CN106880733A - A kind of additive for reducing stress of baby pigs caused ablaction and preparation method and application - Google Patents
A kind of additive for reducing stress of baby pigs caused ablaction and preparation method and application Download PDFInfo
- Publication number
- CN106880733A CN106880733A CN201710139852.2A CN201710139852A CN106880733A CN 106880733 A CN106880733 A CN 106880733A CN 201710139852 A CN201710139852 A CN 201710139852A CN 106880733 A CN106880733 A CN 106880733A
- Authority
- CN
- China
- Prior art keywords
- date seed
- spina date
- piglet
- stress
- additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of additive for reducing stress of baby pigs caused ablaction and preparation method and application.It is by the 25g of spina date seed (stir-fry) 15, the 9g of the wind-weed 6, the 9g of Poria cocos 6, the 6g of Ligusticum wallichii 3, the 6g of radix rehmanniae recen 3, the 12g of Radix Codonopsis 6, the 9g of dried orange peel 6, the 5g of balloonflower root 3, the 5g of Radix Glycyrrhizae 3 composition.The present invention further discloses stress of baby pigs caused ablaction additive reduce weanling pig stress degree, regulation piglet central nervous system and endocrine and improve resisting stress capability in terms of application.Result shows：Dissipated by adding wean protection in weaning pigs, to reach regulation piglet central nervous system and endocrine effect, while reaching the generation for reducing stress of baby pigs caused ablaction syndrome.
Description
Technical field
The invention belongs to farm animals nutrition technique research field, it is related to a kind of additive for reducing stress of baby pigs caused ablaction
And preparation method and application.
Background technology
Early weaning piglet stress cause weanling pig feed intake to decline 15%-20%, growth retardation, breeding cycle extension
Deng.Early weaning piglet irritability syndrome is a great problem in whole world Swine Production.Its reason includes the following aspects.
（1）Environment is changed.Early weaned stress mainly includes that female young separation, nutrition are turned to from breast milk and coordinate grain ration and son
Pig is converted in terms of three from the environment on childbirth column to nursing cote.The result performance of its influence is clinically weanling pig feed intake
Reduced with efficiency of feed utilization, indigestion, and cause the generation of diarrhoea.
（2）Immunosupress.Early weaned stress can reduce circulating antibody level, suppress cellular immunity.With suck the breast naturally
Piglet is compared, and 2-3 weeks weanling pig shows significant immune response and suppress, and causes piglet disease-resistant power weak.On the other hand because
The active immunity of piglet typically just tends to perfect at 2 monthly age.The problem that early-weaned pigletses are present is piglet is passed through breast milk
The passive immunity of acquisition is interrupted, and now piglet immune system in itself not yet develops perfect.Early-weaned pigletses are by eating liquid
When body breast switchs to the feed for eating solid, easily cause intestinal wall damage, the enteron aisle of Villus atrophy " stress ".
（3）Digestive enzyme activity reduction.During piglet 0-4 week old, stomach cardia decomposes enzymatic activity and is doubled and redoubled by week, but 28 days
Various digestive enzyme activities are reduced to the 1/3 of the preceding level of wean in age wean one week after.Early-weaned pigletses gastric acid secretion reduction, breast
Acid source terminates, and stomach pH value rising also directly affects pepsin, trypsase, chymotrypsin, icepro peptase, amylase, fat
Enzyme, maltose, the function of lactase, the activity of various enzymes can just increase again after l-2 weeks, after this is early weaning piglet
Indigestion during l-2 weeks, causes one of major reason of diarrhoea.
（4）Other unfavorable external conditions：Bad miniclimate such as low temperature is unbalanced with moist, supplementary feeding, unexpected replacing is raised
Grain, feeding moldy metamorphism, lack trace element in feed and vitamin, drinking-water are contaminated by bacterial, can aggravate piglet stress
Degree.
The content of the invention
This research is dissipated by adding wean protection in weaning pigs, adjusts piglet nerve and endocrine, reduces son
The generation of pig ablactation stress syndrome.
To achieve the above object, the invention discloses following technology contents：
It is a kind of reduce weanling pig stress additive（Wean protection dissipates）, it is characterised in that it is by the raw material group of following weight
Into：
Spina date seed (stir-fry) 15-25g, wind-weed 6-9g, Poria cocos 6-9g, Ligusticum wallichii 3-6g, radix rehmanniae recen 3-6g,
Radix Codonopsis 6-12g, dried orange peel 6-9g, balloonflower root 3-5g, Radix Glycyrrhizae 3-5g.
It is currently preferred reduce weanling pig stress additive（Wean protection dissipates）, it is characterised in that it is by following
The raw material composition of weight：
Spina date seed (stir-fry) 15g, wind-weed 6g, Poria cocos 6g, Ligusticum wallichii 6g, radix rehmanniae recen 3g, Radix Codonopsis 9g, dried orange peel 6g, balloonflower root 4g, Radix Glycyrrhizae 3g.
The present invention further discloses reduce weanling pig stress additive preparation method：
（1）Oil cake is separated：Spina date seed carries out oil cake separation with mechanical expression method.First by spina date seed through screening impurity elimination, and it is divided into
Two panels, reexamines spina date seed water content in 3-5%（W/W）, it is directly entered oil press and is squeezed, squeeze twice altogether.Finally
Filtering and impurity removing, the spina date seed cake and spine date seed oil of separator well is standby.
（2）Pulverize and sieve：Spina date seed cake first crushed 150 mesh sieves with General low temperature pulverizer；Remaining medicine is respectively with small
Type low temperature is fixed beater grinder and is crushed, and crosses 120 mesh sieves standby；
（3）Mixed components：Based on being first well mixed in spina date seed and Poria cocos addition mixer, then by the wind-weed, Ligusticum wallichii,
The dried rhizome of rehmannia, Radix Codonopsis is mixed in adding mixer, is finally gradually added in mixer remaining traditional Chinese medicine powder by several times and is mixed and spray
Spine date seed oil, until whole traditional Chinese medicine powders are mixed, all traditional Chinese medicine powders are weighed by prescribed dose electronic scale.
（4）Quality inspection is packed：Finished product should be dried, loose, well mixed, color and luster is consistent.Packaging uses built-in vinyon
Bag film, external application plastic-aluminum vacuum valve bag.Moisture absorption, caking are preferably prevented, discoloration is decomposed, so as to guaranteed quality and take effect
Really.
The present invention further discloses reduce weanling pig stress additive for adjusting piglet endocrine, improve machine
Application in terms of body non-specific immune function.Particularly：The general non-specificity indication that weaned piglet factor causes.Examination
Result is tested to show：In Piglet Diets add wean protection dissipate can significantly reduce weanling pig stress, while diet add
Wean protection dissipates the daily gain that can improve piglet 28-42 ages in days.
The present invention to adjust central nervous system and endocrine is principle, by strengthen body non-specific immune function come
Improve resisting stress capability.Be mainly used in prevent and treat weanling pig many reasons cause stress syndrome, effect is significant.
Semen Ziziphi Spinosae (parched) is main ingredient in formula of the invention, is aided with the wind-weed, Poria cocos, Ligusticum wallichii etc., and wherein spina date seed consumption should not
More than 25g.
According to the various Chinese medicine physicochemical properties and active ingredient in this formula, the preparation technology to traditional Chinese powder medicine does the present invention
System optimization, at utmost playing its drug action.We have mainly investigated following condition in development process：
1st, oil cake isolation technics：
Crucial medicinal material spina date seed in formula has carried out oil cake separation, separates oil cake with mechanical expression method.First by wild jujube
Benevolence is through screening impurity elimination and into two pieces, reexamines spina date seed water content in 3-5%（W/W）, it is directly entered oil press and is squeezed,
Squeeze twice altogether.Last filtering and impurity removing, the spina date seed cake and spine date seed oil of separator well is standby.After spina date seed biscuit is dry again
Crushing mixes with other traditional Chinese medicine powders, and spine date seed oil sprays mixing in above-mentioned mixed process.
2nd, mix：Mixed using equal increments method.
3rd, divided dose：By the contrast with gravimetric method and volumetric method, we determine to use gravimetric method, and this method dosage is accurate,
Error is small, easily adjustment.
4th, pack：Packaging is using built-in sealed polyethylene plastic bag, external application plastic-aluminum vacuum valve bag.Preferably prevent from inhaling
Wet, caking, discoloration is decomposed, so as to guaranteed quality and take effect.
The pharmacological action of the Chinese medicine used in the present invention is as follows：
Spina date seed (stir-fry)
Process：Net jujube kernel is taken, is put in frying container, heated with slow fire, fried to heaving, there is cracker, color is micro- to be deepened, and taking-up is dried in the air
It is cool.
Pharmacology：Tonifying liver, calming heart is calmed the nerves, the function of arrest sweating.
The wind-weed
Process：Crude drug is taken, is cleaned, run through, cut sheet, dried, remove soft flocks.
Pharmacology：Clearing heat-fire, the function of fluid dryness.
Poria cocos
Process：Crude drug is taken, is sieved, immersion is cleaned, and is run through, and sheet is cut while hot after slightly steaming, and is dried.
Pharmacology：With clearing damp and promoting diuresis, invigorating the spleen calming heart effect is used for oedema, phlegm and retained fluid, heat gonorrhea, diarrhea, vomiting.
Ligusticum wallichii
Process：Crude drug is taken, impurity is removed, size is separate, cleaned.With bubble to soft and soggy, take out, run through, shave, dry,
Weed out chip.
Pharmacology：Blood-activating and qi-promoting, the function of wind-expelling pain-stopping.
Radix rehmanniae recen
Process：Dried rehamnnia root medicinal material is taken, impurity is removed, is slightly steeped with water, cleaned, vexed profit cuts sheet, dried.Weed out chip.
Pharmacology：Clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid, for the deep red polydipsia of pyreticosis tongue, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, interior heat
Quench one's thirst, spit blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis etc..
Radix Codonopsis
Process：Crude drug is taken, except removing LU, is cleaned, run through, cut sheet, dried.
Pharmacology：Tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung effect.For spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, virtual asthma cough is interior
Heat is quenched one's thirst.
Dried orange peel
Process：Crude drug is taken, impurity is removed, clear water is sprayed, run through, chopping is dried in the shade.
Pharmacology：With regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function.
Balloonflower root
Process：Crude drug is taken, impurity is removed, cleaned, run through, cut sheet, dried.
Pharmacology：Tool facilitaing lung relieving sore-throat, eliminating the phlegm apocenosis effect is usually used in coughing with a lot of sputum, and uncomfortable in chest not smooth, pharyngalgia, sound is mute, and lung carbuncle is told
Blood, sore purulence is not into bursting.
Radix Glycyrrhizae
Process：Crude drug is taken, impurity is removed, cleaned, run through, cut sheet, dried, weed out chip.
Pharmacology：It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, the function of coordinating the drug actions of a prescription.
More detailed description of the present invention is as follows：
1 materials and methods
1.1 feed addictive prescriptions
Title：Weaned piglet protection dissipates
Formula：Spina date seed (stir-fry) 15g, wind-weed 6g, Poria cocos 6g, Ligusticum wallichii 6g, radix rehmanniae recen 3g, Radix Codonopsis 9g, dried orange peel 6g, balloonflower root 4g are sweet
Careless 3g.
Indication：Nourishing blood and tranquilization, clearing heat and relieving fidgetness, nourishing heart blood-nourishing, tonifying Qi Li Shui.For preventing weanling pig to cause
Various syndromes, be improved immunity, stimulate circulation, protection mucous membrane and anti-inflammatory effect.
Usage and dosage：It is for oral administration, piglet consumption 0.3-1g/Kg body weight.
When using, the protection of above-mentioned weaned piglet is dissipated and is used after being mixed with baby pig feedstuff by the addition of 1-3%.
Experiment uses corn-soybean meal diet, with reference to NRC（1998）Swine rearing standard preparation piglet cradling material.Experiment day
The composition of grain is as follows：
Corn 60.30, dregs of beans 25.11, whey powder 4, fish meal 5, soya-bean oil 2, calcium monohydrogen phosphate 1.1, stone flour, 1.04, salt 0.3, bad ammonia
Acid 0.15, premix 1.
Wherein every kilogram premix ㎎ containing VA 1300000 IU, VD3 450000 IU, VE 6000 IU, VK3 250,
VB1 350 ㎎, VB2 550 ㎎, VB6 330 ㎎, VB12 2760 IU, the ㎎ of calcium pantothenate 1460, the ㎎ of choline 50000, cigarette
Acid 3000 ㎎, the ㎎ of biotin 2.5, the ㎎ of copper 3000, the ㎎ of manganese 3000, the ㎎ of zinc 11000, the ㎎ of iron 11000, the ㎎ of selenium 30,
The ㎎ of iodine 30.
1.2 experimental designs
Experiment 28 ages in days of selection（Du × long × big）Weanling pig 120, average weight be 7.40 ± 0.13 kg, by completely with
Machine divides into two treatment, blank control group, and diet is without herbal prescription；Test group, diet is by 2% addition Chinese herbal medicine
Prescription.Each 6 repetition for the treatment of, each repeats 10 piglets, tests in after the wean of the age in days of piglet 28, and 42 ages in days terminate,
Experimental period is 14 d.
1.3 feedings and managements
Pig enclosed grazing during experiment, test pig uses identical feeding and management and environmental condition, and dry mash feeding is freely adopted
Food and drinking-water, are immunized during experiment by pig farm normal procedure, are carried out disinfection and sanitation and hygiene by pig farm feeding and management code
Deng work.
1.4 Testing index and method
1.4.1 daily gain
In whole process of the test, the whose body weight of 28 ages in days and 42 age in days test pigs is claimed respectively, calculate the average of 28-42 ages in days
Daily gain（ADG）.
1.4.2 serum cortisol
Respectively at experiment 0 d, 7 d, 14 d with aseptic disposable syringe through vena cava anterior blood sampling 5 mL, after after blood clotting with
3000r/min low-temperature centrifugation 15min, prepare blood serum sample, are stored in -20 DEG C of refrigerators.Each repeats random selection two piglet
Blood sampling, each treatment amounts to 12, for determining serum cortisol.
1.5 statistical analyses
The indexs such as average daily gain, the serum cortisol of statistical analysis each group, using one-way ANOVA（IBM SPSS
Statistics 20.0）Variance test is analyzed.Data are represented with " means standard deviation " in text, probabilityP <Think when 0.05
Significant difference, probabilityP <Think that difference is extremely notable when 0.01.
2 results and analysis
2.1 daily gains
As shown in Table 1,28 age in days original body mass of test group piglet do not have difference with control group, and at the end of experiment, test group is young
The 42 age in days weight ratio control groups of pig improve 2.74%, significant difference（P<0.05）；The 28-42 age in days daily gains of test group piglet
8.54% is improved than control group, difference is extremely notable（P<0.01）.Knowable to result above, diet addition wean protection dissipates and can carry
The daily gain of piglet 28-42 ages in days high.
The piglet growth performance of table 1
Note：Colleague's shoulder notes different capitalizations and represents that control group is extremely notable with test group difference（p<0.01）.Different lowercases
Represent control group and test group significant difference（p<0.05）.
2.2 serum cortisols
As shown in Table 2, when 28 ages in days of piglet wean, serum cortisol test group does not have difference, piglet 35 with control group
During age in days, serum cortisol test group reduces 37.40% than control group, and difference is extremely notable（P<0.01）.42 days of piglet
When age weans, serum cortisol test group does not have difference with control group.Control group piglet blood is also seen that from the result of table 2
Clear cortisol levels are raised from wean to wean one week is rapid, are fallen after rise afterwards and gradually, illustrate piglet stress degree weaning one
It is the most serious when all, normal level is tended to afterwards；Test group piglet serum cortisol maintains stability range, do not occur compared with
Great fluctuation process.Diet addition wean protection dissipate can reduce weanling pig stress degree.
The piglet serum cortisol of table 2
Note：Colleague's shoulder notes different capitalizations and represents that control group is extremely notable with test group difference（p<0.01）.
The present invention adds 2% feed addictive in pig starter feed（Wean protection dissipates）, to feed addictive（Wean protection
Dissipate）Safety experiment is carried out, its method is as follows：
1 step：
（1）Material and method：Du × length × big the piglet 6 of 28 ages in days is selected, clinical health, development are normal, 14 days experimental periods,
Poisoning manifestations and death condition are observed in experimental period at any time.
（2）The pig starter feed raw material composition of feeding：
Corn 60.30, dregs of beans 25.11, whey powder 4, fish meal 5, soya-bean oil 2, calcium monohydrogen phosphate 1.1, stone flour, 1.04, salt 0.3, bad ammonia
Acid 0.15, premix 1.
Wherein every kilogram premix ㎎ containing VA 1300000 IU, VD3 450000 IU, VE 6000 IU, VK3 250,
VB1 350 ㎎, VB2 550 ㎎, VB6 330 ㎎, VB12 2760 IU, the ㎎ of calcium pantothenate 1460, the ㎎ of choline 50000, cigarette
Acid 3000 ㎎, the ㎎ of biotin 2.5, the ㎎ of copper 3000, the ㎎ of manganese 3000, the ㎎ of zinc 11000, the ㎎ of iron 11000, the ㎎ of selenium 30,
The ㎎ of iodine 30.
To wean in 2% ratio, protection is scattered to be added in pig starter feed, is made experiment and is tested with daily ration.
2 results：Dissipated to pig starter feed addition wean protection, continuous feeding 14 days has no obvious intoxicating phenomenon, observation period
It is interior without death, each main organs of cut open inspection show no obvious abnormalities.
3 conclusions：The wean protection of addition 2% in pig starter feed dissipates feeding piglet, feeding effect safety.
The good effect that the additive for reducing stress of baby pigs caused ablaction disclosed by the invention has compared with prior art
It is：
（1）The Chinese medicine that the present invention is selected has the advantages that integration of drinking and medicinal herbs, has no toxic side effect, feeding effect safety.
（2）Spina date seed in the present invention is the Chinese herbal medicine of arresting convulsion of calming the nerves, and group's syndrome effect is significant is turned to weanling pig.
（3）The wind-weed, Poria cocos in the present invention, Ligusticum wallichii, radix rehmanniae recen, Radix Codonopsis, dried orange peel, balloonflower root, Radix Glycyrrhizae are used in combination, and play and carry
High productivity can be with the effect of non-specific immunity.
Specific embodiment
The present invention is described below by specific embodiment.Unless stated otherwise, technological means used in the present invention
It is method known in those skilled in the art.In addition, embodiment is interpreted as illustrative, it is not intended to limit the present invention
Scope, the spirit and scope of the invention are limited only by the claims that follow.To those skilled in the art, without departing substantially from this
On the premise of invention spirit and scope, the various changes that are carried out to the material component and consumption in these embodiments or change
Belong to protection scope of the present invention.Raw materials used and reagent of the invention is commercially available.
Embodiment 1
Wean protection dissipates and is made up of the raw material of following weight：
Spina date seed (stir-fry) 15g, wind-weed 9g, Poria cocos 9g, Ligusticum wallichii 3g, radix rehmanniae recen 6g,
Radix Codonopsis 12g, dried orange peel 9g, balloonflower root 3g, Radix Glycyrrhizae 3g.
Embodiment 2
Wean protection dissipates it and is made up of the raw material of following weight：
Spina date seed (stir-fry) 15g, wind-weed 6g, Poria cocos 6g, Ligusticum wallichii 6g, radix rehmanniae recen 3g, Radix Codonopsis 9g, dried orange peel 6g, balloonflower root 4g, Radix Glycyrrhizae 3g.
Embodiment 3（Embodiment 1-2）
Reduce weanling pig stress additive preparation method：
（1）Oil cake is separated：Spina date seed carries out oil cake separation with mechanical expression method.First by spina date seed through screening impurity elimination, and it is divided into
Two panels, reexamines spina date seed water content in 3-5%（W/W）, it is directly entered oil press and is squeezed, squeeze twice altogether.Finally
Filtering and impurity removing, the spina date seed cake and spine date seed oil of separator well is standby.
（2）Pulverize and sieve：Spina date seed cake General low temperature pulverizer crushed 150 mesh sieves；Remaining medicine is respectively with small-sized
Low temperature is fixed beater grinder and is crushed, and crosses 120 mesh sieves standby；
（3）Mixed components：It is well mixed during spina date seed and Poria cocos first are added into mixer, then by the wind-weed, Ligusticum wallichii, the dried rhizome of rehmannia, party
Mixing in mixer is participated in, finally remaining traditional Chinese medicine powder is gradually added in mixer by several times and is mixed and spray spina date seed
Oil, until whole traditional Chinese medicine powders are mixed, all traditional Chinese medicine powders are weighed by prescribed dose electronic scale.
（4）Quality inspection is packed：Using built-in sealed polyethylene plastic bag, external application plastic-aluminum vacuum valve bag prevents moisture absorption, knot
Block, discoloration is decomposed, so as to guaranteed quality and take effect.
Claims (6)
1. it is a kind of reduce stress of baby pigs caused ablaction additive, it is characterised in that it is made up of the raw material of following weight：
Spina date seed (stir-fry) 15-25g, wind-weed 6-9g, Poria cocos 6-9g, Ligusticum wallichii 3-6g, radix rehmanniae recen 3-6g,
Radix Codonopsis 6-12g, dried orange peel 6-9g, balloonflower root 3-5g, Radix Glycyrrhizae 3-5g.
2. the additive described in claim 1, it is characterised in that it is made up of the raw material of following weight：
Spina date seed (stir-fry) 15g, wind-weed 6g, Poria cocos 6g, Ligusticum wallichii 6g, radix rehmanniae recen 3g, Radix Codonopsis 9g,
Dried orange peel 6g, balloonflower root 4g, Radix Glycyrrhizae 3g.
3. the preparation method of additive described in any one of claim 1-2, it is characterised in that carried out by the steps：
（1）Oil cake is separated：Spina date seed carries out oil cake separation with mechanical expression method, first by spina date seed through screening impurity elimination, and is divided into
Two panels, reexamines spina date seed water content in 3-5%（W/W）, it is directly entered oil press and is squeezed, altogether twice of squeezing, finally
Filtering and impurity removing, the spina date seed cake and spine date seed oil of separator well is standby；
（2）Pulverize and sieve：Spina date seed cake first crushed 150 mesh sieves with General low temperature pulverizer；Remaining medicine is respectively with small-sized low
The fixed beater grinder of temperature is crushed, and crosses 120 mesh sieves standby；
（3）Mixed components：Based on being first well mixed in spina date seed and Poria cocos addition mixer, then by the wind-weed, Ligusticum wallichii,
The dried rhizome of rehmannia, Radix Codonopsis is mixed in adding mixer, is finally gradually added in mixer remaining traditional Chinese medicine powder by several times and is mixed and spray
Spine date seed oil, until whole traditional Chinese medicine powders are mixed；
All traditional Chinese medicine powders are weighed by prescribed dose electronic scale；
（4）Quality inspection is packed：Finished product should be dried, loose, well mixed, color and luster is consistent, and packaging uses built-in sealed polyethylene plastic
Bag, external application plastic-aluminum vacuum valve bag.
4. described in claim 1 reduce stress of baby pigs caused ablaction additive reduce weanling pig stress degree, regulation piglet
Central nervous system and endocrine and improve application in terms of resisting stress capability.
5. the application described in claim 4, raising resisting stress capability therein is referred to：It is complete that weaned piglet factor causes
Body non-specificity indication.
6. the application described in claim 4, wherein regulation piglet central nervous system is referred to：Improve production performance, improve young
The daily gain of pig 28-42 ages in days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710139852.2A CN106880733B (en) | 2017-03-10 | 2017-03-10 | Additive for reducing weaning stress of piglets and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710139852.2A CN106880733B (en) | 2017-03-10 | 2017-03-10 | Additive for reducing weaning stress of piglets and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106880733A true CN106880733A (en) | 2017-06-23 |
| CN106880733B CN106880733B (en) | 2020-05-05 |
Family
ID=59179572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710139852.2A Expired - Fee Related CN106880733B (en) | 2017-03-10 | 2017-03-10 | Additive for reducing weaning stress of piglets and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106880733B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703171A (en) * | 2009-11-24 | 2010-05-12 | 沈阳农业大学 | Natural vegetal anti-weaning stress feed additive and application thereof |
| CN102058021A (en) * | 2009-11-17 | 2011-05-18 | 程显东 | Piglet feed additive |
-
2017
- 2017-03-10 CN CN201710139852.2A patent/CN106880733B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058021A (en) * | 2009-11-17 | 2011-05-18 | 程显东 | Piglet feed additive |
| CN101703171A (en) * | 2009-11-24 | 2010-05-12 | 沈阳农业大学 | Natural vegetal anti-weaning stress feed additive and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李丹等: "仔猪断奶应激及其调控的研究进展", 《饲料博览》 * |
| 王利利等: "酸枣仁散的药效学作用", 《中国兽医杂志》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106880733B (en) | 2020-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103141709B (en) | Carp feed and preparation method thereof | |
| CN104397465B (en) | There is traditional Chinese powder medicine promoting sow galactogogue action and preparation method thereof and application | |
| CN102178183A (en) | Five-bean comprehensive nutritional food | |
| CN106577543A (en) | Squab breeding method capable of preventing diseases | |
| CN106306533A (en) | Traditional Chinese medicine feed for preventing and treating infectious bronchitis and preparation method thereof | |
| CN103719944A (en) | Rye-based food therapeutic health powder and preparation method thereof | |
| CN101926432A (en) | Coix seed snack health-care food and processing technique thereof | |
| CN107616289A (en) | A kind of mushroom pressed candy and preparation method thereof | |
| CN104921133A (en) | Female cereal, vegetable and fruit nutritious food and preparation method thereof | |
| CN106889341A (en) | A kind of feed addictive for improving pigling immunity and preparation method and application | |
| CN106615971A (en) | Traditional Chinese medicine chicken feed for improving egg quality and preparation method of traditional Chinese medicine chicken feed | |
| CN109497458A (en) | A kind of giant salamander nutrient equilibrium health-preserving food and preparation method thereof | |
| CN106173450A (en) | Improve compound feed additive and the feedstuff of pigeon immunity | |
| CN108936601A (en) | A kind of health food and preparation method thereof preventing children anorexia, partial eclipse | |
| CN109170916A (en) | One kind keeps fit and healthy food compositions and preparation method thereof | |
| CN108771016A (en) | One boar Chinese herbal feed additive and its application | |
| CN104431434A (en) | Bean residue fermented formula chicken feed and preparation method thereof | |
| CN106071125A (en) | A kind of Chinese herbal medicine compound feed preventing meat son's rabbit flatulence | |
| CN106804916A (en) | Boer goat pregnancy ewes complete feed and preparation method thereof | |
| CN106212901A (en) | Improve health-care feed of Trionyx sinensis Wiegmann immunity and preparation method thereof | |
| CN102524325A (en) | Pregnant woman dedicated whole wheat flour and making method thereof | |
| CN102578179A (en) | Special flour for pregnant women and preparation method thereof | |
| CN104970220A (en) | Compound feed for sows in suckling period and preparation method thereof | |
| CN109329602A (en) | A kind of weaned lamb cultivation full-valence pellet feed and preparation method thereof | |
| CN104783159A (en) | Nutrient enhancer for middle-aged goat milk powder and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210107 Address after: 300192, 26 Nankai District Aerospace Road, Tianjin Patentee after: Tianjin Academy of Agricultural Sciences Address before: 300381 17 kilometers, Jin Jing Road, Xiqing District, Tianjin Patentee before: TIANJIN INSTITUTE OF ANIMAL HUSBANDRY AND VETERINARY |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200505 Termination date: 20210310 |