CN106890477A - Bark of eucommia natural medicinal ingredients extraction process and its extraction equipment - Google Patents
Bark of eucommia natural medicinal ingredients extraction process and its extraction equipment Download PDFInfo
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- CN106890477A CN106890477A CN201710043738.XA CN201710043738A CN106890477A CN 106890477 A CN106890477 A CN 106890477A CN 201710043738 A CN201710043738 A CN 201710043738A CN 106890477 A CN106890477 A CN 106890477A
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- eucommia
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0215—Solid material in other stationary receptacles
- B01D11/0253—Fluidised bed of solid materials
- B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
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- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
A kind of bark of eucommia natural medicinal ingredients extraction process, comprises the following steps：(1) bark of eucommia raw material enzymolysis processing, the separation of (2) enzymolysis liquid, filtering, (3) filtering enzymolysis liquid low temperature concentration, the sterilization of (4) concentrate normal temperature, precipitate and separate, (5) drug ingedient is refined.A kind of bark of eucommia natural medicinal ingredients extraction equipment, including gutta-percha and natural medicinal ingredients separator, gutta-percha and natural medicinal ingredients separator sidepiece are provided with spiral centrifugal separator, spiral centrifugal separator sidepiece is provided with core and filtering bag filter, the sidepiece of core and filtering bag filter is provided with film filter, film filter sidepiece is provided with medicine vacuum concentrator, medicine vacuum concentrator sidepiece is provided with the stainless-steel vacuum mixer with stirring, stainless-steel vacuum mixer sidepiece is provided with bark of eucommia natural drug fine powder load device, the sidepiece of bark of eucommia natural drug fine powder load device is provided with ethyl alcohol purification equipment；The present invention can fast and efficiently extract the bark of eucommia natural medicinal ingredients in enzymolysis liquid.
Description
Technical field
It is especially a kind of to extract for bark of eucommia natural medicinal ingredients the present invention relates to a kind of medicine extraction process and equipment
Technique and the equipment of extraction.
Background technology
The Eucommiaceae plant bark of eucommia (Eucommia ulmoides Oliver), is the distinctive medicinal material of China and economic resources,
The characteristics of integrating economic forest and Timber stands, the bark of eucommia also has many days for having special efficacy to human body in addition to gutta-percha
Right active medicine, has Hydrolyze method, alcohol extracting method, three kinds of enzymatic isolation method to decompose bark of eucommia raw material, with water extraction and alcohol extracting on the market
Method is compared, and the natural products in the enzymolysis and extraction bark of eucommia is much more.Analyzed from extraction components, all of material can be in enzymolysis
Corresponding material peak is found in chromatographic absorption peak, and there are four kinds of materials to be also only present in enzyme-extracting solution, so enzymolysis is carried
Take the species of the bark of eucommia natural products that method is extracted apparently higher than the extracting method of pure water, that is to say, that apparently higher than common Du
Secondary decocting for Chinese herbal medicine method, and extracted amount is also more much higher than decocting method；Alcohol dissolves the very capable of chlorophyll, it is likely to chlorophyll
Interference, but there is chlorophyll bitter taste to be unfavorable for bark of eucommia drug administration, even so, the substance classes of alcohol extract still do not have
The bark of eucommia natural products material for having enzymatic isolation method to extract is more, so often being carried out at enzymolysis to bark of eucommia raw material using enzymatic isolation method on the market
Reason, but bark of eucommia natural drug abstraction process is complicated, is carried out using distinct device substep to bark of eucommia natural drug,
Can not effectively integrate and reach whole process and carry out, than larger, efficiency is low, and the amount of substance of extraction is few for artificial disturbance, it is impossible to
Enough a large amount of, high efficiency extraction bark of eucommia natural medicinal ingredients, and substep extract requirement of the bark of eucommia natural drug to people higher,
So as to cause extraction cost high, and the discarded object that each step is produced can not be used effectively, so as to cause the very big of resource
Waste.
The content of the invention
The invention solves the problems that the shortcoming of above-mentioned prior art, there is provided a kind of a large amount of, high efficiency extraction bark of eucommia natural drug fine powder
Bark of eucommia natural medicinal ingredients extraction process and its extraction equipment, meet manufacturing enterprise for bark of eucommia natural drug extracted amount
Greatly, the demand of low cost.
The present invention solves the technical scheme that its technical problem is used：This bark of eucommia natural medicinal ingredients extraction process, including
Following steps：
(1) bark of eucommia raw material enzymolysis processing：Bark of eucommia raw material is put into the interior bucket of gutta-percha and natural medicinal ingredients separator
Place, add water to submerge bark of eucommia raw material, gradually respectively by containing protease, cellulase, pectase, cutinase solution according to 1:1
Proportioning carry out being mixed into mixed solution, being configured to PH buffer solutions using food-grade citric acid and sodium citrate is poured into mixed liquor
In, pH value is made into for 3.2,4.0,5.5 3 kind digest solution, enzymolysis solution is poured into gutta-percha and natural medicinal ingredients are separated
In the water of device, enzymolysis is constantly stirred to bark of eucommia raw material, and it is molten to the enzymolysis in gutta-percha and natural medicinal ingredients separator
Liquid carries out heating water bath, and at 40 DEG C~50 DEG C, every kind of enzyme digestion reaction time is 4~6 hours to heating and temperature control；
(2) separation of enzymolysis liquid, filtering：Bark of eucommia colloid stays in gutta-percha and natural medicinal ingredients point after bark of eucommia raw material enzymolysis
From device, interior its enzymolysis liquid discharged by the leakage fluid dram of gutta-percha and natural medicinal ingredients separator and by spiral it is continuous from
The heart is separated, and removes big slag and chip, and the separating liquid after spiral centrifugal slagging-off carries out core and filter bag carries out coarse filtration, by coarse filtration
Enzymolysis liquid is filtered by film filter again, is obtained by the brown clear solution transparent, without suspended solid residue of refined filtration；
(3) filtering enzymolysis liquid low temperature concentration；Limpid transparent brown solution injection of medicine vacuum concentrator (5), medicine
Vacuum concentrator (5), the enzymolysis liquid to filtering carries out cryogenic vacuum concentration；
(4) sterilization of concentrate normal temperature, precipitate and separate：Enzymolysis liquid injection of medicine precipitate and separate device (6) after low temperature is concentrated
In, add 95% edible ethanol and constantly the enzymolysis liquid after concentration is stirred at ambient pressure, the rear static enzyme made after concentration
Being significantly reduced without effective component solubility in solution liquid underflow, precipitates from the concentrated extract of enzyme-extracting solution, and molecular state
Natural bark of eucommia drug ingedient then can be sufficiently mixed and dissolve with ethanol solution under conditions of being sufficiently stirred for；
(5) drug ingedient is refined：Supernatant liquor is extracted, supernatant liquor is then injected into the load of bark of eucommia natural drug fine powder
In device (7), cyclodextrin is loaded to supernatant and heating water bath treatment is carried out under vacuum conditions, heating and temperature control is at 55 DEG C
~60 DEG C, alcohol and residual moisture in evaporation clear liquid, and obtain bark of eucommia fine powder.
This bark of eucommia natural medicinal ingredients extraction equipment, including gutta-percha and natural medicinal ingredients separator, gutta-percha
Be provided with spiral centrifugal separator with the sidepiece of natural medicinal ingredients separator, the sidepiece of spiral centrifugal separator be provided with core and
The sidepiece of filtering bag filter, core and filtering bag filter is provided with film filter, and the sidepiece of film filter is provided with medicine vacuum concentration
Device, the sidepiece of medicine vacuum concentrator is provided with the stainless-steel vacuum mixer of rabbling mechanism, the side of stainless-steel vacuum mixer
Portion is provided with ethyl alcohol purification equipment, and the sidepiece of stainless-steel vacuum mixer is provided with bark of eucommia natural drug fine powder load device；Gutta-percha
Enzymolysis liquid holding vessel, spiral centrifugal separator and sand are provided with and natural medicinal ingredients separator and spiral centrifugal separator between
Coarse filtration liquid holding vessel is provided between core and filtering bag filter, the storage of refined filtration liquid is provided between core and filtering bag filter and film filter
Tank is deposited, fine filtrate holding vessel is provided between film filter and medicine vacuum concentrator, the sidepiece of medicine vacuum concentrator is provided with
Hot-water cylinder and water tank with heating function and temperature controller；The leakage fluid dram of gutta-percha and natural medicinal ingredients separator and enzymolysis
Communicating pipe one is installed between the top of liquid holding vessel, the bottom of enzymolysis liquid holding vessel and the inlet of spiral centrifugal separator it
Between communicating pipe two is installed, between the liquid outlet of spiral centrifugal separator and the top of coarse filtration liquid holding vessel be installed communicating pipe
Three, communicating pipe four, core and filter bag are installed between the bottom of coarse filtration liquid holding vessel and core and the inlet of filtering bag filter
Communicating pipe five, bottom and the film mistake of refined filtration liquid holding vessel are installed between the liquid outlet of filter and the top of refined filtration liquid holding vessel
Communicating pipe six, the company of being provided between film filter liquid outlet and the top of fine filtrate holding vessel are installed between filter inlet
Siphunculus seven, is provided with triple valve, bottom and triple valve one end of fine filtrate holding vessel at the inlet of medicine vacuum concentrator
Communicating pipe eight is installed between import, is installed between another end opening of triple valve and the entrance point of stainless-steel vacuum mixer
There is communicating pipe nine, hot water conveying pipe and efferent duct, medicine vacuum concentrator are installed between hot-water cylinder and medicine vacuum concentrator
Water storage cavity and water storage pot bottom between communicating pipe ten is installed, be provided between the bottom of water tank and hot-water cylinder top and connected
Guan Shiyi；Bark of eucommia natural drug fine powder load device includes the bucket with opening, and a cavity is fixed with the cavity of bucket
Upper and lower two-part dividing plate is divided into, the cast dividing plate of tapered setting, the top of cast dividing plate are provided with the cavity above dividing plate
End is fixed on the inner peripheral wall of bucket, and the bottom of cast dividing plate is fixed on the top surface of dividing plate, on the inside of cast dividing plate and outer
Side is respectively the cavity one and cavity two for separating, and the through hole connected with cavity one is provided with dividing plate, and the opening of bucket is provided with
For the end cap of closed opening, support is fixed with bucket, band valve cylinder is fixed with support, the piston rod with valve cylinder is consolidated
It is scheduled on end cap top surface, montant is rotatably connected on end cap, the bottom of montant is rotatably connected to the briquetting with taper, the cone of briquetting
Spend identical with the taper of cast dividing plate and with cast dividing plate inner surface to coordinate, montant is electric by being fixed on the servo on end cap top
Machine drives, and is fixed with the bottom wheel profile surface of montant and having heaters is installed in stirring sheet, cavity two；The sidepiece of bucket be provided with by
Condenser, cooler, separator, the alcohol vapour collector of accumulator composition, the condenser and cavity of alcohol vapour collector
Connecting tube is connected between one, between the accumulator and ethyl alcohol purification equipment of alcohol vapour collector is installed communicating pipe 12；
Liquid suction pipe is installed between stainless-steel vacuum mixer and bark of eucommia natural drug fine powder load device；Triple valve is dense with medicine vacuum
Magnetic valve one is installed between the inlet of contracting device, magnetic valve two is installed on communicating pipe one, drawing liquid is installed on communicating pipe two
Pump one, is provided with drawing liquid pump two on communicating pipe three, drawing liquid pump three is provided with communicating pipe four, and drawing liquid pump is provided with communicating pipe five
Four, drawing liquid pump five is installed on communicating pipe six, drawing liquid pump six is installed on communicating pipe seven, magnetic valve is installed on communicating pipe nine
Three, drawing liquid pump 12 is installed on communicating pipe ten, drawing liquid pump is installed on liquid suction pipe, drawing liquid pump is installed on communicating pipe 11
Eight, drawing liquid pump nine is installed on communicating pipe 12, apparatus for vacuum producing is installed on bark of eucommia natural drug fine powder load device.Here shut out
Secondary glue and natural medicinal ingredients separator use the product of Application No. 201521047806.2；Here spiral centrifugal separator
It is equipment general on the market, Science and Technology Co., Ltd., Zhejiang sky environmental protection equipment Co., Ltd is protected using Zhejiang threefold ring
Deng the product of company；Here core and filtering bag filter are common apparatus on the market, and the limited public affairs of filtering technique are quite strangled using Shanghai
Department, the equipment of Wuxi Hua Ao environmental protection equipment Chang Deng companies；Film filter is product general on the market, using Hefei wind and cloud film point
From the product of the companies such as Technology Co., Ltd., the triumphant conjunctiva isolation technics Co., Ltd in Hangzhou；Medicine vacuum concentrator is on the market
General product, using the product of the companies such as Shanghai Jia Pai automation equipments Co., Ltd, Hefei calf light industry and machinery Co., Ltd
Product；Stainless-steel vacuum mixer common apparatus on the market, using Dongguan Dongzheng Environmental Protection Equipment Technology Products Co., Ltd., the huge person of outstanding talent in Wenzhou
The product of the companies such as mechanical Science and Technology Ltd.；Here ethyl alcohol purification equipment is common apparatus on the market, dry using Hangzhou Qianjiang
The product of the companies such as dry equipment Co., Ltd, the European rich Machinery Co., Ltd. in Zhengzhou.Bark of eucommia natural drug fine powder load device
Use process：Supernatant containing bark of eucommia natural medicinal ingredients is injected into cavity one by liquid suction pipe, Cyclodextrin by containing
Charge door on charging basket is added in cavity one, and starts servomotor drive montant rotation, using the stirring sheet on montant not
Disconnected stirring cyclodextrin and supernatant, mix it, at the same time, heating agent and startup in heating cavity two vacuumize machine,
Extract the air in cavity one out, cavity one is made the heating agent in cavity two in class vacuum state and by the control of temperature controller
Temperature control all the time between 55 DEG C~60 DEG C so as to the mixture of continuous heating water bath supernatant and cyclodextrin, enter without
Disconnected to evaporate ethanol and residual moisture, the alcohol vapour and residual moisture of evaporation carry out condensation and become liquid by alcohol vapour collector
Collect, can be gathered in as the bark of eucommia fine powder particle for drying shape after the ethanol evaporation in mixture (containing supernatant and Cyclodextrin) is complete
In the bottom of funnelform cast dividing plate, at this moment, stop heater heating, and stop apparatus for vacuum producing work, start band valve gas
Cylinder, moves, on briquetting so as to make bark of eucommia fine powder be discharged in charge cask from through hole by gravity；Alcohol vapour collector is city
The universal product on face, can select Wuxi City along demulcen Equipment Limited, the product of Tai'an Teng Yang General Devices Co., Ltd.；
When briquetting is pressed in cast dividing plate and closes through hole, servomotor can drive montant to rotate and drive stirring sheet to rotate, at this moment
Briquetting is motionless；Apparatus for vacuum producing is the universal product on the market, can select the product of Dongguan City great Lang Hao Bao vacuum equipments manufactory
Product.
Further perfect, being provided between gutta-percha and natural medicinal ingredients separator for the bottom of water tank is connected
Guan Shisan, is provided with drawing liquid pump ten on communicating pipe 13.Here the effect of communicating pipe 13 and drawing liquid pump ten is, can be being located at
Water in holding vessel is pumped into the enzyme digestion reaction for bark of eucommia raw material in gutta-percha and natural medicinal ingredients separator.
It is further perfect, vibrator is installed on bucket.Here the effect of vibrator be can accelerate bark of eucommia fine powder from
Dropped in charge cask by through hole in cavity one, and bark of eucommia fine powder can also be made more thoroughly to drop to charge cask
It is interior.
It is further perfect, between the liquid storing barrel and stainless-steel vacuum mixer of ethyl alcohol purification equipment be installed communicating pipe ten
Four, drawing liquid pump 11 is installed on communicating pipe 14.Here the effect of communicating pipe 14 and drawing liquid pump 11 is, can be ethanol
High-purity edible ethanol after purification in equipment for purifying is after being newly injected into and being carried out to concentration in stainless-steel vacuum mixer
What enzymolysis liquid underflow was carried out is processed without the reduction precipitation of effective component solubility.
It is further perfect, temperature controller is installed on cavity two.Here the effect of temperature controller is can conveniently to control cavity two
The temperature of interior heating agent.
Further perfect, the sidepiece of bark of eucommia natural drug fine powder load device is provided with supporting plate, and PLC is provided with supporting plate
Controller, PCL controllers and gutta-percha and natural medicinal ingredients separator, spiral centrifugal separator, medicine vacuum concentrator,
Ethyl alcohol purification equipment, bark of eucommia natural drug fine powder load device, hot-water cylinder, each drawing liquid pump and triple valve, magnetic valve one, magnetic valve
2nd, the connection of magnetic valve three.Here PLC is programmable logic controller (PLC) general on the market, be can select on the market
General Mitsubishi PLC, still Schneider PLC, the brand such as Nikon Unitronics, Delta PLC and Matsushita PLC, PLC passes through
Control drawing liquid pump and electric control part are so as to reach extraction and processing fine powder treatment to bark of eucommia natural medicinal ingredients, automation
High, recruitment is few, and the raising for can greatly improve the bark of eucommia natural medicinal ingredients fine powder amount extracted, contributing to bark of eucommia fine powder quality is simultaneously
And reduce production cost；Here triple valve is three-way magnetic valve.
The invention has the advantages that：Smart structural design of the present invention, rationally, using bark of eucommia colloid extraction element, spiral
Whizzer, core and filtering bag filter, core and filtering bag filter, film filter, medicine vacuum concentrator, stainless steel are true
Interconnection and synergy between empty mixer, ethyl alcohol purification equipment, bark of eucommia natural drug fine powder load device, can be fast
Speed, efficiently the bark of eucommia natural medicinal ingredients in bark of eucommia raw material, by filtering, concentration, refine, fine powder extracts integration stream
Journey, not only substantially increases fine powder extraction efficiency, and quality is higher, is worthy of popularization.
Brief description of the drawings
Fig. 1 is structural representation of the invention；
Fig. 2 is the topology view of medicine vacuum concentrator in the present invention；
Fig. 3 is the topology view of bark of eucommia natural drug fine powder load device in the present invention；
Fig. 4 is state diagram when bark of eucommia natural drug fine powder load device upper holder block is lifted in the present invention.
Description of reference numerals：Bark of eucommia colloid extraction element 1, spiral centrifugal separator 2, core and filtering bag filter 3, film mistake
Filter 4, medicine vacuum concentrator 5, stainless-steel vacuum mixer 6, the bark of eucommia natural drug fine powder load device 7, bucket 7-1,
Dividing plate 7-2, cast dividing plate 7-3, the 7-4 of cavity one, cavity two 7-5, end cap 7-6, support 7-7, band valve cylinder 7-8, montant 7-9,
Briquetting 7-10, alcohol vapour collector 7-11, connecting tube 7-12, enzymolysis liquid holding vessel 8, coarse filtration liquid holding vessel 9, the storage of refined filtration liquid
Tank 10, fine filtrate holding vessel 11, hot-water cylinder 12, water tank 13, ethyl alcohol purification equipment a, communicating pipe 1, communicating pipe 2 15,
Communicating pipe 3 16, communicating pipe 4 17, communicating pipe 5 18, communicating pipe 6 19, communicating pipe 7 20, triple valve 21, communicating pipe 8 22, even
Siphunculus 9 23, liquid suction pipe 24, hot water conveying pipe 25, efferent duct 26, communicating pipe 10, communicating pipe 11, communicating pipe 12,
Magnetic valve 1, the c of drawing liquid pump 12, drawing liquid pump 1, drawing liquid pump 2 32, drawing liquid pump 3 33, drawing liquid pump 4 34, drawing liquid pump five
35, drawing liquid pump 6 36, magnetic valve 3 37, drawing liquid pump 8 38, drawing liquid pump 9 39, apparatus for vacuum producing 40, magnetic valve 2 41, communicating pipe ten
3 42, drawing liquid pump 10, vibrator 44, communicating pipe 14, drawing liquid pump 11, supporting plate 47, PLC 48.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings：
Referring to the drawings：This bark of eucommia natural medicinal ingredients extraction process, comprises the following steps：
(1) bark of eucommia raw material enzymolysis processing：Bark of eucommia raw material is put into the interior bucket of gutta-percha and natural medicinal ingredients separator 1
Place, add water to submerge bark of eucommia raw material, gradually respectively by containing protease, cellulase, pectase, cutinase solution according to 1:1
Proportioning carry out being mixed into mixed solution, being configured to PH buffer solutions using food-grade citric acid and sodium citrate is poured into mixed liquor
In, pH value is made into for 3.2,4.0,5.5 3 kind digest solution, enzymolysis solution is poured into gutta-percha and natural medicinal ingredients are separated
In the water of device 1, enzymolysis is constantly stirred to bark of eucommia raw material, and to the enzymolysis in gutta-percha and natural medicinal ingredients separator 1
Solution carries out heating water bath, and at 40~50 DEG C, every kind of enzyme digestion reaction time is 4~6 hours to heating and temperature control；
(2) separation of enzymolysis liquid, filtering：Bark of eucommia colloid stays in gutta-percha and natural medicinal ingredients point after bark of eucommia raw material enzymolysis
In device 1, its enzymolysis liquid is discharged and continuous by spiral by the leakage fluid dram of gutta-percha and natural medicinal ingredients separator 1
Centrifugation, removes big slag and chip, and the separating liquid after spiral centrifugal slagging-off carries out core and filter bag carries out coarse filtration, by coarse filtration
Enzymolysis liquid again by film filter filter, obtain by the brown clear solution transparent, without suspended solid residue of refined filtration；
(3) filtering enzymolysis liquid low temperature concentration；Limpid transparent brown solution injection of medicine vacuum concentrator 5, medicine is true
Empty inspissator 5, the enzymolysis liquid to filtering carries out cryogenic vacuum concentration；
(4) sterilization of concentrate normal temperature, precipitate and separate：In enzymolysis liquid injection of medicine precipitate and separate device 6 after low temperature is concentrated,
Add 95% edible ethanol and constantly the enzymolysis liquid after concentration is stirred at ambient pressure, the rear static enzymolysis liquid made after concentration
Being significantly reduced without effective component solubility in underflow, precipitates from the concentrated extract of enzyme-extracting solution, and the day of molecular state
Right bark of eucommia drug ingedient then can be sufficiently mixed and dissolve under conditions of being sufficiently stirred for ethanol solution；
(5) drug ingedient is refined：Supernatant liquor is extracted, supernatant liquor is then injected into the load of bark of eucommia natural drug fine powder
In device 7, supernatant is loaded cyclodextrin and carries out heating water bath treatment under vacuum conditions, heating and temperature control 55 DEG C~
60 DEG C, alcohol and residual moisture in evaporation clear liquid, and obtain bark of eucommia fine powder.
This bark of eucommia natural medicinal ingredients extraction equipment, including gutta-percha and natural medicinal ingredients separator 1, gutta-percha
Spiral centrifugal separator 2 is provided with the sidepiece of natural medicinal ingredients separator 1, the sidepiece of spiral centrifugal separator 2 is provided with sand
The sidepiece of core and filtering bag filter 3, core and filtering bag filter 3 is provided with film filter 4, and the sidepiece of film filter 4 is provided with medicine
Vacuum concentrator 5, the sidepiece of medicine vacuum concentrator 5 is provided with the stainless-steel vacuum mixer 6 of rabbling mechanism, stainless-steel vacuum
The sidepiece of mixer 6 is provided with ethyl alcohol purification equipment a, and the sidepiece of stainless-steel vacuum mixer 6 is provided with bark of eucommia natural drug fine powder and bears
Carry and put 7；Enzymolysis liquid holding vessel 8 is provided between gutta-percha and natural medicinal ingredients separator 1 and spiral centrifugal separator 2,
Coarse filtration liquid holding vessel 9, core and filtering bag filter 3 and film are provided between spiral centrifugal separator 2 and core and filtering bag filter 3
Refined filtration liquid holding vessel 10 is provided between filter 4, fine filtrate storage is provided between film filter 4 and medicine vacuum concentrator 5
Tank 11, the sidepiece of medicine vacuum concentrator 5 is provided with hot-water cylinder 12 and water tank 13 with heating function and temperature controller；Gutta-percha and
Communicating pipe 1, enzymolysis liquid are installed between the leakage fluid dram of natural medicinal ingredients separator 1 and the top of enzymolysis liquid holding vessel 8
Communicating pipe 2 15 is installed between the bottom of holding vessel 8 and the inlet of spiral centrifugal separator 2, spiral centrifugal separator 2
Communicating pipe 3 16, bottom and core and the filter of coarse filtration liquid holding vessel 9 are installed between the top of liquid outlet and coarse filtration liquid holding vessel 9
The liquid outlet and refined filtration liquid holding vessel of communicating pipe 4 17, core and filtering bag filter 3 are installed between the inlet of bag type filter 3
Communicating pipe 5 18 is installed between 10 top, is provided between the bottom of refined filtration liquid holding vessel 10 and the inlet of film filter 4
Between the top of communicating pipe 6 19, the liquid outlet of film filter 4 and fine filtrate holding vessel 11 be installed communicating pipe 7 20, medicine is true
Triple valve 21 is provided with the inlet of empty inspissator 5, at the bottom of fine filtrate holding vessel 11 and the import of the one end of triple valve 21
Between communicating pipe 8 22 is installed, between another end opening of triple valve 21 and the entrance point of stainless-steel vacuum mixer 6 install
There is communicating pipe 9 23, hot water conveying pipe 25 and efferent duct 26 are installed between hot-water cylinder 12 and medicine vacuum concentrator 5, medicine is true
Communicating pipe 10, bottom and the hot-water cylinder 12 of water tank 13 are installed between the water storage cavity of empty inspissator 5 and the bottom of water tank 13
Communicating pipe 11 is installed between top；Bark of eucommia natural drug fine powder load device 7 includes the bucket 7-1 with opening, contains
It is fixed with the cavity of charging basket 7-1 and cavity is divided into upper and lower two-part dividing plate 7-2, is provided with the cavity above dividing plate 7-2
The cast dividing plate 7-3 of tapered setting, the top of cast dividing plate 7-3 is fixed on the inner peripheral wall of bucket 7-1, cast dividing plate
The bottom of 7-3 is fixed on the top surface of dividing plate 7-2, and cast dividing plate 7-3 inner sides and outside are respectively the 7-4 of cavity one and chamber for separating
The 7-5 of body two, is provided with the through hole 7-2a connected with the 7-4 of cavity one on dividing plate 7-2, the opening of bucket 7-1 is provided with for closed
The end cap 7-6 of opening, is fixed with support 7-7 on bucket 7-1, band valve cylinder 7-8, band valve cylinder 7-8 are fixed with support 7-7
Piston rod be fixed on end cap 7-6 top surfaces, be rotatably connected to montant 7-9 on end cap 7-6, the bottom of montant 7-9 rotates connection
Have a briquetting 7-10 with taper, the taper of briquetting 7-10 it is identical with the taper of cast dividing plate 7-3 and with the interior table of cast dividing plate 7-3
Face coordinates, and montant 7-9 is driven by being fixed on the servomotor 7-14 on end cap 7-6 tops, solid in the bottom wheel profile surface of montant 7-9
Surely have and having heaters 7-13 is installed in stirring sheet 7-15, the 7-5 of cavity two；The sidepiece of bucket 7-1 is provided with by condenser, cooling
Device, separator, the alcohol vapour collector 7-11 of accumulator composition, condenser and the 7- of cavity one of alcohol vapour collector 7-11
Connecting tube 7-12 is connected between 4, is provided between the accumulator and ethyl alcohol purification equipment a of alcohol vapour collector 7-11 and connected
Pipe 12；Liquid suction pipe 24 is installed between stainless-steel vacuum mixer 6 and bark of eucommia natural drug fine powder load device 7；Threeway
Magnetic valve 1 is installed between the inlet of valve 21 and medicine vacuum concentrator 5, magnetic valve two is installed on communicating pipe 1
41, drawing liquid pump 1 is installed on communicating pipe 2 15, drawing liquid pump 2 32 is installed on communicating pipe 3 16, installed on communicating pipe 4 17
There is drawing liquid pump 3 33, drawing liquid pump 4 34 is installed on communicating pipe 5 18, drawing liquid pump 5 35, communicating pipe are installed on communicating pipe 6 19
Drawing liquid pump 6 36 is installed on 7 20, magnetic valve 3 37 is installed on communicating pipe 9 23, drawing liquid pump is installed on communicating pipe 10
12 c, are provided with drawing liquid pump b on liquid suction pipe 24, drawing liquid pump 8 38 is provided with communicating pipe 11, pacify on communicating pipe 12
Equipped with drawing liquid pump 9 39, apparatus for vacuum producing 40 is installed on bark of eucommia natural drug fine powder load device 7.
The bottom of water tank 13 is provided with communicating pipe 13 between gutta-percha and natural medicinal ingredients separator 1
42, drawing liquid pump 10 is installed on communicating pipe 13.
Vibrator 44 is installed on bucket 7-1.
Communicating pipe 14, communicating pipe are installed between the liquid storing barrel and stainless-steel vacuum mixer 6 of ethyl alcohol purification equipment a
Drawing liquid pump 11 is installed on 14.
Temperature controller 7-16 is installed on the 7-5 of cavity two.
The sidepiece of bark of eucommia natural drug fine powder load device 7 is provided with supporting plate 47, and PLC is provided with supporting plate 47
48, PCL controllers and gutta-percha and natural medicinal ingredients separator 1, spiral centrifugal separator 2, medicine vacuum concentrator 5,
Ethyl alcohol purification equipment a, bark of eucommia natural drug fine powder load device 7, hot-water cylinder 12, each drawing liquid pump and triple valve 21, magnetic valve one
30th, magnetic valve 2 41, the connection of magnetic valve 3 37.
The equipment extracts the process of bark of eucommia natural drug fine powder：Bark of eucommia raw material is put into gutta-percha and natural medicinal ingredients
In the screen roller of separator 1, drawing liquid pump 43 is then started by PLC 48, the water in water tank 13 is taken out
Enter in gutta-percha and the liquid holding groove of natural medicinal ingredients separator 1, gutta-percha and natural medicinal ingredients separator 1 add good liquid
Afterwards, gradually respectively by containing protease, cellulase, pectase, cutinase solution according to 1:1 proportioning be mixed into mixed
Close solution, PH buffer solutions be configured to using food-grade citric acid and sodium citrate and be poured into mixed liquor, be made into pH value for 3.2,
4.0th, 5.5 3 kinds of enzymolysis solution, enzymolysis solution is poured into the water of gutta-percha and natural medicinal ingredients separator 1, to Du
Secondary raw material constantly stirs enzymolysis, then the servo electricity on the control gutta-percha of PLC 48 and natural medicinal ingredients separator 1
Machine rotates, so as to drive the screen roller of gutta-percha and natural medicinal ingredients separator 1 to rotate, constantly bark of eucommia raw material is carried out
Stirring enzymolysis, while carrying out heating water bath, heating-up temperature to the enzymolysis solution in gutta-percha and natural medicinal ingredients separator 1
At 40 DEG C~50 DEG C, every kind of enzyme digestion reaction time is 4~6 hours for control, in order to improve enzymolysis amount, can be using multiple gutta-percha
The mode that bark of eucommia raw material is digested with natural medicinal ingredients separator 1 is carried out, after reaching 4~6 hours enzymolysis times, PLC controls
Device control magnetic valve 2 41 processed is opened, and the enzymolysis liquid for having digested bark of eucommia raw material is stored into storage in enzymolysis liquid holding vessel 8 (to be located at
The Folium glue wire of screen roller is separately taken out Folium glue wire purification plants and is separately purified, and what the present invention was introduced is the bark of eucommia day
The extraction of right drug ingedient, is not described to Folium glue wire purifying here), the enzymolysis liquid in enzymolysis liquid holding vessel 8 leads to
Cross drawing liquid pump 1 and enzymolysis liquid is pumped into (the now control of the PLC 48 spiral centrifugal separator 2 of spiral centrifugal separator 2
Motor operation) in carry out big slag and the treatment of big chip, the enzymolysis liquid after filtering is pumped into coarse filtration liquid by drawing liquid pump 2 32
The enzymolysis liquid in coarse filtration liquid holding vessel 9, is then pumped into core and filter bag by storage by drawing liquid pump 3 33 in holding vessel 9
Carefully filtered in filter 3, the enzymolysis liquid being carefully filtrated to get is sent to storage in refined filtration liquid holding vessel 10 by drawing liquid pump 4 34,
Then the enzymolysis liquid in refined filtration liquid holding vessel 10 is sent in film filter 4 by drawing liquid pump 5 35 carries out finely mistake
Filter, the solution obtained by fine filtering is stored into fine filtrate holding vessel 12 by drawing liquid pump 6 36, starts medicine true
Apparatus for vacuum producing in empty inspissator 5, at this moment triple valve 21 is between communicating pipe 8 22 and the inlet of medicine vacuum concentrator 5
Circuit is dense medicine vacuum is pumped into positioned at enzymolysis liquid in fine filtrate holding vessel 12 using the negative pressure produced by apparatus for vacuum producing
Communicating pipe 8 22 and the feed liquor of medicine vacuum concentrator 5 are closed in the heating chamber of contracting device 5, after the completion of extraction by magnetic valve 1
Circuit between mouthful, so as to reach the continuous heat cycles for passing through hot-water cylinder 12 to heating chamber vacuumize process, heating chamber so that
Temperature on medicine vacuum concentrator 5 in heating chamber is controlled at 55 DEG C~60 DEG C all the time, and concentration time was controlled at 3~4 hours, dense
Contract after enzymolysis liquid, triple valve 21 opens the inlet of medicine vacuum concentrator 5 and the circuit between communicating pipe 9 23, at this moment starts
Apparatus for vacuum producing on stainless-steel vacuum mixer 6, using negative pressure the enzymolysis liquid after the concentration in medicine vacuum concentrator 5
It is drawn into the tank body of stainless-steel vacuum mixer 6, after suction is good, closes magnetic valve 3 37, and take out by drawing liquid pump 11
Take in the high concentration edible ethanol injection stainless-steel vacuum mixer 6 in ethyl alcohol purification equipment a, pumping high-concentration edible ethanol is complete
Bi Hou, it is then continuous using the rabbling mechanism on stainless-steel vacuum mixer 6 to the vacuumize process of stainless-steel vacuum mixer 6
Concentrate after enzymolysis is stirred, under the effect of high concentration edible ethanol, these are dissolved in enzymolysis liquid without drug effect
The polymer solubility of composition is significantly reduced, and can be precipitated from the concentrated extract of enzyme-extracting solution, and natural Du of molecular state
Secondary drug ingedient can then be sufficiently mixed under conditions of being sufficiently stirred for high concentration edible ethanol solution, and be dissolved in the molten of ethanol
(high concentration edible ethanol not only has the effect of dissolving bark of eucommia natural medicinal ingredients, and the effect with sterilizing in liquid
Really), mixing time control control is at 1 hour, the time arrive after stop stirring, wait makes solution for 15 minutes in inactive state, at this moment,
A macromolecule polyalcohol for metabolite without effective component can precipitate in solid form, and have that drug effect is divided into is secondary
Metabolite is dissolved in high concentration edible ethanol, positioned at the brown clear liquid shape in the top of sediment, starts bark of eucommia natural drug
Apparatus for vacuum producing 40 on fine powder load device 7, due to negative pressure, brownish supernatant is drawn into the bark of eucommia day by liquid suction pipe 24
In the 7-4 of cavity one of right medicine fine powder load device 7 and a certain amount of Cyclodextrin is manually added by charge door, at the same time,
Heater 7-13 heating on bark of eucommia natural drug fine powder load device 7 is located at the heating agent in the 7-5 of cavity two, and temperature control exists
55 DEG C~60 DEG C, meanwhile, PLC 48 starts servomotor 7-14 rotations, drives montant 7-9 to rotate and drive stirring sheet 2-
15 are stirred continuously Cyclodextrin is mixed with supernatant, and the mixture of Cyclodextrin and supernatant is heated while be stirred,
Ethanol and residual moisture in mixture are heated rapid evaporation, and steam is condensed by alcohol vapour collector 7-11, become
Liquid is collected again, and after ethanol evaporation is complete, mixture is by dried process just into bark of eucommia natural drug fine powder, bark of eucommia crude drug
Thing fine powder all gathers cast dividing plate 7-3 bottoms, and at this moment PLC 48 starts band valve cylinder 7-8, drives and moved on montant 7-9,
And briquetting 7-10 is opened, bark of eucommia natural drug fine powder is drained into charge cask by through hole 7-2a, now, PLC 48
Control vibrator 44 works, so that bark of eucommia natural drug fine powder more rapidly, efficiently, without remaining is drained into charge cask,
Ethanol liquid in alcohol vapour collector 7-11 is stored by the purification of ethyl alcohol purification equipment a, can be utilized again；
Condensed water in medicine vacuum concentrator 5 can also be drawn into water tank 13 and be reused；So that bark of eucommia natural drug
In composition fine powder extraction process, discarded object can be recycled utilization, and so as to reach environmental protection, energy-conservation, extraction efficiency is high, be produced into
This low effect, is worthy of popularization.
Although the present invention is shown and described by reference to preferred embodiment, this professional ordinary skill
Personnel are it is to be appreciated that in the range of claims, can make the various change in form and details.
Claims (7)
1. a kind of bark of eucommia natural medicinal ingredients extraction process, it is characterised in that comprise the following steps：
(1) bark of eucommia raw material enzymolysis processing：Bark of eucommia raw material is put into the interior bucket of gutta-percha and natural medicinal ingredients separator (1)
Place, add water to submerge bark of eucommia raw material, gradually respectively by containing protease, cellulase, pectase, cutinase solution according to 1:1
Proportioning carry out being mixed into mixed solution, being configured to PH buffer solutions using food-grade citric acid and sodium citrate is poured into mixed liquor
In, pH value is made into for 3.2,4.0,5.5 3 kind digest solution, enzymolysis solution is poured into gutta-percha and natural medicinal ingredients are separated
In the water of device (1), enzymolysis is constantly stirred to bark of eucommia raw material, and in gutta-percha and natural medicinal ingredients separator (1)
Enzymolysis solution carries out heating water bath, and at 40 DEG C~50 DEG C, every kind of enzyme digestion reaction time is 4~6 hours to heating and temperature control；
(2) separation of enzymolysis liquid, filtering：Bark of eucommia colloid stays in gutta-percha and natural medicinal ingredients device after bark of eucommia raw material enzymolysis
(1) in, its enzymolysis liquid discharged by the leakage fluid dram of gutta-percha and natural medicinal ingredients separator (1) and by spiral continuously from
The heart is separated, and removes big slag and chip, and the separating liquid after spiral centrifugal slagging-off carries out core and filter bag carries out coarse filtration, by coarse filtration
Enzymolysis liquid is filtered by film filter again, is obtained by the brown clear solution transparent, without suspended solid residue of refined filtration；
(3) filtering enzymolysis liquid low temperature concentration；Limpid transparent brown solution injection of medicine vacuum concentrator (5), medicine vacuum
Inspissator (5), the enzymolysis liquid to filtering carries out cryogenic vacuum concentration；
(4) sterilization of concentrate normal temperature, precipitate and separate：In enzymolysis liquid injection of medicine precipitate and separate device (6) after low temperature is concentrated, plus
Enter 95% edible ethanol and constantly the enzymolysis liquid after concentration is stirred at ambient pressure, the rear static enzymolysis liquid made after concentration is dense
Being significantly reduced without effective component solubility in slurry, precipitates from the concentrated extract of enzyme-extracting solution, and molecular state is natural
Bark of eucommia drug ingedient then can be sufficiently mixed and dissolve under conditions of being sufficiently stirred for ethanol solution；
(5) drug ingedient is refined：Supernatant liquor is extracted, supernatant liquor is then injected into bark of eucommia natural drug fine powder load device
(7) in, cyclodextrin is loaded to supernatant and heating water bath treatment is carried out under vacuum conditions, heating and temperature control is 55 DEG C~60
DEG C, alcohol and residual moisture in evaporation clear liquid, and obtain bark of eucommia fine powder.
2. a kind of bark of eucommia natural medicinal ingredients extraction equipment, including gutta-percha and natural medicinal ingredients separator (1), Du
The sidepiece of secondary glue and natural medicinal ingredients separator (1) is provided with spiral centrifugal separator (2), the spiral centrifugal separator
(2) sidepiece is provided with core and filtering bag filter (3), and the sidepiece of the core and filtering bag filter (3) is provided with film filter
(4), the sidepiece of the film filter (4) is provided with medicine vacuum concentrator (5), and the sidepiece of the medicine vacuum concentrator (5) is matched somebody with somebody
There is the stainless-steel vacuum mixer (6) with rabbling mechanism, the sidepiece of the stainless-steel vacuum mixer (6) is provided with ethyl alcohol purification and sets
Standby (a), it is characterized in that：The sidepiece of the stainless-steel vacuum mixer (6) is provided with bark of eucommia natural drug fine powder load device (7)；
Enzymolysis liquid storage is provided between the gutta-percha and natural medicinal ingredients separator (1) and spiral centrifugal separator (2)
Tank (8), is provided with coarse filtration liquid holding vessel (9) between the spiral centrifugal separator (2) and core and filtering bag filter (3), described
Refined filtration liquid holding vessel (10), the film filter (4) and medicine are provided between core and filtering bag filter (3) and film filter (4)
Fine filtrate holding vessel (11) is provided between thing vacuum concentrator (5), the sidepiece of the medicine vacuum concentrator (5) is provided with band and adds
The hot-water cylinder (12) and water tank (13) of hot merit energy and temperature controller；The gutta-percha and natural medicinal ingredients separator (1)
Communicating pipe one (14), the bottom of the enzymolysis liquid holding vessel (8) are installed between the top of leakage fluid dram and enzymolysis liquid holding vessel (8)
And the inlet of spiral centrifugal separator (2) between be installed, the spiral centrifugal separator (2) goes out liquid communicating pipe two (15)
Communicating pipe three (16), the bottom of the coarse filtration liquid holding vessel (9) and sand are installed between mouth and the top of coarse filtration liquid holding vessel (9)
Be installed, the core and filtering bag filter (3) go out liquid communicating pipe four (17) between the inlet of core and filtering bag filter (3)
Mouthful between the top of refined filtration liquid holding vessel (10) be installed communicating pipe five (18), the bottom of the refined filtration liquid holding vessel (10) and
Communicating pipe six (19), film filter (4) liquid outlet and fine filtrate holding vessel are installed between film filter (4) inlet
(11) communicating pipe seven (20) is installed between top, triple valve is provided with the inlet of the medicine vacuum concentrator (5)
(21), between the import of the bottom and triple valve (21) one end of the fine filtrate holding vessel (11) be installed communicating pipe eight
(22), between another end opening of the triple valve (21) and the entrance point of stainless-steel vacuum mixer (6) be installed communicating pipe
Nine (23), hot water conveying pipe (25) and efferent duct (26) are installed between the hot-water cylinder (12) and medicine vacuum concentrator (5),
Communicating pipe ten (27), the water storage are installed between the water storage cavity of the medicine vacuum concentrator (5) and water tank (13) bottom
Between the bottom of tank (13) and hot-water cylinder (12) top be installed communicating pipe ten one (28)；
The bark of eucommia natural drug fine powder load device (7) includes the bucket (7-1) with opening, the bucket (7-1)
It is fixed with cavity and cavity is divided into upper and lower two-part dividing plate (7-2), is provided with the cavity above the dividing plate (7-2) and is in
The cast dividing plate (7-3) that taper is set, the top of the cast dividing plate (7-3) is fixed on the inner peripheral wall of bucket (7-1),
The bottom of the cast dividing plate (7-3) is fixed on the top surface of dividing plate (7-2), and cast dividing plate (7-3) inner side and outside are divided
The cavity one (7-4) and cavity two (7-5) that Wei do not separate, the through hole connected with cavity one (7-4) is provided with the dividing plate (7-2)
(7-2a), the opening of the bucket (7-1) is provided with the end cap (7-6) for closed opening, solid on the bucket (7-1)
Surely there is support (7-7), band valve cylinder (7-8) is fixed with the support (7-7), the piston rod with valve cylinder (7-8) is consolidated
It is scheduled on end cap (7-6) top surface, montant (7-9) is rotatably connected on the end cap (7-6), the bottom of the montant (7-9) turns
It is dynamic to be connected with the briquetting (7-10) with taper, the taper of the briquetting (7-10) it is identical with the taper of cast dividing plate (7-3) and with
The inner surface of cast dividing plate (7-3) coordinates, and the montant (7-9) is by being fixed on the servomotor (7- on end cap (7-6) top
14) drive, be fixed with the bottom wheel profile surface of the montant (7-9) in stirring sheet (7-15), the cavity two (7-5) and be provided with
Heater (7-13)；The sidepiece of the bucket (7-1) is provided with the ethanol being made up of condenser, cooler, separator, accumulator
Steam accumulator (7-11), is connected between the condenser and cavity one (7-4) of the alcohol vapour collector (7-11) and is connected
Pipe (7-12), communicating pipe ten is provided between the accumulator and ethyl alcohol purification equipment (a) of the alcohol vapour collector (7-11)
Two (29)；
Liquid suction pipe (24) is installed between the stainless-steel vacuum mixer (6) and bark of eucommia natural drug fine powder load device (7)；
Magnetic valve one (30), the communicating pipe one are installed between the triple valve (21) and the inlet of medicine vacuum concentrator (5)
(14) magnetic valve two (41) is installed on, drawing liquid pump one (31), the communicating pipe three is installed on the communicating pipe two (15)
(16) drawing liquid pump two (32) is installed on, drawing liquid pump three (33), the communicating pipe five is installed on the communicating pipe four (17)
(18) drawing liquid pump four (34) is installed on, drawing liquid pump five (35), the communicating pipe seven is installed on the communicating pipe six (19)
(20) drawing liquid pump six (36) is installed on, magnetic valve three (37), the communicating pipe ten is installed on the communicating pipe nine (23)
(27) drawing liquid pump 12 (c) is installed on, drawing liquid pump (b), the communicating pipe ten one (28) is installed on the liquid suction pipe (24)
On drawing liquid pump eight (38) is installed, drawing liquid pump nine (39), the bark of eucommia natural drug are installed on the communicating pipe ten two (29)
Apparatus for vacuum producing (40) is installed on fine powder load device (7).
3. bark of eucommia natural medicinal ingredients extraction equipment according to claim 2, it is characterized in that：The bottom of the water tank (13)
Portion is provided with communicating pipe ten three (42), the communicating pipe 13 between gutta-percha and natural medicinal ingredients separator (1)
(42) drawing liquid pump ten (43) is installed on.
4. bark of eucommia natural medicinal ingredients extraction equipment according to claim 3, it is characterized in that：On the bucket (7-1)
Vibrator (44) is installed.
5. bark of eucommia natural medicinal ingredients extraction equipment according to claim 4, it is characterized in that：The ethyl alcohol purification equipment
Between the liquid storing barrel and stainless-steel vacuum mixer (6) of (a) be installed communicating pipe ten four (45), on the communicating pipe ten four (45)
Drawing liquid pump ten one (46) is installed.
6. bark of eucommia natural medicinal ingredients extraction equipment according to claim 5, it is characterized in that：On the cavity two (7-5)
Temperature controller (7-16) is installed.
7. bark of eucommia natural medicinal ingredients extraction equipment according to claim 6, it is characterized in that：The bark of eucommia natural drug essence
The sidepiece of powder load device (7) is provided with supporting plate (47), and PLC (48), the PCL are provided with the supporting plate (47)
Controller and gutta-percha and natural medicinal ingredients separator (1), spiral centrifugal separator (2), medicine vacuum concentrator (5),
Ethyl alcohol purification equipment (a), bark of eucommia natural drug fine powder load device (7), hot-water cylinder (12), each drawing liquid pump and triple valve (21),
Magnetic valve one (30), magnetic valve two (41), the connection of magnetic valve three (37).
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| CN201710043738.XA CN106890477B (en) | 2017-01-19 | 2017-01-19 | Cortex Eucommiae natural medicinal ingredients extraction process and its extract equipment |
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| CN201710043738.XA CN106890477B (en) | 2017-01-19 | 2017-01-19 | Cortex Eucommiae natural medicinal ingredients extraction process and its extract equipment |
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| CN106890477B CN106890477B (en) | 2019-10-15 |
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| CN108783350A (en) * | 2018-05-16 | 2018-11-13 | 张敬春 | A kind of honey method for concentration of membrane filtration retentive activity invertase |
| CN112716906A (en) * | 2021-01-17 | 2021-04-30 | 洪学云 | Preparation method of phospholipid chitosan medicine |
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| US20020150638A1 (en) * | 2001-02-05 | 2002-10-17 | Nobuyoshi Kuboyama | Solid form compositions containing an extract of a raw material as the active ingredient and process of preparing the same |
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| US20020150638A1 (en) * | 2001-02-05 | 2002-10-17 | Nobuyoshi Kuboyama | Solid form compositions containing an extract of a raw material as the active ingredient and process of preparing the same |
| CN103550951A (en) * | 2013-11-20 | 2014-02-05 | 青岛农业大学 | Novel method for extracting or purifying effective components of traditional Chinese medicine |
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| CN108783350A (en) * | 2018-05-16 | 2018-11-13 | 张敬春 | A kind of honey method for concentration of membrane filtration retentive activity invertase |
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