CN106794183A - 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 - Google Patents
含有细胞周期蛋白抑制剂的药物制剂及其制备方法 Download PDFInfo
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- CN106794183A CN106794183A CN201580043546.8A CN201580043546A CN106794183A CN 106794183 A CN106794183 A CN 106794183A CN 201580043546 A CN201580043546 A CN 201580043546A CN 106794183 A CN106794183 A CN 106794183A
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
本发明涉及一种以6‑乙酰基‑8‑环戊基‑5‑甲基‑2‑(5‑哌嗪‑1‑基‑吡啶‑2‑基氨基)‑8H‑吡啶并[2,3‑d]嘧啶‑7‑酮或其盐为活性成分的药物制剂，所述盐包括盐酸盐、羟乙基磺酸盐，所述药物剂型包括片剂、胶囊剂。所述剂型均具有良好的稳定性以及优异的溶出行为。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014106238102 | 2014-11-07 | ||
| CN201410623810.2A CN105616418A (zh) | 2014-11-07 | 2014-11-07 | 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 |
| PCT/CN2015/093953 WO2016070834A1 (zh) | 2014-11-07 | 2015-11-06 | 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
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| CN106794183A true CN106794183A (zh) | 2017-05-31 |
| CN106794183B CN106794183B (zh) | 2021-06-18 |
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| CN201410623810.2A Pending CN105616418A (zh) | 2014-11-07 | 2014-11-07 | 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 |
| CN201580043546.8A Active CN106794183B (zh) | 2014-11-07 | 2015-11-06 | 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 |
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| CN201410623810.2A Pending CN105616418A (zh) | 2014-11-07 | 2014-11-07 | 含有细胞周期蛋白抑制剂的药物制剂及其制备方法 |
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| Country | Link |
|---|---|
| US (1) | US20180280392A1 (zh) |
| EP (1) | EP3216450B1 (zh) |
| JP (1) | JP6682739B2 (zh) |
| CN (2) | CN105616418A (zh) |
| TW (1) | TWI704918B (zh) |
| WO (1) | WO2016070834A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11464779B2 (en) | 2016-03-29 | 2022-10-11 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| US11471418B2 (en) | 2020-09-29 | 2022-10-18 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical compositions of amorphous solid dispersions and methods of preparation thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314148A (zh) * | 2019-05-07 | 2019-10-11 | 安徽金太阳生化药业有限公司 | 一种磷酸氢钙片的制备方法 |
| WO2022063119A1 (zh) * | 2020-09-24 | 2022-03-31 | 南京济群医药科技股份有限公司 | 一种羟乙磺酸哌柏西利的组合物及药物 |
| WO2024104448A1 (zh) * | 2022-11-18 | 2024-05-23 | 轩竹生物科技股份有限公司 | CDKs抑制剂的药物组合物及制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101001857A (zh) * | 2002-01-22 | 2007-07-18 | 沃尼尔·朗伯有限责任公司 | 2－(吡啶－2－基氨基)－吡啶并[2,3－d]嘧啶－7－酮 |
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| US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
| ATE412650T1 (de) * | 2003-07-11 | 2008-11-15 | Warner Lambert Co | Isethionat salz eines selektiven cdk4 inhibitors |
| EP2076249A2 (en) * | 2006-10-27 | 2009-07-08 | FMC Corporation | Dry granulation binders, products, and use thereof |
| TW201129386A (en) * | 2009-11-05 | 2011-09-01 | Fmc Corp | Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients |
| WO2014128588A1 (en) * | 2013-02-21 | 2014-08-28 | Pfizer Inc. | Solid forms of a selective cdk4/6 inhibitor |
| WO2016030439A1 (en) * | 2014-08-28 | 2016-03-03 | Ratiopharm Gmbh | Method of producing palbociclib and pharmaceutical compositions comprising the same |
| KR102369405B1 (ko) * | 2015-06-04 | 2022-03-02 | 화이자 인코포레이티드 | 팔보시클립의 고체 투여 형태 |
| CN104892604B (zh) * | 2015-06-19 | 2016-08-24 | 北京康立生医药技术开发有限公司 | 一种cdk4抑制剂的合成方法 |
| CN105213322A (zh) * | 2015-10-30 | 2016-01-06 | 南京正大天晴制药有限公司 | 一种干法制粒工艺制备的药物组合物 |
-
2014
- 2014-11-07 CN CN201410623810.2A patent/CN105616418A/zh active Pending
-
2015
- 2015-11-06 US US15/524,394 patent/US20180280392A1/en not_active Abandoned
- 2015-11-06 CN CN201580043546.8A patent/CN106794183B/zh active Active
- 2015-11-06 TW TW104136656A patent/TWI704918B/zh not_active IP Right Cessation
- 2015-11-06 WO PCT/CN2015/093953 patent/WO2016070834A1/zh active Application Filing
- 2015-11-06 JP JP2017521077A patent/JP6682739B2/ja not_active Expired - Fee Related
- 2015-11-06 EP EP15857367.5A patent/EP3216450B1/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101001857A (zh) * | 2002-01-22 | 2007-07-18 | 沃尼尔·朗伯有限责任公司 | 2－(吡啶－2－基氨基)－吡啶并[2,3－d]嘧啶－7－酮 |
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| Title |
|---|
| ANONYMOUS: "HIGHLIGHTS OF PRESCRIBING INFORMATION.IBRANCE(palbociclib) capsules, for oral use", 《HIGHLIGHTS OF PRESCRIBING INFORMATION.IBRANCE(PALBOCICLIB) CAPSULES, FOR ORAL USE》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11464779B2 (en) | 2016-03-29 | 2022-10-11 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| US11471418B2 (en) | 2020-09-29 | 2022-10-18 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical compositions of amorphous solid dispersions and methods of preparation thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016070834A1 (zh) | 2016-05-12 |
| EP3216450A4 (en) | 2018-06-13 |
| EP3216450A8 (en) | 2018-02-07 |
| TW201617082A (zh) | 2016-05-16 |
| CN105616418A (zh) | 2016-06-01 |
| JP6682739B2 (ja) | 2020-04-15 |
| TWI704918B (zh) | 2020-09-21 |
| JP2017532347A (ja) | 2017-11-02 |
| US20180280392A1 (en) | 2018-10-04 |
| CN106794183B (zh) | 2021-06-18 |
| EP3216450A1 (en) | 2017-09-13 |
| EP3216450B1 (en) | 2021-09-22 |
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