CN104352523A - Human placenta pure powder superfine decoction pieces and preparation method thereof - Google Patents

Human placenta pure powder superfine decoction pieces and preparation method thereof Download PDF

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CN104352523A
CN104352523A CN201410539572.7A CN201410539572A CN104352523A CN 104352523 A CN104352523 A CN 104352523A CN 201410539572 A CN201410539572 A CN 201410539572A CN 104352523 A CN104352523 A CN 104352523A
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placenta hominis
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傅苗青
何任
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PAN'AN DAODI PANYAO CHINESE MEDICINE INSTITUTE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a preparation method of human placenta pure powder superfine decoction pieces. A fresh placenta is washed by a large amount of water and steamed in a bamboo steamer for about half an hour, the well steamed placenta is dried with a freeze-drying technology, the freeze-dried placenta is processed into coarse powder by a grinder, the coarse powder is subjected to superfine grinding in a jet mill to obtain micro powder, the particle diameters of the micro powder range from 0.5 to 3, then, sterilization treatment is adopted, sterilized human placenta pure powder superfine decoction pieces and an auxiliary material meeting the agent requirement are mixed, and finally, tablets, capsules and regular oral dosage forms are prepared. Compared with the prior art, the human placenta pure powder superfine decoction pieces prepared with the method have efficacy of warming the kidney, replenishing essence, reinforcing qi and nourishing blood and can be further used for treating various diseases such as insufficient blood gas, infertility, little milk and the like of women; and the human placenta pure powder superfine decoction pieces are prepared with a special grinding technology and a special method and contain nutritional substances which are particularly beneficial to human body absorption.

Description

Pure powder ultramicro decoction piece of Placenta Hominis and preparation method thereof
technical field
The present invention relates to technical field of traditional Chinese medicine preparation, particularly pure powder ultramicro decoction piece of Placenta Hominis and preparation method thereof.
background technology
" Placenta Hominis " said in the traditional Chinese medical science, the namely Placenta Hominis of people.Placenta Hominis after healthy parturient childbirth, make decoction pieces through process of preparing Chinese medicine means---cutting off amniotic membrane and umbilical cord, repeatedly rinsing to removing blood, after steaming or putting and slightly boil in boiling water, dry.Used time, except dedust bits, pounds into fritter, or grinds into powder.From the traditional Chinese medical science theoretically, Placenta Hominis sweet-salty, warm in nature, return lung, liver, kidney channel; Flesh and blood is in love, and matter profit gas is male, and effect is that the kidney warming mends essence, benefiting QI and nourishing blood.Be mainly used in asthenia weakness and emaciation, impotence and seminal emission, women's vim and vigour be not enough, infertile or breast less, chronic cough dyspnea due to deficiency, hectic fever due to YIN-deficiency chronic cough, shallow complexion, lack of appetite breathe hard.Say more plain, for suffering from bronchial asthma, chronic bronchitis, pulmonary tuberculosis, easy to catch cold, sweating due to debility etc. belong to deficiency of both the lung and kidney or puerperal breast few, dysplasia of children, body void belongs to the patient of deficiency of qi and blood after being ill, and the Placenta Hominis of edible healthy puerpera can play certain auxiliary treatment or improve the effect of resistance against diseases, containing Multiple Antibodies in Placenta Hominis, antitoxin, interferon, hormone and multiple enzyme, these compositions can play to human body the effect well supplemented the nutrients, the needs of modern healthy, in field of traditional Chinese in succession, revive and develop middle formation numerous Chinese medicine old established firm brand, as Tongrentang (1669), Hu Qingyu Pharmaceutical Workshop (1874), large life auspicious (1885), Han Xingtang (1901), Fu Tong (1644), Fructus Pruni and hall (1600), public good is large, Chen Zhi father-in-law, bosom moral crane (1948), old man and Tai, father-in-law Changchun (1699), Fu Jichun, refined vegetarian (between bright year in Wanli year), first-class and the Chinese medicine health-care tea old established firm brand of Lei Yun is as ten thousand safe units (1860), Zhu Qiansheng, roc red sun, universe Thailand is poly-, and wherein ten thousand safe first tea No. win ten thousand state's World's Fair gold medals in 1915 especially, the first-class Grand Prix of nineteen twenty-six U.S. Philadelphia World's Fair and nineteen twenty-nine first West Lake Exposition gold medal.But use traditional method to eat, such as by or steam or the Placenta Hominis that eaten by human body after boiling or stewing, its nutritive value possessed is with the meat not too big-difference of general animal, and above-mentioned a lot of nutritional labeling is also not easy to be absorbed by the body.
summary of the invention
For solving the problems of the technologies described above, the invention discloses a kind of new technical scheme.
The invention discloses the preparation method of the pure powder ultramicro decoction piece of a kind of Placenta Hominis, this preparation method specifically comprises following steps: step one: get fresh Placenta Hominis and first rinse with volume water, the impurity of the inside and thing inferior are cleared out, then soak 3 hours in cold water, change washing again 3 hours, remove sewage; Step 2: taken out the Placenta Hominis that cleans up, then gets tape and is tied by described Placenta Hominis and put into pepper water and boil 40-60 minute, pull out in time, be placed in basin, add yellow wine and stir, put in food steamer and steam about half an hour; Step 3: adopt Freeze Drying Technique to carry out drying on steamed Placenta Hominis, being finally dried to water content is 10%-20%; Step 4: cryodesiccated Placenta Hominis will be carried out and adopt pulverizer to carry out being processed into coarse powder, the particle diameter size of described coarse powder is below 200 μm, and then by described coarse powder micronizing in jet mill, obtain micropowder, the particle diameter size of described micropowder is between 0.5-3, and the condition of described micronizing is: pulverize temperature 30-45 DEG C, pressure when entering super micron mill is 3-5Mpa, air velocity 150-200m/s, the time 3-5h of pulverizing, finally obtain the pure powder of Placenta Hominis; Step 5: the pure powder of Placenta Hominis obtained in described step 4 is adopted sterilization treatment, pure for the Placenta Hominis carried out after sterilizing powder is made the pure powder ultramicro decoction piece of Placenta Hominis.
Further, step 5 also comprises: then mixed with the adjuvant meeting medicament requirement by pure for Placenta Hominis powder ultramicro decoction piece, finally obtained tablet, capsule, oral normal release dosage form.
Preferably, described adjuvant comprise in disintegrating agent, lubricant, binding agent and filler one or more, the addition of described adjuvant is 20%-30%, and described percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.
Preferably, described disintegrating agent is one or more in starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, sodium alginate, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose, and the addition of described disintegrating agent is 10%-20%; Described lubricant is one or more in magnesium stearate, sodium laurylsulfate and boric acid, and the addition of described lubricant is 5%-10%; Described binding agent is micropowder silica gel and/or Pulvis Talci, and the addition of described binding agent is 1%-5%; Described filler is for being lactose and/or calcium sulfate, and the addition of described filler is 1%-15%; Described percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.
Preferably, the cryodesiccated temperature in described step 3 is-30 DEG C--20 DEG C, and cooling time is 4 hours.
Preferably, the powder in described step 4 measures through dry laser particle size analyzer, and the particulate accumulation of particle diameter size between 1-2 μm is no less than 80%.
Preferably, the squeeze pressure extruding granulation in described step 5 is 10-20MPa, and side seal power is 3-5 MPa, and adds the binding agent of 2%-5%.
Preferably, in described step 5, the pure powder of Placenta Hominis carries out the temperature of sterilizing is 90 DEG C-110 DEG C, and pressure is 45MPa-55 MPa.
Preferably, the sterilization treatment in described step 5 adopts any one or several in ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization method.
In a second aspect of the present invention, adopt the pure powder ultramicro decoction piece of Placenta Hominis that above-mentioned preparation method is obtained.
Adopt Placenta Hominis ultramicro decoction piece of the present invention, compared with prior art, there is the good result that prior art does not possess, therefore creativeness is possessed, adopt Placenta Hominis ultramicro decoction piece of the present invention to have the kidney warming and mend effect that is smart, benefiting QI and nourishing blood, asthenia weakness and emaciation, impotence and seminal emission can also be used for the treatment of, women's vim and vigour are not enough, the infertile or newborn various disease such as few, and this Placenta Hominis ultramicro decoction piece adopts special disintegrating process and special method to make, and the nutrient substance of the inside is particularly useful for absorption of human body.
detailed description of the invention
Below in conjunction with instantiation, the invention will be further described.
The prepared slices of Chinese crude drugs are Chinese medicine means of middle medical drugs, along with the development in epoch, the progress of science and technology and the raising of people's drug level, Chinese medicine " y decoction pieces is used as medicine; face with decocting soup " day by day show inconvenience and uncertainty, because it is more time-consuming, also reducing in the whole frequency of utilization gradually of modern times allegro life." Placenta Hominis " said in the traditional Chinese medical science, the namely Placenta Hominis of people, present invention employs a kind of method and Placenta Hominis is made into the nutrient substance being more conducive to absorption of human body, the pure powder ultramicro decoction piece of Placenta Hominis adopting the present invention to make effectively can change the health status of health, such as there is effect that the kidney warming mends essence, benefiting QI and nourishing blood, asthenia weakness and emaciation, impotence and seminal emission can also be used for the treatment of, women's vim and vigour are not enough, the infertile or newborn various disease such as few, women's vim and vigour are not enough, infertile or breast less, chronic cough dyspnea due to deficiency, hectic fever due to YIN-deficiency chronic cough, shallow complexion, lack of appetite breathe hard.Say more plain, for suffer from bronchial asthma, chronic bronchitis, pulmonary tuberculosis, easy to catch cold, sweating due to debility etc. belong to deficiency of both the lung and kidney or puerperal breast less, dysplasia of children, after being ill body void belongs to the patient of deficiency of qi and blood, the Placenta Hominis of edible healthy puerpera can play certain auxiliary treatment or improve the effect of resistance against diseases, and this Placenta Hominis ultramicro decoction piece adopts special disintegrating process and special method to make, and the nutrient substance of the inside is particularly useful for absorption of human body.
Embodiment one:
The present invention specifically comprises following steps:
Step one: get 1000KG Placenta Hominis and first rinse with volume water, take out the impurity of the inside and thing inferior, then soak 3 hours in cold water, change washing again 3 hours, remove sewage, also can soak in warm water, the increase that time of immersion can be suitable, a lot of soil above Placenta Hominis can be got rid of like this, also can not affect the nutritive value of Placenta Hominis;
Step 2: the Placenta Hominis cleaned up is taken out, then get tape described Placenta Hominis is tied to put into pepper water and boil 40-60 minute, pull out in time, be placed in basin, add yellow wine to stir, to be mixed evenly after, and then put in food steamer and steam about half an hour, fishy smell in Placenta Hominis can be got rid of by this process, also the effect thoroughly sterilized by Placenta Hominis can be played, thus obtaining ripe Placenta Hominis (Placenta Hominis), the final like this Placenta Hominis powder made just can directly eat, and does not need to carry out to heat or other process again.
Step 3: steamed Placenta Hominis is carried out lyophilization, cryodesiccated temperature is-30 DEG C--20 DEG C, and cooling time is 3-6 hour, and the most preferred time is 4 hours, and being finally dried to water content is 10%-20%;
Step 4: cryodesiccated Placenta Hominis will be carried out and adopt pulverizer to carry out being processed into coarse powder, the particle diameter size of described coarse powder is below 200 μm, and then by described coarse powder micronizing in jet mill, the condition of micronizing is: pulverize temperature 30-45 DEG C, pressure when entering super micron mill is 3-5Mpa, air velocity 150-200m/s, the time 3-5h pulverized, finally obtain the pure powder of Placenta Hominis and obtain micropowder, the particle diameter size of micropowder is between 0.5-3, and described micropowder measures through dry laser particle size analyzer, the particulate accumulation of particle diameter size between 1-2 μm is no less than 80%.; Step 5: the pure powder of Placenta Hominis obtained in described step 4 is adopted sterilization treatment, the mode of sterilizing can adopt any one or several in ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization method, the temperature of carrying out sterilizing is 90 DEG C-110 DEG C, pressure is 45MPa-55 MPa, pure for the Placenta Hominis carried out after sterilizing powder is made the pure powder ultramicro decoction piece of Placenta Hominis, then the pure powder ultramicro decoction piece of described Placenta Hominis mixes with the adjuvant meeting medicament requirement.
Adjuvant comprise in disintegrating agent, lubricant, binding agent and filler one or more, the addition of described adjuvant is 20%-30%, and described percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.Disintegrating agent is one or more in starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, sodium alginate, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose, and the addition of disintegrating agent is 10%-20%; Lubricant is one or more in magnesium stearate, sodium laurylsulfate and boric acid, and the addition of lubricant is 5%-10%; Binding agent is micropowder silica gel and/or Pulvis Talci, and the addition of binding agent is 1%-5%; Filler is for being lactose and/or calcium sulfate, and the addition of filler is 1%-15%; Above-mentioned percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.
Then the pure powder of Placenta Hominis finally obtained tablet, capsule, the oral normal release dosage form will carried out after sterilizing, tablet, capsule, oral normal release dosage form are advantageously in absorption of human body, squeeze pressure is adjustable, but preferred squeeze pressure is 10-20MPa, side seal power is 3-5 MPa, and the effect that the binding agent adding 2%-5% adds binding agent to make powder better condense together, and can not scatter.
Placenta Hominis pure powder ultramicro decoction piece prepared by above-mentioned preparation method causes the aspect of the medicine of disease to have outstanding curative effect for insufficiency of vital energy and blood in puerperal, described Disease Clinical symptom is insufficiency of vital energy and blood in puerperal, pale complexion, myasthenia of limbs.
Embodiment two:
The present invention specifically comprises following steps:
Step one: get 1000KG Placenta Hominis and first rinse with volume water, take out the impurity of the inside and thing inferior, then in cold water, 3-5 hour is soaked, change washing 3-5 hour again, remove sewage, also can soak in warm water, soak time can be suitable increase, step 2: the Placenta Hominis cleaned up is taken out, then get tape described Placenta Hominis is tied to put into pepper water and boil 40-60 minute, pull out in time, be placed in basin, add yellow wine to stir, to be mixed evenly after, and then to put in microwave container about half an hour, this process can play the effect thoroughly sterilized by Placenta Hominis, thus obtain ripe Placenta Hominis (Placenta Hominis), step 3: the Placenta Hominis carrying out microwave is carried out lyophilization, cryodesiccated temperature is-30 DEG C--20 DEG C, and cooling time is 3-6 hour, and the most preferred time is 4 hours, and being finally dried to water content is 10%-20%, step 4: will carry out cryodesiccated Placenta Hominis and adopt super micron mill to carry out being processed into powder, the granular size of powder at 0.2-3 μm, thus obtains the pure powder of Placenta Hominis.Step 5: the pure powder of Placenta Hominis above-mentioned steps obtained adopts sterilization treatment, adopt any one or several in ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization method, the temperature of carrying out sterilizing is 90 DEG C-110 DEG C, pressure is 45MPa-55 MPa, after being granulated by pure for the Placenta Hominis carried out after sterilizing powder, tabletting can obtain lamellar decoction pieces, then described lamellar decoction pieces is carried out vacuum compression packaging, finally make the pure powder ultramicro decoction piece of Placenta Hominis.
Placenta Hominis pure powder ultramicro decoction piece prepared by above-mentioned preparation method causes the aspect of the medicine of disease to have outstanding curative effect for insufficiency of vital energy and blood in puerperal, described Disease Clinical symptom is insufficiency of vital energy and blood in puerperal, pale complexion, myasthenia of limbs.
The pure powder ultramicro decoction piece of Placenta Hominis that the present invention makes has the good result that prior art does not possess, therefore creativeness is possessed, the present invention compared with prior art, there is following beneficial effect: 1, the present invention is the major reform done Chinese medicine decoction pieces, it is a kind of novel Chinese medicine tablet, it changes on the basis of traditional " decoction made from powder " or " bag bubble " technological merit in suction, adopt micronizing, pulverize at low temperature, Chinese crude drug is processed into ultra micro Chinese medicinal granule and carries out pollution-free sterilization again by the modern technologies such as dry granulation, damp-prrof packing, the granule that this processing method is made can replace traditional Chinese medicine, the needs of Chinese herb decoction opinion can be adapted to, face disease adding simplify carry, formula is flexible, do not need to decoct when using, directly soak with boiled water and can take for about 3-20 minute, both the nature,taste and action of Chinese medicine had been maintained, turn avoid the trouble of decoction, clothes for patients is facilitated to use, and economic health, efficient and convenient.
2, during modern advanced application is processed with Chinese medicinal material by the present invention, its superfine communication technique makes the ultra tiny efflorescence of Chinese medicinal material, in the medical material of identical deal, its surface area is increased, and can increase and attract speed and absorbtivity, improves curative effect of medication, effective clear powder dissolution also can be made greatly to improve, thus improve the effective rate of utilization of natural resources of Chinese medicinal materials, medical material 1/2-2/3 can be saved, contribute to the sustainable development of herb resource.
3, the present invention adopts dry crowded formula pears or wet granulation technique that superfine powder is directly compressed into granule, after overcoming micronizing, powder size is superfine, poor fluidity, is inconvenient to the shortcoming of packing, transporting, using, not only instant packed, use, transport, but also do not affect the leaching of medicament effective component.
4, the present invention adopt pollution-free sterilization method gram reduce the prepared slices of Chinese crude drugs containing bacterium number, simple to operate: vacuum packaging can make medicine have good barrier, it is moistureproof, anti-mildew, the quality guarantee period is much better than traditional decoction pieces.
5, raw material of the present invention adopts healthful Chinese crud drug, and carry out standardization Preparation process according to " Chinese Pharmacopoeia ", " concocted specification ", its granule all specifies normalized quality standard, comprise electron-microscope scanning powder characteristics, main chemical compositions TLC differentiates, fineness of powder, moisture, microorganism limitation and water, ferment extractum magnitude TLC differentiate (containing finger printing), heavy metal, arsenic salt and fly healthful Chinese crud drug pesticide residues quantitative determination etc., the equal relevant requirements that can reach international mainstream city field alignment medicine, creates condition for entering international market.
Chinese Traditional Medicine characteristic combines with modern technologies by the present invention, fill up the blank of domestic and international prepared slices of Chinese crude drugs processing industry, not only significant to the development of Chinese medical theory, and facilitate the standardization of Chinese medicine, standardization, scientific, greatly can strengthen Chinese medicine, Chinese patent medicine competitiveness in the international market.The pure powder ultramicro decoction piece of Placenta Hominis that the present invention makes has the good result that prior art does not possess, and therefore possesses creativeness.
Below the case history eye-candy to QI invigorating of the present invention:
Lee so-and-so, female, 24 years old, Shanghai people, adolescence has a lot of comedo on the face, and menstruation stomachache for many years, takes Placenta Hominis ultramicro decoction piece of the present invention after 6 months, the disappearance gradually of small pox on the face, skin starts the smooth of change, has rosy cheeks, and dysmenorrhea defect for many years might as well.
Zhang, female, 45 years old, people from Henan, after wedding young man, face wrinkles was more, and xerosis cutis, upsets, and is easy to fly into a rage, and has now a lot of involutional symptom, also easy cold perspiration when sleep in evening.Take Placenta Hominis ultramicro decoction piece of the present invention after 7 months, sleep quality improves, wrinkle reduces gradually, skin starts to become ruddy, and the skin of face is more flexible, mood also becomes so irritable, and the relation of household also starts to become more to relax, and whole person also youthens a lot.
King so-and-so, female, 60 years old, adhere to taking Placenta Hominis ultramicro decoction piece of the present invention 2 years, old man's skin was bright and clean, and high resilience, and wrinkle is little, does not have eye pouch and senile disease, looks as one's mid-40s, physical and spirit is also well a lot of than age cohorts.
Certainly; the present invention also can have other various embodiments; when not deviating from the present invention's spirit and essence, those of ordinary skill in the art are when making various corresponding change and distortion according to the present invention, but these change accordingly and distortion all should belong to protection scope of the present invention.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.

Claims (9)

1. a preparation method for the pure powder ultramicro decoction piece of Placenta Hominis, is characterized in that, specifically comprise following steps:
Step one: get fresh Placenta Hominis and first rinse with volume water, clears out the impurity of the inside and thing inferior, then soaks 3 hours in cold water, then change washing 3 hours, remove sewage;
Step 2: taken out the Placenta Hominis that cleans up, then gets tape and is tied by described Placenta Hominis and put into pepper water and boil 40-60 minute, pull out in time, be placed in basin, add yellow wine and stir, put in food steamer and steam about half an hour;
Step 3: adopt Freeze Drying Technique to carry out drying on steamed Placenta Hominis, being finally dried to water content is 10%-20%;
Step 4: cryodesiccated Placenta Hominis will be carried out and adopt pulverizer to carry out being processed into coarse powder, the particle diameter size of described coarse powder is below 200 μm, and then by described coarse powder micronizing in jet mill, obtain micropowder, the particle diameter size of described micropowder is between 0.5-3, and the condition of described micronizing is: pulverize temperature 30-45 DEG C, pressure when entering super micron mill is 3-5Mpa, air velocity 150-200m/s, the time 3-5h of pulverizing, finally obtain the pure powder of Placenta Hominis;
Step 5: the pure powder of Placenta Hominis obtained in described step 4 is adopted sterilization treatment, pure for the Placenta Hominis carried out after sterilizing powder is made the pure powder ultramicro decoction piece of Placenta Hominis.
2. preparation method as claimed in claim 1, is characterized in that: described step 5 also comprises and then being mixed with the adjuvant meeting medicament requirement by pure for Placenta Hominis powder ultramicro decoction piece, finally obtained tablet, capsule, oral normal release dosage form.
3. preparation method as claimed in claim 1, it is characterized in that: described adjuvant comprise in disintegrating agent, lubricant, binding agent and filler one or more, the addition of described adjuvant is 20%-30%, and described percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.
4. preparation method as claimed in claim 3, it is characterized in that: described disintegrating agent is one or more in starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, sodium alginate, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose, and the addition of described disintegrating agent is 10%-20%;
Described lubricant is one or more in magnesium stearate, sodium laurylsulfate and boric acid, and the addition of described lubricant is 5%-10%;
Described binding agent is micropowder silica gel and/or Pulvis Talci, and the addition of described binding agent is 1%-5%;
Described filler is for being lactose and/or calcium sulfate, and the addition of described filler is 1%-15%;
Described percentage ratio is the mass percent accounting for the pure powder of described Placenta Hominis.
5. the preparation method of the pure powder ultramicro decoction piece of the Placenta Hominis according to claim 1,2 or 3, is characterized in that, the cryodesiccated temperature in described step 3 is-30 DEG C--20 DEG C, and cooling time is 4 hours.
6. the preparation method according to claim 1,2 or 3, is characterized in that, the powder in described step 4 measures through dry laser particle size analyzer, and the particulate accumulation of particle diameter size between 1-2 μm is no less than 80%.
7. the preparation method of the pure powder ultramicro decoction piece of the Placenta Hominis according to claim 1,2 or 3, is characterized in that, in described step 5, the pure powder of Placenta Hominis carries out the temperature of sterilizing is 90 DEG C-110 DEG C, and pressure is 45MPa-55 MPa.
8. the preparation method of the pure powder ultramicro decoction piece of the Placenta Hominis according to claim 1,2 or 3, it is characterized in that, sterilization treatment in described step 5 adopts any one or several in ray sterilizing, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization method.
9. the pure powder ultramicro decoction piece of Placenta Hominis that the preparation method according to any one of claim 1-8 is obtained.
CN201410539572.7A 2014-10-14 2014-10-14 Human placenta pure powder superfine decoction pieces and preparation method thereof Pending CN104352523A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104887708A (en) * 2015-05-07 2015-09-09 磐安县道地磐药中药研究所 Donkey-hide gelatin pure powder ultramicro decoction pieces and preparation method thereof
CN105030831A (en) * 2015-09-19 2015-11-11 山东中泰药业有限公司 Placental drug and preparation method thereof
CN106727710A (en) * 2017-03-29 2017-05-31 张庆平 A kind of preparation method of placenta nutrient powder
CN106983725A (en) * 2017-04-12 2017-07-28 华润三九医药股份有限公司 A kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol
CN107582569A (en) * 2017-09-02 2018-01-16 发贵科技(贵州)有限公司 A kind of vacuum-packed dried human placenta
CN108379294A (en) * 2018-03-07 2018-08-10 甘肃龙麒生物科技股份有限公司 The technique that liquid nitrogen frozen polishing prepares donkey placenta freeze-dried powder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083627A (en) * 2011-11-03 2013-05-08 青岛康地恩药业股份有限公司 Preparation method of placentophagy shiitake powder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083627A (en) * 2011-11-03 2013-05-08 青岛康地恩药业股份有限公司 Preparation method of placentophagy shiitake powder

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
南省食品药品监督管理局编: "《湖南省中药饮片炮制规范:2010年版》", 31 May 2010, 湖南科学技术出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104887708A (en) * 2015-05-07 2015-09-09 磐安县道地磐药中药研究所 Donkey-hide gelatin pure powder ultramicro decoction pieces and preparation method thereof
CN105030831A (en) * 2015-09-19 2015-11-11 山东中泰药业有限公司 Placental drug and preparation method thereof
CN106727710A (en) * 2017-03-29 2017-05-31 张庆平 A kind of preparation method of placenta nutrient powder
CN106983725A (en) * 2017-04-12 2017-07-28 华润三九医药股份有限公司 A kind of new application for the method and PVPP for improving the molten extract content of Chinese medicinal granule alcohol
CN106983725B (en) * 2017-04-12 2020-12-29 华润三九医药股份有限公司 Method for improving content of alcohol-soluble extract of traditional Chinese medicine particles and new application of crospovidone
CN107582569A (en) * 2017-09-02 2018-01-16 发贵科技(贵州)有限公司 A kind of vacuum-packed dried human placenta
CN108379294A (en) * 2018-03-07 2018-08-10 甘肃龙麒生物科技股份有限公司 The technique that liquid nitrogen frozen polishing prepares donkey placenta freeze-dried powder
CN108379294B (en) * 2018-03-07 2020-10-09 甘肃龙麒生物科技股份有限公司 Process for preparing donkey placenta freeze-dried powder by liquid nitrogen freezing and grinding method

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