CN106822248A - A kind of saline cistanche composition and the health-oriented products containing said composition - Google Patents
A kind of saline cistanche composition and the health-oriented products containing said composition Download PDFInfo
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- CN106822248A CN106822248A CN201710092194.6A CN201710092194A CN106822248A CN 106822248 A CN106822248 A CN 106822248A CN 201710092194 A CN201710092194 A CN 201710092194A CN 106822248 A CN106822248 A CN 106822248A
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- cistanche
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- hippophae rhamnoides
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- 241000005787 Cistanche Species 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 66
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title claims abstract description 29
- 239000011780 sodium chloride Substances 0.000 title claims abstract description 29
- 239000000284 extract Substances 0.000 claims abstract description 92
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims abstract description 50
- 240000000950 Hippophae rhamnoides Species 0.000 claims abstract description 48
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 230000036039 immunity Effects 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- 239000003814 drug Substances 0.000 claims description 38
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 20
- 235000019359 magnesium stearate Nutrition 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 17
- 239000011122 softwood Substances 0.000 claims description 16
- 239000000047 product Substances 0.000 claims description 15
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 12
- 240000008397 Ganoderma lucidum Species 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
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- 239000002245 particle Substances 0.000 claims description 7
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
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- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- ILRCGYURZSFMEG-RKQHYHRCSA-N Salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RKQHYHRCSA-N 0.000 description 2
- 244000000231 Sesamum indicum Species 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
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- 241000336316 Cistanche tubulosa Species 0.000 description 1
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- 206010057315 Daydreaming Diseases 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 241001489091 Ganoderma sinense Species 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- GQODBWLKUWYOFX-UHFFFAOYSA-N Isorhamnetin Natural products C1=C(O)C(C)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 GQODBWLKUWYOFX-UHFFFAOYSA-N 0.000 description 1
- DBLDQZASZZMNSL-QMMMGPOBSA-N L-tyrosinol Natural products OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 description 1
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- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000010792 Phyllostachys aurea Nutrition 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- 241000997135 Rhodiola crenulata Species 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
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- 210000000936 intestine Anatomy 0.000 description 1
- 235000008800 isorhamnetin Nutrition 0.000 description 1
- IZQSVPBOUDKVDZ-UHFFFAOYSA-N isorhamnetin Chemical compound C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
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- 235000005875 quercetin Nutrition 0.000 description 1
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- 150000003648 triterpenes Chemical class 0.000 description 1
- 235000004330 tyrosol Nutrition 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Disclosure of the invention a kind of saline cistanche composition and the health-oriented products containing said composition, described composition is made up of the raw material of following weight portion, 50 100 parts of Ganodenna Lucidum P.E, 80 120 parts of gadol extract, 50 100 parts of hippophae rhamnoides, 150 250 parts of cistanche extracts.This product each component compatibility, is complemented each other, and the purpose that righting is got rid of evils is reached jointly, while there is the function of strengthen immunity, and effect is significant.Pharmaceutical composition of the invention is capable of the mood of keeping tensions down anxiety, improves notice and memory, while appetite and sleep quality can be improved, antitoxic heart-soothing and sedative makes insomniac quickly enter sleep state, strengthens the immunity of body.
Description
Technical field
The present invention relates to a kind of saline cistanche, sea-buckthorn, ganoderma lucidum, rhodiola root composition, and health-oriented products containing said composition,
The effect of with strengthen immunity.
Background technology
Immunity, refers to the ability for resisting disease development from for biologically.Immunity is the defence machine of human body itself
System is human bioequivalence and eliminates any foreign matter (virus, bacterium etc.) of external intrusion；Treatment aging, damages, death, be denatured
The ability of own cells and identification and treatment vivo mutations cell and virus infected cell.Immunology Today thinks, immunity
It is the physiological reaction of human bioequivalence and exclusion " dissident ".Perform this function in human body is immune system.Hypoimmunity
Show as body and be easy to infected or cancer stricken.Because often ill, the consumption of body is aggravated, so typically have a delicate constitution,
Malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, sleep-disorder etc. show, it is sick, have an injection take medicine become the daily life of a family just
Meal.It is sick every time to be lot more time to recover, and usually recurrent exerbation.Body and intelligence development can if things go on like this be caused
It is bad, also easily induce major disease.The influence factor of hypoimmunity is broadly divided into following a few classes：1) age factor：Life
There are two immunocompetences low stage, i.e. children's stage and old stage.The immune system of children is not yet ripe, and function is not good for
Entirely, hypoimmunity；And old functions of biological organs decline, acquisition nutritional capacity decline, immune organ gradually atrophy in addition
Decline, causes immunity degradation, and corresponding, children and old man are also disease two stages occurred frequently.2) bad life
Mode and custom：Nervous, malnutritive, shortage motion is had not enough sleep, and abuse of alcohol and smoking etc. can all suppress immune
System, reduces immunity of organisms.3) other factors：Noxious material, some drugses, radiotherapy and excess in environment it is anti-
Raw element also can all suppress immune system.By the analysis to hypoimmunity main cause, the elderly is not difficult to find out and by society
Factor and bad life style crowd of the influence in sub-health state are the major risk crowds of hypoimmunity.
The prefix of inferior health one time occur be in 20th century the mid-80, the former Russian scholar N Bu Heman it has been investigated that,
Human body also has a kind of intermediateness of non-health non-diseases, i.e. sub-health state in addition to health and morbid state.It
Refer to without clinical symptoms and sign, or there is illness to feel and without clinical examination evidence, but existing potential morbidity tendency information,
Body goes down in a kind of structure degradation and physiological function, the state of psychological unbalance.One whole world of the World Health Organization (WHO)
Sex investigation shows that the people in the world in true health state accounts for 5%, and the people for being diagnosed with disease accounts for 20%, and remaining 75%
People be in sub-health state.According to statistics, the U.S. has 6,000,000 people under a cloud in sub-health state every year, and the age is more in 20-45
Between year, there are 14% adult male and 20% women to be presented with obvious fatigue, wherein 1/8 develops into CFS (confirmed fatigues
Syndrome).The investigation of Britain shows, about 20% male and 25% women's panesthesia to fatigue, wherein about 1/4 may be
CFS.The once investigation that state-run public health institute of Japan does shows, in 15-65 Sui personage of national more than 5000 name, represents
Really feel unexpectedly up to the 60% of " very tired ", wherein because workload is big, have weighty housework, it is nervous account for 44%, also
36% could not explain reason.
With the raising of people's quality of life, health care consciousness gradually strengthens, health care of the exploitation with strengthen immunity function
Food will have extensive market prospects.
The content of the invention
It is an object of the invention to provide a kind of saline cistanche composition and the health-oriented products containing said composition, this product be with
《Pharmacopoeia of People's Republic of China》And scientific research document is foundation, on the basis of scientific experiment, with Ganodenna Lucidum P.E, red scape
Its extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch, magnesium stearate are the health care food that main supplementary material is made
Product.This product formulation uses tablet, and dosage is accurate, and content is uniform；The technical maturity of tablet, production mechanization, automaticity compared with
Height, yield is big, and cost is relatively low；Tablet be drying solid formulation, small volume, densification, by outside air, light, moisture etc. because
The influence of element is less, and chemical stability is preferable；Carry, transport, taking more convenient.
To achieve the above object, the present invention is achieved by the following technical solutions：
A kind of first aspect present invention, there is provided saline cistanche composition, is made up of, Ganodenna Lucidum P.E the raw material of following weight portion
50-100 parts, gadol extract 80-120 parts, hippophae rhamnoides 50-100 parts, cistanche extracts 150-250 parts.
Preferably：A kind of saline cistanche composition, is made up of the raw material of following weight portion, Ganodenna Lucidum P.E 80-90 parts, red scape
90-100 parts, hippophae rhamnoides 70-80 parts, cistanche extracts 180-230 parts of its extract.
More preferably：A kind of saline cistanche composition, is made up of the raw material of following weight portion, 80 parts of Ganodenna Lucidum P.E, red scape
95 parts of its extract, 80 parts of hippophae rhamnoides, 200 parts of cistanche extracts.
The Ganodenna Lucidum P.E can be that the medicinal extract for obtaining is extracted from ganoderma lucidum, and extractant is alcohols solvent, such as methyl alcohol
Or ethanol；Extracting mode is extraction, refluxing extraction or seepage pressure effects；It can also be commercially available Ganodenna Lucidum P.E product.
The gadol extract can extract the medicinal extract for obtaining in rhodiola root, and Extraction solvent is alcohols solvent, for example
Methyl alcohol or ethanol；Extracting mode is extraction, refluxing extraction or seepage pressure effects；It can also be commercially available gadol extract product.
The hippophae rhamnoides can be that the medicinal extract for obtaining is extracted from sea-buckthorn, and Extraction solvent is alcohols solvent, such as first
Alcohol or ethanol；Extracting mode is extraction, refluxing extraction or seepage pressure effects；It can also be commercially available hippophae rhamnoides product.
The cistanche extracts can be that the medicinal extract for obtaining is extracted from saline cistanche, and Extraction solvent is alcohols solvent, example
Such as methyl alcohol or ethanol；Extracting mode is extraction, refluxing extraction or seepage pressure effects；Can also be that commercially available cistanche extracts are produced
Product.
It is preferred that:The Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts are by with lower section
What method was prepared：Respectively by ganoderma lucidum, rhodiola root, sea-buckthorn and saline cistanche, flowed back with 30~100% ethanol (percentage by volume) and carried
Take 1~6 time, each solvent load is 1~15 times of medicinal material weight, each extraction time is 0.5~10 hour；Merge and extract
Ethanol is reclaimed in liquid, filtering, is concentrated, dried, and obtains final product Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides and saline cistanche
Extract；
Preferably, the Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts are by following
What method was prepared：Respectively by Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides and cistanche extracts, 50~
95% ethanol (percentage by volume) refluxing extraction 2~4 times, the consumption of each solvent is 3~7 times of medicinal material weight, is extracted every time
Time is 0.5~2 hour；Merge extract solution, ethanol is reclaimed in filtering, is concentrated, dried, and obtains final product Ganodenna Lucidum P.E, rhodiola root
Extract, hippophae rhamnoides and cistanche extracts.
The preparation method of above-mentioned saline cistanche composition, each material composition is well mixed.
Application of the above-mentioned saline cistanche composition in the medicine or health products for preparing enhance immunity is also of the invention
Within protection domain.
The second aspect of the present invention, there is provided a kind of pharmaceutical preparation of enhance immunity, by above-mentioned saline cistanche composition and medicine
Acceptable auxiliary material is prepared from；Or mix above-mentioned Chinese medicine composition to the medicine with enhance immunity with other,
Add again or be prepared from without pharmaceutically acceptable auxiliary material.
Said medicine preparation can be made various pharmaceutical dosage forms, such as tablet, powder, pill, film.
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, and preferably starch is (preferably：Pregelatinated forms sediment
Powder) and magnesium stearate.
A kind of preparation method of saline cistanche composition tablet, comprises the following steps that：
(1) sieving is weighed：By the Ganodenna Lucidum P.E of raw material components consumption, gadol extract, hippophae rhamnoides, saline cistanche
Extract, pregelatinized starch, magnesium stearate cross 30-100 mesh sieves respectively；
(2) mix：By Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch
Mixing is (preferably：Put and mix 10-60min in mixer), obtain total mixed powder；
(3) softwood processed：With the ethanol of volume fraction 50% by the total mixed powder softwood in step (2)；(preferably：Mixing
Powder is 100g with the mass volume ratio of the ethanol that volume fraction is 50%：10-50ml, advantage：It is obtained under conditions of this consumption
Softwood humidity it is suitable, gently hold agglomerating with hand, that pinches is i.e. scattered.
(4) pelletize, dry:By softwood obtained in step (3) cross 10-30 mesh sieves granulation, wet granular at 40-80 DEG C (preferably
60 DEG C) under be dried and make moisture≤5.0%；
(5) whole grain:Dry particl crosses 10-30 mesh sieve whole grains；
(6) it is total mixed：The particle that magnesium stearate prepared with step (5) is taken to be well mixed (preferably：In putting mixer), time 5-
30min, obtains and always mixes particle；
(7) it is molded；
The composition of the weight portion of the raw material is as follows, Ganodenna Lucidum P.E 50-100 parts, gadol extract 80-120 parts, husky
50-100 parts of spine extract, cistanche extracts 150-250 parts, starch and magnesium stearate 400-700 parts.
Preferably：The composition of the weight portion of the raw material is as follows, Ganodenna Lucidum P.E 80-90 parts, gadol extract 90-
100 parts, hippophae rhamnoides 70-80 parts, cistanche extracts 180-230 parts, starch and magnesium stearate 500-650 parts.
More preferably：The composition of the weight portion of the raw material is as follows, 80 parts of Ganodenna Lucidum P.E, 95 parts of gadol extract,
600 parts of 80 parts of hippophae rhamnoides, 200 parts of cistanche extracts, starch and magnesium stearate.
The compatibility of Chinese medicine be particular about mutual reinforcement between, mutually make, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, conversely, because existing not between different Chinese medicine
With compatibility relationship, therefore when using two taste above Chinese medicine, it is necessary to be allowed a choice, give full play to what mutual reinforcement between medicine mutually made
Compatibility relationship, makes the clinical effectiveness of product be significantly improved.
On the other hand, traditional Chinese medicine ingredients are complicated, existing water soluble ingredient in a kind of medicinal material, have again oil-soluble or alcohol-soluble into
Divide, and some active components are easily inactivated at high temperature, therefore by selecting suitable extracting method and extraction process to Chinese medicine
Active ingredient carries out extraction separation, can to greatest extent extract active ingredient and ensure the activity of active ingredient, so as to protect
Demonstrate,prove the clinical effectiveness of product.
The present invention carries out compatibility by by the extract of kinds of traditional Chinese medicines, and based on modern medical theory, creative adopts
With material combinations such as ganoderma lucidum, rhodiola root, saline cistanche, sea-buckthorns, the absorption of each functional component is improved, action effect becomes apparent from.
The effect of each raw material is described below in composition of the invention：
Rhodiola root, it is crassulaceae plants rhodiola Rhodiola crenulata that pharmacopeia records rhodiola root
(Hook.f.et Thoms.) H.Ohba's dries root and rhizome.Sweet, hardship, it is mild-natured.Qi and activate blood circulation, promotes blood circulation and relievings asthma.For gas
Empty blood stasis, chest impediment and cardialgia, hemiplegia, burnout asthma.Main chemical compositions are rhodioloside, tyrosol.Modern pharmacological research table
Bright, rhodiola root has protective effect to hepatic injury.
Ganoderma lucidum is On Polyporaceae red sesame Ganoderma lucidum (Leyss.ex Fr.) Karst. or purple sesame
Ganoderma sinense Zhao, Xu et Zhang's dries fructification.It is sweet, it is mild-natured.The thoughts of returning home, lung, liver and kidney channel.Tool is mended
Gas is calmed the nerves, relieving cough and asthma work(, for dizziness egersis, palpitation, consumptive disease cough and asthma.Ganoderma lucidum chemical composition is polysaccharide, triterpene
Class, ucleosides, alkaloid, amino acid and trace element etc..
Sea-buckthorn is a kind of to contain multivitamin, various trace elements, several amino acids and other bioactivators
Medicinal food.The Ministry of Public Health of China first formally lists sea-buckthorn within 1977《Chinese Pharmacopoeia》Afterwards, medicine office of country and the Ministry of Public Health
It is medicinal and edible plant that joint announces sea-buckthorn.Contain 7 kinds of flavones such as Isorhamnetin and its glucoside, Quercetin, Kaempferol in sea-buckthorn
Material, with cough-relieving, eliminating the phlegm of relievining asthma, expansion coronary vasodilator, reduce cholesterol the effects such as.《Pharmacopoeia of People's Republic of China》Middle note
Carry the Mongols of sea-buckthorn system, Tibetan conventional crude drugs.It is being dried to for Elaeangnaceae plant sea-buckthorn Hippophae rhamnoides L.
Ripe fruit.It is sour, puckery, it is warm in nature.Returns spleen, stomach, lung, the heart channel of Hang-Shaoyin.For spleen eating less, dyspeptic abdominalgia, coughing with a lot of sputum, chest impediment and cardialgia,
Extravasated blood Amenorrhea, fall flutter the stasis of blood swell.
Desert cistanche, also known as big rue.The traditional Chinese medical science is called ground essence or golden bamboo shoot, is extremely rare Chinese medicine, have " desert ginseng "
Good reputation.Desert cistanche is used as medicine, long-standing.It is sweet and warm in nature, and salty and matter is moistened, not dry with yang-tonifying, and temperature logical kidney yang kidney tonifying is empty；Tonifying yin
It is oiliness, the characteristics of the logical abdomen of ease constipation treats constipation.Just because of its benefit property is gentle, just there is the title of desert cistanche (calm).《The People's Republic of China (PRC)
Pharmacopeia》Described in saline cistanche for orobanchaceae plant cistanche Cistanche tubulosa (Schrenk) Wight dry zone squama
The fleshy stem of leaf.It is sweet, salty, it is warm in nature.Return kidney, large intestine channel.For the insufficiency of the kidney yang, menses virtual loss, impotence is infertile, soreness and weakness of waist and knees,
Muscles and bones is powerless, dry constipation of intestines.
The present invention has advantages below：
Raw material of the present invention not in " eighteen incompatibilities ", the row of " nineteen counteraction ", without incompatibility；With saline cistanche as monarch drug in a prescription in formula,
Temperature logical kidney yang kidney tonifying is empty, and yang-tonifying is not dry, and tonifying yin is oiliness, with ganoderma lucidum and rhodiola root as ministerial drug, fills blood, strengthening the essence god, supports the five internal organs, dispels
Evil gas, mends various symptims and signs of deficiency, with sea-buckthorn as adjutant, enriching yin, rising Yang, the stagnation resolvation of sharp lung, cough-relieving apophlegmatic, relieving dyspepsia, promoting blood circulation to remove blood stasis, with
Upper four compatibility, is complemented each other, and the purpose that righting is got rid of evils is reached jointly.
Pharmaceutical composition of the invention is capable of the mood of keeping tensions down anxiety, notice and memory is improved, while can
Appetite and sleep quality are improved, antitoxic heart-soothing and sedative makes insomniac quickly enter sleep state, strengthens the immunity of body.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Involved instrument, reagent, material etc. in following embodiments, unless otherwise noted, are existing in the prior art
Conventional instrument, reagent, material etc., can be obtained by regular commercial sources.Involved experimental technique in following embodiments, inspection
Survey method etc., unless otherwise noted, is existing normal experiment method in the prior art, detection method etc..
Embodiment 1
(1) combination matching：Ganodenna Lucidum P.E 100g, gadol extract 120g, hippophae rhamnoides 100g, saline cistanche
150g, starch and auxiliary material 530g；
(2) sieving is weighed：Take qualified Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts,
Pregelatinized starch, magnesium stearate respectively cross 80 mesh sieves after weigh it is standby.
(3) mix：By Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch
Put and mix 30min in mixer, obtain total mixed powder, it is standby.
(4) softwood processed：With 50% ethanol by above-mentioned total mixed powder softwood, gently hold agglomerating with hand, pinch dissipate be degree
(adding the ethanol of 30ml 50% per 100g powder).
(5) pelletize, dry:Softwood cross 16 mesh sieves granulation, wet granular be dried at 60 DEG C (it is required that：Moisture≤
5.0%).
(6) whole grain:Dry particl crosses 16 mesh sieve whole grains.
(7) it is total mixed：Take magnesium stearate and put in mixer with above-mentioned particle and be well mixed, time 10min or so obtained and always mix
Grain.
(8) it is molded：The tablet of 0.6g/ pieces is made as requested.
Embodiment 2
(1) combination matching：Ganodenna Lucidum P.E 75g, gadol extract 100g, hippophae rhamnoides 65g, saline cistanche 200g,
Starch and auxiliary material 560g；
(2) sieving is weighed：Take qualified Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts,
Pregelatinized starch, magnesium stearate respectively cross 30 mesh sieves after weigh it is standby.
(3) mix：By Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch
Put and mix 10min in mixer, obtain total mixed powder, it is standby.
(4) softwood processed：With 50% ethanol by above-mentioned total mixed powder softwood, gently hold agglomerating with hand, pinch dissipate be degree
(adding the ethanol of 20ml 50% per 100g powder).
(5) pelletize, dry:Softwood cross 10 mesh sieves granulation, wet granular be dried at 60 DEG C (it is required that：Moisture≤
5.0%).
(6) whole grain:Dry particl crosses 10 mesh sieve whole grains.
(7) it is total mixed：Take magnesium stearate and put in mixer with above-mentioned particle and be well mixed, time 10min or so obtained and always mix
Grain.
(8) it is molded：Capsule product is made as requested.
Embodiment 3
(1) combination matching：Ganodenna Lucidum P.E 50g, gadol extract 120g, hippophae rhamnoides 50g, saline cistanche 200g,
Starch and auxiliary material 520g；
(2) sieving is weighed：Take qualified Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts,
Pregelatinized starch, magnesium stearate respectively cross 30 mesh sieves after weigh it is standby.
(3) mix：By Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch
Put and mix 30min in mixer, obtain total mixed powder, it is standby.
(4) softwood processed：With 50% ethanol by above-mentioned total mixed powder softwood, gently hold agglomerating with hand, pinch dissipate be degree
(adding the ethanol of 10ml 50% per 100g powder).
(5) pelletize, dry:Softwood cross 16 mesh sieves granulation, wet granular be dried at 60 DEG C (it is required that：Moisture≤
5.0%).
(6) whole grain:Dry particl crosses 16 mesh sieve whole grains.
(7) it is total mixed：Take magnesium stearate and put in mixer with above-mentioned particle and be well mixed, time 10min or so obtained and always mix
Grain.
(8) it is molded：Tablet is made as requested.
Comparative example 1：
In composition of the invention, each raw material components are an organic wholes, indispensable.Inventor is in R＆D process
Middle discovery, reduces any one of above-mentioned composition raw material components, or with the bulk drug with the similar property of medicine in the present invention
The raw material components of drug composition are replaced, then the overall action effect of Chinese medicine composition is significantly reduced；In combination of the invention
Other raw material components are further added by the basis of thing, the whole structure of composition does not improve significantly, or even has composition
Whole structure reduction situation occur.
The present inventor is replaced with similar cistanche extracts in the pharmaceutical formulation of embodiment 1 in R＆D process
The deer antler extract of effect；Ganodenna Lucidum P.E is replaced with into Radix Codonopsis or Astragalus Root P.E, is as a result found, although a few taste bulk drugs
Between similar but different from other the bulk drug compatibility use of the property of medicine after, its effect significant difference.
Comparative example 2
The dose of each bulk drug is the mark efficacy of a drug in Chinese medicine composition, even if the medicine composition of prescription is identical, if but medicine
The consumption of thing is different, its efficacy of a drug then have size point, compatibility relationship then has the change of monarch, thus its work(cure mainly it is then each
It is different.The present inventor has carried out grinding for investigation and drug effect in R＆D process to the content of each raw material in Chinese medicine composition
Study carefully, as a result find, inappropriate raw material proportioning relation, its effect significant difference.For example：Ganoderma lucidum in embodiment 1 is extracted
Thing 78g, gadol extract 130g, hippophae rhamnoides 110g, saline cistanche 130g, starch and auxiliary material 600g；, and by embodiment 1
Method prepare.
Diagnostic criteria：With reference to clinical criteria, and with symptom indexing it is light, in, severe.
Treatment method：Experimental group takes in the morning and evening the tablet of Chinese medicine composition of the present invention.In stopping other during treatment
Western medicine.
Observation of curative effect：The present invention clinically achieves preferable curative effect, in 100 insomniacs, takes the present invention
After the Chinese medicine composition tablet 8 days, cure 95, cure rate accounts for 95%, takes a turn for the better 4, and obvious effective rate accounts for 4%, and total effective rate is
99%, invalid 1, inefficiency accounts for 1%.Control group cure rate is 42.3%, and two groups of cure rates relatively have significant difference (P<
0.05)。
The clinical observation on the therapeutic effect of Chinese medicine composition of the present invention：
Lee, man 30 years old, company clerk.Suffer from insomnia existing 1 year, poor sleep, and slowness of thinking all the time, reaction
Blunt, absent minded, Sleep latency is long, can not all fall asleep after 12 points often, cannot be fallen asleep the whole night when serious, and people disappears
Thin, listless, mood is irritated.Daily tablet obtained in the embodiment of the present invention 1, after continuously taking 3 days, lies down small half
When or so can fall asleep, sleep stable, after continuous a week after taking, various insomnias disappear, and enter by lying down 15 minutes or so
Sleep, happy, notice is concentrated, in high spirits.
Zhai, female 53 years old, retired worker.Suffer from insomnia existing more than ten years, have difficulty in going to sleep for a long time daily, all night cannot when serious
Sleep, and shallower, dreaminess of sleeping, Yi Xing cause lean body mass, lassitude to be off one's feed, and often feel that dizzy, mood is tired of
It is hot-tempered.Daily tablet obtained in the embodiment of the present invention 1, after continuously taking 5 days, falls asleep by or so half an hour of lying down, essence
The symptom that god is depressed, be off one's feed disappears；After continuous a week after taking, sleep stable, sleep is relatively deep, few dream, every night 20 minutes left sides
Right to fall asleep, insomnia is wholly absent, happy, in high spirits.
Claims (10)
1. a kind of saline cistanche composition, it is characterized in that：It is made up of the raw material of following weight portion, it is Ganodenna Lucidum P.E 50-100 parts, red
80-120 parts, hippophae rhamnoides 50-100 parts, cistanche extracts 150-250 parts of red-spotted stonecrop extract.
2. a kind of saline cistanche composition as claimed in claim 1, it is characterized in that：It is made up of the raw material of following weight portion, ganoderma lucidum
Extract 80-90 parts, gadol extract 90-100 parts, hippophae rhamnoides 70-80 parts, cistanche extracts 180-230 parts；
Preferably：A kind of saline cistanche composition, is made up of the raw material of following weight portion, 80 parts of Ganodenna Lucidum P.E, and rhodiola root is extracted
95 parts of thing, 80 parts of hippophae rhamnoides, 200 parts of cistanche extracts.
3. composition as claimed in claim 1 or 2, it is characterized in that：The Ganodenna Lucidum P.E, gadol extract, sea-buckthorn carry
Take thing, cistanche extracts and be prepared by the following method and obtain：Respectively by Ganodenna Lucidum P.E, gadol extract, sea-buckthorn
Extract and cistanche extracts, are extracted 1~6 time with 30~100% alcohol refluxs, and each solvent load is the 1 of medicinal material weight
~15 times, each extraction time is 0.5~10 hour；Merge extract solution, ethanol is reclaimed in filtering, is concentrated, dried, and is obtained final product
Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides and cistanche extracts；
Preferably, the Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts are by the following method
Prepare：Respectively by Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides and cistanche extracts, 50~95% second
Alcohol reflux is extracted 2~4 times, and the consumption of each solvent is 3~7 times of medicinal material weight, and each extraction time is 0.5~2 hour；Close
And extract solution, filtering, reclaim ethanol, concentrated, dry, obtain final product Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides and
Cistanche extracts.
4. the preparation method of the composition described in claim 1 or 2, it is characterized in that：Each material composition is well mixed.
5. application of the composition described in claim 1 or 2 in the medicine or health products for preparing enhance immunity.
6. a kind of pharmaceutical preparation of enhance immunity, saline cistanche composition as described in claim 1 or 2 and pharmaceutically acceptable
Auxiliary material be prepared from.
7. pharmaceutical dosage form as claimed in claim 6, it is characterized in that：The formulation is tablet, powder, pill, film.
8. a kind of preparation method of saline cistanche composition tablet, it is characterized in that：Comprise the following steps that：
(1) sieving is weighed：The Ganodenna Lucidum P.E of raw material components consumption, gadol extract, hippophae rhamnoides, saline cistanche are extracted
Thing, pregelatinized starch, magnesium stearate cross 30-100 mesh sieves respectively；
(2) mix：Ganodenna Lucidum P.E, gadol extract, hippophae rhamnoides, cistanche extracts, pregelatinized starch are mixed,
Obtain total mixed powder；
(3) softwood processed：With the ethanol of volume fraction 50% by the total mixed powder softwood in step (2)；
(4) pelletize, dry:Softwood obtained in step (3) is crossed into the granulation of 10-30 mesh sieves, wet granular is dried at 60 DEG C to be made
Moisture≤5.0%；
(5) whole grain:Dry particl crosses 10-30 mesh sieve whole grains；
(6) it is total mixed：Take the particle that magnesium stearate prepared with step (5) to be well mixed, time 5-30min is obtained and always mixed particle；
(7) it is molded；
The composition of the weight portion of the raw material is as follows, Ganodenna Lucidum P.E 50-100 parts, and gadol extract 80-120 parts, sea-buckthorn carries
Take thing 50-100 parts, cistanche extracts 150-250 parts, starch and magnesium stearate 400-700 parts.
9. preparation method as claimed in claim 8, it is characterized in that：The composition of the weight portion of the raw material is as follows, and ganoderma lucidum is extracted
Thing 80-90 parts, gadol extract 90-100 parts, hippophae rhamnoides 70-80 parts, cistanche extracts 180-230 parts, starch and
Magnesium stearate 500-650 parts.
10. preparation method as claimed in claim 8, it is characterized in that：The composition of the weight portion of the raw material is as follows, and ganoderma lucidum is extracted
600 parts of 80 parts of thing, 95 parts of gadol extract, 80 parts of hippophae rhamnoides, 200 parts of cistanche extracts, starch and magnesium stearate.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111280448A (en) * | 2020-02-14 | 2020-06-16 | 山东博奥克生物科技有限公司 | Sea-buckthorn and cistanche slice and processing production equipment thereof |
-
2017
- 2017-02-21 CN CN201710092194.6A patent/CN106822248A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 北京世纪中康医药科技有限公司 销售主管: "《保健食品注册-侯的博客 http://blog.sina.com.cn/s/blog_a561b16001016hc0.html》", 11 July 2012 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111280448A (en) * | 2020-02-14 | 2020-06-16 | 山东博奥克生物科技有限公司 | Sea-buckthorn and cistanche slice and processing production equipment thereof |
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