CN106962354A - A kind of microbicide compositions comprising anthraquinone analog compound and quinoxyfen - Google Patents
A kind of microbicide compositions comprising anthraquinone analog compound and quinoxyfen Download PDFInfo
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- CN106962354A CN106962354A CN201710286558.4A CN201710286558A CN106962354A CN 106962354 A CN106962354 A CN 106962354A CN 201710286558 A CN201710286558 A CN 201710286558A CN 106962354 A CN106962354 A CN 106962354A
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- quinoxyfen
- physcion
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- emodin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
Abstract
The invention provides a kind of microbicide compositions comprising anthraquinone analog compound and quinoxyfen, said composition includes two kinds of effective constituents As and B, active component A is one kind in Physcion and aloe-emodin in anthraquinone analog compound, active component B is that the weight ratio between quinoxyfen, two components is 1:0.1~80.Present invention also offers the Preparation method and use of said composition.Result of the test shows that the above-mentioned bactericidal composition synergy that the present invention is provided is obvious, it is often more important that amount of application is reduced, use cost reduction.The bactericidal composition can effectively prevent and treat some specific bacteriums or the fungal disease of crop.By the way that the bactericide of different mechanism of action and the mode of action is compounded, there is effect well in terms of germ resistance and raising prevention effect for expanding fungicidal spectrum and delaying.
Description
Technical field
It is more particularly to a kind of that there is the bactericidal composition for improving performance, tool the invention belongs to agriculture plant protection field
Say it is to be related to a kind of microbicide compositions comprising anthraquinone analog compound and quinoxyfen body.
Background technology
Rheum emodin, Rhein, Physcion, Chrysophanol and aloe-emodin etc. belong to anthraquinone analog compound.
These compounds of field of medicaments are widely used, such as immunoregulation effect, scavenging activated oxygen effect, antibacterial, anti-inflammatory, antiviral
Effect, diuresis, the protective effect damaged to cerebrum ischemia, cardiovascu- lar effects, antitumor action.In recent years, these
Anthraquinone analog compound is just progressively applied to agriculture field, particularly Physcion and aloe-emodin, is used for preventing and treating true
Bacterium property, bacillary or Disease, to veterinary antibiotics, the powdery mildew of cereal, downy mildew, gray mold, anthracnose, eye spot disease
Preventive effect is notable, at the same to people and animals' low toxicity, it is environmentally friendly, with other chemical agent no interactions resistances, passed with preferably interior inhale
Effect is led, lasting effect is strong.Its bactericidal action mechanism is the biosynthesis by disturbing disease fungus cell membrane chitin, suppresses disease
The sprouting of opportunistic pathogen spore, the growth of mycelia, the formation of haustorium, so as to block spreading for disease, also can induce crop generation degeneration-resistant
Defense reaction, reaches the effect of diseases prevention.
Quinoxyfen (Quinoxyfen) is systemic fungicide, has special efficacy, foliage application to cereals controlling powdery mildew
Afterwards, medicament can be rapidly infiltrated into plant tissue, and is shifted to top, and the lasting period is up to 70 days.Suitable for cereal species crop,
Grape, vegetables, beet etc..Mechanism of action feature is not sterol biosynthesis inhibitor, nor mitochondrial respiratory inhibitor.Make
It is unique with mechanism, but the specific mechanism of action is unknown.
Actual agricultural chemicals experience have shown that, repeat and single-minded apply a kind of reactive compound to prevent and treat harmful fungoid very
It will cause the fast selective of fungal bacterial strain in the case of many, it is current usual for the danger of reduction refractory fungal bacterial strain selectivity
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the way that the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance generation, reduction amount of application, reduction cost accounting.
The content of the invention
The purpose of the present invention is to be directed to bactericide resistance and pedo relict problem in actual applications, filters out difference and kills
The bactericide of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide the preparation method comprising two kinds of effective constituents As and B bactericidal compositions and
Application in agriculture field preventing and treating corps diseases.
The purpose of the present invention can be reached by following measures：
A kind of microbicide compositions with synergistic effect, said composition includes two kinds of active components of A and B, active component A
For anthraquinone analog compound, active component B is that the weight ratio between quinoxyfen, two components is 1:0.1~80, wherein, Anthraquinones
The one kind of compound in Physcion or aloe-emodin.
Inventor is found by experiment that composition of the invention is to be used to prevent and treat bacillary crops, fungoid or virus
Property disease control synergy it is obvious, it is often more important that amount of application reduce, reduce use cost.Compound containing component A Yu component B
Structure type is different, and mechanism of action is different, and both can expand fungicidal spectrum at compounding, and can delay cause of disease to a certain extent
No interactions resistance between the generation of bacterium resistance and development speed, and component A and component B.
Weight ratio between two components in microbicide compositions of the present invention is 1:0.1~80.To make the medicine between two components
Effect synergistic effect is more notable, and the weight ratio between component A and component the B component of weight two can further be optimized to 1：1~
70.The weight ratio of i.e. described Physcion or aloe-emodin and quinoxyfen is 1:1~70.
In a kind of preferred scheme, the weight ratio between A and the components of B two arbitrarily can enter in the range of following proportionings
Row adjustment 10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:
9、1:10、1:11、1:12、1:13、1:14、1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、
1:25、1:26、1:27、1:28、1:29、1:30、1:31、1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:
40、1:41、1:42、1:43、1:44、1:45、1:46、1:47、1:48、1:49、1:50、1:51、1:52、1:53、1:54、1:
55、1:56、1:57、1:58、1:59、1:60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:68、1:69、1:
70、1:71、1:72、1:73、1:74、1:75、1:76、1:77、1:78、1:79、1:80, can also be in two proportionings of any of the above
Selected in the range of constituting, these ratios can be understood as weight ratio, mol ratio can also be included.
The formulation allowed on agricultural chemicals can be made by active component and insecticides adjuvant or auxiliary material in the composition of the present invention.Enter one
Step, said composition constitutes agriculture by the active component of 2~85% parts by weight and the insecticides adjuvant of 98~15% parts by weight or auxiliary material
The formulation allowed on medicine.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, the particularly purposes in terms of the fungi or bacterium that prevent and treat some crops.Described corps diseases are vegetables, water
Really, the powdery mildew of cereal, downy mildew, gray mold, anthracnose, eye spot disease etc..
Above-mentioned composition can specifically include insecticides adjuvant or auxiliary material, for example carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickener, adhesive, surfactant or fertilizer etc..It can be mixed during administration conventional
Auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, and they are typically the material commonly used during formulation,
For example natural or regeneration mineral matter, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The application process of the present composition includes being used for the composition of the present invention into the aerial part of plant growth, especially
It is leaf portion or blade face.It can select to soak seed or be applied to controlling object surface.The frequency and amount of application of administration depend on pathogen
Biology and weather life condition.The growth place of plant, such as rice field can be soaked with the liquid preparation of composition, or
Composition is applied in soil by person in solid form, such as in granular form (soil application), and composition can be by soil through planting
Thing root enters in plant (systemic action).
The composition of the present invention can be prepared into acceptable various formulations on agricultural chemicals, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, aqua, aqueous emulsion, microemulsion, encapsulated form, mother liquor, female powder etc.,
In a kind of preferred scheme, formulation of the invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.Root
The purpose and ambient conditions to be reached according to the property of these compositions and using composition, can select composition to spray
Mist, atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
The composition of the present invention can be prepared into various formulations with known method, can be by active ingredient with helping
Agent, such as solvent, solid carrier, it is necessary to when can uniformly mix, grind together with surfactant, be prepared into required agent
Type.
Above-mentioned solvent may be selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
The octanoic acid of esters of gallic acid, such as Dibutyl phthalate or phthalandione two, such as fat hydrocarbon, thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, such as highly polar solvent, N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, is such as used for the typically natural mineral fillers, such as talcum, kaolinite of pulvis and dispersible dose
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, polymolecularity silicic acid or polymolecularity can also be added
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or having
The prefabricated material granulated of machine property is used as carrier, particularly dolomite.
The chemical property of active ingredient in the composition of the present invention, suitable surfactant is sulfomethylated lignin
Acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
The condensation product of alcohol sulfate, aliphatic acid and sulphated fatty alcohol glycol ether, also sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
Naphthalene sulfonic acids and phenol and the condensation product of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, bay acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Two kinds of active ingredients show as synergistic effect in the composition of the present invention, and the activity of said composition is than using individualized
The expected summation of activity of compound, and the independent activity of single compound are more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal control spectrum, instant effect, more longlasting prevention effect, by only once or a small number of several times using more
Good control plant pest fungi and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
During especially need.
In terms of the microbicide compositions of the present invention can be applied to agriculture field preventing and treating corps diseases, farming referred herein
Thing disease particularly cereal powdery mildew, cucurbits powdery mildew, downy mildew, uncinula necator, downy mildew, anthracnose, peach powdery mildew,
Powdery mildew of strawberry, capsicum and tomato powdery mildew, anthracnose, beet powdery mildew, golden hop powdery mildew etc..But the composition of the present invention
In addition to it can prevent and treat foregoing disease, moreover it is possible to which the specific illness of preventing and treating includes but is not limited to wheat diseases (such as：It is wheat scab, small
Wheat powdery mildew, wheat rust etc.), rice disease (such as：Rice sheath blight disease, rice green smut, paddy bacterial streak etc.), corn
Disease is (such as：Smut of maize, the leaf blight of corn, corn southern leaf blight), cucumber disease (such as：Cucumber anthracnose, gray mold of cucumber,
Cucumber bacterial angular leaf spot etc.), tomato disease (such as：Anthracnose of tomato, tomato virus disease, tomato bacterial angular leaf spot etc.), Portugal
Grape disease is (such as：Grape grey mould etc.), apple disease (such as：Ring rot of apple, apple anthracnose etc.), citrus disease (such as：Citrus
Shot hole, citrus anthracnose etc.), tobacco diseases (such as：Wildfire, Alternaria alternate etc.), rape disease (such as：Rape frost
Mildew, sclerotinia sclerotiorum), cotton disease (such as：Cotton verticillium wilt, cotton wilt), beet disease (beet cercospora leaf spot, beet
Damping-off) etc..
Other features for showing of bactericidal composition of the present invention are mainly：1st, composition mixture of the invention has obvious
Synergistic effect；2nd, because two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, in the absence of friendship
Mutual resistance, can delay two single doses that produced resistance problem is used alone；3rd, composition of the invention is to crop safety, preventive effect
It is good.Tests prove that, microbicide compositions chemical property of the present invention is stable, and synergy significantly, is shown significantly to controlling object
Synergy and complementation.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to limit only to explain the present invention
The fixed present invention, any modifications, equivalent replacements and improvementsmade within the spirit and principles of the invention, should be included in
Within protection scope of the present invention.
Percentage is weight percentage in all formulas of following examples.The processing work of the various preparations of the present composition
Skill is prior art, can be varied from according to different situations.
First, formulation prepares embodiment
(1) processing of suspending agent and embodiment
By active component active component A and active component B, with each component such as dispersant, wetting agent, thickener and water by matching somebody with somebody
The ratio of side is well mixed, and after sand milling and/or high speed shear, obtains semi-finished product, is mended after analysis and is mixed with water filtering i.e.
Obtain finished product.
(1) active component A (Physcion) prepares suspending agent with quinoxyfen
Embodiment 1：20% Physcion quinoxyfen suspending agent
Physcion 10%, quinoxyfen 10%, methyl naphthalene sulfonate formaldehyde condensate 8%, xanthans 5%, diformazan
Benzene 6%, ammonium sulfate 5%, water complements to 100%.
Embodiment 2：62% Physcion quinoxyfen suspending agent
Physcion 2%, quinoxyfen 60%, remaining component is prepared according to the method for embodiment 1.
(2) active component A (aloe-emodin) prepares suspending agent with quinoxyfen
Embodiment 3：20% aloe-emodin quinoxyfen suspending agent
Aloe-emodin 10%, quinoxyfen 10%, remaining component is prepared according to the method for embodiment 1.
Embodiment 4：62% aloe-emodin quinoxyfen suspending agent
Aloe-emodin 2%, quinoxyfen 60%, remaining component is prepared according to the method for embodiment 1.
(2) processing of aqueous emulsion and embodiment
By active component activity packet A and active component B, with each component such as solvent, emulsifying agent, thickener and water by formula
Ratio be well mixed, after high speed shear, obtain semi-finished product, the filtering that is mixed with water mended after analysis and produces aqueous emulsion.
(1) active component A (Physcion) prepares aqueous emulsion with quinoxyfen
Embodiment 5：11% Physcion quinoxyfen aqueous emulsion
Physcion 10%, quinoxyfen 1%, alkyl polyoxyethylene ether 8%, xanthans 5%, dimethylbenzene 6%, second two
Alcohol 5%, water complements to 100%.
Embodiment 6：44% Physcion quinoxyfen aqueous emulsion
Physcion 4%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 5.
(2) active component A (aloe-emodin) prepares aqueous emulsion with quinoxyfen
Embodiment 7：11% aloe-emodin quinoxyfen aqueous emulsion
Aloe-emodin 10%, quinoxyfen 1%, remaining component is prepared according to the method for embodiment 5.
Embodiment 8：44% aloe-emodin quinoxyfen aqueous emulsion
Aloe-emodin 4%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 5.
(3) processing of wettable powder and embodiment
Active components A and B activity composition and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Obtained wettable powder after broken.
(1) active component A (Physcion) prepares wettable powder with quinoxyfen
Embodiment 9：21% Physcion quinoxyfen wettable powder
Physcion 1%, quinoxyfen 20%, lignosulfonates 6%, alkylsulfonate 6%, xanthans 5% is swollen
Profit soil 8%, precipitated calcium carbonate complements to 100%.
Embodiment 10：41% Physcion quinoxyfen wettable powder
Physcion 1%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 9.
(2) active component A (aloe-emodin) prepares wettable powder with quinoxyfen
Embodiment 11：21% aloe-emodin quinoxyfen wettable powder
Aloe-emodin 1%, quinoxyfen 20%, remaining component is prepared according to the method for embodiment 9.
Embodiment 12：41% aloe-emodin quinoxyfen wettable powder
Aloe-emodin 1%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 9.
(4) processing of microemulsion and embodiment
By active components A and quinoxyfen, mixed in the ratio of formula with solvent, surfactant, stabilizer, water
It is even, microemulsion product is made afterwards.
(1) active component A (Physcion) prepares microemulsion with quinoxyfen
Embodiment 13：76.5% Physcion quinoxyfen microemulsion
Physcion 1.5%, quinoxyfen 75%, dimethyl sulfoxide (DMSO) 12%, the contracting of diphenyl phenol polyethenoxy polyformaldehyde
Compound 6%, magnesium stearate 4%, water complements to 100%.
Embodiment 14：30.5% Physcion quinoxyfen microemulsion
Physcion 0.5%, quinoxyfen 30%, remaining component is prepared according to the method for embodiment 13.
(2) active component A (aloe-emodin) prepares microemulsion with quinoxyfen
Embodiment 15：76.5% aloe-emodin quinoxyfen microemulsion
Aloe-emodin 1.5%, quinoxyfen 75%, remaining component is prepared according to the method for embodiment 13.
Embodiment 16：30.5% aloe-emodin quinoxyfen microemulsion
Aloe-emodin 0.5%, quinoxyfen 30%, remaining component is prepared according to the method for embodiment 13.
(5) processing of water dispersible granules and embodiment
It is well mixed, active component activity packet A and active component B through gas in the ratio of formula with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, and water dispersible granules production is made after drying screening
Product.
(1) active component A (Physcion) prepares microemulsion with quinoxyfen
Embodiment 17：35.5% Physcion quinoxyfen water dispersible granules
Physcion 0.5%, quinoxyfen 35%, gelatin 2%, sodium acid carbonate 5%, polyacrylamide 4%, white carbon
Complement to 100%.
Embodiment 18：40.5% Physcion quinoxyfen water dispersible granules
Physcion 0.5%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 17.
(2) active component A (aloe-emodin) prepares microemulsion with quinoxyfen
Embodiment 19：35.5% aloe-emodin quinoxyfen water dispersible granules
Aloe-emodin 0.5%, quinoxyfen 35%, remaining component is prepared according to the method for embodiment 17.
Embodiment 20：40.5% aloe-emodin quinoxyfen water dispersible granules
Aloe-emodin 0.5%, quinoxyfen 40%, remaining component is prepared according to the method for embodiment 17.
2nd, drug effect checking test
(1) Assays Example
The incidence of whole strain blade is investigated according to experiment grade scale, disease index and prevention effect is calculated.
Prevention effect is converted into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with least square method
Concentration EC50 in calculating virulence equation and suppressing, the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated according to the abundant methods of Sun Yun.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
A percentage composition+B medicament toxicity index * mixtures in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
Middle B percentage composition
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] * 100
CTC≤80, composition shows as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1st, Physcion and quinoxyfen compounding are tested powdery mildew of pea toxicity test
The Physcion of table 1. is compounded to powdery mildew of pea toxicity test interpretation of result with quinoxyfen
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Physcion | 2.18 | 100.00 | \ | \ |
| Quinoxyfen | 18.32 | 11.90 | \ | \ |
| Physcion：Quinoxyfen=1:90 | 14.50 | 15.03 | 12.87 | 116.81 |
| Physcion：Quinoxyfen=1:80 | 13.93 | 15.65 | 12.99 | 120.52 |
| Physcion：Quinoxyfen=1:70 | 13.15 | 16.58 | 13.14 | 126.16 |
| Physcion：Quinoxyfen=1:60 | 12.60 | 17.30 | 13.34 | 129.67 |
| Physcion：Quinoxyfen=1:50 | 12.22 | 17.85 | 13.63 | 130.95 |
| Physcion：Quinoxyfen=1:40 | 11.29 | 19.31 | 14.05 | 137.43 |
| Physcion：Quinoxyfen=1:30 | 9.98 | 21.84 | 14.74 | 148.18 |
| Physcion：Quinoxyfen=1:20 | 9.63 | 22.64 | 16.10 | 140.64 |
| Physcion：Quinoxyfen=1:10 | 8.14 | 26.79 | 19.91 | 134.57 |
| Physcion：Quinoxyfen=1:1 | 3.07 | 70.99 | 55.95 | 126.89 |
| Physcion：Quinoxyfen=1:0.1 | 1.94 | 112.55 | 91.99 | 122.35 |
| Physcion：Quinoxyfen=1:0.05 | 2.01 | 108.71 | 95.80 | 113.47 |
As a result (table 1) shows, in Physcion：Quinoxyfen=1:In 0.1~80 interval range, Physcion with
Quinoxyfen is compounded to be significantly improved to the prevention effect of powdery mildew of pea, illustrates that the two compounding has significantly to powdery mildew of pea preventing and treating
Synergistic effect.And outside above protection domain, both then show the effect of addition.
2nd, aloe-emodin and quinoxyfen compounding are tested pepper anthracnose toxicity test
The aloe-emodin of table 2. is compounded to pepper anthracnose toxicity test interpretation of result with quinoxyfen
As a result (table 2) shows, in aloe-emodin：Quinoxyfen=1:In 0.1~80 interval range, aloe-emodin with
Quinoxyfen is compounded to be significantly improved to the prevention effect of pepper anthracnose, illustrates that the two compounding has significantly to pepper anthracnose preventing and treating
Synergistic effect.And outside above protection domain, both then show the effect of addition.
(2) field efficacy checking test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second of dispenser is carried out after 7 days, 4 are each handled
Individual cell, each square meter of cell 20.In 11 days investigation statisticses incidences before medicine and after second medicine, each 5 points of cell is random
Sampling, 5 plants of crops of every investigation, investigates percentage and classification that the lesion area in whole strain per blade accounts for blade area, calculates
Disease index and prevention effect.
It is expected that preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and more than 50% or the full leaf that lesion area accounts for leaf area are withered.
1st, Physcion and quinoxyfen compounding field efficacy experiment
The Physcion of table 3 is with quinoxyfen mixture to cotton controlling powdery mildew effect
Measurement result (table 3) shows that Physcion is significantly improved with quinoxyfen mixture to the preventive effect of cotton powdery mildew,
Illustrate that the two compounding has significant synergistic effect to cotton powdery mildew.
2nd, aloe-emodin and quinoxyfen compounding field efficacy experiment
The aloe-emodin of table 4 is with quinoxyfen mixture to beet cercospora leaf spot prevention effect
Measurement result (table 4) shows that aloe-emodin is significantly improved with quinoxyfen mixture to the preventive effect of beet cercospora leaf spot,
Illustrate that the two compounding has significant synergistic effect to beet cercospora leaf spot.
Claims (9)
1. a kind of microbicide compositions, it is characterised in that described composition includes two kinds of active components of A and B, active component A is
Anthraquinone analog compound, active component B is that the weight ratio between quinoxyfen, two components is 1:0.1~80, wherein, Anthraquinones
The one kind of compound in Physcion or aloe-emodin.
2. microbicide compositions according to claim 1, it is characterised in that active component A and active component B weight ratio
For 1:1~70.
3. microbicide compositions according to claim 1, it is characterised in that Physcion or aloe-emodin and benzene oxygen
The weight ratio of quinoline is 1:1~70.
4. the microbicide compositions according to any one in claims 1 to 3, it is characterised in that said composition by activity into
Divide and the formulation allowed on agricultural chemicals is made with insecticides adjuvant or auxiliary material.
5. microbicide compositions according to claim 4, it is characterised in that said composition by 2~85% parts by weight activity
Component and the formulation allowed on insecticides adjuvant or auxiliary material the composition agricultural chemicals of 98~15% parts by weight.
6. microbicide compositions according to claim 4, it is characterised in that described formulation be suspending agent, aqueous emulsion, can
WP, microemulsion or water dispersible granules.
7. the microbicide compositions according to claim 4 or 5, it is characterised in that described insecticides adjuvant or auxiliary material, which are selected from, to be carried
One or more in body, solvent, dispersant, wetting agent, adhesive, thickener, adhesive, surfactant or fertilizer.
8. the microbicide compositions in claims 1 to 3 described in any one are in terms of agriculture field preventing and treating corps diseases
Purposes.
9. purposes according to claim 8, it is characterised in that described corps diseases be veterinary antibiotics, cereal it is white
Powder disease, downy mildew, gray mold, anthracnose, eye spot disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Citations (4)
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| CN1255830A (en) * | 1997-05-15 | 2000-06-07 | 诺瓦提斯公司 | Fungicidal combinations comprising 4-phenoxyquinoline |
| CN1387765A (en) * | 2002-06-20 | 2003-01-01 | 河北农业大学植物保护学院 | Germicide containing rhubarb extract and its composition |
| CN1602692A (en) * | 2003-09-29 | 2005-04-06 | 湖北省农业科学院植保土肥研究所 | Emodin monomethyl ether for preventing plant fungus disease |
| CN102548418A (en) * | 2009-07-30 | 2012-07-04 | 玛珑生物创新有限公司 | Plant pathogen inhibitor combinations and methods of use |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1255830A (en) * | 1997-05-15 | 2000-06-07 | 诺瓦提斯公司 | Fungicidal combinations comprising 4-phenoxyquinoline |
| CN1387765A (en) * | 2002-06-20 | 2003-01-01 | 河北农业大学植物保护学院 | Germicide containing rhubarb extract and its composition |
| CN1602692A (en) * | 2003-09-29 | 2005-04-06 | 湖北省农业科学院植保土肥研究所 | Emodin monomethyl ether for preventing plant fungus disease |
| CN102548418A (en) * | 2009-07-30 | 2012-07-04 | 玛珑生物创新有限公司 | Plant pathogen inhibitor combinations and methods of use |
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