CN1067892A - 新的吡咯并[2，3-b]吡啶衍生物的制备方法 - Google Patents

新的吡咯并[2，3-b]吡啶衍生物的制备方法 Download PDF

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Publication number
CN1067892A
CN1067892A CN92102170A CN92102170A CN1067892A CN 1067892 A CN1067892 A CN 1067892A CN 92102170 A CN92102170 A CN 92102170A CN 92102170 A CN92102170 A CN 92102170A CN 1067892 A CN1067892 A CN 1067892A
Authority
CN
China
Prior art keywords
compound
definition
pyridine
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92102170A
Other languages
English (en)
Chinese (zh)
Inventor
C·布赖芬
M·埃利布林
S·卡尔松
R·卡特
T·屈勒
P·努德贝里
I·施塔克
A·施文松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CN1067892A publication Critical patent/CN1067892A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN92102170A 1991-03-27 1992-03-27 新的吡咯并[2，3-b]吡啶衍生物的制备方法 Pending CN1067892A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9100920A SE9100920D0 (sv) 1991-03-27 1991-03-27 New active compounds
SE9100920 1991-03-27

Publications (1)

Publication Number Publication Date
CN1067892A true CN1067892A (zh) 1993-01-13

Family

ID=20382295

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92102170A Pending CN1067892A (zh) 1991-03-27 1992-03-27 新的吡咯并[2，3-b]吡啶衍生物的制备方法

Country Status (30)

Country Link
US (1) US5439917A (enExample)
EP (2) EP0509974B1 (enExample)
JP (1) JP3122792B2 (enExample)
CN (1) CN1067892A (enExample)
AP (1) AP309A (enExample)
AT (1) ATE175672T1 (enExample)
AU (1) AU655634B2 (enExample)
BG (1) BG98124A (enExample)
CA (1) CA2106880A1 (enExample)
DE (1) DE69228142T2 (enExample)
DK (1) DK0509974T3 (enExample)
ES (1) ES2129039T3 (enExample)
FI (1) FI934203A0 (enExample)
GR (1) GR3029834T3 (enExample)
HU (1) HUT65948A (enExample)
IE (1) IE920915A1 (enExample)
IL (1) IL101347A0 (enExample)
IS (1) IS3827A (enExample)
JO (1) JO1704B1 (enExample)
MA (1) MA22477A1 (enExample)
MX (1) MX9201324A (enExample)
NO (1) NO933425L (enExample)
NZ (1) NZ241943A (enExample)
SE (1) SE9100920D0 (enExample)
SK (1) SK103093A3 (enExample)
TN (1) TNSN92026A1 (enExample)
TW (1) TW198032B (enExample)
WO (1) WO1992017477A1 (enExample)
YU (1) YU30292A (enExample)
ZA (1) ZA921823B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100920D0 (sv) * 1991-03-27 1991-03-27 Astra Ab New active compounds
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
DZ3377A1 (fr) * 1999-12-24 2001-07-05 Aventis Pharma Ltd Azaindoles
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
EP1490364B1 (en) * 2002-03-28 2007-09-26 Eisai R&D Management Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
GB0305142D0 (en) * 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
PL1606261T3 (pl) 2003-03-10 2010-04-30 Astrazeneca Ab Nowy sposób przygotowania roflumilastu
US6981980B2 (en) 2003-03-19 2006-01-03 Phagia Technology Self-inflating intragastric volume-occupying device
US7612086B2 (en) * 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
EP1861074B1 (en) * 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100920D0 (sv) * 1991-03-27 1991-03-27 Astra Ab New active compounds

Also Published As

Publication number Publication date
MA22477A1 (fr) 1992-10-01
IE920915A1 (en) 1992-10-07
NZ241943A (en) 1993-12-23
SK103093A3 (en) 1994-08-10
NO933425L (no) 1993-10-25
WO1992017477A1 (en) 1992-10-15
ES2129039T3 (es) 1999-06-01
CA2106880A1 (en) 1992-09-28
ZA921823B (en) 1992-11-25
TW198032B (enExample) 1993-01-11
AU1426092A (en) 1992-11-02
FI934203A7 (fi) 1993-09-24
ATE175672T1 (de) 1999-01-15
AP309A (en) 1994-01-13
EP0509974B1 (en) 1999-01-13
HU9302741D0 (en) 1993-12-28
DE69228142D1 (de) 1999-02-25
HUT65948A (en) 1994-08-29
DE69228142T2 (de) 1999-07-22
AU655634B2 (en) 1995-01-05
FI934203L (fi) 1993-09-24
SE9100920D0 (sv) 1991-03-27
IS3827A (is) 1992-09-28
JPH06506448A (ja) 1994-07-21
YU30292A (sh) 1995-01-31
DK0509974T3 (da) 1999-08-30
IL101347A0 (en) 1992-11-15
US5439917A (en) 1995-08-08
TNSN92026A1 (fr) 1993-06-08
BG98124A (bg) 1994-11-15
EP0509974A1 (en) 1992-10-21
JP3122792B2 (ja) 2001-01-09
FI934203A0 (fi) 1993-09-24
EP0580616A1 (en) 1994-02-02
AP9200369A0 (en) 1992-04-30
MX9201324A (es) 1992-10-01
NO933425D0 (no) 1993-09-24
GR3029834T3 (en) 1999-06-30
JO1704B1 (en) 1992-12-15

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