CN106902190A - A kind of Chinese medicine patcher formula for treating insomnia and preparation method thereof - Google Patents
A kind of Chinese medicine patcher formula for treating insomnia and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of Chinese medicine patcher formula for treating insomnia and preparation method thereof.The Chinese medicine patcher formula of insomnia is treated, is made up of the active compound material of following parts by weight：The weight portion of spina date seed 17-23, the weight portion of cortex albiziae 14-20, the weight portion of valerian 15-19, the weight portion of wilsonii 9-14, the weight portion of RADIX POLYGALAE PREPARATA 8-11, the weight portion of the vine of multiflower knotweed 6-10, the weight portion of radix bupleuri 5-9, the weight portion of radix rehmanniae recen 3-7, the weight portion of hops 2-6.Safely and effectively treatment insomnia is realized, and improves curative effect.
Description
Technical field
The present invention relates to Chinese medicine preparation, more particularly to a kind of Chinese medicine patcher formula for treating insomnia and preparation method thereof.
Background technology
At present, with the increase of people's life stress, increasing people is perplexed by insomnia.Insomnia is also known as sleep and maintains
Sleep-disorder (DIMS), is often referred to a kind of subjective body that patient is unsatisfactory on the length of one's sleep or quality and influences social function on daytime
Test.Have by clinical common insomnia form:1. Sleep latency extension：Time for falling asleep is more than 30min；2. sleep maintains obstacle:
Night awakening number of times >=2 time or morning early awakening；3. sleep quality declines:The shallow, dreaminess of sleep；4. total sleep time shortens:Generally
Less than 6h；5. residual effect in the daytime:Secondary morning feels giddy, lassitude, drowsiness, weak etc..It is divided into according to the course of disease:1. acute mistake
Sleep:The course of disease is less than 4 weeks；2. subacute insomnia:The course of disease was more than 4 weeks, less than 6 months；3. chronic insomnia:The course of disease is more than 6 months.It is existing
Some treatment methods have using oral hypnotic, but, injury of the long-term taking to human body is larger；And China Patent No.
201410493860 disclose a kind of Traditional Chinese medicine for tranquilization pillow, but the effect calmed the nerves mainly is reached by smell, and it plays medicine and makees
Composition is mainly volatile matter, it is impossible to whole effects of medicine are given full play to, that is to say, that to insomniac's simultaneous phenomenon
Its preventing and treating is limited with potential development tendency.Based on this, how to realize treatment insomnia safely and effectively and curative effect is good, be desirable
Research and the key technical problem for solving, this also exactly technical problems to be solved by the invention.
The content of the invention
The technical problems to be solved by the invention are：A kind of Chinese medicine patcher formula for treating insomnia is provided, safety is realized
Effective treatment insomnia, and improve curative effect.
The present invention provide technical scheme be, a kind of Chinese medicine patcher formula for treating insomnia, by following parts by weight
Active compound material is made：The weight portion of spina date seed 17-23, the weight portion of cortex albiziae 14-20, the weight portion of valerian 15-19, wilsonii 9-14
Weight portion, the weight portion of RADIX POLYGALAE PREPARATA 8-11, the weight portion of the vine of multiflower knotweed 6-10, the weight portion of radix bupleuri 5-9, the weight portion of radix rehmanniae recen 3-7, beer
The weight portion of hops 2-6.
Further, the Chinese medicine patcher formula of the treatment insomnia is made up of the active compound material of following parts by weight：Wild jujube
The weight portion of benevolence 18-22, the weight portion of cortex albiziae 16-19, the weight portion of valerian 16-18, the weight portion of wilsonii 10-13, RADIX POLYGALAE PREPARATA
9-10 weight portions, the weight portion of the vine of multiflower knotweed 7-9, the weight portion of radix bupleuri 6-8, the weight portion of radix rehmanniae recen 4-6, the weight of hops 3-5
Part.
Further, the active compound material is：The weight portion of spina date seed 18, the weight portion of cortex albiziae 16, the weight portion of valerian 16, thorn five
Plus 12 weight portions, the weight portion of RADIX POLYGALAE PREPARATA 10, the weight portion of the vine of multiflower knotweed 9, the weight portion of radix bupleuri 8, the weight portion of radix rehmanniae recen 6, the weight of hops 5
Part.
Further, the active compound material is：The weight portion of spina date seed 20, the weight portion of cortex albiziae 18, the weight portion of valerian 18, thorn five
Plus 10 weight portions, the weight portion of RADIX POLYGALAE PREPARATA 10, the weight portion of the vine of multiflower knotweed 8, the weight portion of radix bupleuri 7, the weight portion of radix rehmanniae recen 5, the weight of hops 4
Part.
Further, the active compound material is：The weight portion of spina date seed 22, the weight portion of cortex albiziae 19, the weight portion of valerian 17, thorn five
Plus 13 weight portions, the weight portion of RADIX POLYGALAE PREPARATA 9, the weight portion of the vine of multiflower knotweed 7, the weight portion of radix bupleuri 6, the weight portion of radix rehmanniae recen 4, the weight of hops 3
Part.
The present invention provides a kind of preparation method of the Chinese medicine patcher formula for treating insomnia, in being had a sleepless night using above-mentioned treatment
Medicine cataplasm is formulated, and specific preparation technology is as follows：
Step one, radix bupleuri, RADIX POLYGALAE PREPARATA, the supercritical CO of the taste medicine of spina date seed three2Extract：Radix bupleuri, RADIX POLYGALAE PREPARATA, acid are weighed respectively
The taste recipe quantity medicinal material of jujube kernel three, grinds to form 20 mesh~40 mesh medicinal powder and is fitted into extraction kettle, with 55 DEG C of extraction temperature, extracting pressure
20MPa, CO2Flow 40Lh-1, extraction time 2h, entrainer is that the extraction conditions of 50% ethanol carry out supercritical CO2Extract,
The supercritical CO of acquisition2Extract low-temperature storage, it is standby；
It is prepared by step 2, cortex albiziae, valerian, the vine of multiflower knotweed, radix rehmanniae recen, the water extraction solution of hops five kinds of Chinese medicine：By silk tree
Skin, valerian, the vine of multiflower knotweed, radix rehmanniae recen, hops five tastes recipe quantity medicinal material, and radix bupleuri, polygala, spina date seed three after means of supercritical extraction
The dregs of a decoction of taste medicine, are extracted 3 times with water, and three amount of water are followed successively by 12 times, 10 times and 8 times of medicinal material weight, each extraction time
For 90 minutes after boiling；Extract solution is filtered, merged, being concentrated under reduced pressure into water extraction concentrate, is placed standby；
It is prepared by step 3, wilsonii micropowders：The superfine acanthopanax powder of prescription proportional quantities is broken into 10 μm of medium particle diameter
Following Ultramicro-powder；
It is prepared by step 4, cataplasm：Arabic gum 25g, polyvinyl alcohol 10g, sodium alginate 15g are weighed respectively, and respectively
Soaked with extract solution 100ml, 50ml and the 100ml in step 2, heating water bath to swelling, be respectively prepared homogeneous transparent I
Primary glue clear gum liquid, sodium alginate clear gum liquid, polyvinyl alcohol clear gum liquid；By 10ml glycerine, 4.5ml azones,
0.75g methyl hydroxybenzoates, 0.75g ethylparabens grind well in being sequentially added mortar, then by Arabic gum clear gum liquid, marine alga
Supercritical CO in sour sodium clear gum liquid, polyvinyl alcohol clear gum liquid, step one2Extract 22.6g~25.8g, step
Wilsonii micropowders 65g in three is poured into mortar and is ground well to form lotion, finally, being excluded uniform when lotion taken advantage of into temperature after bubble
Coat without 0.5h is dried under baking oven below 40 DEG C of juxtaposition on anti-cloth, cover anti-stick layer, the cataplasm for being cut into suitable size is made
Product.
Compared with prior art, advantages and positive effects of the present invention are：The Chinese medicine bar of the treatment insomnia that the present invention is provided
Cloth agent prescription and preparation method thereof, above composition and effectiveness is configured to ultrafine powder traditional Chinese medicine, and percutaneous acupuncture point controlled release drug administration can make medicine straight
Up to sick institute, sufferer is released, its effect is quick, and few side effects are pollution-free, overcome the toxic and side effect of oral or intravenous administration, no
Infringement skin texture；The treatment of this form is acted on of both having：First is direct effect, refers to drugs through skin, hole
The positions such as key, Yu cave directly absorb, defeated to be distributed in locally and systemically into blood vessels network warp, to play its pharmacological action, while may be used also
Stimulate by warm etc., accelerate blood circulation, increase the infiltration of medicine, absorb and propagate, strengthen systemic effect, promote medicine
The performance of direct therapeutic action；Second is indirectly-acting, and external therapy of Chinese herb is to produce certain stimulation to local first, is passed through
Stimulus information is delivered to human body viscera by channels and collaterals, plays regulation or therapeutic action.Using Chinese medicine tranquilizing and allaying excitement, soothing liver-qi stagnation is supported
Heart sedate, Yin Yang balancing, orderly and clearly qi and blood effect reaches ataraxia, and QI movement being in harmonious way, heart kidney is joined, and receives and expected controls curative effect
Really；By the way of cataplasm, with easy to operate, curative effect reliability, non-invasive, safely and effectively, have no toxic side effect, without stomach and intestine
Road head mistakes, without hepatorenal damage, patient's no pain is acceptant, easy to use, and effect is direct, works quick, non-environmental-pollution,
And use natural traditional Chinese medicine to be processed through ultramicro grinding and supercritical extract etc. and prepare, medicine usage amount is significantly reduced, with resource section
About, the utilization rate of Chinese medicine is effectively raised.
Specific embodiment
Embodiment one
The Chinese medicine patcher formula of the present embodiment treatment insomnia, is made up of the active compound material of following parts by weight：Spina date seed
17-23 weight portions, the weight portion of cortex albiziae 14-20, the weight portion of valerian 15-19, the weight portion of wilsonii 9-14, RADIX POLYGALAE PREPARATA 8-
11 weight portions, the weight portion of the vine of multiflower knotweed 6-10, the weight portion of radix bupleuri 5-9, the weight portion of radix rehmanniae recen 3-7, the weight portion of hops 2-6.
Embodiment two
The Chinese medicine patcher formula of the present embodiment treatment insomnia is made up of the active compound material of following parts by weight：Spina date seed 18-
22 weight portions, the weight portion of cortex albiziae 16-19, the weight portion of valerian 16-18, the weight portion of wilsonii 10-13, the weight of RADIX POLYGALAE PREPARATA 9-10
Amount part, the weight portion of the vine of multiflower knotweed 7-9, the weight portion of radix bupleuri 6-8, the weight portion of radix rehmanniae recen 4-6, the weight portion of hops 3-5.
Preferably, the active compound material of the Chinese medicine patcher formula of the present embodiment treatment insomnia is：The active compound material is：Spina date seed
18 weight portions, the weight portion of cortex albiziae 16, the weight portion of valerian 16, the weight portion of wilsonii 12, the weight portion of RADIX POLYGALAE PREPARATA 10, the weight of the vine of multiflower knotweed 9
Amount part, the weight portion of radix bupleuri 8, the weight portion of radix rehmanniae recen 6, the weight portion of hops 5.
Preferably, the active compound material of the Chinese medicine patcher formula of the present embodiment treatment insomnia is：The weight portion of spina date seed 20, silk tree
The weight portion of skin 18, the weight portion of valerian 18, the weight portion of wilsonii 10, the weight portion of RADIX POLYGALAE PREPARATA 10, the weight portion of the vine of multiflower knotweed 8, the weight of radix bupleuri 7
Part, the weight portion of radix rehmanniae recen 5, the weight portion of hops 4.
Preferably, the active compound material of the Chinese medicine patcher formula of the present embodiment treatment insomnia is：The weight portion of spina date seed 22, silk tree
The weight portion of skin 19, the weight portion of valerian 17, the weight portion of wilsonii 13, the weight portion of RADIX POLYGALAE PREPARATA 9, the weight portion of the vine of multiflower knotweed 7, the weight of radix bupleuri 6
Part, the weight portion of radix rehmanniae recen 4, the weight portion of hops 3.
Wherein, the compatibility theory for above-mentioned formulation of drug is as follows：
Spina date seed has the effect of antitoxic heart-soothing and sedative, and to restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis etc. have remarkable effect.Close
Joyous leatherware has Xie Yu and blood, tranquilizing mind, and to confused and worried, melancholy insomnia etc. has remarkable effect.Valerian has mental-tranquilization, reason
Effect of gas, promoting blood circulation and stopping pain, using its effect calmed the nerves can be used to treatment have no peace of mind, the disease such as palpitaition dreaminess, often and wild jujube
The compatibilities such as benevolence, cortex albiziae, the vine of multiflower knotweed.Valerian has sedation, can strengthen corticocerebral process of inhibition, lowers reflex irritation
Property, smooth muscle spasm being released, can merge with bromide for various nervous excitation states.Wilsonii with replenishing qi to invigorate the spleen, pacify by kidney tonifying
God, physically weak weak for the spleen kidney deficiency of yang, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep is especially effective, and modern medicine research
Prove that the action character of wilsonii is essentially identical with ginseng, it is disorderly with regulation body, it is allowed to tend to normal function, have good
Antifatigue effect, and can significantly improve hypoxia-bearing capability compared with ginseng significantly.RADIX POLYGALAE PREPARATA has tranquilize the mind and promote the intelligence, and eliminating the phlegm is had one's ideas straightened out,
Xie Yu, to palpitation with fear, forgetful, nocturnal emission, insomnia is contained, insane most important with tranquilize the mind and promote the intelligence to the coma phlegm of phlegmatic mental confusion especially
Medicinal efficacy, to having no peace of mind and insomnia and dreamful sleep etc. has obvious therapeutic action；Meanwhile, RADIX POLYGALAE PREPARATA has outstanding anti-oxidant and anti-
Aging is acted on, and it is reduced into the oxidation reaction that can be allowed after human body in human body, a large amount of free radicals can be removed, while can also improve
The cytoactive of each organ, subtracts the appearance from the various senile symptoms of the mankind.The vine of multiflower knotweed has mental-tranquilization, dispelling wind and removing obstruction in the meridians, to losing
Dormancy disease, internal lesion caused by overexertion, hidrosis effect is significant.Radix bupleuri has harmonizing Sharyang, and relax liver and stomach, and yang invigorating, modern pharmacological research is proved：Bavin
Have recklessly：Calm, analgesia, there is releasing distending pain uncomfortable in chest, opens strongly fragrant through effect.Radix rehmanniae recen has clearing heat and cooling blood effect for warm heat disease heat
Enter ying blood, high fever coma, dry tongue is deep red, in injury thirst, Heat Diabetes.Hops has tranquilizing the mind and aiding digestion, preventing phlegm from forming and stopping coughing calming heart
For diseases such as indigestion, insomnias.
But, do not only have therapeutic action, also side effect in itself for each herbal medicine.Valerian in the present invention, wilsonii,
Three kinds of uses of component of RADIX POLYGALAE PREPARATA, especially wilsonii and RADIX POLYGALAE PREPARATA both components, prepare through our technique and have reached increasing
Effect is acted on, and traditional preparation technology is significantly better than in clinical observation；And valerian, being used in combination for hops mainly eliminate valerian
The ill-effect of three esters, such as valerian can cause patient that drowsiness, dysbasia, fatigue symptom occur, but, using hops
Fragrance appetizing effect, and can effectively contain muscle containing abundant isoamylene radical chromocor class compound in combination hops
Atrophy, stiff effect, eliminate dysbasia, can have balance prescription, the positive function of enhancing with dispelling fatigue.For long-term
Insomniac, it may appear that the associated disease such as some anxieties, depression, agitation, poor memory, absent minded, poor appetite
Shape, these symptoms occur causing insomnia to form vicious circle, and in the present invention, medicine has function for assisting sleep in itself, meanwhile, also foundation
Combination principle and the clinical symptoms identification of Chinese medicine, have carried out comprehensive medical treatment, such as to greatest extent:Radix bupleuri soothing liver-qi stagnation；Thorn five
Plus regulation body is disorderly, improves brain function, dispelling fatigue；The remote eliminating the phlegm of will processed is had one's ideas straightened out, tranquilize the mind and promote the intelligence；Valerian mental-tranquilization, except frightened
Throb with fear dreaminess；Heat is dry tired in radix rehmanniae recen energy removing summer-heat；Make refining formula, treatment is clear and definite, and clinical verification is effectively reliable.And user
Just, hurtless measure.
Wherein, the Chinese medicine patcher formula of the present embodiment treatment insomnia can be made of following preparation technology, specifically such as
Under：
Step one, radix bupleuri, RADIX POLYGALAE PREPARATA, the supercritical CO of the taste medicine of spina date seed three2Extract：Radix bupleuri, RADIX POLYGALAE PREPARATA, acid are weighed respectively
The taste recipe quantity medicinal material of jujube kernel three, grinds to form 20 mesh~40 mesh medicinal powder and is fitted into extraction kettle, with 55 DEG C of extraction temperature, extracting pressure
20MPa, CO2Flow 40Lh-1, extraction time 2h, entrainer are that the extraction conditions of 50% ethanol carry out supercritical CO2Extract,
The supercritical CO of acquisition2Extract solution low-temperature storage, it is standby；Specifically, so that inventory is calculated by 5 times of recipe quantities as an example, at three tastes
Square proportional quantities medicinal material 185g, the supercritical CO of acquisition2Extract amountIt is 22.6g~25.8g.
It is prepared by step 2, cortex albiziae, valerian, the vine of multiflower knotweed, radix rehmanniae recen, the water extraction solution of hops five kinds of Chinese medicine：By silk tree
Skin, valerian, the vine of multiflower knotweed, radix rehmanniae recen, hops five tastes recipe quantity medicinal material, and radix bupleuri, polygala, spina date seed three after means of supercritical extraction
The dregs of a decoction of taste medicine, are extracted 3 times with water, and three amount of water are followed successively by 12 times, 10 times and 8 times of medicinal material weight, each extraction time
For 90 minutes after boiling；Extract solution is filtered, merged, being concentrated under reduced pressure into water extraction concentrate, is placed standby；Specifically, cortex albiziae, figured silk fabrics
Grass, the vine of multiflower knotweed, radix rehmanniae recen, hops five tastes prescription proportional quantities medicinal material 250g, extract solution are filtered, merge, are concentrated under reduced pressure into 250ml
Water extracts concentrate, and the concentration of concentrate is relative to every ml medicinal materials containing 1g.
It is prepared by step 3, wilsonii micropowders：The superfine acanthopanax powder of just prescription proportional quantities is broken into the μ of medium particle diameter 10
Below m Ultramicro-powders；Specifically, the injected volume of wilsonii is 65g, the Ultramicro-powder medium particle diameter 90% of formation is below 10 μm.
It is prepared by step 4, cataplasm：Arabic gum 25g, polyvinyl alcohol 10g, sodium alginate 15g are weighed respectively, and respectively
Soaked with extract solution 100ml, 50ml and the 100ml in step 2, heating water bath to swelling, be respectively prepared homogeneous transparent I
Primary glue clear gum liquid, sodium alginate clear gum liquid, polyvinyl alcohol clear gum liquid；By 10ml glycerine, 4.5ml azones,
0.75g methyl hydroxybenzoates, 0.75g ethylparabens grind well in being sequentially added mortar, then by Arabic gum clear gum liquid, marine alga
Supercritical CO_2 extraction thing 22.6g~25.8g, step in sour sodium clear gum liquid, polyvinyl alcohol clear gum liquid, step one
Wilsonii micropowders 65g in three is poured into mortar and is ground well to form lotion, lotion thickness about 0.3mm, finally, will after exclusion bubble
Lotion is spread evenly across when taking advantage of temperature without 0.5h is dried under baking oven below 40 DEG C of juxtaposition on anti-cloth, covers anti-stick layer, is cut into suitable big
Small cataplasm manufactured goods.
Specifically, different medicine point is processed using Different Preparation, Chinese medicine is set to refine to greatest extent and dissolution,
Play the multicomponent effect of Chinese medicine, it is ensured that effect of medicine is maximized；Meanwhile, Different Preparation can make the association of drug component
Dramatically increased with efficiency, therefore, clinical efficacy is notable；The tailor-made preparation method of characteristic according to every herbal medicine, maximum limit
Degree unifies medicine effect, clinical effectiveness, safe and reliable, practical convenient, the result that formation brings out the best in each other.
1 clinical data
1.1 physical data：
Data source all cases are the August of 1 years Mays in 2010 and are the court's consulting patients in out-patient department, meet liver depression
Spleen-deficient.Totally 120, it is randomly divided into two groups.Treatment group 60, man 40, female 20；45~70 years old age, average (50.2 ±
8.3) year；The course of disease 6 months~15 years, average (7.2 ± 2.5) year；Difficulty falling asleep is main person 36, can be fallen asleep and easily awake, awake
Should not again sleep afterwards to lead 20, lie awake all night to lead 4.Control group 60, man 36, female 24；At 44~69 years old age, put down
Equal (50.5 ± 2.3) years；The course of disease 5 months~14 years, average (7.1 ± 2.6) year；Difficulty falling asleep is main person 32, can be fallen asleep
And easily wake up, wake up after should not to sleep again be main 18, lie awake all night as main 10.Two groups with deficiency of food in the daytime, it is indigestion and loss of appetite, tired,
The symptoms such as decreased attention, anxiety, agitation.Two groups of sexes, age, courses of disease etc. compare no difference of science of statistics (P ＞ 0.05), have
Comparativity.
1.2 diagnostic criteria：
1.2.1 tcm diagnosis standard：Formulated with reference to Ministry of Health of the People's Republic of China《New Chinese medicine clinical research is instructed
Principle》.Difficulty falling asleep, awakens often, sleeps and unstable or rear difficult sleep of waking up；It is too early that morning wakes up, and night can not fall asleep, daytime murky desire
Sleep, the length of one's sleep, tongue fur was white or white greasy, and veins string or string are thin less than 5h.
1.2.2 Western medicine diagnostic criteria：With reference to 2001《Chinese Spirit Obstacles classification and diagnostic criteria》[5]The third edition
(CCMD-3) diagnostic criteria.(1) symptom standard:Subjective criterion：Difficulty falling asleep, when wake up when sleeping, it is even difficult whole night sleep, daytime occurs
Giddy, lassitude and weak, distending pain in the head etc..Objective standard：The length of one's sleep significantly reduces, is less than 6h every night, and time for falling asleep extension exceedes
30min, the awakening time rises appreciably, is more than 30min every night.Dominant idea with insomnia and extreme concern insomnia result.⑵
Serious standard：Cause obvious worried or social function impaired sleep quantity, the discontented of quality.Course of disease standard is at least sent out weekly
It is raw 3 times, and at least 1 month.(3) exclusion standard:Exclude insomnia secondary caused by physical disease or phrenoblabia symptom.
1.3 case inclusive criterias and exclusion standard：
18 years old to 75 years old inclusive criteria age.More than 2 months insomnia time.There is disorder of emotion inducement.Be a cup too low Split disease
And depression.It is no abnormal through each system and laboratory examination.With being irritable and getting angry easily, dry, bitter taste, dizziness and distending sensation of the head, two sides of body
It is swollen vexed, the disease such as sighing frequently, tongue vein：Tongue nature is light red or dark, and tongue fur color and luster is white or yellowish-white alternate or thin or thickness, or greasy；Arteries and veins has string
As, or string slides, or string is fine and smooth.
2. treatment method
2.1 treatment groups
Treatment method：Select cave, Zusanli, Shenque, interior pass, spring.Treatment time, 19-21 points of selection are used, daily 6-
8h, once a day.
2.2 control groups
Treatment method：With Western medicine surazepam 2mg, preceding half an hour is slept every night and is taken.
15 days is 1 course for the treatment of, and 2 courses for the treatment of of Continuous Observation make clinical evaluation.Setting：It is within 30 days short-term clinical effect；3 months with
Visit is evaluated as clinical late result.
3. result
3.1 efficacy evaluations
Promulgated according to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》.Clinical recovery：The length of one's sleep recovers
Or Nighttime sleep is in more than 6h, sleep deep, it is hale and hearty after waking up.It is effective：Sleep is clearly better, and the length of one's sleep increases 3h
More than, Depth of sleep increases.Effectively：Symptom mitigation, sleep increases less than 3h earlier above.It is invalid：Insomnia is not improved after treatment
Or anti-exacerbation.Pittsburgh Sleep Quality Index (PSQI) is evaluated.PSQI scales are made up of 23 entries, and the entry for participating in score can
It is combined into 6 compositions, including sleep quality, time for falling asleep, the length of one's sleep, Sleep efficiency, sleep-disorder and daytime function barrier
Hinder.By 0~3 point of score, it is PSQI total scores (0~21 point) to add up each component score to each composition, and score is higher to represent sleep matter
Amount is poorer.The data obtained is taken statistics analysis using the statistical package of SPSS11.5 editions, and measurement data is with average value ± mark
Quasi- difference is represented.
3.2 observation of curative effect
3.2.1 Short Term Clinical comparitive study：
Treatment group patient：The people of total number of persons 60, the patient of healing is 29 people, and the patient of effect is significant is 15 people, effective
Patient is 10 people, invalid patient is 6 people, and total effective rate is 90.0%.
Control group patient：The people of total number of persons 60, the patient of healing is 25 people, and the patient of effect is significant is 19 people, effective
Patient is 8 people, invalid patient is 8 people, and total effective rate is 86.7%.
3.2.2 Long-term Clinical Effect compares：
Treatment group patient：The people of total number of persons 60, the patient of healing is 24 people, and the patient of effect is significant is 16 people, effective
Patient is 8 people, invalid patient is 12 people, and total effective rate is 80.0%.
Control group patient：The people of total number of persons 60, the patient of healing is 17 people, and the patient of effect is significant is 15 people, effective
Patient is 9 people, invalid patient is 19 people, and total effective rate is 68.3%.
3.2.3 PSQI integral contrasts before and after two groups of patients treat
3.2.4 Epworth Sleepiness Scales scoring is compared before and after two groups of patient's treatments
| Group | Number of cases | Before treatment | After treatment |
| Treatment group | 60 | 16.29±3.51 | 12.29±2.69 |
| Control group | 60 | 15.28±3.61 | 13.13±4.38 |
From the foregoing, it will be observed that over the course for the treatment of, treatment group has no adverse reaction and uncomfortable diseases, the compliance and adaptability of patient
It is good, protrude the characteristic of the simplicity green of Methods of TCM.
4. discussion of results
Insomnia is insomnia, and is insomnia《Interior warp》" must not referred to as crouch ", " mesh is not dark ", common disease factor has eating and drinking without temperance, feelings will
Not normal, work and rest imbalance, physically weak after being ill etc..In case of feelings will is unsuccessful, required by must not, stagnation of liver qi, hepatic depression and change fire, pathogenic fire disturbance
The mind, god is uneasy and be insomnia.With the transformation of modern way of life, the quickening of rhythm of life, make the mood of people more nervous and
Anxiety.Liver is organ of general, main catharsis, regulating spirit and emotion by oneself, and happiness bar is depressed up to disliking, and the feelings will of old friend most easily influences liver.Irritability catharsis
The fluent flat gas of then blood and, be in a cheerful frame of mind.If stagnation of liver qi is not smooth, catharsis is incompetent, then feelings will is depressed does not find pleasure in, sentimental.If
Strongly fragrant longization fire, liver-yang is high inverse, then impetuous irritability occur, and dysphoria with smothery sensation palpitaition, insomnia is easily frightened, the disease such as have a dizzy spell.If liver-qi attacking stomach,
Dysfunction of spleen and stomach just occurs, the change of gastrointestinal function is showed, with the passing of time will trigger the decline of spleen and stomach function.The traditional Chinese medical science thinks stomach
Discord person's restless sleep, so can aggravate sleep-disorder again.In this therapeutic scheme, spina date seed, the vine of multiflower knotweed with nourishing the liver, calming heart, calm the nerves,
Intelligence, radix rehmanniae recen heat-clearing life are determined in radix bupleuri dispersing stagnated hepatoqi, harmonizing the functional activities of vital QI, valerian, cortex albiziae, wilsonii RADIX POLYGALAE PREPARATA tranquilizing and allaying excitement, calming heart
Tianjin enriching yin, with fixed attention, hops centering is refreshing, help sleeping for blood-nourishing.In the preparation technology of Chinese medicine, we are according to the spy per herbal medicine
The tailor-made preparation method of property, makes Chinese medicine refine to greatest extent and dissolution, and reaching medicine effect-clinical effectiveness-safety can
By the result that the coordinating and unifying of-practical convenient, formation bring out the best in each other.The traditional Chinese medical science is have followed " to make up a deficiency, reducing for the excess syndrome adjusts it empty
Method in fact ", makes qi and blood reconcile, yin and yang in equilibrium.
Fat-reducing case citing
Case 1：Certain is brought up, man, 41 years old, in November, 2011 went to a doctor.There is insomnia medical history 3 years, sleep shallow, dream is more, easily wakes up with a start, difficult
To sleep again, dysphoria, poor appetite, giddy is heavy, lassitude hypodynamia, bitter taste pantothenic acid, often takes the medicine such as surazepam, stable
Thing, effect is undesirable eventually.Using our treatment method, symptom is relieved after a course for the treatment of, and the duration of sleep, depth are obvious
Improve, through two course of therapy after, it is basic to cure.
Case 2：So-and-so is thanked, female, 27 years old.In June, 2012 goes to a doctor.There is insomnia medical history 1 year.Patient is because busy, and pressure is big,
, there is night excited, it is impossible to fall asleep, 3 points or so of the frequent time after midnight could fall asleep in often overtime work, and sleeps shallow, has sound just to wake up, the heart
Tired, do not feel like eating, black eye, energy is not concentrated, poor memory, is often forgotten things.Once Western medicine sedative was eaten, sleeping to have changes
It is kind, but morning giddy burnout, weak, lassitude influence work.Symptom is relieved after a course for the treatment of, does not occur substantially
Insomnia situation.
Case 3：Wang, female, 46 years old.In December, 2011 goes to a doctor, insomnia medical history 6 years.There is insomnia repeatedly in patient, and mood is tired of
It is hot-tempered, when headache and dizzy, sleep shallow, night dream is more, pain in low back and legs, dilute when being done during stool, two side of body turgors, malaise, once used west
Medicine sedative and sleeping Chinese patent drug, symptom still occur repeatedly, and minor depressive and anxiety symptom occurs in patient, and has memory
Difference, energy is not concentrated.Symptom is relieved after a course for the treatment of, and simultaneous phenomenon is obviously improved, clinical cure of having a sleepless night.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
Modified with to the technical scheme described in foregoing embodiments, or equivalent is carried out to which part technical characteristic；
And these modification or replace, do not make appropriate technical solution essence depart from various embodiments of the present invention technical scheme spirit and
Scope.
Claims (6)
1. a kind of Chinese medicine patcher formula for treating insomnia, it is characterised in that be made up of the active compound material of following parts by weight：Wild jujube
The weight portion of benevolence 17-23, the weight portion of cortex albiziae 14-20, the weight portion of valerian 15-19, the weight portion of wilsonii 9-14, RADIX POLYGALAE PREPARATA
8-11 weight portions, the weight portion of the vine of multiflower knotweed 6-10, the weight portion of radix bupleuri 5-9, the weight portion of radix rehmanniae recen 3-7, the weight of hops 2-6
Part.
2. the Chinese medicine patcher formula that treatment according to claim 1 is had a sleepless night, it is characterised in that in the treatment insomnia
Medicine cataplasm formula is made up of the active compound material of following parts by weight：The weight portion of spina date seed 18-22, the weight portion of cortex albiziae 16-19,
The weight portion of valerian 16-18, the weight portion of wilsonii 10-13, the weight portion of RADIX POLYGALAE PREPARATA 9-10, the weight portion of the vine of multiflower knotweed 7-9, radix bupleuri
6-8 weight portions, the weight portion of radix rehmanniae recen 4-6, the weight portion of hops 3-5.
3. the Chinese medicine patcher formula for the treatment of insomnia according to claim 2, it is characterised in that the active compound material is：Acid
The weight portion of jujube kernel 18, the weight portion of cortex albiziae 16, the weight portion of valerian 16, the weight portion of wilsonii 12, the weight portion of RADIX POLYGALAE PREPARATA 10, the vine of multiflower knotweed
9 weight portions, the weight portion of radix bupleuri 8, the weight portion of radix rehmanniae recen 6, the weight portion of hops 5.
4. the Chinese medicine patcher formula for the treatment of insomnia according to claim 2, it is characterised in that the active compound material is：Acid
The weight portion of jujube kernel 20, the weight portion of cortex albiziae 18, the weight portion of valerian 18, the weight portion of wilsonii 10, the weight portion of RADIX POLYGALAE PREPARATA 10, the vine of multiflower knotweed
8 weight portions, the weight portion of radix bupleuri 7, the weight portion of radix rehmanniae recen 5, the weight portion of hops 4.
5. the Chinese medicine patcher formula for the treatment of insomnia according to claim 2, it is characterised in that the active compound material is：Acid
The weight portion of jujube kernel 22, the weight portion of cortex albiziae 19, the weight portion of valerian 17, the weight portion of wilsonii 13, the weight portion of RADIX POLYGALAE PREPARATA 9, the vine of multiflower knotweed 7
Weight portion, the weight portion of radix bupleuri 6, the weight portion of radix rehmanniae recen 4, the weight portion of hops 3.
6. the preparation method that a kind of Chinese medicine patcher for treating insomnia is formulated, it is characterised in that any using such as claim 1-5
The Chinese medicine patcher formula of described treatment insomnia, specific preparation technology is as follows：
Step one, radix bupleuri, RADIX POLYGALAE PREPARATA, the supercritical CO of the taste medicine of spina date seed three2Extract：Radix bupleuri, RADIX POLYGALAE PREPARATA, spina date seed are weighed respectively
Three taste recipe quantity medicinal materials, grind to form 20 mesh~40 mesh medicinal powder and are fitted into extraction kettle, with 55 DEG C of extraction temperature, extracting pressure
20MPa, CO2Flow 40Lh-1, extraction time 2h, entrainer is that the extraction conditions of 50% ethanol carry out supercritical CO2Extract,
The supercritical CO of acquisition2Extract low-temperature storage, it is standby；
It is prepared by step 2, cortex albiziae, valerian, the vine of multiflower knotweed, radix rehmanniae recen, the water extraction solution of hops five kinds of Chinese medicine：By cortex albiziae, figured silk fabrics
Grass, the vine of multiflower knotweed, radix rehmanniae recen, hops five tastes recipe quantity medicinal material, and radix bupleuri, polygala, the taste medicine of spina date seed three after means of supercritical extraction
The dregs of a decoction, extracted 3 times with water, three amount of water are followed successively by 12 times, 10 times and 8 times of medicinal material weight, and each extraction time is boiling
90 minutes afterwards；Extract solution is filtered, merged, being concentrated under reduced pressure into water extraction concentrate, is placed standby；
It is prepared by step 3, wilsonii micropowders：The superfine acanthopanax powder of prescription proportional quantities is broken into below 10 μm of medium particle diameter
Ultramicro-powder；
It is prepared by step 4, cataplasm：Arabic gum 25g, polyvinyl alcohol 10g, sodium alginate 15g are weighed respectively, and respectively with step
Extract solution 100ml, 50ml and 100ml immersion in rapid two, heating water bath is respectively prepared the Arabic gum of homogeneous transparent to swelling
Clear gum liquid, sodium alginate clear gum liquid, polyvinyl alcohol clear gum liquid；By 10ml glycerine, 4.5ml azones, 0.75g Buddhist nun
Pool tortoise beetle ester, 0.75g ethylparabens grind well in being sequentially added mortar, then Arabic gum clear gum liquid, sodium alginate is saturating
Supercritical CO in gelatin-like liquid, polyvinyl alcohol clear gum liquid, step one2In extract 22.6g~25.8g, step 3
Wilsonii micropowders 65g is poured into mortar and is ground well to form lotion, finally, is spread evenly across when lotion being taken advantage of into temperature after exclusion bubble
Without 0.5h is dried under baking oven below 40 DEG C of juxtaposition on anti-cloth, anti-stick layer is covered, be cut into the cataplasm manufactured goods of suitable size.
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Citations (2)
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|---|---|---|---|---|
| CN1742941A (en) * | 2005-09-28 | 2006-03-08 | 徐涛 | External medicine formulation for treating anhypnia-depression and technology for making plaster using same |
| CN105998803A (en) * | 2016-06-16 | 2016-10-12 | 孙中莎 | Traditional Chinese medicine acupoint patch for treating insomnia of women in perimenopausal period |
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2017
- 2017-03-22 CN CN201710173890.XA patent/CN106902190A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742941A (en) * | 2005-09-28 | 2006-03-08 | 徐涛 | External medicine formulation for treating anhypnia-depression and technology for making plaster using same |
| CN105998803A (en) * | 2016-06-16 | 2016-10-12 | 孙中莎 | Traditional Chinese medicine acupoint patch for treating insomnia of women in perimenopausal period |
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| 王迎昌等: "疏肝健脾方治疗失眠症60例观察", 《实用中医药杂志》 * |
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