CN106692872A - Medicine for treating angina pectoris and preparation method thereof - Google Patents

Medicine for treating angina pectoris and preparation method thereof Download PDF

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Publication number
CN106692872A
CN106692872A CN201611164586.0A CN201611164586A CN106692872A CN 106692872 A CN106692872 A CN 106692872A CN 201611164586 A CN201611164586 A CN 201611164586A CN 106692872 A CN106692872 A CN 106692872A
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medicine
preparation
treatment
angina pectoris
dose
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李代红
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a medicine for treating angina pectoris and a preparation method thereof. The medicine comprises, by weight parts, 16 g of red peony root, 9 g of snake gourd fruit, 16 g of ligusticum wallichii, 18 g of salvia miltiorrhiza, 16 g of curcuma aromatica, 18 g of rhizoma corydalis, 1 8 of raw hawthorn, 16 g of pheretima, 9 g of cassia twigs, 4 g of asarum sieboldii, 9 g of mallow, 18 g of astragalus, 18 g of epimedium herb and 4 g of raw leech powder. According to the method for preparing and using the traditional Chinese medicine composition, the medicine is decocted in water for oral dose, a dose is taken every day, 3 doses serve as a course of treatment, and 2-6 courses f treatment need to be used.

Description

One kind treats anginal medicine and preparation method thereof
Technical field
It is to be related to a kind of treat anginal medicine and its preparation side specifically the invention belongs to Chinese medicine composition Method.
Background technology
Angina pectoris refer to because coronary atherosclerosis cause coronary insufficiency, myocardium ischemia with With precordialgia as main clinical manifestation one group of syndrome caused by anoxic.Its feature is the shirtfront squeezing property of paroxysmal Sensation of pain, can be with other symptoms, and pain is predominantly located at breastbone rear portion, can be radiated to pareordia and left upper extremity, often betides When working or be excited, last for several minutes is rested or is disappeared with after nitrate preparations.This disease is more common in male, most patients It is tired, excited more than 40 years old, it to be satiated with food, catches cold, rainy weather, acute circulatory failure etc. is common inducement.The property heart Angina should squeeze to tighten, compressing asphyxia, and heavy vexed swollen property pain is frequently located in breastbone or its is neighbouring outside tract pain or discomfort, May also occur at upper abdomen to any level between pharyngeal.Risk factor is secondly excited based on physical fatigue, is stepped on Building, level land skelps, and exposed to cold environment, enters cold drink, the pain at other positions of body, and terrified, anxiety, gets angry, and is tired of The emotional change such as angry, can all induce.Symptom being treated Western medicine, it is impossible to effectively treat the disease, and utilize Chinese herbal treatment, with peace more Entirely, effective advantage.
The present invention is used to treat medicine of angina pectoris nursing and preparation method thereof, for angina pectoris etiology and pathogenesis, with heat-clearing Removing toxic substances, clearing heat and promoting diuresis, cleaning heat and expelling wind, restore menstrual flow and invigorate blood circulation, promoting circulation of blood detumescence, promoting blood circulation to remove blood stasis, dissipating bind dredging collateral be the rules for the treatment of, reach cold dispelling temperature Sun, coronary circulation-promoting pain-relieving treats anginal effect.
The content of the invention
Present invention aim to address the problem in prior art, spy provide a kind of effect substantially, the course for the treatment of is shorter controls Treat anginal medicine and preparation method thereof.
In order to realize foregoing invention purpose, the present invention is made the raw material composition and its weight proportion of the effective ingredient For：Radix paeoniae rubrathe 16g, Snakegourd Fruit 9g, Ligusticum wallichii 16g, red sage root 18g, root tuber of aromatic turmeric 16g, corydalis tuber 18g, raw hawthorn 18g, LUMBRICUS 16g, cassia twig 9g, asarum 4g , Bi Plantain 9g, Radix Astragali 18g, barrenwort 18g, unprocessed leech powder 4g.The preparation of Chinese medicine composition of the present invention and user Method：It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the medication 2-6 courses for the treatment of.
Invent for treating anginal medicine and preparation method thereof, select natural drug, for angina pectoris etiology and pathogenesis, Ingredients respectively has its effect, coordinates mutually, with Radix Astragali benefiting qi for promoting granulation in side, recovers cardiomyocyte viability；Kidney tonifying that barrenwort is supporing yang, The radix paeoniae rubrathe, Ligusticum wallichii, the red sage root, root tuber of aromatic turmeric, corydalis tuber, hawthorn LUMBRICUS are promoting blood circulation and removing blood stasis, relieve pain promote blood circulation Snakegourd Fruit dissipating bind slit phlegm, qi-regulating chest wide； Cassia twig, asarum, pyrene Plantain promote blood circulation Wen Jing, and the logical numbness of Xuan Yang is controlling its mark.Above-mentioned all herbal medicines are shared, and mutually collaboration brings out the best in each other, altogether Play clearing heat and detoxicating, clearing heat and promoting diuresis, cleaning heat and expelling wind, restore menstrual flow and invigorate blood circulation, promoting circulation of blood detumescence, promoting blood circulation to remove blood stasis, the effect of dissipating bind dredging collateral, reach the stasis of blood Blood is lived, unobstructed vessel, and phlegm network leads to, and treats anginal effect.
Specific embodiment
Embodiment 1：It is a kind of to treat anginal medicine and preparation method thereof, by weight including following Chinese medicine into Point：Radix paeoniae rubrathe 16g, Snakegourd Fruit 9g, Ligusticum wallichii 16g, red sage root 18g, root tuber of aromatic turmeric 16g, corydalis tuber 18g, raw hawthorn 18g, LUMBRICUS 16g, cassia twig 9g, asarum 4g , Bi Plantain 9g, Radix Astragali 18g, barrenwort 18g, unprocessed leech powder 4g.
Embodiment 2：If patient has peripheral coldness symptom, red ginseng 9g, fruit of Chinese magnoliavine 9g, RADIX ACONITI LATERALIS PREPARATA are added in said components 16g, rhizoma zingiberis 9g, Chinese cassia tree 6g.
It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the medication 2-6 courses for the treatment of.
The clinic of the medicine for angina pectoris nursing of the present invention and preparation method thereof is illustrated below by way of practical example Therapeutic effect.
1st, clinical data
50 patient with angina pectoris, patient's average age 45 ± 20 years old (25~65 years old), meet "《Chinese medical disease Standardization of diagnosis and curative effect》 Angina diagnostic criteria in (State Administration of Traditional Chinese Medicine's promulgation) ", full diagnostics is patient with angina pectoris.
50 patient with angina pectoris all have the symptoms such as pectoralgia, cardiac arrhythmia, heart failure.
Criterion of therapeutical effect
Cure：Clinical symptom disappearance, cardiac muscle detection is normal；
It is effective：Clinical symptoms substantially mitigate, and patient's rhythm of the heart is neat, painless；
It is invalid：Clinical symptoms are without substantially mitigation, exacerbation of symptoms, and it is invalid to be judged to.
3rd, treatment results
After 50 patient with angina pectoris treat 3~4 courses for the treatment of, cure 38, treat effective 8, invalid 2.Treating total effective rate is 93%.
Typical case：
Chen, man, 66 years old.Because of precordialgia 2 years after activity, exacerbation is admitted to hospital for 2 months.Patient started appearance during upper 4 floor before 2 years Precordialgia, in vexed pain, aches with left upper extremity, and tens seconds to 1 minute are continued every time, and rest about l/min can be alleviated, every month Breaking-out 1~2 time.Started before 2 months firmly, it is excited when there is precordial fullness bitterly, last up to 10 minutes, with cold sweat, head Confused, weak, while there is whole left upper extremity to ache or uncomfortable, precordialgia is broken out, is disappeared simultaneously with left upper extremity pain, sometimes left Upper extremity pain first sends out l~2 minute compared with precordialgia, through rest or buccal " suxiao jiuxin pills " or " sorbitrate tablet " 3~5 minutes Can alleviate, break out every month 5~6 times.There is hyperpiesia history 10 years, controlling of blood pressure is unknown, treatment by Chinese herbs is determined afterwards. 6 doses of inventive formulation is taken, is decocted in water for oral dose, daily 1 dose, daily 3 clothes.Second examines：Spinning sensation substantially mitigates, 12 doses of following the service, and three examine： Pain elementary solution is removed, and is after treatment effect afterwards, is advised and is continued to take 12 doses.Follow-up 1 year, all goes well.

Claims (3)

1. one kind treats anginal medicine and preparation method thereof, it is characterised in that：The medicine and preparation method thereof is by weight Number includes following traditional Chinese medicine ingredients：Radix paeoniae rubrathe 16g, Snakegourd Fruit 9g, Ligusticum wallichii 16g, red sage root 18g, root tuber of aromatic turmeric 16g, corydalis tuber 18g, raw hawthorn 18g, LUMBRICUS 16g, cassia twig 9g, asarum 4g , Bi Plantain 9g, Radix Astragali 18g, barrenwort 18g, unprocessed leech powder 4g.
2. anginal medicine and preparation method thereof is treated as claimed in claim 1, it is characterised in that：The medicine and its preparation Method also includes red ginseng 9g, fruit of Chinese magnoliavine 9g, RADIX ACONITI LATERALIS PREPARATA 16g, rhizoma zingiberis 9g, Chinese cassia tree 6g.
3. the preparation and application of Chinese medicine composition of the present invention：It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to medication 2-6 The course for the treatment of.
CN201611164586.0A 2016-12-16 2016-12-16 Medicine for treating angina pectoris and preparation method thereof Pending CN106692872A (en)

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