CN106860646A - A kind of Chinese medicine composition for treating gastroduodenal ulcer and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating gastroduodenal ulcer and preparation method thereof Download PDFInfo
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- CN106860646A CN106860646A CN201710235703.6A CN201710235703A CN106860646A CN 106860646 A CN106860646 A CN 106860646A CN 201710235703 A CN201710235703 A CN 201710235703A CN 106860646 A CN106860646 A CN 106860646A
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating gastroduodenal ulcer and preparation method thereof, the Chinese medicine material of the Chinese medicine composition includes：Hawthorn, Divine Comedy, radish seed, Poria cocos, the bighead atractylodes rhizome, dried orange peel, Buddha's hand, Pericarpium Citri, Ligusticum wallichii, nutmeg, dandelion, cuttle bone, Endothelium Corneum Gigeriae Galli (parched), rhubarb；Its preparation method is to weigh Chinese medicine, mixes and be ground into particle in proportion；Decoct；Extract solution is heated and is concentrated, prepare liquid extract；Spray drying powder processed.Compared with prior art, Chinese medicine composition of the present invention, its preparation method is simple, each compatibility of drugs rationally, effect clearly, have no adverse reaction, have functions that to help digestion with stomach, clearing damp of being amusing, promoting qi circulation and removing obstruction in the collateral, remove necrosis and promote granulation, it is evident in efficacy in terms of gastroduodenal ulcer is treated, it is particularly suited for the treatment of gastroduodenal ulcer that stress cause.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of Chinese medicine composition for treating gastroduodenal ulcer and
Its preparation method.
Background technology
Gastroduodenal ulcer is extremely common disease of digestive tract.Its topical manifestations are the limitations of gastroduodenal wall
Property circular or ellipse defect.Patient has the symptoms such as periodicity upper abdomen pain, acid reflux, belch.This sick ulcer surface should not be more
Close, be easy to recurrence after healing again, in chronic repeatability process.
Research finds that the cause of gastroduodenal ulcer is close with psychoneural factor relation.It is various that modern humans face
Acute and chronic physiology, psychological pressure, medical science referred to as stress.Intestines and stomach are one of organs most sensitive to stress reaction, bad
Psychological stress can induce gastroduodenal ulcer.
At present, the medicine for the treatment of gastroduodenal ulcer is many both at home and abroad, such as：Gastropine, magnalium gel, SIDASHU etc.,
Because gastroduodenal ulcer is chronic disease, and easily recurrence, it is healed completely, it is necessary to adhere to Long-term taking medicine, and it is many western
Medicine preparation inevitably has the obvious adverse reactions such as fash, diarrhoea, hepatic lesion in this kind of disease is treated, while Western medicine one
As can only alleviate the state of an illness or for clinical a certain symptom treatment, often do not reach the effect of healing.China's Chinese Traditional Medicine is being controlled
Treat disease aspect with the obvious advantage, not only focus on taking stopgap measures, more focus on originally.Traditional Chinese medical theory is reached by dialectical treatmert, strengthening vital QI to eliminate pathogenic factors
To the purpose for the treatment of a disease by looking into both its root cause and symptoms.Gastroduodenal ulcer is referred to as " epigastric pain " " stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach " etc. in the traditional Chinese medical science, and its complication is then with
" vomiting ", " mass formed by blood stasis " in medical science is identical.The dialectical cause of disease of gastroduodenal ulcer is divided into deficiency-cold in spleen and stomach, stomach-Yin not by the traditional Chinese medical science
Foot, liver-stomach disharmony, syndrome of liver-stomach heat etc..
In recent years have developed polytype Chinese medicine to treat stomach trouble, such as Chinese patent CN101703734B discloses one kind and controls
Treat stomach trouble Chinese medicine preparation, it includes 33 kinds of Chinese medicines such as Ligusticum wallichii, FRUCTUS CITRI SARCODACTYLIS from Sichuan of China, coloured malt, rhizoma atractylodis, its can be used for treat gastric ulcer,
Acute gastritis, chronic gastritis, chronic superficial gastritis, liver-stomach disharmony, indigestion, sigmoiditis；Chinese patent
CN103041280B discloses a kind of anti-inflammatory, antidiarrheal, the herbal mixture of analgesic, and it includes Poria cocos, the bighead atractylodes rhizome, Semen Lablab Album, Chinese yam etc.
Chinese medicine in 31, it can be used to treat gastroenteritis, chronic gastritis, duodenal ulcer, antidiarrheal, analgesic and aid digestion stomach invigorating intestines；
Chinese medicine species is more various in above-mentioned two patent, its price costly, and its treatment stomach trouble without clearly specific aim, pin
The curative effect routed to the gastroduodenal that stress cause needs further raising.
The content of the invention
It is a primary object of the present invention to provide a kind of Chinese medicine composition for treating gastroduodenal ulcer and its preparation side
Method, mainly for the gastroduodenal ulcer that treatment stress cause, Chinese medicine material species is few, and cost is relatively low, and curative effect is preferable.
To achieve the above object, the present invention is adopted the following technical scheme that：
On the one hand, the present invention provides a kind of Chinese medicine composition for treating gastroduodenal ulcer, and its Chinese medicine material includes：Mountain
Short, bristly hair or beard, Divine Comedy, radish seed, Poria cocos, the bighead atractylodes rhizome, dried orange peel, Buddha's hand, Pericarpium Citri, Ligusticum wallichii, nutmeg, dandelion, cuttle bone, Endothelium Corneum Gigeriae Galli (parched),
Rhubarb.
Preferably, the weight proportion of the Chinese medicine material is：
Hawthorn 25-40 parts, Divine Comedy 9-20 parts, radish seed 6-10 parts, Poria cocos 10-25 parts, bighead atractylodes rhizome 12-18 parts, dried orange peel 3-10
Part, Buddha's hand 10-20 parts, Pericarpium Citri 10-20 parts, Ligusticum wallichii 3-9 parts, nutmeg 3-9 parts, dandelion 25-35 parts, cuttle bone 20-35
Part, Endothelium Corneum Gigeriae Galli (parched) 9-15 parts, rhubarb 6-12 parts.
Preferably, the Chinese medicine material and weight proportion of the Chinese medicine composition are：
30 parts of hawthorn, 15 parts of Divine Comedy, 9 parts of radish seed, 15 parts of Poria cocos, 15 parts of the bighead atractylodes rhizome, 9 parts of dried orange peel, 15 parts of Buddha's hand, Pericarpium Citri
15 parts, 6 parts of Ligusticum wallichii, 6 parts of nutmeg, 30 parts of dandelion, 30 parts of cuttle bone, 12 parts of Endothelium Corneum Gigeriae Galli (parched), 9 parts of rhubarb.
The Chinese medicine composition for the treatment of gastroduodenal ulcer of the present invention fully follows the diagnosis and treatment principle of the traditional Chinese medical science,
Invented particular for the gastroduodenal ulcer that stress cause for the treatment of.This Chinese medicine composition have help digestion with stomach, clearing damp of being amusing,
Promoting qi circulation and removing obstruction in the collateral, the effect of remove necrosis and promote granulation.
We reuse hawthorn digesting and stomach, regulating qi to disperse stagnation, are the monarch of we to treat the key medicine of gastroduodenal ulcer
Medicine；Divine Comedy, radish seed promoting digestion and removing indigestion, Poria cocos, the bighead atractylodes rhizome, dried orange peel are amusing clearing damp, are altogether the ministerial drug of we；Buddha's hand, Pericarpium Citri, river
Rhizome of chuanxiong, nutmeg promoting qi circulation and removing obstruction in the collateral, dandelion, cuttle bone clearing heat, releasing toxin, removing swelling, Endothelium Corneum Gigeriae Galli (parched) help digestion to remove necrosis and promote granulation and are conducive to ulcer surface
Healing, the logical abdomen of the moderate promoting the circulation of qi of rhubarb consumption, without regard to diarrhoea, is altogether the adjutant of we.All medicine phases are closed, both helped digestion with stomach,
It is amusing clearing damp, and promoting qi circulation and removing obstruction in the collateral, removes necrosis and promote granulation, the disease of gastroduodenal ulcer is controlled in conjunction.We follow traditional Chinese medical theory and control cause of disease
Then, rationally, therapeutic effect is satisfied with compatibility of drugs.
Hawthorn：Sour, sweet, tepor.Returns spleen, stomach, Liver Channel.There is promoting digestion and removing indigestion, regulating qi to disperse stagnation.Suitable for diet product
Stagnant, greasy inner product etc., often with Divine Comedy with use.Modern study shows that hawthorn can increase the secretion of digestive ferment in stomach, promotes digestion.
Divine Comedy：Sweet, pungent, temperature.Returns spleen, stomach.Have functions that to help digestion and stomach.Often with hawthorn, radish seed with use.
Radish seed：It is pungent, sweet, flat.Return lung, spleen, stomach.Have functions that promoting digestion and removing indigestion, de-swelling row be stagnant, lowering the adverse-rising QI to resolve phlegm.Often
With hawthorn, Divine Comedy with use.Modern study shows that radish seed can make stomach and intestinal motility enhancing.
Poria cocos：It is sweet, light, flat.The thoughts of returning home, spleen, stomach, kidney channel.There is clearing damp and promoting diuresis, bowl spares invigorating the spleen, antitoxic heart-soothing and sedative.
The bighead atractylodes rhizome：Bitter, sweet, temperature.Returns spleen, stomach.Have functions that reinforcing spleen and kidney, eliminating dampness and in.Collocation Poria cocos, cures mainly taste
The deficiency of vital energy, anorexia and loose stool, abdominal distension body are tired.Modern study shows that the bighead atractylodes rhizome has dual regulation to intestinal tube function.
Dried orange peel：Acrid, bitter, warm.Returns spleen, lung channel.With regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.Collocation Poria cocos, the bighead atractylodes rhizome, it is main
Control the insufficiency of the spleen stagnation of the circulation of vital energy.Modern study shows that dried orange peel suppresses intestinal motility, promotes gastric secretion, the obvious ulcer that suppresses to occur and be resistant to
Pathologic gastric secretion increases.
Buddha's hand：Pungent, bitter, sweet, temperature.Return liver, spleen, stomach.Work(with regulating qi-flowing for eliminating phlegm, preventing or arresting vomiting dissipate-swelling, soothing liver and strengthening spleen and stomach
Effect.
Pericarpium Citri：Pungent, bitter, sour, temperature.Return liver, lung, the spleen channel.There is regulating the flow of vital energy Xie Yu, dissolving phlegm profit diaphragm.
Ligusticum wallichii：Pungent, temperature.Return liver, courage, pericardium channel.There is blood-activating and qi-promoting, wind-expelling pain-stopping.Modern study shows river
Rhizome of chuanxiong Central nervous system has sedation.
Nutmeg：Pungent, temperature.Returns spleen, stomach, large intestine channel.There is relieving diarrhea with astringents, middle benefit gas promoting the circulation of qi.
Dandelion：It is pungent, sweet, cold.Return liver, stomach.There is clearing heat and detoxicating, dissipating bind.
Cuttle bone：Salty, puckery, temperature.Returns spleen, kidney channel.With the work(that hygroscopic sore, astringing to arrest bleeding, relieving leukorrhea by astringents, relieving haperacidity are relieved pain
Effect.
The membrane of a chicken's gizzard：It is sweet, flat.Returns spleen, stomach, small intestine, bladder warp.With stomach strengthening and digestion promoting, fossil is treating stranguria, controlling nocturnal emission with astringent drugs stops the work(of something lost
Effect.
Rheum officinale：It is bitter, cold.Returns spleen, stomach, large intestine, liver, pericardium channel.With stasis removing, purging fire and cooling blood, promoting blood circulation, clear profit
Damp and hot effect.Modern study shows that rheum officinale has treatment and prevention to act on gastric ulcer, has obvious guarantor to gastric mucosa damage
Shield is acted on；Bleeding and clotting time can substantially be shortened, for treatment hemorrhage of digestive tract determined curative effect.
On the other hand, the present invention provides a kind of preparation method of the Chinese medicine composition for treating gastroduodenal ulcer, described
Preparation method it is as follows：
Step one, above-mentioned Chinese medicine material is weighed, mixed in proportion, and mixed Chinese medicine material is ground into particle；
Step 2, by the feed particles obtained by step one with water soak 1-2h；
Step 3, the immersion raw material in step 2 is boiled with decocting, decocted 2 times, merge decocting liquid；
Step 4, by obtained by step 3 decocting liquid heating concentration prepare liquid extract；
Step 5, the liquid extract obtained by step 4 is spray-dried, obtain containing this Chinese medicine composition effectively into
The dry powder for dividing.
Preferably, the crushing is by the way of mechanical ball mill.By the way of mechanical ball mill each component can mix equal
The even extraction for being beneficial to traditional Chinese medicine effective ingredient in subsequent step.
Preferably, the particle diameter of the feed particles is 80~200 mesh, most preferably more preferably 120~200 mesh, 120 mesh
Or 140 mesh.Using active ingredient of the herb powder of this particle diameter in being more easy to obtain Chinese medicine in soaking decoction process.Preferably,
Decoction water is 6-10 times of raw material in step 3, and decocting time is 40-70min.
Preferably, the relative density of the liquid extract is 1.15-1.35 (35 DEG C).
Finally, the present invention also provides a kind of application of Chinese medicine composition in treatment gastroduodenal ulcer medicine is prepared,
And the Chinese medicine composition as therapeutically effective amount and the preparation made by pharmaceutically acceptable pharmaceutic adjuvant.
The preparation of the preparation uses conventional fabrication process, by liquid extract obtained in Chinese medicine composition of the present invention or
Dry powder presses this area Conventional wisdom, selects suitable auxiliary material, is obtained required formulation according to a conventional method, such as granule, oral liquid,
Capsule, tablet, pill, syrup, tea bag etc..
Compared with prior art, the invention has the advantages that：Treatment gastroduodenal ulcer of the present invention
Chinese medicine composition, rationally, effect is clear and definite, has no adverse reaction for each material medicine compatibility, without drug dependence, and preparation method letter
It is single.Chinese medicine composition of the present invention have functions that to help digestion with stomach, clearing damp of being amusing, promoting qi circulation and removing obstruction in the collateral, remove necrosis and promote granulation, it is adaptable to stomach
The treatment of duodenal ulcer, is particularly suited for the treatment of gastroduodenal ulcer that stress cause.
Specific embodiment
With reference to embodiment, specific embodiment of the invention is further described.Following examples are only used for more
Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.
Embodiment one
A kind of Chinese medicine composition for treating gastroduodenal ulcer, its Chinese medicine material and weight proportion are：40 parts of hawthorn, god
Bent 20 parts, 10 parts of radish seed, 25 parts of Poria cocos, 18 parts of the bighead atractylodes rhizome, 10 parts of dried orange peel, 20 parts of Buddha's hand, 20 parts of Pericarpium Citri, 9 parts of Ligusticum wallichii, Pork and beans
Cool 9 parts, 35 parts of dandelion, 35 parts of cuttle bone, 15 parts of Endothelium Corneum Gigeriae Galli (parched), 12 parts of rhubarb.
Preparation method is as follows：(1) Chinese medicine is weighed, is mixed in proportion；(2) it is ground into particle；(3) dregs of a decoction are with 6-
40-70min is boiled in 10 times of decoctings, is decocted 2 times, merges decocting liquid；(4) heating is concentrated into relative density for 1.15-1.35 (35 DEG C)
Liquid extract；(5) it is spray-dried, obtains the dry powder of Chinese medicine composition active ingredient of the present invention.
Embodiment two
A kind of Chinese medicine composition for treating gastroduodenal ulcer, its Chinese medicine material and weight proportion are：25 parts of hawthorn, god
Bent 9 parts, 6 parts of radish seed, 10 parts of Poria cocos, 12 parts of the bighead atractylodes rhizome, 3 parts of dried orange peel, 10 parts of Buddha's hand, 10 parts of Pericarpium Citri, 3 parts of Ligusticum wallichii, nutmeg 3
Part, 25 parts of dandelion, 20 parts of cuttle bone, 9 parts of Endothelium Corneum Gigeriae Galli (parched), 6 parts of rhubarb.
Preparation method is identical with embodiment one.
Embodiment three
A kind of Chinese medicine composition for treating gastroduodenal ulcer, its Chinese medicine material and weight proportion are：30 parts of hawthorn, god
Bent 15 parts, 9 parts of radish seed, 15 parts of Poria cocos, 15 parts of the bighead atractylodes rhizome, 9 parts of dried orange peel, 15 parts of Buddha's hand, 15 parts of Pericarpium Citri, 6 parts of Ligusticum wallichii, nutmeg
6 parts, 30 parts of dandelion, 30 parts of cuttle bone, 12 parts of Endothelium Corneum Gigeriae Galli (parched), 9 parts of rhubarb.
Preparation method is identical with embodiment one.
Example IV
Preparation prepared by the Chinese medicine composition described in a kind of use embodiment of the present invention three.
Capsule：The active dry powder of the Chinese medicine composition prepared by embodiment one is crushed, mix, load gelatin hard
Capsule.
Pill：The active component dry powder of the Chinese medicine composition prepared by embodiment one is crushed, is mixed, add starch as
Excipient, add ethanol as adhesive, add agar as disintegrant, be made pill.
Granule：The active component dry powder of the Chinese medicine composition prepared by embodiment one is crushed, is mixed, adding ethanol to make
For adhesive, add starch as filler, be pressed into particle.
Embodiment five
Patient 243, wherein man 102, female 141, age 23-52 Sui, the course of disease 3 days to 3.5 years.By above-mentioned trouble
Person is equally divided into 3 groups, every group of 81 people.
The present embodiment uses two groups of control groups：Raw material, proportioning system of the control group one using Chinese patent CN101703734B
It is standby into Chinese medicine capsules；Raw material, the proportioning Chinese medicinal capsule that is prepared into of the control group two using Chinese patent CN103041280B
Agent.
Chinese medicine capsules using the embodiment of the present invention four, control group one and control group two are daily oral 3 times, each 4-6
Grain, 15 days is a course for the treatment of, and continuously with after the 2-3 course for the treatment of, therapeutic effect see the table below：
As seen from the above table, the curative effect of Chinese medicine capsules prepared by the present embodiment four is relatively better than control group one and control group
Two, and Chinese medicine material of the present invention only contains 14 kinds of Chinese medicines, its species is effectively reduced far fewer than control group one and control group two
Treatment cost.
In therapeutic process, adverse reaction is had no.Model case is as follows：
Case 1 in ×, female, 32 years old, white collar, because work it is unsatisfactory, add father's critical illness be in hospital cause its psychology pressure
Power is excessive, and nearly 1 week upper abdomen hurt like hell, diarrhoea are serious, pale complexion, and gastroduodenal ulcer is diagnosed as through looking into.Through taking
After 7 days, upper abdomen pain symptom is clearly better the capsule of the present embodiment 4, defecation is normal.Display stomach 12 is checked after 2 months to refer to
Enterelcosis healing is good.
Case 2 is permitted ××, male, 46 years old, and white collar, because working strength is big, is often travelled on business trips, and eating and drinking without temperance rule causes long-term stomach
Functional disorder of intestine, nearly 3 years of upper abdomen pain, belch, acid reflux, is diagnosed as repeatability gastroduodenal ulcer, with obvious tidal air
Short, insomnia and dreamful sleep, burnout deficiency of food, tongue is weak and fat tender have indentation.After through taking the capsule 20 days of the present embodiment four, symptom of having a stomachache
It is clearly better, sleep quality improves, has rosy cheeks, appetite is recovered.Display ulcer surface is checked after March and reduces 95%.Returned after 2 years
Visit, have no and recommit.
The king's ×× of case 3, man, 37 years old, soldier, because long-term work task is heavy, thought pressure is big, causes gastrointestinal function to lose
Adjust half a year to have a surplus, with obvious poor appetite, failure of memory, depressed, recent upper abdomen pain exacerbation, be diagnosed as on inspection
Duodenal ulcer.After through taking the capsule 14 days of the present embodiment four, upper abdomen pain is clearly better, appetite is recovered；Continue
Take the capsule of the present embodiment 4 30 days, mood is optimistic；Display duodenal ulcer is checked after March and recovers good.
From above-described embodiment, the Chinese medicine composition for the treatment of gastroduodenal ulcer of the present invention, each bulk drug
Rationally, effect is clear and definite, has no adverse reaction, and without drug dependence, and preparation method is simple for thing compatibility.Chinese traditional medicine composition of the present invention
Thing have functions that to help digestion with stomach, clearing damp of being amusing, promoting qi circulation and removing obstruction in the collateral, remove necrosis and promote granulation, it is adaptable to the treatment of gastroduodenal ulcer, especially
Its treatment for being applied to the gastroduodenal ulcer that stress cause.
Specific embodiment of the invention has been described in detail above, but it is only used as example, and the present invention is not intended to limit
In particular embodiments described above.To those skilled in the art, any equivalent modifications carried out to the practicality and replace
In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied
Change, all should be contained within the scope of the invention.
Claims (8)
1. a kind of Chinese medicine composition for treating gastroduodenal ulcer, it is characterised in that the Chinese medicine material of the Chinese medicine composition
Including：Hawthorn, Divine Comedy, radish seed, Poria cocos, the bighead atractylodes rhizome, dried orange peel, Buddha's hand, Pericarpium Citri, Ligusticum wallichii, nutmeg, dandelion, cuttle bone, stir-fry
The membrane of a chicken's gizzard, rhubarb.
2. the Chinese medicine composition for the treatment of gastroduodenal ulcer according to claim 1, it is characterised in that the Chinese medicine is former
The weight proportion of material is：
Hawthorn 25-40 parts, Divine Comedy 9-20 parts, radish seed 6-10 parts, Poria cocos 10-25 parts, bighead atractylodes rhizome 12-18 parts, dried orange peel 3-10 parts, Buddhist
Hand 10-20 parts, Pericarpium Citri 10-20 parts, Ligusticum wallichii 3-9 parts, nutmeg 3-9 parts, dandelion 25-35 parts, cuttle bone 20-35 parts, stir-fry
The membrane of a chicken's gizzard 9-15 parts, rhubarb 6-12 parts.
3. it is according to claim 1 treatment gastroduodenal ulcer Chinese medicine composition, it is characterised in that the Chinese medicine group
The Chinese medicine material and weight proportion of compound be：
30 parts of hawthorn, 15 parts of Divine Comedy, 9 parts of radish seed, 15 parts of Poria cocos, 15 parts of the bighead atractylodes rhizome, 9 parts of dried orange peel, 15 parts of Buddha's hand, Pericarpium Citri 15
Part, 6 parts of Ligusticum wallichii, 6 parts of nutmeg, 30 parts of dandelion, 30 parts of cuttle bone, 12 parts of Endothelium Corneum Gigeriae Galli (parched), 9 parts of rhubarb.
4. a kind of method of the Chinese medicine composition prepared as any one of claims 1 to 3, it is characterised in that including such as
Lower step：
Step one, weigh Chinese medicine material as any one of claims 1 to 3, mix in proportion, and will be mixed in
Medicine raw material is ground into particle；
Step 2, by the feed particles obtained by step one with water soak 1-2h；
Step 3, the immersion raw material in step 2 is boiled with decocting, decocted 2 times, merge decocting liquid；
Step 4, by obtained by step 3 decocting liquid heating concentration prepare liquid extract；
Step 5, the liquid extract obtained by step 4 is spray-dried, acquisition contains this Chinese medicine composition active ingredient
Dry powder.
5. method according to claim 4, it is characterised in that water is decocted in the step 3 for 6-10 times of raw material,
Decocting time is 40-70min.
6. method according to claim 4, it is characterised in that the relative density of the liquid extract is 1.15-1.35 (35
℃)。
7. a kind of Chinese medicine composition as any one of claims 1 to 3 is preparing treatment gastroduodenal ulcer medicine
In application.
8. a kind of Chinese medicine composition as any one of claims 1 to 3 containing therapeutically effective amount with pharmaceutically may be used
The preparation of the pharmaceutic adjuvant composition of receiving.
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