CN106913487A - Compound mango leaf extract face cream and preparation method thereof - Google Patents
Compound mango leaf extract face cream and preparation method thereof Download PDFInfo
- Publication number
- CN106913487A CN106913487A CN201710277346.XA CN201710277346A CN106913487A CN 106913487 A CN106913487 A CN 106913487A CN 201710277346 A CN201710277346 A CN 201710277346A CN 106913487 A CN106913487 A CN 106913487A
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- Prior art keywords
- mango leaf
- leaf extract
- extract
- face cream
- mango
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Links
- 235000014826 Mangifera indica Nutrition 0.000 title claims abstract description 91
- 235000004936 Bromus mango Nutrition 0.000 title claims abstract description 90
- 235000009184 Spondias indica Nutrition 0.000 title claims abstract description 90
- 239000000284 extract Substances 0.000 title claims abstract description 76
- 239000006071 cream Substances 0.000 title claims abstract description 36
- 150000001875 compounds Chemical class 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 240000007228 Mangifera indica Species 0.000 title description 7
- 241001093152 Mangifera Species 0.000 claims abstract description 84
- AEDDIBAIWPIIBD-ZJKJAXBQSA-N mangiferin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(OC=2C(=CC(O)=C(O)C=2)C2=O)C2=C1O AEDDIBAIWPIIBD-ZJKJAXBQSA-N 0.000 claims abstract description 74
- YWQSXCGKJDUYTL-UHFFFAOYSA-N Mangiferin Natural products CC(CCC=C(C)C)C1CC(C)C2C3CCC4C(C)(C)CCCC45CC35CCC12C YWQSXCGKJDUYTL-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229940043357 mangiferin Drugs 0.000 claims abstract description 37
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 30
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 19
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims abstract description 16
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 15
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 14
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 239000012071 phase Substances 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 12
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 claims description 11
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
- 238000007654 immersion Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 9
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 8
- 235000021355 Stearic acid Nutrition 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 235000010241 potassium sorbate Nutrition 0.000 claims description 8
- 239000004302 potassium sorbate Substances 0.000 claims description 8
- 229940069338 potassium sorbate Drugs 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 239000012043 crude product Substances 0.000 claims description 5
- 125000004122 cyclic group Chemical group 0.000 claims description 5
- 230000001804 emulsifying effect Effects 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000008719 thickening Effects 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 241000220317 Rosa Species 0.000 claims description 3
- 241001409018 Anthracothorax viridis Species 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 2
- 239000008868 Flower Essence Substances 0.000 claims description 2
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 2
- 235000019082 Osmanthus Nutrition 0.000 claims description 2
- 241000333181 Osmanthus Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960004365 benzoic acid Drugs 0.000 claims description 2
- 235000010331 calcium propionate Nutrition 0.000 claims description 2
- 239000004330 calcium propionate Substances 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 240000005385 Jasminum sambac Species 0.000 claims 1
- 241000219000 Populus Species 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 206010017553 Furuncle Diseases 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 208000003512 furunculosis Diseases 0.000 abstract description 7
- 241000256113 Culicidae Species 0.000 abstract description 6
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 6
- 238000005461 lubrication Methods 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 3
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 2
- 239000003908 antipruritic agent Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 12
- 238000010438 heat treatment Methods 0.000 description 9
- 230000001741 anti-phlogistic effect Effects 0.000 description 7
- 239000006210 lotion Substances 0.000 description 7
- 239000000686 essence Substances 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
- 238000002390 rotary evaporation Methods 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000207840 Jasminum Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 244000242564 Osmanthus fragrans Species 0.000 description 1
- 235000019083 Osmanthus fragrans Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- 241000977602 Swertia mussotii Species 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003602 anti-herpes Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 229940049101 care-creme Drugs 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 238000013138 pruning Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention belongs to health care and daily chemical products field, and in particular to a kind of compound mango leaf extract face cream with mango leaf extract as main active and preparation method thereof.Compound mango leaf extract face cream of the present invention is red and swollen to pruitus caused by skin furunculosis, bite by mosquitos to have good prevention effect；Main active is mango leaf extract, ursin, salicylic acid, titanium dioxide；Its weight proportion is 1~2 part of mango leaf extract, 0.8~1.2 part of ursin, 0.8~1.2 part of salicylic acid, 0.8~1.2 part of titanium dioxide；Mangiferin content is 60% 70% in mango leaf extract.Corresponding auxiliary material is coordinated to be made creme using mangiferin, ursin, salicylic acid, titanium dioxide, melt quickly after being applied on skin and disappear, skin has lubrication, moistening and reflecting feel, has obvious antipruritic, anti-inflammatory for pruitus caused by skin furunculosis, bite by mosquitos and promotes the effect of skin recovery.
Description
Technical field
The invention belongs to health care and daily chemical products field, and in particular to one kind is with mango leaf extract as chief active
Compound mango leaf extract face cream of composition and preparation method thereof.
Background technology
Mango (Mangifera indica L.) is the common tropical fruit (tree) in south China area.Panxi Area, Sichuan Province mango
Cultivated area up to more than 30 ten thousand mu, with yield is high, quality better the characteristics of, occupy domestic late-maturing mango market, mango industry turns into
The leading industry of local agricultural.Through the long-term measure analysis shows of inventor, mangiferin in Panxi Diqu mango leaf
(mangiferin) content is up to 2~8%, far above the content in the other plants such as the wind-weed, also far above other producing regions of China
The content of mangiferin in mango leaf.
Mangiferin, also known as mangiferin, light lark acicular crystal (50% ethanol) has for treating chronic bronchitis
Good therapeutic effect, is principle active component that Swertia mussotii treats hepatitis, is antiviral active component in Asphodeloides Bge Rhizome.Modern medicine
Research has confirmed, mangiferin also have anti-oxidant, anti-inflammatory, antibacterial, radioresistance, preventing and treating skin aging, hypoglycemic, anti-trioxypurine,
Antitumor, immunological regulation, cholagogic, suppression central nervous system, anti-inflammatory anti-herpes simplex virus HSV-2, alleviation HSV-2 viruses are drawn
Many pharmacological actions such as the sacrum nerve root disease for rising.In China's pharmacopeia and several kinds of Chinese medicinal materials, the quality standard of Chinese patent drug,
Mangiferin content is often used as quality control index.The new type of health product or medicine developed as main component with mangiferin at present
Raw materials used is generally the sterling of mangiferin, and is typically generally oral formulations.Because mangiferin is extremely low to the bioavilability of human body,
Thus the clinical trial result of these oral formulations products is unsatisfactory.Bibliography is such as：[1] Li Y J, Sui Y J, Dai Y
H, et a1.LC determination and pharmacokinetics study of mangiferin in rat
Plasma and tissues [J] .Chromatographia, 2008,67 (11-l2)：957-960；[2] Huang Huixue, Tan Zhen
Beautiful woman, Deng Jiagang waits research [J] CHINA JOURNAL OF CHINESE MATERIA MEDICAs that people's gut flora is converted to mangiferin In vitro metabolism, 2011,36 (4)：
443–445。
The present inventor looks for another way, with mango leaf extract (mangiferin content 60-70%) be chief active into
Divide and be made compound external-use preparation, the shortcoming that can not only overcome oral mangiferin bioavilability low gives full play to its drug action,
The mango leaf resource of mango planting site can also be made full use of, production cost is reduced, the economic benefit of mango industry is improved.
The content of the invention
Technical problem solved by the invention is to provide a kind of compound mango leaf with mango leaf extract as primary raw material
Extract face cream and preparation method thereof.Face cream of the present invention is to the red and swollen tool of pruitus caused by skin furunculosis, bite by mosquitos
There is good prevention effect.
The main active of compound mango leaf extract face cream of the present invention is mango leaf extract, ursin, bigcatkin willow
Acid, titanium dioxide；Its weight proportion is 1~2 part of mango leaf extract, 0.8~1.2 part of ursin, 0.8~1.2 part of salicylic acid, titanium
0.8~1.2 part of white powder；Mangiferin content is 60%-70% in mango leaf extract.
In compound mango leaf extract face cream of the present invention, there is active component mangiferin extremely strong anti-inflammatory, antioxygen to be turned into
With being core functional component；Ursin except mangiferin can be cooperateed with to play anti-inflammatory, in addition to antioxidation, also with whitening spot-removing
Effect；Salicylic acid is traditional external-use antiphlogistic, can strengthen the antiphlogistic effects of mangiferin；These three compositions turn into this product jointly
Active component；Titanium dioxide can both cover the yellow of mangiferin, on the other hand because it is small to ultraviolet ray transmissivity, skin can be produced
The certain sun-proof result of life.
Further, on the basis of the main active of face cream, add conventional auxiliary material and be prepared into external-application cream.
Particularly, due to mango leaf extract water-soluble and fat-soluble not good in itself, and with certain color, routinely creme
The physics and appearance character that preparation method is made skin care creme are difficult to reach the use requirement of product, therefore inventor's especial manufacture
Specific auxiliary material combination collaboration inventive compound plays effect, and reaches appearance character requirement when product is used.
In order to improve the water-soluble and fat-soluble of mangiferin, the present invention uses creme formulation, and its weight proportion is：
1) main active：1~2 part of mango leaf extract, 0.8~1.2 part of ursin, 0.8~1.2 part of salicylic acid,
0.8~1.2 part of titanium dioxide；Mangiferin content is 60%-70% in mango leaf extract.
2) auxiliary material：4~6 parts of stearic acid, 0.8~1.2 part of glycerin monostearate, 3~5 parts of butyl stearate, hexadecanol 1
~3 parts, 6~10 parts of glycerine, 0.8~1.2 part of atoleine, 0.2~0.3 part of potassium hydroxide, 0.4~0.6 part of preservative, distillation
30~50 parts of water or deionized water.
Further, essence can also be added in auxiliary material, addition is calculated as 0.1~0.3 part of essence, is used to by weight ratio
Flavouring seasoning.
Preferably, the essence can be using conventional seasoning essences such as jasmine flower essence, rose essence, osmanthus flower fragrances.
Preferably, the preservative can use benzoic acid, Sodium Benzoate, sorbic acid, potassium sorbate, calcium propionate, preferably
Using potassium sorbate.
The auxiliary material of face cream of the present invention uses stearic acid and potassium hydroxide, is in order to react production potassium stearate, with list firmly
The compositions such as glycerol, butyl stearate, hexadecanol play good emulsification jointly, make the homogeneous lubrication of product.
Using glycerine used as water-loss reducer and lubricant；Atoleine therein plays solidification in the product, makes product
Shape is more stablized, and has certain barrier action and lubrication to skin；Potassium sorbate is cosmetics Common Preservatives, safety
Property and dosage have obtained long-term checking.Proved through repetition test, due to mangiferin it is water-soluble and fat-soluble not
It is good, using above-mentioned each component and corresponding ratio, can just obtain the ideal face cream lotion of proterties.
The preparation method of face cream of the present invention, main active and auxiliary material, preparation method are weighed by above-mentioned weight proportion
Step is as follows：
It is prepared by A, two phase liquid：
1) stearic acid, glycerine, glycerin monostearate, butyl stearate, hexadecanol, atoleine are mixed, side stirring
Change is heated to 90~100 DEG C, maintains 20~40min, obtains oil-phase solution；
2) by water, potassium hydroxide mixed dissolution, 90~100 DEG C are heated to while stirring, maintain 10~15min, obtain water
Phase solution；
B, stirring and emulsifying：By the temperature control of step A gained oil-phase solutions at 85~95 DEG C, step A gained is subsequently adding
Aqueous phase solution, stirs 10~20min, sequentially adds mango leaf extract, ursin, salicylic acid, titanium dioxide, stirs,
And temperature is gradually reduced to 55~60 DEG C, obtain even cream.
C, stand cooling, filling obtain final product.
Being tested by inventor is proved, the addition sequence of each material can not be overturned, and the product for otherwise finally obtaining is difficult to reach
To satisfied appearance character requirement.Product of the present invention coordinates corresponding auxiliary material system using mangiferin, ursin, salicylic acid, titanium dioxide
Melt quickly into creme, after being applied on skin and disappear, skin has lubrication, moistening and reflecting feel, is stung for skin furunculosis, mosquito
Sting the effect that caused pruitus has obvious antipruritic, anti-inflammatory and promotes skin to recover.
Specific embodiment
Beneficial effects of the present invention are illustrated below by way of preparating example of the present invention.
Mangiferin content of the present invention for 60%-70% mango leaf extract be use Chinese Patent Application No. for
Prepared by a kind of 201720057903.7 method that separation mangiferin is extracted from mango leaf, extracted specifically from mango leaf and divided
From the mango leaf extract that mangiferin content is 60%-70% is obtained, comprise the following steps：
A, raw material prepare：With mango leaf as raw material, 20-40 mesh sieves were dry, pulverize, obtained mango leaf powder；
B, ester propose removal of impurities：Mango leaf powder is weighed, 2-4L ethyl acetate is added by every kilogram of mango leaf powder, sealing immersion >=
4h, room temperature shakes >=10min, filtering；Extract 3-5 times repeatedly, until the green mango leaf residue that disappears substantially to obtain of extract solution；
C, methyl alcohol are extracted：The mango leaf residue after step B is extracted is taken, 2-4L methyl alcohol is added by every kilogram of mango leaf residue,
30~40 DEG C of sealing immersion >=4h, 50~60 DEG C of stirrings are extracted 0.5~1h, are filtered while hot, extract 4~6 times repeatedly, each time is carried
Liquid merging is taken, precipitation at room temperature >=8h, filtering obtains filtrate；
D, thickening and washing：By the filtrate obtained by step C, equivalent extract is condensed into, 2~4L methyl alcohol is added by every kilogram of medicinal extract,
The agitator treating at 50~60 DEG C, lets cool, filtering, cyclic washing 3-5 times, until filter residue is in yellowish-white coloured particles；Filter residue is dried, is obtained
To the mangiferin crude product of purity 60~70%.
Wherein, mango leaf described in step A uses fresh mango leaf；Especially, mango leaf described in step A uses fresh awns
Fruit tender leaf.But in view of the collection situation of raw material, general tender leaf, the old leaf of branch base portion using mango, and theirs is mixed
Compound.Because inventor's detection finds：Mangiferin content very different in the mango leaf of different cultivars and old tender degree, such as
The content of the kinds such as the larger Kate of cultivated area, Hayden, Ji Lu is general in 2~4%, and the content of the old kind of tradition such as newborn awns
Up to 6~8%, the old leaf of the content far above branch base portion of the tip point tender leaf of same kind.Therefore, extracting method of the present invention
Used in raw material be mainly the tender leaf of various mango, the old leaf of branch base portion, and their mixture, typically can dredge
Collection fresh mango leaf is used as mixed material when pruning when flower fruit thinning or after mango harvesting.
Preferably, dried described in step A to dry naturally or 45-65 DEG C of drying is to moisture<8%.
Preferably, the filtering of precipitation at room temperature >=8h described in step C, using the filter screen fine filtering of >=200 mesh.
Preferably, filtrate concentration is concentrated using 5~65 DEG C of rotary evaporation in vacuo described in step D.
Preferably, described in step D at 50~60 DEG C agitator treating 10-20min.
Preferably, the strainer filtering of use >=200 mesh is filtered described in step D.
Preferably, drying described in step D is to be dried at 50~60 DEG C.
Mango leaf extract embodiment 1
A, raw material prepare：With fresh mango leaf as raw material, dry naturally or 50 DEG C of drying, crushed 20 mesh sieves.
B, ester propose removal of impurities：1000g mango leaf powder is weighed, 3L ethyl acetate is added, sealing immersion 5h, room temperature shakes extraction
15min, filtering；Extract 4 times repeatedly, extract solution green is basic to disappear.
C, methyl alcohol are extracted：The residue after step B is extracted is taken, 2.5L methyl alcohol is added, after 30 DEG C of sealing immersion 5h, 55 DEG C of stirrings
0.5h is extracted, is filtered while hot, extracted 5 times repeatedly, each extract solution merged, precipitation at room temperature 9h, with the fine mistake of the filter screen of 200 mesh
Filter.
D, thickening and washing：By the filtrate of step C, 50 DEG C of rotary evaporation in vacuo are concentrated to give equivalent extract about 50g, add 150mL
Methyl alcohol, agitator treating 10min, lets cool at 55 DEG C, and with the strainer filtering of 200 mesh, cyclic washing 4 times, filter residue is in yellow-white
Grain.Filter residue is dried at 55 DEG C, the mangiferin crude product (i.e. present invention mango leaf extract used) of purity 62.5% is obtained, produced
Rate is about 84.5%.
Mango leaf extract embodiment 2
A, raw material prepare：With fresh mango leaf as raw material, dry naturally, crushed 30 mesh sieves.
B, ester propose removal of impurities：The mango leaf powder of 1000g is weighed, 4L ethyl acetate is added, sealing immersion 4h, room temperature is shaked
10min, filtering；Extract 3 times repeatedly, extract solution green is basic to disappear.
C, methyl alcohol are extracted：The residue after step B is extracted is taken, 4L methyl alcohol is added, after 40 DEG C of sealing immersion 4h, 60 DEG C of stirrings are carried
0.5h is taken, is filtered while hot, extracted 4 times repeatedly, each extract solution merged, precipitation at room temperature 10h, with the fine mistake of the filter screen of 200 mesh
Filter.
D, thickening and washing：By the filtrate of step C, 65 DEG C of rotary evaporation in vacuo are condensed into equivalent extract, add 200mL methyl alcohol,
Agitator treating 20min, lets cool at 50 DEG C, and with the strainer filtering of 200 mesh, cyclic washing 5 times, filter residue is in yellowish-white coloured particles.Will
Filter residue is dried at 50 DEG C, obtains the mangiferin crude product 43.4g (i.e. present invention mango leaf extract used) of purity 67.6%.
Mango leaf extract embodiment 3
A, raw material prepare：With fresh mango leaf as raw material, 40 mesh sieves were crushed in 65 DEG C of drying.
B, ester propose removal of impurities：1000g mango leaf powder is weighed, 2L ethyl acetate is added, sealing immersion 6h, room temperature shakes 20min,
Filtering；Extract 5 times repeatedly, extract solution green is basic to disappear.
C, methyl alcohol are extracted：The residue after step B is extracted is taken, 2L methyl alcohol is added, after 30 DEG C of sealing immersion 6h, 60 DEG C of stirrings are carried
1h is taken, is filtered while hot, extracted 6 times repeatedly, each extract solution merged, precipitation at room temperature 12h, with the filter screen fine filtering of 200 mesh.
D, thickening and washing：By the filtrate of step C, 65 DEG C of rotary evaporation in vacuo are condensed into equivalent extract, add 130mL methyl alcohol,
Agitator treating 20min, lets cool at 50 DEG C, and with the strainer filtering of 200 mesh, cyclic washing 5 times, filter residue is in yellowish-white coloured particles.Will
Filter residue is dried at 60 DEG C, obtains the mangiferin crude product 48.2g (i.e. present invention mango leaf extract used) of purity 66.5%.
It is below the preparation embodiment of face cream of the present invention, the mango leaf extract mangiferin content for using is 60%-
70%.
Embodiment 1
1st, composition of raw materials：
Stearic acid 50g, glycerin monostearate 10g, butyl stearate 40g, hexadecanol 20g, glycerine 80g, atoleine
10g, potassium hydroxide 2.5g, ursin 10g, mango leaf extract 15g, titanium dioxide 10g, salicylic acid 10g, potassium sorbate 5g, jasmine
Jasmine extrait 2g, deionized water 400g
2nd, preparation method：Comprise the following steps：
It is prepared by A, two phase liquid：According to the amount in formula, first by glycerine, glycerin monostearate, butyl stearate, 16
The materials such as alcohol, atoleine put into the stainless steel heating kettle of carrying vapour chuck, and side stirring change is heated to 95 DEG C, maintains 30min, obtains
To oil-phase solution.Water in formula, potassium hydroxide are put into the stainless steel heating kettle of another carrying vapour chuck again, side stirring change adds
Heat maintains 12min to 95 DEG C, obtains aqueous phase solution.
B, stirring and emulsifying：The oil-phase solution that will be prepared is put into emulsification agitated kettle, and heating stirring, control kettle temperature is steady
After being scheduled on 90 DEG C, aqueous phase solution is put into pot, stirs 15min, then the other components in formula all added in pot, stirring
Uniformly, and kettle temperature is stepped down to 60 DEG C, obtain even cream.
C, standing cooling：The even cream that will be emulsified in agitated kettle is extruded, and is stood, and allows lotion temperature to be cooled to 35 DEG C.
It is D, filling：Lotion after cooling is put into automatic filling machine, skin care item packing container is distributed into, sealed, produced
Product.
Embodiment 2
1st, composition of raw materials：
Stearic acid 40g, glycerin monostearate 8g, butyl stearate 30g, hexadecanol 10g, glycerine 60g, atoleine
8g, potassium hydroxide 2g, ursin 8g, mango leaf extract 10g, titanium dioxide 8g, salicylic acid 8g, potassium sorbate 4g, Rose Essentielle
Smart 1g, distilled water 300g.
2nd, preparation method：Comprise the following steps：
It is prepared by A, two phase liquid：According to the amount in formula, first by glycerine, glycerin monostearate, butyl stearate, 16
The materials such as alcohol, atoleine put into the stainless steel heating kettle of carrying vapour chuck, and side stirring change is heated to 90 DEG C, maintains 20min, obtains
To oil-phase solution.Water in formula, potassium hydroxide are put into the stainless steel heating kettle of another carrying vapour chuck again, side stirring change adds
Heat maintains 10min to 90 DEG C, obtains aqueous phase solution.
B, stirring and emulsifying：The oil-phase solution that will first prepare is put into emulsification agitated kettle, and heating stirring controls kettle temperature
Be put into aqueous phase solution in pot after 85 DEG C by stabilization, after stirring 20min, then the other components in formula is all added in pot,
Stir, and kettle temperature is stepped down to 55 DEG C, obtain even cream.
C, standing cooling：The even cream that will be emulsified in agitated kettle is extruded, and is stood, and allows lotion temperature to be cooled to 30 DEG C.
It is D, filling：Lotion after cooling is put into automatic filling machine, skin care item packing container is distributed into, sealed, produced
Product.
Embodiment 3
1st, composition of raw materials：
Stearic acid 60g, glycerin monostearate 12g, butyl stearate 50g, hexadecanol 30g, glycerine 100g, atoleine
12g, potassium hydroxide 3g, ursin 12g, mango leaf extract 20g, titanium dioxide 12g, salicylic acid 12g, potassium sorbate 6g, sweet osmanthus
Essence 1g, deionized water 300g
2nd, preparation method：Comprise the following steps：
It is prepared by A, two phase liquid：According to the amount in formula, first by glycerine, glycerin monostearate, butyl stearate, 16
The materials such as alcohol, atoleine put into the stainless steel heating kettle of carrying vapour chuck, and side stirring change is heated to 100 DEG C, maintains 20min,
Obtain oil-phase solution.Water in formula, potassium hydroxide are put into the stainless steel heating kettle of another carrying vapour chuck again, side stirring becomes
100 DEG C are heated to, 10 are maintained, aqueous phase solution is obtained.
B, stirring and emulsifying：The oil-phase solution that will first prepare is put into emulsification agitated kettle, and heating stirring controls kettle temperature
Be put into aqueous phase solution in pot at 95 DEG C by stabilization, after stirring 10min, then the other components in formula is all added in pot, stirs
Mix uniform, and kettle temperature is stepped down to 60 DEG C, obtain even cream.
C, standing cooling：The even cream that will be emulsified in agitated kettle is extruded, and is stood, and allows lotion temperature to be cooled to 30 DEG C.
It is D, filling：Lotion after cooling is put into automatic filling machine, skin care item packing container is distributed into, sealed, produced
Product.
According to the ointment product that above-described embodiment 1-3 makes, its qualitative character is shown in Table 1.
The outward appearance and qualitative character of the face cream product of the present invention of table 1
For face cream of the present invention, inventor passes through " experiment of mice caused by dimethylbenzene xylene ear swelling ", with the inhibiting rate to inflammation
As index, analysis is compared to its antiphlogistic effects.Three kinds of different cremes are made according to the embodiment of the present invention 1 to make respectively
It is control group and test group：A (negative control group)：According to 1 addition auxiliary material of embodiment, creme is prepared without active component；B
(being not added with mango leaf extract test group)：The composition added in addition to mango leaf extract according to embodiment 1 prepares creme；C (adds
Plus mango leaf extract test group)：Creme is prepared according to embodiment 1.The different groups of experiment point three, smear with dimethylbenzene
After mouse side auricle causes it that swelling occurs, mice auricle swelling position is smeared with above-mentioned three kinds of cremes respectively, surveyed after 2 hours
Determine the swelling and inflammation inhibiting rate of each group Mice Auricle, the results are shown in Table 2.From table 2, without the control group of active component
There is no an antiphlogistic effects, two test groups for adding active component all generate antiphlogistic effects, but addition mango leaf extract and not
Plus the antiphlogistic effects between two test groups of mango leaf extract have significant difference, the former antiphlogistic effects are higher than the latter
74.9%.
The face cream product clinical trial result investigation of the present invention of table 2
For face cream of the present invention, inventor enters for pruitus redness patient caused by skin furunculosis, bite by mosquitos
Go clinical trial result observation, statistical analysis has been carried out to its efficient and effective time, the results are shown in Table 3.It can be seen that, the present invention
Product to the total effective rate of the scytitises such as redness, itch caused by skin furunculosis, bite by mosquitos more than 71%, to protection skin
Skin has good effect.
The face cream product clinical trial result investigation of the present invention of table 3
| Patient class | Patient populations | Effectively | It is invalid | Effective time (h) | Efficient (%) |
| Skin furunculosis | 32 | 23 | 9 | 8~24 | 71.8 |
| Pruitus is red and swollen caused by bite by mosquitos | 35 | 31 | 4 | 0.2-2 | 88.6 |
Claims (7)
1. compound mango leaf extract face cream, it is characterised in that：Main active is mango leaf extract, ursin, water
Poplar acid, titanium dioxide；Its weight proportion be 1~2 part of mango leaf extract, 0.8~1.2 part of ursin, 0.8~1.2 part of salicylic acid,
0.8~1.2 part of titanium dioxide；Wherein, mangiferin content is 60-70% in mango leaf extract.
2. compound mango leaf extract face cream according to claim 1, it is characterised in that：In the base of main active
On plinth, add conventional auxiliary material and be prepared into face cream.
3. compound mango leaf extract face cream according to claim 1, it is characterised in that：Its weight proportion is：
Main active：1~2 part of mango leaf extract, 0.8~1.2 part of ursin, 0.8~1.2 part of salicylic acid, titanium dioxide
0.8~1.2 part；
Auxiliary material：4~6 parts of stearic acid, 0.8~1.2 part of glycerin monostearate, 3~5 parts of butyl stearate, 1~3 part of hexadecanol,
6~10 parts of glycerine, 0.8~1.2 part of atoleine, 0.2~0.3 part of potassium hydroxide, 0.4~0.6 part of preservative, distilled water go
30~50 parts of ionized water.
4. compound mango leaf extract face cream according to claim 3, it is characterised in that：The auxiliary material also includes perfume
Essence；
Preferably, essence addition is calculated as 0.1~0.3 part of essence by weight ratio；
Preferably, the essence can use jasmine flower essence, rose essence, osmanthus flower fragrance.
5. compound mango leaf extract face cream according to claim 4, it is characterised in that：The preservative can be used
Benzoic acid, Sodium Benzoate, sorbic acid, potassium sorbate, calcium propionate；It is preferred that using potassium sorbate.
6. the compound mango leaf extract face cream according to claim any one of 1-5, it is characterised in that：Mangiferin content
For the preparation method of the mango leaf extract of 60%-70% comprises the following steps：
A, raw material prepare：With mango leaf as raw material, 20-40 mesh sieves were dry, pulverize, obtained mango leaf powder；
B, ester propose removal of impurities：Mango leaf powder is weighed, 2-4L ethyl acetate is added by every kilogram of mango leaf powder, seal immersion >=4h, room
Temperature shakes >=10min, filtering；Extract 3-5 times repeatedly, until the green mango leaf residue that disappears substantially to obtain of extract solution；
C, methyl alcohol are extracted：The mango leaf residue after step B is extracted is taken, 2-4L methyl alcohol is added by every kilogram of mango leaf residue, 30~
40 DEG C of sealing immersion >=4h, 50~60 DEG C of stirrings are extracted 0.5~1h, are filtered while hot, extract 4~6 times repeatedly, by each extract solution
Merge, precipitation at room temperature >=8h, filtering obtains filtrate；
D, thickening and washing：By the filtrate obtained by step C, equivalent extract is condensed into, 2~4L methyl alcohol is added by every kilogram of medicinal extract, 50
Agitator treating at~60 DEG C, lets cool, filtering, cyclic washing 3-5 times, until filter residue is in yellowish-white coloured particles；Filter residue is dried, obtains pure
The mangiferin crude product of degree 60~70%, i.e., described mango leaf extract.
7. the preparation method of compound mango leaf extract face cream described in any one of claim 1-6, it is characterised in that：By weight
Proportioning weighs main active and auxiliary material, and preparation method step is as follows：
It is prepared by A, two phase liquid：
1) stearic acid, glycerine, glycerin monostearate, butyl stearate, hexadecanol, atoleine are mixed, side stirring change adds
Heat maintains 20~40min to 90~100 DEG C, obtains oil-phase solution；
2) water, potassium hydroxide are mixed, 90~100 DEG C is heated to while stirring, maintain 10~15min, obtain aqueous phase solution；
B, stirring and emulsifying：By the temperature control of step A gained oil-phase solutions at 85~95 DEG C, step A gained water phases are subsequently adding
Solution, stirs 10~20min, adds mango leaf extract, ursin, salicylic acid, titanium dioxide, stirs, and make progressively
Temperature is reduced to 55~60 DEG C, obtains even cream；
C, stand cooling, filling obtain final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012705A (en) * | 2019-12-18 | 2020-04-17 | 广州市巧美化妆品有限公司 | Extraction process of kapok leaf extract and essence cream thereof |
| WO2022090322A1 (en) * | 2020-10-28 | 2022-05-05 | Givaudan Sa | Improvements in or relating to extracts |
| CN116549359A (en) * | 2023-06-16 | 2023-08-08 | 诺德溯源(广州)生物科技有限公司 | Acne-removing composition for optimizing skin grease quality and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008079898A1 (en) * | 2006-12-20 | 2008-07-03 | Pharmwest, Inc. | Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions |
| CN103655381A (en) * | 2013-12-27 | 2014-03-26 | 茂名职业技术学院 | Method for extracting sun shielding ingredient from mango or orange leaves |
| CN103768112A (en) * | 2012-10-26 | 2014-05-07 | 昆明制药集团股份有限公司 | Mango leaf extract and application thereof |
| CN106176536A (en) * | 2016-08-24 | 2016-12-07 | 李斌 | A kind of whitening beauty treatment emulsion |
-
2017
- 2017-04-25 CN CN201710277346.XA patent/CN106913487B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008079898A1 (en) * | 2006-12-20 | 2008-07-03 | Pharmwest, Inc. | Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions |
| CN103768112A (en) * | 2012-10-26 | 2014-05-07 | 昆明制药集团股份有限公司 | Mango leaf extract and application thereof |
| CN103655381A (en) * | 2013-12-27 | 2014-03-26 | 茂名职业技术学院 | Method for extracting sun shielding ingredient from mango or orange leaves |
| CN106176536A (en) * | 2016-08-24 | 2016-12-07 | 李斌 | A kind of whitening beauty treatment emulsion |
Non-Patent Citations (2)
| Title |
|---|
| 国家食品药品监督管理总局: "《化妆品安全技术规范 2015年版》", 31 December 2015 * |
| 陈仪新等: "芒果不同部位化学成分和药理作用的研究近况", 《广西中医药大学学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012705A (en) * | 2019-12-18 | 2020-04-17 | 广州市巧美化妆品有限公司 | Extraction process of kapok leaf extract and essence cream thereof |
| WO2022090322A1 (en) * | 2020-10-28 | 2022-05-05 | Givaudan Sa | Improvements in or relating to extracts |
| CN116549359A (en) * | 2023-06-16 | 2023-08-08 | 诺德溯源(广州)生物科技有限公司 | Acne-removing composition for optimizing skin grease quality and preparation method and application thereof |
| CN116549359B (en) * | 2023-06-16 | 2024-02-06 | 诺德溯源(广州)生物科技有限公司 | Acne-removing composition for optimizing skin grease quality and preparation method and application thereof |
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