CN106728924A - It is a kind of to treat Chinese medicine composition of leukaemia and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of leukaemia and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of Chinese medicine composition for treating leukaemia.The Chinese medicine composition is made up of indigo naturalis (nanometer), realgar (nanometer), oldenlandia diffusa, subprostrate sophora, Cordyceps militaris, the red sage root, felwort, edible tulip；The invention also discloses the preparation method of the Chinese medicine composition.There is Chinese medicine composition of the present invention clearing heat and detoxicating, promoting blood circulation and removing blood stasis, righting of getting rid of evils etc. to act on, and clinically for treating leukaemia, with preferable curative effect, and security is good.
Description
Technical field
The present invention is to be related to a kind of Chinese medicine composition, specifically, be related to a kind of Chinese medicine composition for treating leukaemia and
Its preparation method.
Background technology
Leukaemia, also referred to as leukemia, are the abnormal Clonal malignant diseases of a class candidate stem cell.White blood in its clone
Sick cell loses the different phase for being further differentiated into ripe ability and being stuck in cell development.In marrow and other hematopoietic tissues
The middle a large amount of hyperplasia of leukaemia are gathered and infiltrate other organs and tissue, while making normal hematopoiesis suppressed, clinical manifestation is
Anaemia, bleeding, infection and each organ infiltration's symptom.In recent years, the incidence of disease of leukaemia is in the trend for increasing, according to statistics, China
Increase the people of leukaemia about more than 40,000 newly every year, annual people more than 30,000 dies from leukaemia.
At present, the essential therapeutic arsenals of leukaemia are still chemotherapy, and chemotherapy is in strong a large amount of killing leukaemia
While cell, the normal function of body is also inflicted heavy losses on, the result is that not only having got rid of evils but also having hindered just, show as getting rid of evils and just declining, impairment of both QI and YIN.
The traditional Chinese medical science is studied history without leukaemia name of disease, is attributed to " mass formed by blood stasis " " acute pulmonary tuberculosis " " hot labor " " damp evil " more.It is healthy tendency to trace it to its cause
Deficiency, accumulates in evil poison, impairment of yin blood, damages marrow " stasis of blood is stagnant in marrow " and falls ill.Nowadays right evil poison does not fall ill immediately, but it is deep lie prostrate in
Marrow, accumulation morbidity, through treatment, Healthy energy reises and evil falls, and evil poison is lied prostrate in marrow deeply, is inside accumulate in brain, is dealt with improperly and is caused recurrence, in dialogue
In blood disease Pathologic Study, it was demonstrated that syndrome of blood stasis is the pathologic basis of leukaemia.
Therefore, the present inventor's Chinese medicine composition has：Clearing heat and detoxicating, promoting blood circulation and removing blood stasis, righting of getting rid of evils etc. is acted on, and is clinically used
In treatment leukaemia, with preferable curative effect, and security is good.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating leukaemia.
The present invention also aims to provide a kind of preparation method of the Chinese medicine composition for treating leukaemia.
The scheme that the present invention is solved is inventor, many for the mechanism of leukaemia morbidity under the guidance of traditional Chinese medical theory
Oneself clinical experience is combined over year, is developed meticulously.
The present invention is realized by following scheme, and medicine of the present invention is mainly the bulk drug system matched by following weight parts
Into：
1-10 parts oldenlandia diffusa 10-50 parts of realgar (nanometer) of 1-10 parts of indigo naturalis (nanometer)
Subprostrate sophora 10-50 parts Cordyceps militaris 1-10 parts red sage root 10-80 parts
Felwort 10-50 portions of 10-50 parts of edible tulip 10-50 portions of dandelion
The preferred weight part of the main each raw material of medicine of the present invention matches and is：
2-6 parts oldenlandia diffusa 20-30 parts of realgar (nanometer) of 2-8 parts of indigo naturalis (nanometer)
Subprostrate sophora 20-30 parts Cordyceps militaris 3-7 parts red sage root 30-50 parts
Felwort 20-30 portions of 20-30 parts of edible tulip 20-30 portions of dandelion
The optimum weight part of the main each raw material of medicine of the present invention matches and is：
6 parts of 4 parts of realgar (nanometer), 25 parts of oldenlandia diffusas of indigo naturalis (nanometer)
25 parts of subprostrate sophora, 5 parts of Cordyceps militaris, 40 parts of the red sage root
25 portions of felwort, 25 portions of edible tulip, 25 parts of dandelion
The preparation method of medicine of the present invention, its method and step is as follows：
(1) by the realgar fine grinding of weight described in formula, 30-40 DEG C of drying, nanometer is finely ground, standby；
(2) by the indigo naturalis of weight described in formula, plus 30-90% ethanol is extracted 1-3 times, is recovered under reduced pressure, 60-80
DEG C drying, nanometer is finely ground, standby；
(3) by the Cordyceps militaris of weight described in formula, plus 30-90% ethanol is extracted 1-3 times, is recovered under reduced pressure, 60-
80 DEG C of dryings, it is finely ground, it is standby；
(4) by the oldenlandia diffusa of weight described in formula, subprostrate sophora, the red sage root, felwort, edible tulip, Pu Gong
English adds water to cook secondary, each plus 6-10 times of water measured, each 1-2 hours, and collecting decoction filtration, filtrate is concentrated into relative density
It is the medicinal extract of 1.15~1.20 (80 DEG C), is cooled to room temperature, add above-mentioned fine powder, stir evenly, 30-40 DEG C of forced air drying is ground into
Subdivision, sieving loads capsule, is made 1000, obtains final product.
Specific embodiment
Embodiment 1：A kind of preparation method of Chinese medicine composition for treating leukaemia of the invention, its step is as follows：
6 parts of indigo naturalis, 4 parts of realgar, 25 parts of oldenlandia diffusa, 25 parts of subprostrate sophora, 5 parts of Cordyceps militaris, 40 parts of the red sage root, felwort 25
Part, 25 parts of edible tulip, 25 parts of dandelion.
(1) by the realgar fine grinding of weight described in formula, 30 DEG C of dryings, nanometer is finely ground, standby；
(2) by the indigo naturalis of weight described in formula, plus 40% ethanol is extracted 2 times, is recovered under reduced pressure, 60 DEG C of dryings,
Nanometer is finely ground, standby；
(3) by the Cordyceps militaris of weight described in formula, plus 90% ethanol is extracted 1 time, is recovered under reduced pressure, and 80 DEG C are done
It is dry, it is finely ground, it is standby；
(4) by the oldenlandia diffusa of weight described in formula, subprostrate sophora, the red sage root, felwort, edible tulip, Pu Gong
English adds water to cook secondary, each plus 8 times of water of amount, and 1.5 hours every time, collecting decoction filtration, filtrate was concentrated into relative density and is
The medicinal extract of 1.15~1.20 (80 DEG C), is cooled to room temperature, adds above-mentioned fine powder, stirs evenly, and 30 DEG C of forced air dryings are ground into subdivision,
Sieving, loads capsule, is made 1000, obtains final product.
Embodiment 2：A kind of preparation method of Chinese medicine composition for treating leukaemia of the invention, its step is as follows：
6 parts of indigo naturalis, 4 parts of realgar, 25 parts of oldenlandia diffusa, 25 parts of subprostrate sophora, 5 parts of Cordyceps militaris, 40 parts of the red sage root, felwort 25
Part, 25 parts of edible tulip, 25 parts of dandelion.
(1) by the realgar fine grinding of weight described in formula, 35 DEG C of dryings, nanometer is finely ground, standby；
(2) by the indigo naturalis of weight described in formula, plus 60% ethanol is extracted 3 times, is recovered under reduced pressure, 80 DEG C of dryings,
Nanometer is finely ground, standby；
(3) by the Cordyceps militaris of weight described in formula, plus 55% ethanol is extracted 2 times, is recovered under reduced pressure, and 70 DEG C are done
It is dry, it is finely ground, it is standby；
(4) by the oldenlandia diffusa of weight described in formula, subprostrate sophora, the red sage root, felwort, edible tulip, Pu Gong
English adds water to cook secondary, each plus 10 times of water of amount, and 1 hour every time, collecting decoction filtration, filtrate was concentrated into relative density and is
The medicinal extract of 1.15~1.20 (80 DEG C), is cooled to room temperature, adds above-mentioned fine powder, stirs evenly, and 40 DEG C of forced air dryings are ground into subdivision,
Sieving, loads capsule, is made 1000, obtains final product.
Embodiment 3：A kind of preparation method of Chinese medicine composition for treating leukaemia of the invention, its step is as follows：
6 parts of indigo naturalis, 4 parts of realgar, 25 parts of oldenlandia diffusa, 25 parts of subprostrate sophora, 5 parts of Cordyceps militaris, 40 parts of the red sage root, felwort 25
Part, 25 parts of edible tulip, 25 parts of dandelion.
(1) by the realgar fine grinding of weight described in formula, 40 DEG C of dryings, nanometer is finely ground, standby；
(2) by the indigo naturalis of weight described in formula, plus 90% ethanol is extracted 1 time, is recovered under reduced pressure, 70 DEG C of dryings,
Nanometer is finely ground, standby；
(3) by the Cordyceps militaris of weight described in formula, plus 35% ethanol is extracted 3 times, is recovered under reduced pressure, and 60 DEG C are done
It is dry, it is finely ground, it is standby；
(4) by the oldenlandia diffusa of weight described in formula, subprostrate sophora, the red sage root, felwort, edible tulip, Pu Gong
English adds water to cook secondary, each plus 6 times of water of amount, and 2 hours every time, collecting decoction filtration, filtrate was concentrated into relative density and is
The medicinal extract of 1.15~1.20 (80 DEG C), is cooled to room temperature, adds above-mentioned fine powder, stirs evenly, and 35 DEG C of forced air dryings are ground into subdivision,
Sieving, loads capsule, is made 1000, obtains final product.
Clinical trial
In January, 2006 is in September, 2013 through clinical research：
Acute promyelocytic leukemia：Accept 18 acute promyelocytic leukemia patients, wherein male 11 for medical treatment in the court
Example, women 7, the median age 30 years old takes Chinese medicinal composition capsules agent of the invention, one time 1-3,3 times a day, the course for the treatment of is most
It is long to be no more than 60 days.As a result all patients obtain complete incidence graph (CR), wherein obtaining within 30 days CR 4, account for the 22.2% of sum；31-
CR 14 is obtained within 45 days, the 77.8% of sum is accounted for.Bone marrow suppression is occurred without in the course for the treatment of, without complication such as serious infection, bleedings,
The therapy-related death rate is 0% in the course for the treatment of.
Chronic myelocytic leukemia：The court accepts 7 chronic leukemia patients for medical treatment, is diagnosed as CML accelerated periods/CML-BC, 4
Male, 3 women, the median age 34.3 years old, one day 1-3,3 times a day, take medicine continuously within first month 30 days；Monthly take medicine 15 later
My god, it is discontinued 15 days；By that analogy, it is within 12 months 1 course for the treatment of.Found through excessive course of therapy result：All patients are after the treatment
Occur in that serum IgG concentation declines.6 patients's (85.7%) reach hematologic response, wherein 5 patients's (71.4%)
It is complete hematologic response.Generally there is a period of time after treatment is started in hematologic response, median time is 5 weeks (scopes
It it is 1-11 weeks).In 6 patients that hematologic response occurs, 5 patients continue complete hematologic response, and have 1 patient to exist
There is progression of disease during the June for the treatment of, with the death in the 20th month after treatment.1 patient does not adhere to medication and is starting
Death in 3 months afterwards.Therefore 5 patients obtain persistently hematologic response completely altogether, and follow-up median is 18 months (14-20
Individual month).
Although being above described in detail to the present invention with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. a kind of Chinese medicine composition for treating leukaemia, it is characterised in that described medicine is mainly and is matched by following weight parts
Bulk drug be made：
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the preferred weight part of the main each raw material of described medicine
Proportioning is：
3. the Chinese medicine composition as described in claim 1-2 is any, it is characterised in that the optimal weight of the main each raw material of the medicine
Amount part matches and is：
4. a kind of preparation method of Chinese medicine composition as described in claim 1-3 is any, comprises the steps：
(1) by the realgar fine grinding of weight described in formula, 30-40 DEG C of drying, nanometer is finely ground, standby；
(2) by the indigo naturalis of weight described in formula, plus 30-90% ethanol is extracted 1-3 times, is recovered under reduced pressure, and 60-80 DEG C is done
Dry, nanometer is finely ground, standby；
(3) by the Cordyceps militaris of weight described in formula, plus 30-90% ethanol is extracted 1-3 times, is recovered under reduced pressure, 60-80 DEG C
Dry, it is finely ground, it is standby；
(4) oldenlandia diffusa of weight described in formula, subprostrate sophora, the red sage root, felwort, edible tulip, dandelion are added
Decocting boils secondary, and the 6-10 times of water measured is added every time, each 1-2 hours, and collecting decoction filtration, filtrate is concentrated into relative density and is
The medicinal extract of 1.15~1.20 (80 DEG C), is cooled to room temperature, adds above-mentioned fine powder, stirs evenly, 30-40 DEG C of forced air drying, is ground into thin
Point, sieving loads capsule, is made 1000, obtains final product.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615970A (en) * | 2004-09-15 | 2005-05-18 | 中国人民解放军第210医院 | Chinese medicine preparation compound Huangdai tablet for treating leukemia and its jpreparing method |
| CN101590103A (en) * | 2008-05-27 | 2009-12-02 | 北京因科瑞斯医药科技有限公司 | A kind of leukemic Chinese medicine composition and preparation method thereof that is used for the treatment of |
| CN101590092A (en) * | 2008-05-27 | 2009-12-02 | 北京因科瑞斯医药科技有限公司 | A kind of leukemic Chinese medicine composition and preparation method thereof that is used for the treatment of |
| CN105362340A (en) * | 2015-12-17 | 2016-03-02 | 亿帆鑫富药业股份有限公司 | Medicine composition for treating leukemia and preparation method thereof |
| CN105560947A (en) * | 2014-10-16 | 2016-05-11 | 宋淑芹 | Medicine composition for treating urinary system infection and preparation method thereof |
-
2017
- 2017-03-01 CN CN201710141250.0A patent/CN106728924A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615970A (en) * | 2004-09-15 | 2005-05-18 | 中国人民解放军第210医院 | Chinese medicine preparation compound Huangdai tablet for treating leukemia and its jpreparing method |
| CN101590103A (en) * | 2008-05-27 | 2009-12-02 | 北京因科瑞斯医药科技有限公司 | A kind of leukemic Chinese medicine composition and preparation method thereof that is used for the treatment of |
| CN101590092A (en) * | 2008-05-27 | 2009-12-02 | 北京因科瑞斯医药科技有限公司 | A kind of leukemic Chinese medicine composition and preparation method thereof that is used for the treatment of |
| CN105560947A (en) * | 2014-10-16 | 2016-05-11 | 宋淑芹 | Medicine composition for treating urinary system infection and preparation method thereof |
| CN105362340A (en) * | 2015-12-17 | 2016-03-02 | 亿帆鑫富药业股份有限公司 | Medicine composition for treating leukemia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 于尔辛: "《癌肿研究基础与临床》", 31 December 2006 * |
| 田德禄: "《中医内科学》", 30 November 2005 * |
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Application publication date: 20170531 |
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