, described step 3) is mixed the premix granule with the Chinese crude drug dry extract, adds other adjuvants again and mixes, and carries out wet granulation or one-step palletizing.
As further improvement, the step of described wet granulation is as follows: in mixer-granulator, add binding agent wet granular processed, and 70～150 rev/mins of paddle rotating speeds, 200～800 rev/mins of fly cutter rotating speeds move 10～30 minutes.Wet granular is placed boiling drier, and 45～85 ℃ of inlet temperature dry 5～30 minutes, get granule, control pellet moisture 4.0%～9.0%.
As further improvement, the step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 ℃, and drying, moisture Control is 4.0%～9.0%.
The present invention is owing to adopted above-mentioned technical scheme, and the mixed method of the volatile oil clathrate compound of employing undried and the former powder of medical material, dry extract is so that mixed material satisfies the needs of Chinese medicine preparation molding.Thereby removed the volatile oil clathrate compound drying process that has many drawbacks, reduced the loss of volatile oil content, greatly shortened the process time, improved the retention rate of volatile oil in the Chinese medicine preparation finished product, guaranteed drug quality and effectiveness.
Every comparison that the wet volatile oil clathrate compound of table 1 is directly granulated and volatile oil clathrate compound is granulated after drying
The technique time shorten consuming time that the technique of directly being granulated by wet as seen from Table 1 volatile oil clathrate compound is granulated after drying than volatile oil clathrate compound more than 8 times, and the volatile oil utilization rate has improved more than 30%, greatly reduce production cost, improved the utilization rate of volatile oil.
The specific embodiment
Embodiment 1
The weight ratio of the composition of present embodiment is: Oleum Curcumae 2.5%, powdered Wuling mycelia in combination 36%, Chinese medicine dry extract 32%, other adjuvants 29.5%.
Contain the preparation method of the granule of Oleum Curcumae, the method comprises the steps:
1) Rhizoma Curcumae is extracted into volatile oil, other Chinese medicine extraction are made dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Oleum Curcumae with 50% dissolve with ethanol of weight ratio, ratio in Oleum Curcumae: beta-schardinger dextrin-=1:6 adds in the saturated aqueous solution, stirring at room 3 hours, 100 rev/mins of mixing speeds, hold over night is removed supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet Oleum Curcumae clathrate and powdered Wuling mycelia in combination are placed premix granulation on the rotary granulator;
4) above granule is mixed with other adjuvants such as Chinese medicine dry extract, calcium hydrogen phosphate, microcrystalline Cellulose place in the high efficient mixed granulator, add binding agent, wet method is made soft material;
5) above-mentioned soft material is put in the boiling drier, drying time 30min, 60～80 ℃ of inlet temperature;
6) with the granule packing pack of drying, become granule.
Embodiment 2
The weight ratio of the composition of present embodiment is: Rhizoma Chuanxiong oil: 3%, and fermented Cordyceps powder 35%, Chinese medicine dry extract 25%, other adjuvants 37%.
Contain the preparation method of the granule of Rhizoma Chuanxiong oil, the method comprises the steps:
1) Rhizoma Chuanxiong is extracted into volatile oil, and other Chinese medicine extraction are made dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Rhizoma Chuanxiong oil with 50% dissolve with ethanol of weight ratio, add in the saturated aqueous solution in the ratio of Oleum Curcumae: beta-schardinger dextrin-=1:5,25 ℃ were stirred 5 hours, and hold over night is removed supernatant, bottom precipitation decompress filter, for subsequent use;
3) wet Oleum Curcumae clathrate and fermented Cordyceps powder are placed premix granulation on the oscillating granulator;
4) adjuvants such as above granule and Chinese medicine dry extract, pregelatinized Starch, microcrystalline Cellulose are added in the Fluidbedgranulatingdrier; Spray into binding agent, 70 ℃ of inlet temperature, temperature of charge is controlled at 50 ± 5 ℃, drying, moisture Control is below 6%;
5) with the granule packing pack of drying, become granule.
Embodiment 3
The weight ratio of the composition of present embodiment is: Folium Perillae volatile oil: 1.5%, and ganoderma lucidum powder: 30%, the Chinese medicine dry extract: 30%, other adjuvants 38.5%.
Contain the preparation method of the granule of perilla oil, the method comprises the steps:
1) Rhizoma Chuanxiong is extracted into volatile oil, and other Chinese medicine extraction are made dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Rhizoma Chuanxiong volatile oil with 50% dissolve with ethanol of weight ratio, ratio in Folium Perillae volatile oil: beta-schardinger dextrin-=1:10 adds in the saturated aqueous solution, stirring at room 1.5 hours, hold over night, take down supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet perilla oil clathrate and ganoderma lucidum powder are placed premix granulation on the oscillating granulator;
4) with above granule and Chinese medicine dry extract, other adjuvants and filler mix homogeneously, place in the method rolling pelletizer, make wet granular;
5) above-mentioned granule is put in the boiling drier, 65 ℃ of inlet temperature are controlled temperature of charge at 50 ± 5 ℃, dry 30min, dried granule control moisture 4.0%～9.0%;
6) with the granule packing pack of drying, become granule.
Claims (10)
1. the granule of a Chinese medicine solid particle is characterized in that the granule of this Chinese medicine solid particle is prepared by solid particle packing pack, and described solid particle is by comprising that following percentage by weight composition mixing granulation obtains:
Chinese crude drug volatile oil 2%～10%
In the former powder of Chinese crude drug and the fermentation mycelium powder one or more 10%～40%
Chinese crude drug dry extract 10%～40%
Other pharmaceutical adjuncts 10%～75%;
Described Chinese crude drug volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Chinese crude drug volatile oil and β – cyclodextrin mass ratio are 1:4～7, the clathrate solid-liquid separation behind the enclose, and drying not, moisture is 35%～50%; Described clathrate with one or more mix rear the granulation in the former powder of Chinese crude drug and the fermentation mycelium, makes described solid particle with described Chinese crude drug dry extract, other pharmaceutical adjunct mixing granulation dryings first again.
2. the granule of a kind of Chinese medicine solid particle according to claim 1 is characterized in that solid particle is obtained by following percentage by weight composition mixing granulation:
Chinese crude drug volatile oil 3%～10%
In the former powder of Chinese crude drug and the fermentation mycelium powder one or more 15%～35%
Chinese crude drug dry extract 10%～40%
Other pharmaceutical adjuncts 10%～60%.
3. the granule of a kind of Chinese medicine solid particle according to claim 1 and 2, it is characterized in that: Chinese crude drug volatile oil is Yu the clathrate of β – cyclodextrin adopts the saturated water solution method preparation, Chinese crude drug volatile oil, β – cyclodextrin, water are than being 1:4～7:15～30, the enclose temperature is controlled at 25～50 ℃, 60～120 rev/mins of mixing speeds, 2～5 hours response time.
4. the granule of a kind of Chinese medicine solid particle according to claim 1 is characterized in that: the preparation of solid particle employing fermentation mycelium powder.
5. the granule of a kind of Chinese medicine solid particle according to claim 1, it is characterized in that: Chinese crude drug volatile oil is selected from one or more combinations in Rhizoma Curcumae, Radix Bupleuri, Rhizoma Chuanxiong, Herba Pogostemonis and the Folium Perillae volatile oil; The former powder of Chinese crude drug is selected from one or more combinations in Radix Ginseng, Radix Panacis Quinquefolii, Cordyceps and the Radix Notoginseng; Described fermentation mycelium is selected from one or more combinations in ganoderma lucidum powder, fermented Cordyceps powder, powdered Wuling mycelia in combination or the Coriolous Dersicolor (Fr.) Quel mycopowder.
6. the granule of a kind of Chinese medicine solid particle according to claim 1, it is characterized in that: other pharmaceutical adjuncts are selected from one or more combinations in filler, binding agent, disintegrating agent and the lubricant.
7. the granule of a kind of Chinese medicine solid particle according to claim 1, it is characterized in that: other pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and the polyvidone.
8. a method for preparing the granule of the described a kind of Chinese medicine solid particle of claim 1 ~ 7 any one claim is characterized in that the method comprises the steps:
1) Chinese crude drug is prepared into Chinese crude drug volatile oil and Chinese crude drug dry extract;
2) Chinese crude drug volatile oil is carried out enclose with beta-schardinger dextrin--water, described Chinese crude drug volatile oil is Yu β – cyclodextrin mass ratio is 1:3～10, and by the Chinese crude drug volatile oil clathrate compound that solid-liquid separation obtains wetting, its moisture is 35%～50%;
3) with moisture be one or more usefulness oscillating granulator premixs granulations of 35%～50% Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug and fermentation mycelium powder body;
4) above-mentioned pre-mixed granule, Chinese crude drug dry extract and other adjuvants put granulator granulation drying, get granule, oven dry finishing control moisture 4.0%～9.0% makes described solid particle;
5) with above-mentioned solid particle packing pack, become granule.
9. the preparation method of the granule of a kind of Chinese medicine solid particle according to claim 8, it is characterized in that: the solid-liquid separating method of Chinese crude drug volatile oil clathrate compound is centrifugal filtration, filter press or decompress filter, the moist material that obtains; The former powder of Chinese crude drug volatile oil clathrate compound and Chinese crude drug or fermentation mycelium premix are granulated 1～3 time, stainless steel mesh 10～30 orders.
10. the preparation method of the granule of a kind of Chinese medicine solid particle according to claim 8, it is characterized in that: step 4) is mixed the premix granule with the Chinese crude drug dry extract, adds other adjuvants again and mixes, and carries out wet granulation or one-step palletizing; As further improvement, the step of described wet granulation is as follows: add binding agent wet granular processed in mixer-granulator, 70～150 rev/mins of paddle rotating speeds, 200～800 rev/mins of fly cutter rotating speeds move 10～30 minutes, and wet granular is placed boiling drier, 45～85 ℃ of inlet temperature, dry 5～30 minutes, get granule, control pellet moisture 4.0%～9.0%; The step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 ℃, and drying, moisture Control is 4.0%～9.0%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493681A (en) * | 2013-09-24 | 2014-01-08 | 成都信息工程学院 | Method for producing medical mycoplasm by using pseudo-ginseng dregs in co-fermentation mode |
| CN106262813A (en) * | 2016-08-04 | 2017-01-04 | 高建新 | A kind of tonic increases powder and preparation method thereof |
| CN113425782A (en) * | 2021-07-02 | 2021-09-24 | 广西纯正堂制药有限公司 | Preparation method of mussaenda pubescens heat clearing preparation |
| CN115025066A (en) * | 2021-05-25 | 2022-09-09 | 重庆市畜牧科学院 | Preparation method of traditional Chinese medicine preparation for piglets |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
-
2012
- 2012-12-17 CN CN201210546786.8A patent/CN103040760B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493681A (en) * | 2013-09-24 | 2014-01-08 | 成都信息工程学院 | Method for producing medical mycoplasm by using pseudo-ginseng dregs in co-fermentation mode |
| CN106262813A (en) * | 2016-08-04 | 2017-01-04 | 高建新 | A kind of tonic increases powder and preparation method thereof |
| CN115025066A (en) * | 2021-05-25 | 2022-09-09 | 重庆市畜牧科学院 | Preparation method of traditional Chinese medicine preparation for piglets |
| CN115025066B (en) * | 2021-05-25 | 2023-05-16 | 重庆市畜牧科学院 | Preparation method of traditional Chinese medicine slow-release particles with stable quality and capable of resisting diarrhea of piglets |
| CN113425782A (en) * | 2021-07-02 | 2021-09-24 | 广西纯正堂制药有限公司 | Preparation method of mussaenda pubescens heat clearing preparation |
| WO2023274344A1 (en) * | 2021-07-02 | 2023-01-05 | 广西纯正堂制药有限公司 | Method for preparing mussaenda pubescens heat-clearing preparation |
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