CN106794185A - Rucaparib的高剂量强度片剂 - Google Patents

Rucaparib的高剂量强度片剂 Download PDF

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Publication number
CN106794185A
CN106794185A CN201580042815.9A CN201580042815A CN106794185A CN 106794185 A CN106794185 A CN 106794185A CN 201580042815 A CN201580042815 A CN 201580042815A CN 106794185 A CN106794185 A CN 106794185A
Authority
CN
China
Prior art keywords
tablet
active pharmaceutical
pharmaceutical ingredient
methyl
rucaparib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580042815.9A
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English (en)
Chinese (zh)
Inventor
J·埃特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clovis Oncology Inc
Original Assignee
Clovis Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clovis Oncology Inc filed Critical Clovis Oncology Inc
Priority to CN202110458329.2A priority Critical patent/CN113209033A/zh
Publication of CN106794185A publication Critical patent/CN106794185A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580042815.9A 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂 Pending CN106794185A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110458329.2A CN113209033A (zh) 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462040849P 2014-08-22 2014-08-22
US62/040,849 2014-08-22
US201562101739P 2015-01-09 2015-01-09
US62/101,739 2015-01-09
PCT/US2015/045522 WO2016028689A1 (en) 2014-08-22 2015-08-17 High dosage strength tablets of rucaparib

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110458329.2A Division CN113209033A (zh) 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂

Publications (1)

Publication Number Publication Date
CN106794185A true CN106794185A (zh) 2017-05-31

Family

ID=55347324

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580042815.9A Pending CN106794185A (zh) 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂
CN202110458329.2A Pending CN113209033A (zh) 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202110458329.2A Pending CN113209033A (zh) 2014-08-22 2015-08-17 Rucaparib的高剂量强度片剂

Country Status (23)

Country Link
US (3) US9987285B2 (https=)
EP (1) EP3182975B1 (https=)
JP (3) JP6574477B2 (https=)
KR (2) KR102803917B1 (https=)
CN (2) CN106794185A (https=)
AU (2) AU2015305696B2 (https=)
BR (1) BR112017000865A2 (https=)
CA (1) CA2955495C (https=)
DK (1) DK3182975T3 (https=)
ES (1) ES3048688T3 (https=)
FI (1) FI3182975T3 (https=)
HR (1) HRP20251484T1 (https=)
IL (1) IL249946B (https=)
LT (1) LT3182975T (https=)
MX (1) MX367260B (https=)
NZ (1) NZ728392A (https=)
PL (1) PL3182975T3 (https=)
PT (1) PT3182975T (https=)
RS (1) RS67356B1 (https=)
RU (1) RU2705156C2 (https=)
SG (1) SG11201700265VA (https=)
SI (1) SI3182975T1 (https=)
WO (1) WO2016028689A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108853030A (zh) * 2018-09-26 2018-11-23 李敏 一种治疗恶性肿瘤的药物制剂及其制备方法
CN109111454A (zh) * 2018-08-01 2019-01-01 宁波金未生物科技有限公司 一种瑞卡帕布s-樟脑磺酸盐
WO2020113500A1 (zh) * 2018-12-06 2020-06-11 上海诚妙医药科技有限公司 芦卡帕利樟脑磺酸盐的新晶型和制备方法及其用途
CN111278433A (zh) * 2017-09-26 2020-06-12 特沙诺有限公司 尼拉帕尼制剂

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JP6491669B2 (ja) 2014-02-05 2019-03-27 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｇｒｐ活性化合物の錠剤製剤
US12168004B2 (en) 2014-02-05 2024-12-17 Merck Sharp & Dohme Llc Treatment of migraine
KR102803917B1 (ko) 2014-08-22 2025-05-07 파르마＆ 슈바이츠 게엠베하 루카파립의 고 용량 강도 정제
CN106008530B (zh) * 2016-07-24 2018-06-26 石家庄久正生物科技有限公司 一种抗卵巢癌药物Rucaparib关键中间体的制备方法
CN108201534A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种瑞卡帕布口服缓控释药物组合物及其用途
US10875870B2 (en) 2017-01-24 2020-12-29 Assia Chemical Industries Ltd. Solid state forms of rucaparib and of rucaparib salts
BR112019020211A2 (pt) 2017-03-27 2020-04-22 Tesaro, Inc. composições de niraparib
WO2019130229A1 (en) 2017-12-28 2019-07-04 Mylan Laboratories Ltd Methods and intermediates for preparing rucaparib
KR20200121800A (ko) 2018-01-05 2020-10-26 싸이브렉사 1, 인크. 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법
US12383545B1 (en) 2018-06-08 2025-08-12 Allergan Pharmaceuticals International Limited Treatment of migraine
CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
EP4143182B1 (en) 2020-04-28 2024-12-11 Rhizen Pharmaceuticals AG Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
EP4182318B1 (en) 2020-07-14 2025-08-27 Assia Chemical Industries Ltd. Solid state forms of rucaparib salts
CN116390712A (zh) 2020-07-29 2023-07-04 阿勒根制药国际有限公司 治疗偏头痛
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
CA3206184A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
IL307339A (en) 2021-04-08 2023-11-01 Rhizen Pharmaceuticals Ag Poly(ADP-ribose) polymerase inhibitors
WO2023049920A1 (en) 2021-09-27 2023-03-30 Allergan Pharmaceuticals International Limited Combination comprising atogepant for treating migraine
WO2023086784A1 (en) * 2021-11-10 2023-05-19 Crititech, Inc. Rucaparib particles and uses thereof
WO2023137060A1 (en) 2022-01-11 2023-07-20 Assia Chemical Industries Ltd. Solid state forms of rucaparib tosylate

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CN102884066A (zh) * 2010-02-12 2013-01-16 辉瑞公司 8-氟-2-{4-[(甲氨基)甲基]苯基}-1,3,4,5-四氢-6H-氮杂*并[5,4,3-cd]吲哚-6-酮的盐和多晶型物

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OA11749A (en) 1999-01-11 2005-07-19 Agouron Pharma Tricyclic inhibitors of poly(adp-ribose)polymerases.
MXPA05010563A (es) 2003-03-31 2005-11-23 Pfizer Sales de los inhibidores triciclicos de las poli(adp-ribosa) polimerasas.
SI1660095T1 (sl) 2003-07-25 2010-05-31 Cancer Rec Tech Ltd Triciklični parp inhibitorji
EP1793830A2 (en) 2004-09-22 2007-06-13 Pfizer, Inc. Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor
EP1799685B1 (en) 2004-09-22 2012-03-28 Pfizer Inc. Polymorphic forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
DK1794163T3 (da) 2004-09-22 2010-04-12 Pfizer Fremgangsmåde til fremstilling af poly(ADP-ribose)polymeraseinhibitorer
JP2011516527A (ja) 2008-04-09 2011-05-26 レツク・フアーマシユーテイカルズ・デー・デー 医薬品有効成分の造粒
CA2869309C (en) 2012-04-05 2021-02-09 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
KR102803917B1 (ko) 2014-08-22 2025-05-07 파르마＆ 슈바이츠 게엠베하 루카파립의 고 용량 강도 정제

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CN102884066A (zh) * 2010-02-12 2013-01-16 辉瑞公司 8-氟-2-{4-[(甲氨基)甲基]苯基}-1,3,4,5-四氢-6H-氮杂*并[5,4,3-cd]吲哚-6-酮的盐和多晶型物

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111278433A (zh) * 2017-09-26 2020-06-12 特沙诺有限公司 尼拉帕尼制剂
TWI843707B (zh) * 2017-09-26 2024-06-01 美商提薩羅有限公司 尼拉帕尼（ｎｉｒａｐａｒｉｂ）調配物
CN109111454A (zh) * 2018-08-01 2019-01-01 宁波金未生物科技有限公司 一种瑞卡帕布s-樟脑磺酸盐
CN108853030A (zh) * 2018-09-26 2018-11-23 李敏 一种治疗恶性肿瘤的药物制剂及其制备方法
CN108853030B (zh) * 2018-09-26 2021-10-01 上海朝晖药业有限公司 一种治疗恶性肿瘤的药物制剂及其制备方法
WO2020113500A1 (zh) * 2018-12-06 2020-06-11 上海诚妙医药科技有限公司 芦卡帕利樟脑磺酸盐的新晶型和制备方法及其用途

Also Published As

Publication number Publication date
RU2705156C2 (ru) 2019-11-05
US10130636B2 (en) 2018-11-20
RU2017109139A (ru) 2018-09-24
US20190099430A1 (en) 2019-04-04
JP6797980B2 (ja) 2020-12-09
ES3048688T3 (en) 2025-12-11
CA2955495C (en) 2023-09-19
JP7127101B2 (ja) 2022-08-29
SG11201700265VA (en) 2017-02-27
MX367260B (es) 2019-08-12
NZ728392A (en) 2023-06-30
PT3182975T (pt) 2025-10-28
KR20230097211A (ko) 2023-06-30
AU2015305696A1 (en) 2017-02-02
RS67356B1 (sr) 2025-11-28
EP3182975A1 (en) 2017-06-28
JP2017525712A (ja) 2017-09-07
AU2019272064A1 (en) 2019-12-19
RU2017109139A3 (https=) 2019-03-06
IL249946A0 (en) 2017-03-30
JP2020002149A (ja) 2020-01-09
LT3182975T (lt) 2025-11-25
PL3182975T3 (pl) 2026-02-23
MX2017001540A (es) 2017-05-11
EP3182975A4 (en) 2018-04-18
HRP20251484T1 (hr) 2026-01-02
US20160051561A1 (en) 2016-02-25
KR102803917B1 (ko) 2025-05-07
CA2955495A1 (en) 2016-02-25
AU2015305696B2 (en) 2019-08-29
JP6574477B2 (ja) 2019-09-11
US9987285B2 (en) 2018-06-05
SI3182975T1 (sl) 2025-12-31
US20180200260A1 (en) 2018-07-19
EP3182975B1 (en) 2025-10-01
AU2019272064B2 (en) 2021-11-18
DK3182975T3 (da) 2025-10-20
IL249946B (en) 2020-05-31
FI3182975T3 (fi) 2025-11-13
KR20170043597A (ko) 2017-04-21
JP2021038242A (ja) 2021-03-11
CN113209033A (zh) 2021-08-06
WO2016028689A1 (en) 2016-02-25
BR112017000865A2 (pt) 2017-12-05

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SE01 Entry into force of request for substantive examination
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RJ01 Rejection of invention patent application after publication

Application publication date: 20170531

RJ01 Rejection of invention patent application after publication