CN106729191A - A kind of preparation method and application of umbilical therapy paste - Google Patents

A kind of preparation method and application of umbilical therapy paste Download PDF

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CN106729191A
CN106729191A CN201710148132.2A CN201710148132A CN106729191A CN 106729191 A CN106729191 A CN 106729191A CN 201710148132 A CN201710148132 A CN 201710148132A CN 106729191 A CN106729191 A CN 106729191A
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preparation
therapy paste
umbilical therapy
liquid
umbilical
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何莲英
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998Hordeum (barley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

The invention provides a kind of preparation method and application of umbilical therapy paste, comprise the following steps:By raw material clear water immersion, boiled medicine after immersion, leached liquid, the dregs of a decoction are added water and boiled medicine again, are repeated 2~3 times, and the liquid that merging is leached simultaneously is staticly settled, evaporation liquid is made ointment, ointment is molded, adds diverting agent, patch processed, obtains the umbilical therapy paste.The preparation method of umbilical therapy paste provided herein, can separate out active ingredient complete, and the utilization rate that is absorbed by the body is relatively also higher, and it is convenient, simple, easily operated to have the advantages that, be adapted to large-scale production and be widely applied.The preparation method of umbilical therapy paste provided herein, at least decocts full " three juice ", and the first juice is to allow medicinal material fully to soak, second juice is in order to the active ingredient of medicinal material is fully fried next, 3rd juice or be afterwards in order to allow medicinal material active ingredient thoroughly to separate out, it is closely linked, it is indispensable.

Description

A kind of preparation method and application of umbilical therapy paste
Technical field
The present invention relates to drug preparation technique field, in particular to a kind of preparation method and application of umbilical therapy paste.
Background technology
In the preparation method of existing patch, directly crushed using by medicine, reconcile mix technique, in medicine it is effective into Decomposite and come very little, relative absorbance is also few.The medicine for reconciling directly is crushed to be difficult to play its real herbal pharmacology effect completely Should.《The reason Chongqing parallel prose》The middle preparation method for having recorded black plaster, medicinal material dose is big and wide in variety added by black plaster, and is boiling cream During medicine oil, not only the effective ingredient coking of many Chinese medicines is destroyed or distillation volatilization loses effective ingredient.In incorporation plaster Medicinal powder is deadened due to being mixed into plaster fat by grease, medicinal powder is reduced with contact human skin face, so as to be difficult to ooze fell Skin, effective ingredient is difficult to play and plays a part of to cure the disease, and reduces actual efficacy.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is the preparation method of the umbilical therapy paste for providing a kind of, described, and the method is related to immersion, three Three filters, concentration are decocted, cream, shaping is received, is added the operations such as diverting agent, can separate out active ingredient complete, be absorbed by the body utilization rate Relatively also higher, it is convenient, simple, easily operated to have the advantages that, is adapted to large-scale production and is widely applied.
The second object of the present invention is to provide a kind of application of the preparation method of described umbilical therapy paste, and the umbilical therapy paste is in system Application in standby treatment abdominal distension, stomach is received poor, loose stool, insufficiency of the spleen weak, kidney deficiency, qi-blood deficiency medicine.
In order to realize above-mentioned purpose of the invention, spy uses following technical scheme:
A kind of preparation method of umbilical therapy paste, comprises the following steps:
Raw material is soaked with clear water, is boiled medicine after immersion, leach liquid, the dregs of a decoction add water and boiled medicine again, repeat 2~3 Secondary, the liquid that leaches of merging is simultaneously staticly settled, and evaporation liquid is made ointment, ointment shaping, plus diverting agent, patch processed, is somebody's turn to do Umbilical therapy paste.
Preferably, after the evaporation liquid is made ointment, before the ointment shaping, also include:After adding grinding Valuable drug or volatile medicine medicinal powder, the particle diameter of the medicinal powder is less than 80 mesh.
Preferably, the process boiled medicine, specifically includes following steps:
First decoct with high heat, decoct boiling, then use slow fire instead, decoct while stirring removal surfactant foam;
The temperature of the intense fire is more than 180 DEG C, and the temperature of the slow fire is 120~150 DEG C.
Preferably, the time boiled medicine is 3~6 hours every time.
Preferably, the time of the immersion is 20~30 hours.
Preferably, it is described the step of merge the liquid that leaches and staticly settle after, also include:By liquid with 3~4 layers of gauze Filter 23~4 time.
Preferably, it is characterised in that the process of the evaporation liquid carries out decocting and concentrating with slow fire, and is stirred continuously.
Preferably, the valuable drug include ginseng, ganoderma lucidum, Cordyceps sinensis, bird's nest, donkey-hide gelatin and pilose antler in one kind or Several combinations..
Preferably, the forming agent includes one or several the group in Radix Notoginseng powder, ginseng powder and Tiepi Fengdou powder Close.
Preferably, the diverting agent includes one or several the combination in Chinese cassia tree, peppermint and Moschus.
Umbilical therapy paste prepared by the preparation method of umbilical therapy paste as described above is preparing treatment abdominal distension, stomach is received poor, loose stool, spleen Application in empty weak, kidney deficiency, qi-blood deficiency medicine.
Compared with prior art, beneficial effects of the present invention are:
(1) preparation method of umbilical therapy paste provided herein, can separate out active ingredient complete, and be absorbed by the body profit Relatively also higher with rate, it is convenient, simple, easily operated to have the advantages that, is adapted to large-scale production and is widely applied.
(2) preparation method of umbilical therapy paste provided herein, at least decocts full " three juice ", and the first juice is to allow medicinal material to fill Sub-dip steep, the second juice be in order to the active ingredient of medicinal material fully it is fried come, the 3rd juice or be afterwards in order to allow medicinal material effectively into Divide and thoroughly separate out, it is closely linked, it is indispensable.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with specific embodiment, but ability Field technique personnel will be understood that, following described embodiment is a part of embodiment of the invention, rather than whole embodiments, The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model of present invention protection Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
A kind of preparation method of umbilical therapy paste, comprises the following steps:
Raw material is soaked with clear water, is boiled medicine after immersion, leach liquid, the dregs of a decoction add water and boiled medicine again, repeat 2~3 Secondary, the liquid that leaches of merging is simultaneously staticly settled, and evaporation liquid is made ointment, ointment shaping, plus diverting agent, patch processed, is somebody's turn to do Umbilical therapy paste.
The preparation method of umbilical therapy paste provided herein, can separate out active ingredient complete, and be absorbed by the body utilization Rate is relatively also higher, and it is convenient, simple, easily operated to have the advantages that, is adapted to large-scale production and is widely applied.
(2) preparation method of umbilical therapy paste provided herein, at least decocts full " three juice ", and the first juice is to allow medicinal material to fill Sub-dip steep, the second juice be in order to the active ingredient of medicinal material fully it is fried come, the 3rd juice or be afterwards in order to allow medicinal material effectively into Divide and thoroughly separate out, it is closely linked, it is indispensable.
Preferably, after the evaporation liquid is made ointment, before the ointment shaping, also include:After adding grinding Valuable drug or volatile medicine medicinal powder, the particle diameter of the medicinal powder is less than 80 mesh.
In the application, if having the valuable drugs such as ginseng, Cordyceps sinensis, donkey-hide gelatin, pilose antler or volatile medicine in prescription, Need for medicine to be ground into fine powder, added when cream is received.
Preferably, the process boiled medicine, specifically includes following steps:
First decoct with high heat, decoct boiling, then use slow fire instead, decoct while stirring removal surfactant foam;
The temperature of the intense fire is more than 180 DEG C, and the temperature of the slow fire is 120~150 DEG C.
Preferably, the time boiled medicine is 3~6 hours every time.
In this application, the duration and degree of heating and the time of decoction are got hold of, it is to avoid Chinese medicine Jiao bottom or can not by Chinese medicine it is effective into Divide and fully leach.
Preferably, the time of the immersion is 20~30 hours.
Fully immersion, it is ensured that medicinal material fully absorbs water, the precipitation of active ingredient during helping to boil medicine.
Preferably, it is described the step of merge the liquid that leaches and staticly settle after, also include:By liquid with 3~4 layers of gauze Filter 23~4 time.
In the application, filtering can as far as possible reduce the impurity in liquid.
Preferably, it is characterised in that the process of the evaporation liquid carries out decocting and concentrating with slow fire, and is stirred continuously.
In this application, ointment is boiled using slow fire, slow fire can prevent liquid from enduring paste, and enter using the fast container of heat conduction Row is boiled, such as stainless-steel pan etc..
Preferably, the valuable drug include ginseng, Cordyceps sinensis, donkey-hide gelatin and pilose antler in one or several.
Preferably, the forming agent includes one or several the group in Radix Notoginseng powder, ginseng powder and Tiepi Fengdou powder Close.
The diverting agent includes one or several the combination in Chinese cassia tree, peppermint and Moschus.
According to constitution situation, forming agent is not fixed, such as the use Radix Notoginseng powder of relatively congealing cold with blood stasis, relatively deficiency of both qi and yin with west American ginseng powder etc., each forming agent is the core of prescription, not only helps be molded, and also plays a part of to help absorb and guide, directly Connect and be related to drug effect, all that has been achieved is spoiled to lack this step.
According to constitution situation, different diverting agents are added.Diverting agent namely promotion Chinese medicine absorb, the medicine of the network that stimulates the menstrual flow away. Not only with safety, low toxicity, also with the double action for promoting infiltration and treatment, such as peppermint has refrigerant, soothing the liver, analgesic.Meat Osmanthus has middle benefit gas, cold dispelling concurrently.Fawn perfume (or spice) has concurrently has one's ideas straightened out, and wards off dirty, dissipates stasis of blood etc..
Umbilical therapy paste prepared by the preparation method of umbilical therapy paste as described above prepare treatment stomachache, abdominal distension, that stomach is received is poor, just Application in half congealed, insufficiency of the spleen weak, kidney deficiency, qi-blood deficiency medicine.
Digestion-promoting spleen-invigorating umbilical therapy paste is prepared using formula as below, often patch includes following component:
Melanoidin malt 6g, charred FRUCTUS CRATAEGI 6g, stir-baked MASSA FERMENTATA MEDICI-NALIS 6g, Endothelium Corneum Gigeriae Galli (parched) 6g, Chinese yam rhizome 6g, lotus seeds 6g, coix seed 20g and Gorgon fruit 3g。
Embodiment 1
Digestion-promoting spleen-invigorating umbilical therapy paste prepared by the present embodiment, comprises the following steps:
Chinese medicine is soaked 20 hours in marmite with clear water, is then first decocted with high heat, decoct boiling, then use slow fire instead, one Side is decocted while stirring and removes surfactant foam, is leached liquid and is staticly settled, and the dregs of a decoction add cold water to be boiled medicine again, are repeated 2 times, and is decocted altogether Medicine 3 hours, the liquid that leaches of merging, liquid 3 layers of filtered through gauze 3 times is made ointment in stainless-steel pan with slow fire evaporation liquid, Add forming agent to be molded with diverting agent, then spread out in 5*5 centimetres of blank navel patch, obtain the digestion-promoting spleen-invigorating umbilical therapy paste.
Embodiment 2
Digestion-promoting spleen-invigorating umbilical therapy paste prepared by the present embodiment, comprises the following steps:
Chinese medicine is soaked 24 hours in marmite with clear water, is then first decocted with high heat, decoct boiling, then use slow fire instead, one Side is decocted while stirring and removes surfactant foam, is leached liquid and is staticly settled, and the dregs of a decoction add cold water to be boiled medicine again, are repeated 3 times, and is decocted altogether Medicine 4 hours, the liquid that leaches of merging, liquid 3 layers of filtered through gauze 4 times is made ointment in stainless-steel pan with slow fire evaporation liquid, Add forming agent to be molded with diverting agent, then spread out in 6*6 centimetres of blank navel patch, obtain the digestion-promoting spleen-invigorating umbilical therapy paste.
Embodiment 3
Digestion-promoting spleen-invigorating umbilical therapy paste prepared by the present embodiment, comprises the following steps:
Chinese medicine is soaked 26 hours in marmite with clear water, is then first decocted with high heat, decoct boiling, then use slow fire instead, one Side is decocted while stirring and removes surfactant foam, is leached liquid and is staticly settled, and the dregs of a decoction add cold water to be boiled medicine again, are repeated 2 times, and is decocted altogether Medicine 5 hours, the liquid that leaches of merging, liquid 4 layers of filtered through gauze 3 times is made ointment in stainless-steel pan with slow fire evaporation liquid, Add forming agent to be molded with diverting agent, then spread out in 7*7 centimetres of blank navel patch, obtain the digestion-promoting spleen-invigorating umbilical therapy paste.
Embodiment 4
Digestion-promoting spleen-invigorating umbilical therapy paste prepared by the present embodiment, comprises the following steps:
Chinese medicine is soaked 30 hours in marmite with clear water, is then first decocted with high heat, decoct boiling, then use slow fire instead, one Side is decocted while stirring and removes surfactant foam, is leached liquid and is staticly settled, and the dregs of a decoction add cold water to be boiled medicine again, are repeated 3 times, and is decocted altogether Medicine 6 hours, the liquid that leaches of merging, liquid 4 layers of filtered through gauze 4 times is made ointment in stainless-steel pan with slow fire evaporation liquid, Add forming agent to be molded with diverting agent, then spread out in a diameter of 2 centimetres of circular blank navel patch, obtain digestion-promoting spleen-invigorating navel treatment Patch.
Comparative example 1
By the direct co-grinding of Chinese medicine, sieving, navel is affixed on.
Comparative example 2
According to《The reason Chongqing parallel prose》The middle method for preparing black plaster prepares ointment, and is made patch.
Influence of the digestion-promoting spleen-invigorating umbilical therapy paste of experimental example 1 to functional dyspepsia FD
(1) experimental animal
SPF grades of rat, weight 80-100g, male and female half and half.Animal credit number:SCXK (Guangdong) 2012-0002, by wide East saves medical faunae center and provides.
(2) Experimental agents
The umbilical therapy paste that the digestion-promoting spleen-invigorating umbilical therapy paste and comparative example 1 and 2 that the embodiment of the present application 1-4 is provided are provided.With Pharmaceutical quantities are according to child weight for 20kg ratios carry out medication.
(3) experimental technique
Rat is randomly divided into Normal group, model group, model excipient group, experimental example group and comparative example group.Except just Outside normal control group, remaining group uses following methods feeding:Meet the odd-numbered day normally to take food, meet even-numbered days to take food, free water is added in water Hydrochloric acid (adds 10molL in every liter of drinking water-1Hydrochloric acid 10mL) destroying acid-base balance in stomach, continuous 10d.Normal group Routine feeding.Comparative example 1 and the by specification of comparative example 2 and body weight ratio perfusion, once a day.Experimental example group, model excipient The animal of group and comparative example 3, is lost hair or feathers using 6% vulcanized sodium belly, and SHENQUE acupoint is sticked, a daily patch.Normal group gives The distilled water of volume.Administration one week.Experiment terminates preceding 1d, and each group Rat Fast prohibits water 24h.Etherization animal, xiphoid-process incision Mouth about 2cm opens abdominal cavity, avoids at vascular ligation pyloric ring, gives corresponding medicine or physiological saline in duodenum, successively Abdominal cavity is closed in suture, puts back in cage and rests, and abdominal aortic blood sampling (anti-freezing), ELISA kit detection rat serum are anaesthetized after 5h Slurry CCK-8 and MTL contents., it is known that the model group can influence animal appetite, but it is not lasting.
Rat plasma CCK-8 and MTL content measuring result is as shown in table 1.
Rat plasma CCK-8 and MTL the content measuring result of table 1
CCK is the polypeptide hormone of the I cell synthesis secretions of small intestine, main to stimulate pancreatin to secrete and synthesize, and strengthens pancreas carbonic acid Hydrogen salt is secreted and gastric emptying, stimulates gallbladder contraction and Oddis SDs, can be secreted with excited hepatic bile, adjusts small intestine With the motion of colon, it is also possible to ingested as the regulation of full sense factor.MTL is in Cycle-release, with strong impulse alimentary canal Mechanical movement and electrical activity effect.
Test result indicate that, model group and model excipient group rat CCK-8 and MTL content are without significant change.With model Group is compared, and digestion-promoting spleen-invigorating umbilical therapy paste provided herein can significantly reduce blood sugar CCK-8 contents (P < 0.01), is improved MTL and is contained Amount (P < 0.01).Embodiment group is much better than comparative example group.Show that digestion-promoting spleen-invigorating umbilical therapy paste uses umbilical therapy paste provided herein Preparation method, the active ingredient in medicine can fully be leached, drug effect fully discharges, improve drug effect, can fully improve The gastroenteritic power of rat.
In sum, the preparation method of umbilical therapy paste provided herein, can separate out active ingredient complete, by human body Absorption rate is relatively also higher, and it is convenient, simple, easily operated to have the advantages that, is adapted to large-scale production and is widely applied. The preparation method of umbilical therapy paste provided herein, at least decocts full " three juice ", and the first juice is in order to allow medicinal material fully to soak second Juice be in order to the active ingredient of medicinal material fully it is fried come, the 3rd juice or be afterwards in order to allow medicinal material active ingredient thoroughly to separate out, It is closely linked, it is indispensable.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that various embodiments above is only used To illustrate technical scheme, rather than its limitations;It will be understood by those within the art that:Without departing substantially from this hair In the case of bright spirit and scope, the technical scheme described in foregoing embodiments can be modified, or to wherein Some or all of technical characteristic carries out equivalent;And these modifications or replacement, do not make the essence of appropriate technical solution Depart from the scope of various embodiments of the present invention technical scheme;It is, therefore, intended that including belonging to the present invention in the following claims In the range of all these substitutions and modifications.

Claims (10)

1. a kind of preparation method of umbilical therapy paste, it is characterised in that comprise the following steps:
Raw material is soaked with clear water, is boiled medicine after immersion, leach liquid, the dregs of a decoction add water and boiled medicine again, repeated 2~3 times, closed And the liquid that leaches and staticly settle, evaporation liquid is made ointment, ointment shaping, plus diverting agent, patch processed, obtains the navel and treats Patch.
2. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the evaporation liquid be made ointment it Afterwards, before the ointment shaping, also include:Add the medicinal powder of valuable drug or volatile medicine after grinding, the medicinal powder Particle diameter be less than 80 mesh.
3. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the process boiled medicine, specifically includes Following steps:
First decoct with high heat, decoct boiling, then use slow fire instead, decoct while stirring removal surfactant foam;
The temperature of the intense fire is more than 180 DEG C, and the temperature of the slow fire is 120~150 DEG C.
4. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the time boiled medicine is 3~6 every time Hour.
5. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the time of the immersion is 20~30 small When.
6. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that liquid that the merging is leached simultaneously stands After the step of precipitation, also include:By liquid 3~4 layers of filtered through gauze 3~4 times.
7. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the process slow fire of the evaporation liquid Decocting and concentrating is carried out, and is stirred continuously.
8. the preparation method of umbilical therapy paste according to claim 2, it is characterised in that the valuable drug includes ginseng, spirit One or several combination in sesame, Cordyceps sinensis, bird's nest, donkey-hide gelatin and pilose antler.
9. the preparation method of umbilical therapy paste according to claim 1, it is characterised in that the forming agent includes Radix Notoginseng powder, west One or several combination in American ginseng powder and Tiepi Fengdou powder;
And/or;
The diverting agent includes one or several the combination in Chinese cassia tree, peppermint and Moschus.
10. the umbilical therapy paste prepared by the preparation method of the umbilical therapy paste according to claim any one of 1-9 is preparing treatment abdomen Application in swollen, stomach is received poor, loose stool, insufficiency of the spleen weak, kidney deficiency, qi-blood deficiency medicine.
CN201710148132.2A 2017-03-13 2017-03-13 A kind of preparation method and application of umbilical therapy paste Pending CN106729191A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731022A (en) * 2019-03-23 2019-05-10 河北厚德汉方医疗器械股份有限公司 A kind of the health-preserving granula foot patch and its processing method of supplementing qi and nourishing yin

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810685A (en) * 2010-05-05 2010-08-25 张振花 Chinese medicinal composition for treating gonitis and preparation method thereof
CN102048933A (en) * 2010-12-20 2011-05-11 崔守凤 Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN102370765A (en) * 2010-08-15 2012-03-14 丁奇 Traditional Chinese medicine plaster for treating children's constipation and preparation method thereof
CN103006986A (en) * 2012-12-21 2013-04-03 西安医学院 Traditional Chinese medicine for treating children cough and preparation method of external use patch thereof
CN103599206A (en) * 2013-11-28 2014-02-26 山西丰源药业有限公司 Chinese herbal medicine navel paste for treating diarrhea and stomachache of children and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810685A (en) * 2010-05-05 2010-08-25 张振花 Chinese medicinal composition for treating gonitis and preparation method thereof
CN102370765A (en) * 2010-08-15 2012-03-14 丁奇 Traditional Chinese medicine plaster for treating children's constipation and preparation method thereof
CN102048933A (en) * 2010-12-20 2011-05-11 崔守凤 Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN103006986A (en) * 2012-12-21 2013-04-03 西安医学院 Traditional Chinese medicine for treating children cough and preparation method of external use patch thereof
CN103599206A (en) * 2013-11-28 2014-02-26 山西丰源药业有限公司 Chinese herbal medicine navel paste for treating diarrhea and stomachache of children and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731022A (en) * 2019-03-23 2019-05-10 河北厚德汉方医疗器械股份有限公司 A kind of the health-preserving granula foot patch and its processing method of supplementing qi and nourishing yin

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