CN106729522A - One kind treats anginal pharmaceutical formulation and preparation method thereof - Google Patents

One kind treats anginal pharmaceutical formulation and preparation method thereof Download PDF

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Publication number
CN106729522A
CN106729522A CN201611165516.7A CN201611165516A CN106729522A CN 106729522 A CN106729522 A CN 106729522A CN 201611165516 A CN201611165516 A CN 201611165516A CN 106729522 A CN106729522 A CN 106729522A
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preparation
treatment
pharmaceutical formulation
chinese medicine
course
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李煜辉
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Anginal pharmaceutical formulation and preparation method thereof is treated the invention discloses one kind, is by weight to include following traditional Chinese medicine ingredients:Cortex magnoliae officinalis 13g, dried immature fruit of citron orange 11g, cassia twig 13g, tuber of pinellia 13g, red sage root 11g, Snakegourd Fruit 16g, radix rehmanniae recen 11g, Poria cocos 11g bighead atractylodes rhizome 13g, caulis perllae 13g rhizoma zingiberis 6g, honey-fried licorice root 13g.The preparation and application of Chinese medicine composition of the present invention:It is decocted in water for oral dose:Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the course for the treatment of of medication 26.

Description

One kind treats anginal pharmaceutical formulation and preparation method thereof
Technical field
It is to be related to a kind of treat anginal pharmaceutical formulation and its system specifically the invention belongs to Chinese medicine composition Preparation Method.
Background technology
Angina pectoris refer to because coronary atherosclerosis cause coronary insufficiency, myocardium ischemia with With precordialgia as main clinical manifestation one group of syndrome caused by anoxic.Its feature is the shirtfront squeezing property of paroxysmal Sensation of pain, can be with other symptoms, and pain is predominantly located at breastbone rear portion, can be radiated to pareordia and left upper extremity, often betides When working or be excited, last for several minutes is rested or is disappeared with after nitrate preparations.This disease is more common in male, most patients It is tired, excited more than 40 years old, it to be satiated with food, catches cold, rainy weather, acute circulatory failure etc. is common inducement.The property heart Angina should squeeze to tighten, compressing asphyxia, and heavy vexed swollen property pain is frequently located in breastbone or its is neighbouring outside tract pain or discomfort, May also occur at upper abdomen to any level between pharyngeal.Risk factor is secondly excited based on physical fatigue, is stepped on Building, level land skelps, exposed to cold environment, enter cold drink, the pain at other positions of body, and terrified, anxiety, get angry, it is tired of The emotional change such as angry, can all induce.Symptom being treated Western medicine, it is impossible to effectively treat the disease, and utilize Chinese herbal treatment, with peace more Entirely, effective advantage.
The present invention for treating pharmaceutical formulation and preparation method thereof of angina pectoris nursing, for angina pectoris etiology and pathogenesis, with It is clearing heat and detoxicating, clearing heat and promoting diuresis, cleaning heat and expelling wind, restore menstrual flow and invigorate blood circulation, promoting circulation of blood detumescence, promoting blood circulation to remove blood stasis, dissipating bind dredging collateral be the rules for the treatment of, reach cold dispelling Wen Yang, coronary circulation-promoting pain-relieving treats anginal effect.
The content of the invention
Present invention aim to address the problem in prior art, spy provide a kind of effect substantially, the course for the treatment of is shorter controls Treat anginal pharmaceutical formulation and preparation method thereof.
In order to realize foregoing invention purpose, the present invention is made the raw material composition and its weight proportion of the effective ingredient For:Cortex magnoliae officinalis 13g, dried immature fruit of citron orange 11g, cassia twig 13g, tuber of pinellia 13g, red sage root 11g, Snakegourd Fruit 16g, radix rehmanniae recen 11g, Poria cocos 11g bighead atractylodes rhizome 13g, Caulis perllae 13g rhizoma zingiberis 6g, honey-fried licorice root 13g.The preparation and application of Chinese medicine composition of the present invention:It is decocted in water for oral dose:Daily 1 dose, 7 doses are One course for the treatment of is, it is necessary to the medication 2-6 courses for the treatment of.
Invent for treating anginal pharmaceutical formulation and preparation method thereof, natural drug is selected, for the angina pectoris cause of disease The interpretation of the cause, onset and process of an illness, ingredients respectively has its effect, coordinates mutually, the dried immature fruit of citron orange, general river, Snakegourd Fruit, caulis perllae Su Chang mechanisms of qi in side;Cassia twig temperature chest activates yang, Poria cocos, the tuber of pinellia, bighead atractylodes rhizome invigorating the spleen to dry, in case mechanism of qi retardance triggers stopping in turbid phlegm, the red sage root, radix rehmanniae recen nourshing blood and promoting blood circulation.Above-mentioned all tastes Medicine is shared, and mutually collaboration brings out the best in each other, play altogether clearing heat and detoxicating, clearing heat and promoting diuresis, cleaning heat and expelling wind, restore menstrual flow and invigorate blood circulation, it is promoting circulation of blood detumescence, living Blood dissipates the stasis of blood, the effect of dissipating bind dredging collateral, reaches the work of stasis of blood blood, and unobstructed vessel, phlegm network leads to, and treats anginal effect.
Specific embodiment
Embodiment 1:It is a kind of to treat anginal pharmaceutical formulation and preparation method thereof, by weight including following Chinese medicine Composition:Cortex magnoliae officinalis 13g, dried immature fruit of citron orange 11g, cassia twig 13g, tuber of pinellia 13g, red sage root 11g, Snakegourd Fruit 16g, radix rehmanniae recen 11g, the Poria cocos 11g bighead atractylodes rhizomes 13g, caulis perllae 13g rhizoma zingiberis 6g, honey-fried licorice root 13g.
It is decocted in water for oral dose:Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the medication 2-6 courses for the treatment of.
The pharmaceutical formulation for angina pectoris nursing of the present invention and preparation method thereof is illustrated below by way of practical example Clinical therapeutic efficacy.
1st, clinical data
50 patient with angina pectoris, patient's average age 45 ± 20 years old (25~65 years old), meet "《Chinese medical disease Standardization of diagnosis and curative effect》 Angina diagnostic criteria in (State Administration of Traditional Chinese Medicine's promulgation) ", full diagnostics is patient with angina pectoris.
50 patient with angina pectoris all have the symptoms such as pectoralgia, cardiac arrhythmia, heart failure.
Criterion of therapeutical effect
Cure:Clinical symptom disappearance, cardiac muscle detection is normal;
It is effective:Clinical symptoms substantially mitigate, and patient's rhythm of the heart is neat, painless;
It is invalid:Clinical symptoms are without substantially mitigation, exacerbation of symptoms, and it is invalid to be judged to.
3rd, treatment results
After 50 patient with angina pectoris treat 3~4 courses for the treatment of, cure 38, treat effective 8, invalid 2.Treating total effective rate is 93%.
Typical case:
Hu, man, 51 years old, patient was with " ictal more than 2 years uncomfortable in chest, exacerbation 2 days." be chief complaint and be admitted to hospital, its main medical history is as follows:2 Occur uncomfortable in chest after feed before year, position is pareordia, after lasting about 5 minutes can spontaneous remission, without pectoralgia, shoulder back Rediating Pain, Without dizziness, blindness, faint, without orthopnea, nocturnal paroxysmal dyspnea, without sour regurgitation, heartburn, do not treat.It is interrupted hair over 2 years Make, occur above-mentioned symptom after being taken food before 2 days again, breaking-out is frequent, about 3 times/day, about 10 minutes is lasted every time, and buccal is " quick-acting to rescue Can alleviate after heart ball ", be treatment, emergency our hospital accepts my section for medical treatment with " coronary disease and angina pectoris ".Since morbidity, mind is clear, spirit Difference, diet sleep can, stool and urine is normal, and recent body weight is without substantially increase and decrease.AD;Coronary atherosclerotic heart disease Unstable angina pectoris.6 doses of inventive formulation is taken afterwards, is decocted in water for oral dose, daily 1 dose, daily 3 clothes.Second examines:Spinning sensation is bright It is aobvious to mitigate, 12 doses of following the service.Three examine:Pain elementary solution is removed, and is after treatment effect afterwards, is advised and is continued to take 12 doses.Follow-up 1 year, All go well.

Claims (2)

1. one kind treats anginal pharmaceutical formulation and preparation method thereof, it is characterised in that:The pharmaceutical formulation and preparation method thereof Include following traditional Chinese medicine ingredients by weight:Cortex magnoliae officinalis 13g, dried immature fruit of citron orange 11g, cassia twig 13g, tuber of pinellia 13g, red sage root 11g, Snakegourd Fruit 16g are raw Glutinous rehmannia 11g, Poria cocos 11g bighead atractylodes rhizome 13g, caulis perllae 13g rhizoma zingiberis 6g, honey-fried licorice root 13g.
2. the preparation and application of Chinese medicine composition of the present invention:It is decocted in water for oral dose:Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to medication 2-6 The course for the treatment of.
CN201611165516.7A 2016-12-16 2016-12-16 One kind treats anginal pharmaceutical formulation and preparation method thereof Withdrawn CN106729522A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596227A (en) * 2017-08-11 2018-01-19 孟广千 For rushing down the Chinese medicine composition of spleen treatment heart real example disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596227A (en) * 2017-08-11 2018-01-19 孟广千 For rushing down the Chinese medicine composition of spleen treatment heart real example disease

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Application publication date: 20170531