CN106890242B - A kind of pharmaceutical composition for treating irregular menstruation and preparation method thereof, preparation and application - Google Patents
A kind of pharmaceutical composition for treating irregular menstruation and preparation method thereof, preparation and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of pharmaceutical composition for treating irregular menstruation and preparation method thereof, preparation and applications.The pharmaceutical composition of the treatment irregular menstruation includes 20~150 parts of Radix Astragali, 20~100 parts of motherwort, 10~80 parts of dried rehamnnia root, 10~50 parts of the raw sangqi ginseng of parts by weight of raw materials, is prepared through pre-treatment, extraction and post-processing step.Preparation is that tablet, powder, capsule, granule and pill prepared by pharmaceutically acceptable auxiliary material are added in the pharmaceutical composition of the treatment irregular menstruation.The application in treating irregular menstruation drug is being prepared using the pharmaceutical composition for the treatment irregular menstruation.The all medicine joints of the present invention, synergistic effect play blood-enrich, the work(of promoting blood circulation cures mainly irregular menstruation altogether.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of pharmaceutical composition for treating irregular menstruation and its preparation side
Method, preparation and application.
Background technology
Menstrual disorder is also referred to as irregular menstruation, is gynaecology's common disease, shows as the exception of menstrual cycle or amount of bleeding, can companion
Abdominal pain and constitutional symptom during month premenstrual, menstrual period.
Irregular menstruation drastically influences the health of women, and irregular menstruation can cause infertile.According to relevant statistical research
It is to cause infertile direct cause to show female irregular menstruation, while is also to cause the infertile frequency in China in recent years
The major reason of rising.In addition irregular menstruation is easy to cause patient and menstruation arthritis, cervicitis, menstruation tooth occurs
Bitterly, the illnesss such as menstruation asthma, irregular menstruation influence that serious prestige can be brought to the health of women caused by women
The side of body.
With the quickening of social rhythm, irregular menstruation has become common gynecological disease, frequently-occurring disease.It is badly in need of exploring menstrual disorder
Comprehensive therapeutic plan.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition for treating irregular menstruation；Second is designed to provide
The preparation method of the pharmaceutical composition of the treatment irregular menstruation；3rd is designed to provide the treatment irregular menstruation
The preparation of pharmaceutical composition；4th is designed to provide the application of the pharmaceutical composition of the treatment irregular menstruation.
The first object of the present invention is achieved in that the pharmaceutical composition of the treatment irregular menstruation includes raw material weight
20~150 parts of the Radix Astragali, 20~100 parts of motherwort, 10~80 parts of dried rehamnnia root, 10~50 parts of raw sangqi ginseng of part are measured, through pre-treatment, is carried
It takes and is prepared with post-processing step.
The second object of the present invention is achieved in that including pre-treatment, extraction and post-processing step, is specifically included：
A, selected and clean bulk pharmaceutical chemicals, then weighing bulk pharmaceutical chemicals by formulation ratio, to be uniformly mixed so as to obtain material a spare；
B, alcohol solution dipping will be added in material a 7~10 days, filtrate b and filter residue c is obtained by filtration；
C, the boiling that 8~12 times of filter residue c weight is added in filter residue c is carried 3~4 times, every time 0.5~1.5h, merging filtrate,
It is concentrated to give thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is uniformly mixed, drying and crushing sieves to obtain object
Treat the pharmaceutical composition of irregular menstruation.
The third object of the present invention, which is achieved in that in the pharmaceutical composition of the treatment irregular menstruation, adds in pharmacy
Tablet, powder, capsule, granule and pill prepared by upper acceptable auxiliary material.
The fourth object of the present invention is achieved in that the pharmaceutical composition of the treatment irregular menstruation is preparing treatment
Application in irregular menstruation drug.
It has been recognised by the inventors that motherland's medicine early has discussion to the formation of menstruation,《Plain Questions ancient times innocent opinion》It says：" woman seven
Year, kidney qi are contained, dental transition hair length；Two or seven and menarche, conception vessel lead to, taichong channel is contained, and lunar eclipse has son at present；Radix Notoginseng kidney is averaged,
Seventy-seven conception vessel of therefore growth of wisdom tooth and mature development of the body ... is empty, and taichong channel, which declines, to be lacked, the menopause, menostasia, therefore shape is gone bad and s.m.p.Illustrate day
The last of the ten Heavenly stems come from it is congenital, Tibetan in kidney, be Kidney-Yin constantly enrich and metaplasia and ripe in kidney qi vigorous period, kidney.
The pathogenetic dominant mechanism of menstruation is visceral dysfunction, and derangement of Qi and blood causes the damage for rushing wantonly two arteries and veins.It is treated
It focuses on and effects a permanent cure with menstruation regulating.It, which treats big method, has kidney tonifying, helps spleen, is soothing the liver, recuperating qi-blood etc.." going out all kidneys through water ", therefore menstruation regulating is originally
In kidney.Kidney tonifying is that benefit is congenital Kidney-Yin, based on replenishing essence blood-nourishing, helps with the product of supporing yang QI invigorating, makes Yin grows while yang is generating, essence and blood is all
It is prosperous, then menstruation self-regulated.Such as《Jing Yue's complete work》It says：" therefore menstruation regulating will, be valued for source of the tonifying spleen and stomach as a means of blood, support kidney qi with pacify blood it
Both this is known in room, then kind to the greatest extent.”
In side of the present invention, Radix Astragali,【Base】For the dry root of legume astragalus or Inner Mongol astragalus etc..【Meridian distribution of property and flavor】
Slightly warm in nature, it is sweet in flavor, enter lung, the spleen channel.【Major function】Life invigorating qi for consolidating superficies, inducing diuresis for removing edema, eliminating toxic, myogenic.Spontaneous perspiration is treated, is stolen
Sweat, blood-arthralgia, edema, un-festering of ulcer or burst do not hold back long.Toast is used：Tonifying middle-Jiao and Qi.Treat internal injury overstrain, splenasthenic diarrhea, rectal prolapse, the deficiency of vital energy
Blood takes off, and collapses band and the card of all laboured breathing deficiency of blood.
Motherwort,【Base】For the herb of labiate motherwort.【Meridian distribution of property and flavor】Cool in nature, acrid flavour is bitter.Enter pericardium, liver
Through.【Major function】Promoting blood circulation, dissolving stasis, menstruation regulating, disappear water.Irregular menstruation is treated, threatened abortion difficult labour is not coated, postpartum anemic fainting, hemostasis
Abdominal pain, metrorrhagia and metrostaxis, carbuncle swells sore.
Dried rehamnnia root,【Base】For the rhizome of scrophulariaceae rehmannia glutinosa plant.【Meridian distribution of property and flavor】It is cool in nature, sweet-bitter flavor.Enter the heart, liver, kidney
Through.【Major function】Enriching yin, blood-nourishing.Treat bleeding from five sense organs or subcutaneous tissue, metrorrhagia, irregular menstruation, fetal irritability, impairment of yin constipation.
Raw sangqi ginseng,【Base】For the root of Araliaceae Panax pseudoginseng.【Meridian distribution of property and flavor】It is warm-natured, mildly bitter flavor.Enter liver, stomach,
Large intestine channel.【Major function】Hemostasis dissipates the stasis of blood, detumescence, analgesic therapy.Treatment is spitted blood, hemoptysis, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, bloody flux, uterine bleeding , Disorder lumps in the abdomen,
Postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatic hemorrhage, carbuncle swells pain etc..
In prescription of the present invention Radix Astragali be legume astragalus root, invigorating qi for consolidating superficies, tonifying middle-Jiao and Qi；Motherwort is invigorated blood circulation, dissolving stasis,
Menstruation regulating；Dried rehamnnia root nourishing yin and nourishing blood, cures mainly irregular menstruation；Raw sangqi ginseng dissipates the stasis of blood, detumescence, analgesic therapy.The all medicine joints of the present invention, collaboration are made
With playing blood-enrich altogether, the work(of promoting blood circulation cures mainly irregular menstruation.
The invention has the advantages that：
Inventor is observed by the clinical application over 5 years, and clinical observation is carried out by 130 irregular menstruation patients,
The medicine total effective rate 94.6%, the pharmaceutical composition has highlighted curative for effect in clinical observation, safely controllable, and patient is easy to connect
The advantages that by, use easy to spread, primary crude drug is all autonomic drug, safe and non-toxic, and clinic further genralrlization is worth to use.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any conversion or replacement made, all belong to the scope of protection of the present invention.
The pharmaceutical composition for the treatment of irregular menstruation of the present invention includes 20~150 parts of the Radix Astragali of parts by weight of raw materials, benefit
20~100 parts of Brittle Falsepimpernel Herb, 10~80 parts of dried rehamnnia root, 10~50 parts of raw sangqi ginseng, are prepared into through pre-treatment, extraction and post-processing step
It arrives.
The pharmaceutical composition of the treatment irregular menstruation includes 50~100 parts of the Radix Astragali of parts by weight of raw materials, motherwort 50
~80 parts, 30~50 parts of dried rehamnnia root, 20~30 parts of raw sangqi ginseng, be prepared through pre-treatment, extraction and post-processing step.
The preparation method of the pharmaceutical composition for the treatment of irregular menstruation of the present invention, including pre-treatment, extraction and rear place
Step is managed, is specifically included：
A, selected and clean bulk pharmaceutical chemicals, then weighing bulk pharmaceutical chemicals by formulation ratio, to be uniformly mixed so as to obtain material a spare；
B, alcohol solution dipping will be added in material a 7~10 days, filtrate b and filter residue c is obtained by filtration；
C, the boiling that 8~12 times of filter residue c weight is added in filter residue c is carried 3~4 times, every time 0.5~1.5h, merging filtrate,
It is concentrated to give thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is uniformly mixed, drying and crushing sieves to obtain object
Treat the pharmaceutical composition of irregular menstruation.
The concentration expressed in percentage by volume of ethanol solution described in step B is 60~80%.
The concentration expressed in percentage by volume of the ethanol solution is 70%.
The temperature impregnated in step B is 20~40 DEG C.
Pulverizing and sieving described in D steps is to crushed 200 mesh sieves.
The preparation of the pharmaceutical composition for the treatment of irregular menstruation of the present invention is the drug of the treatment irregular menstruation
Tablet, powder, capsule, granule and pill prepared by pharmaceutically acceptable auxiliary material are added in composition.
The application of the pharmaceutical composition for the treatment of irregular menstruation of the present invention is the drug of the treatment irregular menstruation
Composition is preparing the application in treating irregular menstruation drug.
Method concrete operations prepared by the pharmaceutical composition for the treatment of irregular menstruation of the present invention are as follows：
(1) selected and clean drug used, Radix Astragali, motherwort, dried rehamnnia root, raw sangqi ginseng impregnate 7-10 with 70% ethyl alcohol
It filters to obtain alcohol liquid, and alcohol liquid is concentrated under reduced pressure to obtain thick paste.
(2) the remaining dregs of a decoction of step (1) are carried 3-4 times with boiling.Filtrate is collected when 1 is small every time, is concentrated to give thick paste.
(3) two kinds of thick pastes obtained by step (1) and (2) are mixed, adds in proper honey and obtain semi-finished product.
(4) semi-finished product are dispensed into obtain finished product, specification is 50 grams/cake, and 100 grams/cake, every gram of finished product is equivalent to primary crude drug
10 grams.
(5) application method and the course for the treatment of：Warm water takes, 3 times a day, each 5-6 grams, per 30 days as one therapeutic course.
Case is embodied, the present invention will be further described below：
Embodiment 1
Raw material Radix Astragali 20g, motherwort 20g, dried rehamnnia root 10g, raw sangqi ginseng 10g are taken, adds in the volume hundred of 5 times of raw material gross weight
The ethanol solution of point concentration 80% impregnates 10 days at 20 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick paste
e；The boiling that 12 times of filter residue is added in filter residue carries 4 times, every time 1 it is small when, filtering collects filtrate, is concentrated to give thick paste d, by thick paste d and
Thick paste e be uniformly mixed crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 2
Raw material Radix Astragali 150g, motherwort 100g, dried rehamnnia root 80g, raw sangqi ginseng 50g are taken, adds in the volume of 3 times of raw material gross weight
The ethanol solution of percentage concentration 60% impregnates 10 days at 40 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick
Cream e；The boiling that 8 times of filter residue is added in filter residue carries 3 times, every time 1 it is small when, filtering collects filtrate, thick paste d is concentrated to give, by thick paste d
Be uniformly mixed with thick paste e crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 3
Raw material Radix Astragali 80g, motherwort 60g, dried rehamnnia root 60g, raw sangqi ginseng 30g are taken, adds in the volume hundred of 4 times of raw material gross weight
The ethanol solution of point concentration 70% impregnates 8 days at 30 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick paste
e；The boiling that 10 times of filter residue is added in filter residue carries 4 times, every time 1 it is small when, filtering collects filtrate, is concentrated to give thick paste d, by thick paste d and
Thick paste e be uniformly mixed crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 4
Raw material Radix Astragali 50g, motherwort 50g, dried rehamnnia root 30g, raw sangqi ginseng 20g are taken, adds in the volume hundred of 5 times of raw material gross weight
The ethanol solution of point concentration 80% impregnates 7 days at 40 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick paste
e；The boiling that 8 times of filter residue is added in filter residue carries 4 times, every time 1 it is small when, filtering collects filtrate, is concentrated to give thick paste d, by thick paste d and
Thick paste e be uniformly mixed crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 5
Raw material Radix Astragali 100g, motherwort 80g, dried rehamnnia root 50g, raw sangqi ginseng 30g are taken, adds in the volume of 3 times of raw material gross weight
The ethanol solution of percentage concentration 60% impregnates 10 days at 40 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick
Cream e；The boiling that 12 times of filter residue is added in filter residue carries 4 times, every time 1 it is small when, filtering collects filtrate, thick paste d is concentrated to give, by thick paste d
Be uniformly mixed with thick paste e crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 6
Raw material Radix Astragali 50g, motherwort 80g, dried rehamnnia root 30g, raw sangqi ginseng 30g are taken, adds in the volume hundred of 4 times of raw material gross weight
The ethanol solution of point concentration 70% impregnates 7 days at 30 DEG C of temperature, filtrate and filter residue is obtained by filtration, filtrate is concentrated to give thick paste
e；The boiling that 10 times of filter residue is added in filter residue carries 4 times, every time 1 it is small when, filtering collects filtrate, is concentrated to give thick paste d, by thick paste d and
Thick paste e be uniformly mixed crushed 200 mesh sieves obtain object treatment irregular menstruation pharmaceutical composition.
Embodiment 7
Pharmaceutically acceptable auxiliary material system is added in the pharmaceutical composition for the treatment irregular menstruation being prepared with embodiment 2
Standby piece agent.
Embodiment 8
Pharmaceutically acceptable auxiliary material system is added in the pharmaceutical composition for the treatment irregular menstruation being prepared with embodiment 1
It is standby into capsule.
Embodiment 9
Pharmaceutically acceptable auxiliary material system is added in the pharmaceutical composition for the treatment irregular menstruation being prepared with embodiment 4
It is standby into granule.
Embodiment 10
Pharmaceutically acceptable auxiliary material system is added in the pharmaceutical composition for the treatment irregular menstruation being prepared with embodiment 6
It is standby into pill.
Embodiment 11
The pharmaceutical composition being prepared respectively with 1~embodiment of embodiment 6 carries out clinical test, total effective rate
94.6%.It is described further below with part real case：
Patient sinus, female, 22 years old, student was unmarried, G0PO, deny the same branch of a family history, because " reducing March through amount " is medical, body usually
Strong, disease is told：Come nearly March it is puckery few through row, color it is purple it is black have a block, underbelly shouting pain tenderness, under clot after subtract bitterly, distending pain in the chest and hypochondrium of suddenly feeling is examined
It is disconnected：" hypomenorrhia ".The pharmaceutical composition that the embodiment of the present invention 2 is prepared is taken, 3 times a day, daily 5-6 grams, warm water is sent
Clothes, patient is gradually more through row menstrual flow after treating January, and color is red, and dysmenorrhea is alleviated, and patient's treatment is effective, and same front and continued is advised to take, is controlled
Treat March after patient's eumenorrhea, regular follow-up.
Patient Zhang, female is 36 years old, married, G1P1, teacher, because of " extending half a year through row ", medical, ferritic is healthy, private prosecution：Closely
Over the past half year often in through row time lengthening, 10-15 days menstrual period were differed, and menstrual flow is more or less, and dark menses have block, and dysmenorrhea is refused
It presses, mood is irritated.Diagnosis：" menostaxis ".The pharmaceutical composition that the embodiment of the present invention 4 is prepared is taken, 3 times a day, often
5-6 grams of day, warm water takes, and the patient that passes through for secondary month shortens in menstrual period earlier above, and scarlet through color, abdominal pain is relieved, and patient's treatment is effective,
Same front and continued is advised to take, patient's eumenorrhea after treating 2 months, regular follow-up.
Patient Sun, female is 42 years old, married, G2P+1 1, because " hyper-menorrhea April " is medical, the past body is good for, and disease is told：It is measured through row
More, color purple is dim, and matter is thick, has clot, dysmenorrhea, lower abdominal distention pain, diagnoses usually：" menorrhalgia ".Take the embodiment of the present invention 5
The pharmaceutical composition being prepared, 3 times a day, daily 5-6 grams, warm water takes, and the patient menstrual that passes through for secondary month amount is gradually normal, warp
Color is dark red, and lower abdominal distention pain is alleviated, and patient's treatment is effective, and same front and continued is advised to take, and patient is normal through measuring after treating March, regular follow-up.
The present invention is not limited to the above embodiments, and the above embodiments and description only describe the present invention's
Principle, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these change and change
Into all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
It defines.
Claims (9)
1. a kind of pharmaceutical composition for treating irregular menstruation, it is characterised in that the pharmaceutical composition of the treatment irregular menstruation by
10~50 parts of 20~150 parts of the Radix Astragali of parts by weight of raw materials, 20~100 parts of motherwort, 10~80 parts of dried rehamnnia root, raw sangqi ginseng compositions,
It is prepared through pre-treatment, extraction and post-processing step.
2. the pharmaceutical composition for the treatment of irregular menstruation according to claim 1, it is characterised in that the treatment menstruation is not
The pharmaceutical composition of tune is by 50~100 parts of the Radix Astragali of parts by weight of raw materials, 50~80 parts of motherwort, 30~50 parts of dried rehamnnia root, raw three
7 20~30 parts of compositions, are prepared through pre-treatment, extraction and post-processing step.
3. a kind of preparation method of the pharmaceutical composition of the treatment irregular menstruation described in claim 1 or 2, it is characterised in that including
Pre-treatment, extraction and post-processing step, specifically include：
A, selected and clean bulk pharmaceutical chemicals, then weighing bulk pharmaceutical chemicals by formulation ratio, to be uniformly mixed so as to obtain material a spare；
B, alcohol solution dipping will be added in material a 7~10 days, filtrate b and filter residue c is obtained by filtration；
C, the boiling that 8~12 times of filter residue c weight is added in filter residue c is carried 3~4 times, 0.5~1.5h, merging filtrate concentrate every time
Obtain thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is uniformly mixed, drying and crushing sieves to obtain object treatment
The pharmaceutical composition of irregular menstruation.
4. preparation method according to claim 3, it is characterised in that the volume basis of the ethanol solution described in step B is dense
It spends for 60~80%.
5. the preparation method according to claim 3 or 4, it is characterised in that the concentration expressed in percentage by volume of the ethanol solution is
70%.
6. preparation method according to claim 3, it is characterised in that the temperature impregnated in step B is 20~40 DEG C.
7. preparation method according to claim 3, it is characterised in that pulverizing and sieving described in D steps is to crushed 200
Mesh sieve.
8. the preparation of the pharmaceutical composition of the treatment irregular menstruation described in a kind of claim 1 or 2, it is characterised in that described controls
Treat the tablet that pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of irregular menstruation and is prepared, powder, capsule, granule and
Pill.
9. the application of the pharmaceutical composition of the treatment irregular menstruation described in a kind of claim 1 or 2, it is characterised in that described controls
The pharmaceutical composition for treating irregular menstruation is preparing the application in treating irregular menstruation drug.
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| CN201710156677.8A CN106890242B (en) | 2017-03-16 | 2017-03-16 | A kind of pharmaceutical composition for treating irregular menstruation and preparation method thereof, preparation and application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856474A (en) * | 2010-06-30 | 2010-10-13 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating hypomenorrhea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336997B (en) * | 2008-08-11 | 2010-12-22 | 江苏济川制药有限公司 | Medicine for hemorrhage after drug abortion |
| CN103041064A (en) * | 2012-12-13 | 2013-04-17 | 青岛天鹅针织有限公司 | Traditional Chinese medicine composition for treating hypermenorrhea |
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| CN101856474A (en) * | 2010-06-30 | 2010-10-13 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating hypomenorrhea and preparation method thereof |
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Effective date of registration: 20220406 Address after: 675000 No. 327 Lucheng West Road, Chuxiong City, Chuxiong Yi Autonomous Prefecture, Yunnan Province Patentee after: Chuxiong Yi Autonomous Prefecture Yi medicine Research Institute Address before: 675000 Room 502, unit 2, building 5, 327 Lucheng West Road, Chuxiong City, Chuxiong Yi Autonomous Prefecture, Yunnan Province Patentee before: Yang Benlei |