CN106820141A - A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof - Google Patents

A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof Download PDF

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Publication number
CN106820141A
CN106820141A CN201710010576.XA CN201710010576A CN106820141A CN 106820141 A CN106820141 A CN 106820141A CN 201710010576 A CN201710010576 A CN 201710010576A CN 106820141 A CN106820141 A CN 106820141A
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China
Prior art keywords
adhesive rehmannia
rehmannia flower
flower polysaccharide
parts
polysaccharide
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Pending
Application number
CN201710010576.XA
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Chinese (zh)
Inventor
李寒冰
吴宿慧
陈磊
李根林
崔红新
徐慧颖
陈鑫
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Henan University of Traditional Chinese Medicine HUTCM
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Henan University of Traditional Chinese Medicine HUTCM
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Priority to CN201710010576.XA priority Critical patent/CN106820141A/en
Publication of CN106820141A publication Critical patent/CN106820141A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, is weight portion:60 parts of adhesive rehmannia flower polysaccharide, 0.45 1 0.75 parts of citric acid, 30 31 parts of microcrystalline cellulose, 0.5 0.75 parts of Aspartame, 38 45 parts of mannitol;The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets:Adhesive rehmannia flower is pulverized, plus 6 10 times of water of weight, shake up into slurries, extracted 1 hour under conditions of 80-90 DEG C, filter to take filtrate, concentrate the filtrate to 100ml or so, polysaccharide is extracted with alcohol precipitating method, vacuum drying grinds to form polysaccharide powder, by citric acid, Aspartame, microcrystalline cellulose, mannitol and adhesive rehmannia flower polysaccharide powder are placed in granulation pot, stir and dry, then to granulation pot in add polyethylene glycol, compressing tablet is carried out after whole grain, adhesive rehmannia flower polysaccharide buccal tablets are obtained, composition and content that the present invention passes through rational allocation raw material using adhesive rehmannia flower, it is made delicate mouthfeel, sweet and sour taste, instant, it is rich in the buccal tablet of adhesive rehmannia flower peculiar taste.

Description

A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof
Technical field
The present invention be more particularly directed to a kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof.
Background technology
Adhesive rehmannia flower is the bud of scrophulariaceae rehmannia glutinosa plant, also known as honey jar, control quench one's thirst, kidney deficiency Low Back Pain the effects such as, its effect It is also the good medicine being worth mentioning though the effect without glutinous rehmannia is strong.For example《Bencao Tujing》In it is on the books --- " for end take With the same glutinous rehmannia of work(".Have again《Detailed outline》Described in --- " controlling kidney deficiency, pain along spinal column is that last wine takes tool for weighing medicine in ancient China, day three ".Same glutinous rehmannia, Adhesive rehmannia flower also has clearing heat and promoting fluid, the function of yin-nourishing strengthening the essence.Glutinous rehmannia is widely used for treating diabetes, Dihuang polysaccharide in traditional Chinese medicine The effect of preferable regulation blood sugar and blood fat, but content and property ratio according to adhesive rehmannia flower polysaccharide and Dihuang polysaccharide are showed Relatively draw, adhesive rehmannia flower polysaccharide acted in terms of reducing blood lipid it is same substantially, be embodied in the triglycerides that reduces in animal body and Cholesterol levels.The polysaccharide is further played anti-ageing having preferable antioxidation to intact animal and pathology animal Always, antineoplastic activity.In addition adhesive rehmannia flower polysaccharide also has effect antifatigue, antianxity.In addition, having help with reference to prepared rhizome of rehmannia Effect, adhesive rehmannia flower can also play certain benefiting action by certain concocting method,《Detailed outline》Described in " being last wine clothes " Treatment kidney deficiency Low Back Pain table is equivalent to various processing procedures now.Current adhesive rehmannia flower is increasingly improved in the utilization rate of Chinese medicine, is also used In dietotherapy, but yet there are no the patent document that adhesive rehmannia flower polysaccharide is processed into buccal tablet.
The content of the invention
It is an object of the invention to provide a kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, adhesive rehmannia flower polysaccharide mouth containing Piece delicate mouthfeel, sweet and sour taste, instant, the peculiar taste for being rich in adhesive rehmannia flower;Its preparation methods steps are rationally, simple easy OK, with high use value.
The object of the present invention is achieved like this:A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, It is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.45-0.75 part of citric acid, 30-31 parts of microcrystalline cellulose, 0.5-0.75 part of Aspartame, 38-45 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is as follows:
(1)Prepare adhesive rehmannia flower polysaccharide:Adhesive rehmannia flower is pulverized, 120 mesh sieves are crossed, -10 times of water of weight of plus 6 shake up into slurry Liquid, extracts 1 hour under conditions of 80 DEG C -90 DEG C, filters to take filtrate, concentrates the filtrate to 100ml or so, adds 95% second Alcohol, and control concentration of alcohol in the range of 80% -85%, 12 hours are stood in 4 DEG C of refrigerating cabinets, after taking-up with centrifugal precipitation mechanism from The heart isolates floccule adhesive rehmannia flower polysaccharide;
(2)Grinding flour:By step(1)In obtained adhesive rehmannia flower polysaccharide place vacuum drying chamber in dry 6 hours, grinding, mistake 120 mesh sieve series powder, obtain final product adhesive rehmannia flower polysaccharide powder;
(3)Mixing:Citric acid, Aspartame, microcrystalline cellulose and mannitol are positioned in granulation pot, step is subsequently adding (2)In obtained adhesive rehmannia flower polysaccharide powder, stir, and be dried;
(4)Produce buccal tablet:To step(3)In granulation pot in add polyethylene glycol, compressing tablet, pressure set points are carried out after whole grain It is 5kg, obtains final product described adhesive rehmannia flower polysaccharide buccal tablets;
A kind of described adhesive rehmannia flower polysaccharide buccal tablets, raw material is as follows, is weight portion:60 parts of adhesive rehmannia flower polysaccharide, citric acid 0.75 Part, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame, 40 parts of mannitol;
The rotating speed of described centrifugal precipitation mechanism is 2000r/min, and the centrifugally operated time is 5min.
Described adhesive rehmannia flower buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
The beneficial effect comprise that:Composition and content that the present invention passes through rational allocation raw material are more by adhesive rehmannia flower Sugar is made delicate mouthfeel, sweet and sour taste, instant, the oral tablet that is rich in adhesive rehmannia flower peculiar taste, extends making for adhesive rehmannia flower With scope, new healthcare function and consumption pattern is formd.
Specific embodiment
The present invention is described in further detail with reference to embodiment, but the scope of the present invention is not limited in described Hold.
Embodiment 1
A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.66 part of citric acid, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame, 38 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is as follows:
(1)Prepare adhesive rehmannia flower polysaccharide:Adhesive rehmannia flower is pulverized, 120 mesh sieves, plus 8 times of water of weight are crossed, slurries are shaken up into, in Extracted 1 hour under conditions of 80 DEG C -90 DEG C, filter to take filtrate, concentrate the filtrate to 100ml or so, add 95% ethanol, and control Concentration of alcohol processed stands 12 hours in the range of 80% -85% in 4 DEG C of refrigerating cabinets, is gone out with centrifugal precipitation mechanism centrifugation after taking-up Floccule adhesive rehmannia flower polysaccharide.
(2)Grinding flour:By step(1)In obtained adhesive rehmannia flower polysaccharide place vacuum drying chamber in dry 6 hours, grind Mill, crosses 120 mesh sieve series powder, obtains final product adhesive rehmannia flower polysaccharide powder.
(3)Mixing:Citric acid, Aspartame, microcrystalline cellulose and mannitol are positioned in granulation pot, step is subsequently adding Suddenly(2)In obtained adhesive rehmannia flower polysaccharide powder, stir, and be dried.
(4)Produce buccal tablet:To step(3)In granulation pot in add polyethylene glycol, compressing tablet is carried out after whole grain, pressure sets Definite value is 5kg, obtains final product described adhesive rehmannia flower polysaccharide buccal tablets.
The rotating speed of described centrifugal precipitation mechanism is 2000r/min, and the centrifugally operated time is 5min.
Described adhesive rehmannia flower buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
Embodiment 2
A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.66 part of citric acid, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame, 40 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is with embodiment 1.
The rotating speed of described centrifugal precipitation mechanism is 2000r/min, and the centrifugally operated time is 5min.
Described adhesive rehmannia flower buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
Embodiment 3
A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.75 part of citric acid, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame, 38 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is with embodiment 1.
The rotating speed of described centrifugal precipitation mechanism is 2000r/min, and the centrifugally operated time is 5min.
Described adhesive rehmannia flower buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
Embodiment 4
A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, raw material is as follows, is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.75 part of citric acid, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame, 40 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is with embodiment 1.
The rotating speed of described centrifugal precipitation mechanism is 2000r/min, and the centrifugally operated time is 5min.
Described adhesive rehmannia flower buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
Adhesive rehmannia flower polysaccharide buccal tablets taste report
Taste personnel placement
Selecting 22 trial test personnel at random carries out the trial test investigation of adhesive rehmannia flower polysaccharide buccal tablets, consisting of men and women half and half, age Between 20 ~ 43 years old;Trial test personnel are required to before tasting every time to be gargled, to ensure the accuracy of trial test result.
It is specific to taste mode
Take and evaluate 1,2,3,4 four parts of samples simultaneously(Respectively made according to embodiment 1, embodiment 2, embodiment 3, embodiment 4 Sample)Method, with "+" be evaluation judge, "+" represent each side satisfaction it is higher, taste personnel taste it is laggard Row tastes filling in for account, and result statistics is carried out finally according to the data collected, and selects optimal portion as final products.
Specific trial test is sequentially
Allow trial test personnel to be tasted successively in sequence, and make a record.
Taste filling in for account
With "+" as assessment method, "+" is more, and representative satisfaction is higher, and " +++ " is highest evaluation criterion.Trial test personnel fill out Write such as following table:
Taste result statistics
With " +++ " for highest evaluation criterion, "+" more at most satisfaction is higher, the comprehensive application form for tasting personnel, makes following Result is counted:
Can be drawn from investigation statisticses table, the sample 4 made according to embodiment 4 is optimal product, i.e., final preferred adhesive rehmannia flower is more Candy buccal tablets.

Claims (4)

1. a kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof, it is characterised in that:Raw material is as follows, is weight portion:
60 parts of adhesive rehmannia flower polysaccharide, 0.45-0.75 part of citric acid, 30-31 parts of microcrystalline cellulose, 0.5-0.75 part of Aspartame, 38-45 parts of mannitol;
The preparation method of described adhesive rehmannia flower polysaccharide buccal tablets, step is as follows:
Prepare adhesive rehmannia flower polysaccharide:Adhesive rehmannia flower is pulverized, 120 mesh sieves are crossed, -10 times of water of weight of plus 6 shake up into slurries, in Extracted 1 hour under conditions of 80 DEG C -90 DEG C, filter to take filtrate, concentrate the filtrate to 100ml or so, add 95% ethanol, and control Concentration of alcohol processed stands 12 hours in the range of 80% -85% in 4 DEG C of refrigerating cabinets, is gone out with centrifugal precipitation mechanism centrifugation after taking-up Floccule adhesive rehmannia flower polysaccharide;
Grinding flour:By step(1)In obtained adhesive rehmannia flower polysaccharide place vacuum drying chamber in dry 6 hours, grinding crosses 120 Mesh sieve series powder, obtains final product adhesive rehmannia flower polysaccharide powder;
Mixing:Citric acid, Aspartame, microcrystalline cellulose and mannitol are positioned in granulation pot, step is subsequently adding(2)In Obtained adhesive rehmannia flower polysaccharide powder, stirs, and be dried;
Produce buccal tablet:To step(3)In granulation pot in add polyethylene glycol, compressing tablet is carried out after whole grain, pressure set points are 5kg, obtains final product described adhesive rehmannia flower polysaccharide buccal tablets.
2. a kind of adhesive rehmannia flower polysaccharide buccal tablets according to claim 1 and preparation method thereof, it is characterised in that:Raw material is such as Under, it is weight portion:60 parts of adhesive rehmannia flower polysaccharide, 0.75 part of citric acid, 30.5 parts of microcrystalline cellulose, 0.55 part of Aspartame is sweet 40 parts of alcohol of dew.
3. a kind of adhesive rehmannia flower polysaccharide buccal tablets according to claim 1 and preparation method thereof, it is characterised in that:It is described from The rotating speed of heart precipitation machine is 2000r/min, and the centrifugally operated time is 5min.
4. a kind of adhesive rehmannia flower polysaccharide buccal tablets according to claim 1 and preparation method thereof, it is characterised in that:Described ground Chrysanthemum buccal tablet specification is every 300mg, thickness 1.8mm, diameter 10mm.
CN201710010576.XA 2017-01-06 2017-01-06 A kind of adhesive rehmannia flower polysaccharide buccal tablets and preparation method thereof Pending CN106820141A (en)

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Application Number Priority Date Filing Date Title
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101041675A (en) * 2006-03-24 2007-09-26 厦门牡丹香化实业有限公司 Method for extracting glutinous rehmannia oligose and glutinous rehmannia polysaccharide from glutinous rehmannia
CN101623313A (en) * 2009-01-22 2010-01-13 九芝堂股份有限公司 Method for preparing traditional Chinese medicine preparation for tonifying blood
CN102372751A (en) * 2010-08-13 2012-03-14 河南爱富帝食品有限公司 Extraction method of rehmannia catalpol
CN106234648A (en) * 2016-08-16 2016-12-21 安徽天乾健食品科技有限公司 A kind of Fols Rehmanniae nourishing kidney the liver benefiting mixed oil and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101041675A (en) * 2006-03-24 2007-09-26 厦门牡丹香化实业有限公司 Method for extracting glutinous rehmannia oligose and glutinous rehmannia polysaccharide from glutinous rehmannia
CN101623313A (en) * 2009-01-22 2010-01-13 九芝堂股份有限公司 Method for preparing traditional Chinese medicine preparation for tonifying blood
CN102372751A (en) * 2010-08-13 2012-03-14 河南爱富帝食品有限公司 Extraction method of rehmannia catalpol
CN106234648A (en) * 2016-08-16 2016-12-21 安徽天乾健食品科技有限公司 A kind of Fols Rehmanniae nourishing kidney the liver benefiting mixed oil and preparation method thereof

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Application publication date: 20170613

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