CN105477191A - Medicine composition for treating aged coronary heart disease - Google Patents
Medicine composition for treating aged coronary heart disease Download PDFInfo
- Publication number
- CN105477191A CN105477191A CN201610047297.6A CN201610047297A CN105477191A CN 105477191 A CN105477191 A CN 105477191A CN 201610047297 A CN201610047297 A CN 201610047297A CN 105477191 A CN105477191 A CN 105477191A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- pharmaceutical composition
- heart disease
- coronary heart
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medicine composition for treating the aged coronary heart disease and a preparing method of the medicine composition. The medicine composition is prepared from whole grass of diplazium donianum (mett.) tard-blot. [asplemum donianum mett.], roots or leaves of adinandra mellettii, trifolirhizin, roots of grewia lantsangensis hu and loewigite according to a ratio. The medicine composition for treating the aged coronary heart disease can be prepared into various forms according to the conventional preparation technology and has a remarkable treatment effect on the aged coronary heart disease.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of aged coronary heart disease and preparation method thereof.
Background technology
Coronary heart disease is mainly in old people, the key factor being primary disease and falling ill worn with age, Huangdi's Internal Classics is said: except ancient times, it (sage) people can all spend at the age of one hundred years old spring and autumn, and undiminished vigour, Jin time people and ordinary person's mostly becoming decrepit in the fifties, explain and only have only a few people can use up eventually its natural life-span, spend and be at the age of one hundred years oldly, so that time old, various diseases is grown thickly.Along with social development, the material life of people improves constantly, but health education and medical and health conditions are delayed far away comparatively speaking, and therefore old to suffer from various diseases inevitable.Addicted to food delicious food savoury, liquor-saturated in tobacco and wine, be worried angry, internal injury caused by excess of seven emotions, irregularity in daily life, fleshliness impairment caused by overstrain, causes taste impaired, disorder of movement of QI, and internal organs human skeleton is deficient, raw in the various pathological product such as expectorant, the stasis of blood, the first day after tomorrow all damages, positive QI-insufficiency, then adds exopathogen invasion and attack, inside and outside coupling, then severe and lingering illness is vertical sends out.When various internal and external factor has influence on lung, taste, kidney, liver function normally play, the gas that just there will be the whole body loses and reaches in bar, and in body, qi-blood-body fluid is lost and promoted in gasification, cloudy Tianjin is lost in moistening foster defeated cloth, the substantial pathogenic factorizations such as expectorant is turbid, blood stasis are raw, blockage of vessel, and are the thoracic obstruction.Therefore deficiency of both QI and YIN, blood-stasis internal-depression, heart BI-syndrome involved the blood vessels and obstructed be the main pathogenesis of incidence of coronary heart disease.
Prairie fire rope: this product is the root white skin of Tiliaceae load bar platymiscium comospore bilobed grewia GrewiaeriocarpaJuss. ［ G.lantsangensisHu ］.Autumn, winter take root, strip root bark, and removing cork, cutting, dries.[nature and flavor] are puckery; Micro-hardship; Cool.[function cures mainly] stops blooding; Synthetism; Granulation promoting; Removing toxic substances.Main traumatic hemorrhage; Weapons damage; Fracture; Furuncle is red and swollen.[original shape state] comospore bilobed grewia shrub or dungarunga, up to 8m.Twig is by the starlike soft fine hair of taupe.Leaf alternate; Time handle long 5-10mm; Stipule wire lanceolar, long 5-10mm; Blade papery, tiltedly avette to ovum shape Long Circle, long 6-13cm, wide 3-6cm, tip is point or anxious point gradually, base portion deflection, tiltedly circular or bevel shape, above scattered stellate hair, blackening brown after dry, below by the starlike soft fine hair of Lycoperdon polymorphum Vitt, there is serration at edge; Trinervious two lateral veins rise and reach 3/4 of leaf length, and the middle arteries and veins first half has lateral vein 3-4 couple.Cyme 1-3 branch axil is raw, long 1.5-3cm, the long 3-8mm of common peduncle; The long 3-5mm of anthocaulus; Bract lanceolar; Flower both sexes; The long and narrow circle of sepal, long 6-8mm, inside and outside two sides is all without hair; The long 3mm of petal; Body of gland is short and small; Androgynophore is by hair; Stamen is from life, different in size, shorter than sepal; Ovary is by hair, and style has pubescence, stigma peltate, and 4 shallowly split or do not divide.Drupe is subsphaeroidal, diameter 6-8mm, by stellate hair, has shallow ridges.Record in Chinese medicine voluminous dictionary.
Comb leaf: this product is Athyriaceae Diplazium donianum (Mett.) Tard. Blet. platymiscium Diplazium donianum (Mett.) Tard. Blet. Diplaziumdonianum(Mett.) herb of Tard-Blot. ［ AspleniumdonianumMett. ］.The whole year all can gather, and cleans, dries.[nature and flavor] micro-hardship; Cold.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main jaundice due to damp-heat; Venom; Traumatic hemorrhage; Dysmenorrhea.[chemical analysis] is containing makisterone (makisterone) A, B and D.[former phytomorph] plant height 30-60cm.Rhizome is long and grow wild, sturdy, top and petiole base close by black, lanceolar scale, there is little tooth at edge.Ye Jinsheng; The long 15-30cm of petiole, straw color, hard; Blade ground paper matter, without hair, Long Circle or ovum shape Long Circle, long 20-40cm, wide 15-20cm, a pinniform; The raw accessory pinna 2-5 couple in side, alternate, obliquely, has short handle, oval shape lanceolar or ovum shape lanceolar, long 10-16cm, wide 2.5-5cm, top gradually point slightly in shape of tail, the wealthy wedge shape of base portion, full edge or dredge sawtooth to top tool, the raw accessory pinna similar shape of the raw accessory pinna in top and side; Middle veinclearing shows, and has shallow groove above, and justify below and swell, lateral vein pinniform bifurcated, slightly obliquely, often group has scun 3-5 bar, through limb.Sporangiorus is linear, usually twin in the both sides up and down of scun, and often organizing on lateral vein has 1-2 bar, and near, arteries and veins stretches out, and severally reaches limb; Indusium similar shape, film quality.Record in Chinese medicine voluminous dictionary.
Adinandra millettii: this product is Theaceae Adinandra millettii platymiscium Adinandra millettii Adinandramillettii(Hook.etArn.) root of Benth.etHook.f. and tender leaf.Root can be adopted the whole year, dries.Tender leaf summer, Qiu Cai, using fresh herb.[nature and flavor] are bitter; Cool.[return through] lung; Liver Channel.[function cures mainly] cooling blood for hemostasis; Removing toxic substances and promoting subsidence of swelling.Main epistaxis; Hematuria; Infectious hepatitis; Parotitis; Furuncle and phyma; Snake bite and insect sting; Cancerous protuberance.[former phytomorph] Adinandra millettii shrub or dungarunga, height is 5m about.Twig and terminal bud dredge raw pubescence.Single leaf alternate; Leaf tool short handle; Blade heavy leather matter, oval shape is oval, long 4.5-9cm, wide 2-3cm, the short point of tip, and base portion is gradually narrow, the full edge in edge, rare at the first half slightly denticulation, and have intensive pubescence during children, rear change is without hair.Flower both sexes, are singly born in axil; Bennet is very thin, is about 2cm, and have and paste volt undercoat, sepal 5, ovum shape triangle, volt undercoat is pasted in outside, and edge is bordering on film quality, has thin gland tooth and eyelashes; Corolla lobe 5, without hair; About 25 pieces, stamen, the white pubescence of the close life of flower pesticide; Ovary is upper, Room 3, and adularescent pubescence, style is without hair.Berry is subsphaeroidal, diameter 7-8mm, has pubescence or is bordering on without hair.Seed is tiny, black, light.Record in Chinese medicine voluminous dictionary.
Fibroferritum: this product is the Ore of Sulfates mineral fibroferritum Fibrofessite.[nature and flavor] acid; Puckery; Salty; Cold; Poisonous.[return through] liver; Large intestine channel.[function cures mainly] removing toxic substances parasite killing; Sore.Main hemorrhoid complicated by anal fistula; Malignant boil; Scabies; Ting ear comes to a head.[character] this product is many in irregular bulk.Faint yellow.Sub-translucent; Silky lustre or pearly luster.Body is comparatively light, and hardness is bordering on fingernail.Micro-have rust gas, and salty in the mouth, acid are micro-puckery.Yellowish with color, glossy, free from admixture person is good.[chemical analysis] main sulfur acid ferrum (Fe
2o
32SO
310H
2o), wherein sulfur trioxide (SO
3) 32%, iron sesquioxide (Fe
2o
3) 32%, water (H
2o) 36%.[original shape state] monoclinic system.Crystallization person is rare, is often the aggregation of fiber fines shape.Color is yellowish.Gloss is spun silk shape or Margarita shape.Sub-translucent.Hardness 2-2.5.Proportion 1.8-1.9.Record in Chinese medicine voluminous dictionary.
Trifolirhizin (Trifolirhizin): CAS 6807-83-6, molecular formula C
22h
22o
10, molecular weight 446.40.[pharmacological action] has antibacterial action.Comparatively other aglycons are strong for the antitumaous effect of this product, but more weak than its dextrorotation.[ingredient origin] Herba Trifolii Pratentis Trifoliumpratense, Radix Sophorae Tonkinensis Sophorasubprostrata ［ Syn.Sophoratonkinensis ］.
The chemical constitution of trifolirhizin:
Trifolirhizin (Trifolirhizin).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment aged coronary heart disease and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this treatment aged coronary heart disease are:
Comb leaf 1710-1760 weight portion Adinandra millettii 2600-2800 weight portion trifolirhizin 50-70 weight portion prairie fire rope 420-440 weight portion fibroferritum 40-60 weight portion.
Preferably be used for the treatment of the pharmaceutical composition of aged coronary heart disease, be made up of the crude drug of following weight portion:
Comb leaf 1735 weight portion Adinandra millettii 2700 weight portion trifolirhizin 60 weight portion prairie fire rope 430 weight portion fibroferritum 50 weight portion.
Treat a pharmaceutical composition for aged coronary heart disease, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a pharmaceutical composition for aged coronary heart disease, it is characterized in that the treatment aged coronary heart disease medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for the pharmaceutical composition of aged coronary heart disease, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: comb leaf 1710-1760 weight portion Adinandra millettii 2600-2800 weight portion trifolirhizin 50-70 weight portion prairie fire rope 420-440 weight portion fibroferritum 40-60 weight portion;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Preferably treat a preparation method for the pharmaceutical composition of aged coronary heart disease, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: comb leaf 1735 weight portion Adinandra millettii 2700 weight portion trifolirhizin 60 weight portion prairie fire rope 430 weight portion fibroferritum 50 weight portion;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Treat a preparation method for the pharmaceutical composition of aged coronary heart disease, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a preparation method for the pharmaceutical composition of aged coronary heart disease, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treat aged coronary heart disease medicine.
Medicine composite for curing aged coronary heart disease is evident in efficacy, effectively can improve clinical symptoms, tcm symptom total effects, tcm symptom total mark, electrocardiogram situation.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of aged coronary heart disease and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are: comb leaf 1735g Adinandra millettii 2700g trifolirhizin 60g prairie fire rope 430g fibroferritum 50g;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 2: pharmaceutical composition for the treatment of aged coronary heart disease and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are: comb leaf 1710g Adinandra millettii 2800g trifolirhizin 50g prairie fire rope 440g fibroferritum 40g;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 3: pharmaceutical composition for the treatment of aged coronary heart disease and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are: comb leaf 1760g Adinandra millettii 2600g trifolirhizin 70g prairie fire rope 420g fibroferritum 60g;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 117g, adds starch 77g, mixing, granulates, dry, adds microcrystalline Cellulose 17g, magnesium stearate 1.7g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 113g, adds starch 84g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 236g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 26g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 6 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.6cm apart from liquid level, drips speed with per minute 46 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition for the treatment of aged coronary heart disease
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are:
Comb leaf 1409 weight portion prairie fire rope 1348 weight portion fibroferritum 40 weight portion.
Embodiment 8: the pharmaceutical composition for the treatment of aged coronary heart disease
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are:
Trifolirhizin 20 weight portion prairie fire rope 1240 weight portion fibroferritum 60 weight portion.
Embodiment 9: the pharmaceutical composition for the treatment of aged coronary heart disease
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of aged coronary heart disease are:
Trifolirhizin 7 weight portion prairie fire rope 1300 weight portion fibroferritum 45 weight portion.
Experimental example 1: the experimental study for the treatment of aged coronary heart disease
1 clinical data
1.1 physical data
The outpatient service that case source is this city hospital in June, 2011 ~ 2012 year June and inpatient, totally 28 examples, the age is 50 ~ 69 years old, wherein male 14 example, women 14 example, and Syndrome Differentiation of Traditional Chinese Medicine is that deficiency of both QI and YIN is held concurrently the patient of blood stasis.Be divided into treatment group and each 14 examples of matched group, two groups of patients all without remarkable significant difference, have comparability in sex, age, the course of disease, angina pectoris degree, the distribution of the traditional Chinese medical science each individual event symptom, tcm syndrome classification.
1.2 diagnostic criteria
Coronary heart disease all meets WHO diagnostic criteria, all there is anginal clinical symptoms: significantly chest pain is often repressive or constriction, physical work or excitedly to bring out, and diet, cold, smoking can be brought out.ECG change during angina pectoris attacks: ST section forces down 0.1mv; 24h ambulatory electrocardiogram changes: ST section horizontal type or declivity type force down >=0.1mv (after J point 60 ~ 80ms), continue 2 minutes.Without severe cardiac, liver, renal damage.The traditional Chinese medical science (obstruction of qi in the chest and cardialgia) diagnosis and CM syndrome differentiation criterion are chest pain, uncomfortable in chest with reference to " new Chinese medicine guideline of clinical investigations " primary symptom.Secondary disease is stabbing pain over the chest, angor, fixes and does not move, cardiopalmus, dim complexion.Purplish tongue, petechia, ecchymosis, hesitant pulse or knot, stringy and thready pulse.Possess primary symptom one namely diagnosable with time disease more than two, include research case in.
1.3 observation index
Observe treatment group and the difference of matched group patient in clinical symptoms, tcm symptom total effects, tcm symptom total mark, electrocardiogram improvement situation and exercise treadmill test before and after treatment.
1.4 Therapeutic Method
Matched group adopts the western medical treatment method of aspirin tablet+sorbitrate, and the patient of complicated hypertension, diabetes gives and corresponding blood pressure lowering, glucose-lowering treatment.Treatment group adds pharmaceutical composition on the basis of conventional Aspirin, and pharmaceutical composition is embodiment 1 pharmaceutical composition lot number 20100627, each 1g, every day three times.Treating the course for the treatment of is one month.
1.5 curative effect determinate standard
1.5.1 clinical symptoms
Effective: angina pectoris attacks number of times obviously reduces, uncomfortable in chest, chest pain symptom is clearly better;
Take a turn for the better: angina pectoris attacks number of times reduces before comparatively treating to some extent, and uncomfortable in chest, chest pain symptom takes a turn for the better to some extent;
Invalid: angina pectoris attacks number of times and clinical symptoms are without improvement.
1.5.2 tcm symptom total effects evaluation criteria
According to following formulae discovery change in value: syndrome integral * 100% before (before treatment the rear syndrome integral of syndrome integral-treatment)/treatment.Effective: syndrome total mark reduces >=70%; Effective: syndrome total mark reduces 30% ~ 70%; Invalid: syndrome total score reduces < 30%; Increase the weight of: syndrome total mark increases by more than 10%.
1.5.3 tcm symptom total mark
With reference to " new Chinese medicine guideline of clinical investigations " (trial version)
1. chest pain 0 point: without episode.2 points: can alleviate through having a rest during outbreak, do not need, containing changing nitrate esters medicine, not affect daily life.4 points: during outbreak, containing changing nitrate esters medicine, after alleviation, normal activity need do not affected.6 points: outbreak is frequent, affect activity orthobiosis (as wear the clothes, take food, defecate, take a walk and all can bring out), need take medicine during outbreak.
2. 0 point uncomfortable in chest: without uncomfortable in chest.2 points: occasionally have uncomfortable in chest, can spontaneous remission.4 points: outbreak uncomfortable in chest is comparatively frequent, but does not affect routine work and life.6 points: uncomfortable in chest continuing is not understood, and affects routine work and life.
3. 0 point is breathed hard: without breathing hard.1 point: breathe hard after activity.2 points: slightly move and namely breathe hard.3 points: also sense is breathed hard usually.
4. cardiopalmus 0 point: without cardiopalmus.1 point: accidental cardiopalmus, can spontaneous remission.2 points: it is frequent that palpitation of the heart comes on, but can adhere to work.3 points: cardiopalmus continues not understand, and affects live and work.
5. spiritlessness and weakness 0 point: without spiritlessness and weakness.1 point: lassitude, physical work can be adhered to.2 points: metal fatigue, adhere to routine work reluctantly.3 points: spirit is extremely tired, can not adhere to daily routines.
6. vexed insomnia 0 point: without vexed insomnia.1 point: degree is slight, do not affect routine work life.2 points: degree is slightly heavy, work is slightly affected.3 points: degree is comparatively serious, affects Working Life, is difficult to adhere to.
7. spontaneous perspiration 0 point: without spontaneous perspiration.1 point: the micro-tide of motionless then skin, slightly move more very.2 points: motionless then moist skin, slightly sweating while acting.3 points: i.e. sweating usually, sweating while acting is as water stain shape.
8. xerostomia 0 point: without xerostomia.1 point: slightly feel xerostomia.2 points: xerostomia is heavier, do not affect orthobiosis.3 points: xerostomia is serious, affect study orthobiosis.
TCM syndrome grade scale
Slight: TCM syndrome integration≤13 point.Moderate: TCM syndrome integration 14 ~ 26 points.Severe: TCM syndrome integration >=27 point.
1.5.4 ECG curative effect standard
Draft with reference to Angina Pectoris from Coronary Artery Disease with Therapy of Combination of TCM with Western Medicines in 1997 and arrhythmia forum " angina pectoris and ECG curative effect evaluation criteria ".
Effective: electrocardiogram returns to normally;
Effective: ST section reduces, rise >=0.05mv after treatment, but does not reach normal level, and the negative T wave that mainly leads shoals (>=25%) or T ripple becomes upright person from smooth, or chamber or intraventricular block improve;
Invalid: electrocardiogram is substantially identical with before treatment, even increases the weight of.
2 results
Before and after two groups of treatments, clinical symptoms, tcm symptom total effects, tcm symptom total mark, electrocardiogram improve situation and exercise treadmill test change.
Before and after 2.1 liang of group treatments, clinical symptoms improvement situation compares in table 1.
Before and after table 1 liang group treatment, clinical symptoms improvement situation compares (example)
| Group | Number of cases | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 14 | 8 | 5 | 1 | 92.86 |
| Matched group | 14 | 4 | 6 | 4 | 71.43 |
Compare between two groups
*p < 0.05.
Before and after 2.2 liang of group treatments, tcm symptom total effects improvement situation compares in table 2.
Before and after table 2 liang group treatment, tcm symptom total effects improvement situation compares (example)
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 14 | 9 | 4 | 1 | 92.86* |
| Matched group | 14 | 4 | 5 | 5 | 64.29 |
Compare between two groups
*p < 0.05.
2.3 liang of group tcm symptom total marks compare in table 3.
A table 3 liang group tcm symptom total mark compares (x ± s)
| Group | Number of cases | Before treatment | After treatment |
| Treatment group | 14 | 17.47±5.24 | 7.23±5.12 *# |
| Matched group | 14 | 17.52±5.32 | 11.78±6.83 * |
Compare before and after treatment
*p < 0.01, after treatment between two groups
#p < 0.05.
Before and after 2.4 liang of group treatments, electrocardiogram improvement situation compares in table 4.
Before and after table 4 liang group treatment, electrocardiogram improvement situation compares (example)
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 14 | 8 | 4 | 2 | 85.71* |
| Matched group | 14 | 3 | 5 | 6 | 57.14 |
* P < 0.05 is compared between two groups.
Result shows, medicine composite for curing coronary heart disease has good clinical efficacy: effectively can improve clinical symptoms, tcm symptom total effects, tcm symptom total mark, electrocardiogram situation.
Claims (8)
1. treat a pharmaceutical composition for aged coronary heart disease, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Comb leaf 1710-1760 weight portion Adinandra millettii 2600-2800 weight portion trifolirhizin 50-70 weight portion prairie fire rope 420-440 weight portion fibroferritum 40-60 weight portion.
2. a kind of pharmaceutical composition for the treatment of aged coronary heart disease according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Comb leaf 1735 weight portion Adinandra millettii 2700 weight portion trifolirhizin 60 weight portion prairie fire rope 430 weight portion fibroferritum 50 weight portion.
3. a kind of pharmaceutical composition for the treatment of aged coronary heart disease according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. a kind of pharmaceutical composition for the treatment of aged coronary heart disease according to claim 1, is characterized in that the treatment aged coronary heart disease medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for the pharmaceutical composition of aged coronary heart disease, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: comb leaf 1710-1760 weight portion Adinandra millettii 2600-2800 weight portion trifolirhizin 50-70 weight portion prairie fire rope 420-440 weight portion fibroferritum 40-60 weight portion;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
6. a kind of preparation method for the treatment of the pharmaceutical composition of aged coronary heart disease according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: comb leaf 1735 weight portion Adinandra millettii 2700 weight portion trifolirhizin 60 weight portion prairie fire rope 430 weight portion fibroferritum 50 weight portion;
Preparation method:
(1) comb leaf is got by crude drug proportioning, Adinandra millettii, trifolirhizin, prairie fire rope, fibroferritum, mixing, with weight percent concentration 26% ethanol as solvent, extract at 32 DEG C of warm macerating, extraction time is 19 times, each extraction time is 2.5 hours, each solvent load is 34 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution A, extracting solution A reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by D641 macroporous adsorptive resins, first wash with water, use weight percent concentration 48% alcoholic solution eluting D641 macroporous adsorptive resins again, collect weight percent concentration 48% ethanol elution, reclaim ethanol, concentrate drying, obtain extract A,
(2) step (1) medicinal residues A is got, with weight percent concentration 43% ethanol as solvent, heating and refluxing extraction 4 times, each extraction time is 1.5 hours, each solvent load is 17 times of medicinal residues A weight, filter, obtain medicinal residues B and extracting solution B, extracting solution B reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP10 macroporous adsorptive resins, first wash with water, use weight percent concentration 78% alcoholic solution eluting HP10 macroporous adsorptive resins again, collect weight percent concentration 78% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) by extract A and extract B mixing, pharmaceutical composition is obtained.
7. a kind of preparation method for the treatment of the pharmaceutical composition of aged coronary heart disease according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. a kind of preparation method for the treatment of the pharmaceutical composition of aged coronary heart disease according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treats aged coronary heart disease medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610047297.6A CN105477191A (en) | 2016-01-25 | 2016-01-25 | Medicine composition for treating aged coronary heart disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610047297.6A CN105477191A (en) | 2016-01-25 | 2016-01-25 | Medicine composition for treating aged coronary heart disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105477191A true CN105477191A (en) | 2016-04-13 |
Family
ID=55664705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610047297.6A Withdrawn CN105477191A (en) | 2016-01-25 | 2016-01-25 | Medicine composition for treating aged coronary heart disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105477191A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727653A (en) * | 2017-01-09 | 2017-05-31 | 宁夏医科大学 | Trifolirhizin as hypoglycemic medicine and treatment medicine for treating diabetic nephropathy application |
-
2016
- 2016-01-25 CN CN201610047297.6A patent/CN105477191A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727653A (en) * | 2017-01-09 | 2017-05-31 | 宁夏医科大学 | Trifolirhizin as hypoglycemic medicine and treatment medicine for treating diabetic nephropathy application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106038678A (en) | Pharmaceutical composition for treating chloasma and preparation method thereof | |
| CN106668348A (en) | Pharmaceutical composition for treating diabetic retinopathy | |
| CN105477191A (en) | Medicine composition for treating aged coronary heart disease | |
| CN106540003A (en) | A kind of pharmaceutical composition for treating hyperosteogeny | |
| CN104147219B (en) | Chinese medicine composition of a kind of pain relieving relieving fainting and preparation method thereof | |
| CN105582224A (en) | Medicine composition for treating senile coronary heart disease and preparation method of medicine composition | |
| CN106924426A (en) | A kind of antipruritic effervescent tablet of radix rehmanniae recen ceases wind | |
| CN106511628A (en) | Pharmaceutical composition for preventing and treating viral pharyngitis and preparation method thereof | |
| CN106728473A (en) | A kind of pharmaceutical composition for preventing and treating diabetic retinopathy | |
| CN106511545A (en) | Medicinal composition for treating vitreous opacity | |
| CN106728467A (en) | A kind of pharmaceutical composition for preventing and treating climacteric metancholia | |
| CN105250572A (en) | Medicine composite for treating senile constipation and preparation method thereof | |
| CN106038626A (en) | Pharmaceutical composition for preventing and treating cervical cancer and preparation method thereof | |
| CN106692512A (en) | Pharmaceutical composition capable of preventing and treating uterine fibroid | |
| CN106540090A (en) | Prevent and treat pharmaceutical composition of optic atrophy and preparation method thereof | |
| CN105708883A (en) | Pharmaceutical composition for preventing and treating benign prostatic hyperplasia and preparation method of pharmaceutical composition | |
| CN106581222A (en) | Pharmaceutical composition for treating suspension of vitreous body | |
| CN106727851A (en) | Prevent and treat pharmaceutical composition of ovarian cyst and preparation method thereof | |
| CN106581099A (en) | Medicine composition for treating rheumatism | |
| CN106511412A (en) | Pharmaceutical composition for preventing and treating arthritis of knee joint | |
| CN106581102A (en) | Pharmaceutical composition for treatment of uterine myoma | |
| CN106581111A (en) | Pharmaceutical composition for treating thyroid disease | |
| CN106728470A (en) | Pharmaceutical composition of anti-rheumatism treating and preparation method thereof | |
| CN106727783A (en) | A kind of pharmaceutical composition for improving the health care of sleep | |
| CN106728476A (en) | Treat the pharmaceutical composition of diabetic retinopathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160413 |
|
| WW01 | Invention patent application withdrawn after publication |